• Restenosis after coronary angioplasty occurs in at least 30% of patients in the first six months and, as yet, there is no known treatment to decrease this event. (duke.edu)
  • With maintenance of the double-blind state, patients were followed-up for at least 6 months to determine the need for repeat angioplasty or surgical coronary revascularisation and the occurrence of ischaemic events. (duke.edu)
  • Approximate 50% reductions in the rates of target lesion restenosis and target vessel myocardial infarction (MI) accounted for the superior findings with the AGENT DCB over conventional balloon angioplasty. (medscape.com)
  • The Cardiology Research Unit's areas of research involve contributing to multi-centre trials, including trials of new devices for coronary angioplasty, and clinical trials of new drugs for management of heart attacks, cholesterol levels, and arrhythmia. (otago.ac.nz)
  • A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. (hopkinsmedicine.org)
  • Treatment with Bivalirudin (Hirulog) as Compared with Heparin During Coronary Angioplasty for Unstable or Postinfarction Angina. (hopkinsmedicine.org)
  • As a recent review has pointed out, 8 most of the evidence relates to the development of accelerated coronary artery disease during immunosuppression in transplanted human hearts, or to coronary restenosis after balloon angioplasty. (bmj.com)
  • Whereas CMV DNA was detected in 11 of 24 restenoses after angioplasty, none was detected in 11 primary lesions. (bmj.com)
  • Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. (hindawi.com)
  • Hypertensive patients undergoing angioplasty of percutaneous coronary intervention (PCI) are highly predisposed to vascular restenosis [ 1 , 2 ]. (hindawi.com)
  • Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
  • Angioplasty using percutaneous coronary intervention techniques revealed satisfying result compared to conservative medical treatment. (researchandmarkets.com)
  • All consecutive patients with diabetes mellitus in Sweden who underwent percutaneous coronary intervention were entered into the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) during 2003-06 with complete follow-up for 1-4 years (median 2.5). (lu.se)
  • Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty PTCA. (vitalraadet.dk)
  • In 2011, Abbott Laboratories introduced a XIENCE V (XIENCE nano)to minimize the risk of restenosis associated with small-vessel coronary angioplasty. (marketsandmarkets.com)
  • Stents revolutionized the treatment of atherosclerosis in coronary and peripheral arteries, but they did little to address one of the chief problems with balloon angioplasty. (technologyreview.com)
  • 1987) Intravascular Stents to Prevent Occlusion and Restenosis after Transluminal Angioplasty. (scirp.org)
  • 1994) A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease. (scirp.org)
  • Percutaneous coronary interventions (PCI) include percutaneous transluminal coronary angioplasty (PTCA) with or without stent insertion. (msdmanuals.com)
  • Percutaneous coronary intervention (PCI), also known as coronary angioplasty, is a nonsurgical technique for treating obstructive coronary artery disease, including unstable angina, acute myocardial infarction (MI), and multivessel coronary artery disease (CAD). (medscape.com)
  • Example of an intravascular ultrasound (IVUS) image in percutaneous transluminal coronary angioplasty (PTCA). (medscape.com)
  • Pigs were randomized into three groups in which the coronary arteries (15 pigs, 10 coronaries in each group) had either sirolimus-eluting stents with PLA (SEP, n = 10), biolimus A9-eluting stents with PLA (BEP, n = 10), or PLA-coated stents (PCS, n = 10). (e-ceth.org)
  • Durable polymer-based first-generation sirolimus-eluting stents (SES) reduce the risks of in-stent restenosis (ISR) and revascularization compared to bare metal stents (BMS)[ 1 , 2 ]. (e-ceth.org)
  • Therefore, drug eluting stents (DES), such as those using sirolimus and paclitaxel, have increasingly become available and used for the treatment of atherosclerotic coronary artery stenosis lesions. (e-ceth.org)
  • BACKGROUND: Percutaneous coronary intervention (PCI) with drug-eluting stents is the standard of care for treatment of native coronary artery stenoses, but optimum treatment strategies for bare metal stent and drug-eluting stent in-stent restenosis (ISR) have not been established. (ox.ac.uk)
  • INTERPRETATION: These findings suggest that two strategies should be considered for treatment of any type of coronary ISR: PCI with everolimus-eluting stents because of the best angiographic and clinical outcomes, and DCB because of its ability to provide favourable results without adding a new stent layer. (ox.ac.uk)
  • There was statistically significant association (p-value=0.02) between stent length and frequency of In-Stent Restenosis and it was commonest in stents longer than 30 mm. (pafmj.org)
  • Impairment of vasorelaxation in nonstented proximal and distal segments of stented coronary arteries is more severe with drug-eluting stents than bare-metal stents, and stent-induced flow disturbances resulting in complex spatiotemporal shear stress can also contribute to increased thrombogenicity and inflammation. (nature.com)
  • Bare-metal coronary artery stents are used in percutaneous coronary intervention (PCI) for a variety of indications, including stable and unstable angina, acute myocardial infarction (MI), and multiple-vessel disease. (medscape.com)
  • DCBs are also used to treat in-stent restenosis due to scar tissue proliferation inside stents, which can cause a vessel to occlude. (researchandmarkets.com)
  • Stents reduced the restenosis rate slightly, but it was still high. (technologyreview.com)
  • Drug-eluting stents now command more than 90 percent of the $3 billion U.S. coronary-stent market, according to the Millennium Research Group. (technologyreview.com)
  • Unfortunately 1/3 of patients with bare metal stents (BMS) suffer from restenosis of the coronary artery, and about 1-2% of patients with DES suffer from in-stent thrombosis, leading to significant morbidity and mortality. (umass.edu)
  • Future research planned includes determining the molecular basis for fluid flow-induced differences in endothelial cell migration, optimization of streamlined stent design, and pre-clinical studies of streamlined stents in coronary heart disease animal models. (umass.edu)
  • Thus new improvements to balloons and stents are always necessary to achieve the best results from percutaneous coronary intervention (PCI). (scirp.org)
  • Garg, S. and Serruys, P.W. (2010) Coronary Stents: Current Status. (scirp.org)
  • Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinical trial. (umassmed.edu)
  • Stents for coronary arteries are expandable wire mesh cylinders that help hold stenotic areas open. (msdmanuals.com)
  • Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. (researchgate.net)
  • We report on an approach for validation of an in silico 3D model of in-stent restenosis in porcine coronary arteries and illustrate this approach by comparing the modelling results to in vivo data for 14 and 28 days post-stenting. (springer.com)
  • The new updates, aimed at innovating and advancing procedures including percutaneous coronary intervention (PCI) to treat the narrowing of coronary arteries, are being announced at the Transcatheter Cardiovascular Therapeutics (TCT) annual meeting (Orlando, USA, November 4-6). (philips.com)
  • 9 The CMV DNA found in transplanted hearts is localised to the medial and adventitial layers of the coronary arteries and not in the intima. (bmj.com)
  • Today, restenosis in coronary arteries afflicts less than 10 percent of patients thanks to the development of the drug-eluting stent (DES), which slowly releases a drug that inhibits the growth of scar tissue. (technologyreview.com)
  • The percent area of stenosis using micro-computed tomography demonstrated similar restenosis rates with histopathological stenosis between SEP and BEP (36.7±13.77% in SEP vs. 41.2±20.00% in BEP vs. 86.5±10.92% in PCS). (e-ceth.org)
  • Recordings during exercise were obtained with the standard 12-leads plus V(3)R through V(5)R. RESULTS: Out of 172 patients, 106 had stenosis in RCA, 35 in LCX, and 31 in both vessels while 6 months later, restenosis was detected in 8 (for RCA), 3 (for LCX), and 3 (for both vessels) patients respectively. (ox.ac.uk)
  • Local research includes assessment of biomarkers as predictors of coronary stent re-stenosis after implantation. (otago.ac.nz)
  • IVUS-derived negative remodeling is associated with adverse long-term clinical outcome in stable patients with intermediate coronary artery stenosis. (hindawi.com)
  • Risk stratification and management strategy of intermediate coronary lesions, defined as 50-70% diameter stenosis (DS) at coronary angiography [ 1 , 2 ], remain a challenging issue [ 3 , 4 ]. (hindawi.com)
  • ISR was defined as a diameter stenosis of 50% within a coronary stent. (summit-tctap.com)
  • There was 80% stenosis of the proximal left anterior descending (LAD) coronary artery and total occlusion in the middle segment of the LAD. (salesandmarketingnetwork.com)
  • The distal segment of the right coronary artery showed 50% stenosis. (salesandmarketingnetwork.com)
  • Gruntzig, A. (1978) Trans Luminal Dilatation of Coronary-Artery Stenosis. (scirp.org)
  • HYPOTHESIS: The purpose of this study was to evaluate any improvement in the ability of exercise testing in detecting restenosis, using additional V(3)R through V(5)R leads, in asymptomatic patients undergoing percutaneous coronary intervention (PCI) in the right coronary artery (RCA) or/and left circumflex (LCX). (ox.ac.uk)
  • Left Anterior Descending was the commonest coronary artery that developed In-Stent Restenosis, followed by Right Coronary Artery and Left Circumflex respectively. (pafmj.org)
  • Anomalous origin of the right coronary artery: preoperative and postoperative hemodynamics. (nih.gov)
  • Approximately 28%-32% had had a prior coronary artery bypass graft , 20%-22% had previous congestive heart failure , and about 22% had a history of left main coronary artery disease . (medscape.com)
  • To study the frequency of In-Stent Restenosis and its treatment in patients undergoing Percutaneous Coronary Intervention for coronary artery disease. (pafmj.org)
  • All the patients who underwent Percutaneous Coronary Intervention for Coronary Artery Disease at our institute were considered for this study. (pafmj.org)
  • Sixty four percent of the patients (n=32) had Single Vessel Coronary Artery Disease, 14 (28%) had Double Vessel Coronary Artery Disease and 4 (8%) had Tripple Vessel Coronary Artery Disease. (pafmj.org)
  • Polymorphisms--genetic risk factors for coronary heart disease? (nih.gov)
  • Coronary artery disease is one of the most widespread causes of mortality in industrialized countries. (springer.com)
  • IntraSight Mobile brings together imaging and physiology applications on a mobile system for coronary and peripheral artery disease therapy. (philips.com)
  • These observations linking CMV infection to arterial disease have led to speculation that CMV may be implicated in coronary atheroma. (bmj.com)
  • 10 The relevance of links between CMV and post-transplant or postangioplasty lesions to the aetiology of primary coronary artery disease is therefore uncertain. (bmj.com)
  • 11 In a case-control study of angiographically proven coronary heart disease, 90% of cases and 86% of controls were seropositive for CMV, but fewer of the cases than controls had high CMV titres (14% v 21%, respectively). (bmj.com)
  • Accordingly, we sought to investigate the impact of arterial remodeling of intermediate lesions on long-term prognosis in patients with stable coronary artery disease. (hindawi.com)
  • Consecutive patients with stable coronary heart disease who received IVUS examination between January 2011 and January 2014 were retrospectively screened. (hindawi.com)
  • Other clinical scenarios requiring IVUS examination (restenosis, acute coronary syndrome, left main disease, and chronic total occlusion) were excluded. (hindawi.com)
  • The new balloons broadened physicians' treatment options for peripheral artery disease (PAD) patients with a high risk of restenosis and expand the Stellarex portfolio. (researchandmarkets.com)
  • This study aims to assess the prognostic value of Gensini, CHA2DS2-VASc, and CHA2DS2-VASc-HSF scores on ISR in patients who had DES implantation for coronary heart disease (CAD). (summit-tctap.com)
  • Patients with diabetes mellitus have more extensive coronary artery disease, more disease progression, and restenosis. (lu.se)
  • This real-life registry study shows that restenosis was halved by DES in diabetic patients with stable or unstable coronary disease, with similar risk of death or MI up to 4 years compared with BMS. (lu.se)
  • Vitamin E and coronary heart disease: The European paradox. (vitalraadet.dk)
  • The exercise electrocardiogram (ECG) is used in the evaluation of symptomatic patients to predict the presence and extent of coronary artery disease (CAD) [1,2]. (who.int)
  • Coronary heart disease is a major cause of death worldwide, and stenting has become one of the preferred therapies for treatment. (umass.edu)
  • The patient is a 48-year-old male, who was diagnosed with coronary artery disease (CAD), heart failure, type II diabetes, and post-PCI before surgery. (salesandmarketingnetwork.com)
  • These benefits and lower costs compared to surgical treatment make the DES an attractive alternative for the treatment of coronary artery disease. (scirp.org)
  • Shamiri, M. , Al Mobeirek, A. , Albackr, H. and Albacker, T. (2014) Percutaneous Coronary Interventional Treatment for Coronary Artery Disease and the Role of Antiplaplatelets Therapy: A Review of the Literature. (scirp.org)
  • 2007) Optimal Medical Therapy with or without PCI for Stable Coronary Disease. (scirp.org)
  • A Heart Team approach (involving interventional cardiologists and cardiac surgeons) should be used in patients with diabetes and multivessel coronary artery disease and in patients with severe left main disease and a high Syntax score. (medscape.com)
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (medscape.com)
  • everolimus , ridaforolimus, zotarolimus) bonded to the metal that limit neointimal proliferation to reduce the risk of restenosis. (msdmanuals.com)
  • The aim of this study was to compare a sirolimus- and a biolimus A9-eluting stent using the same biodegradable polymer (PLA, poly-L-lactic acid) in a porcine coronary overstretch restenosis model. (e-ceth.org)
  • SEP and BEP showed a superior neointima suppressive effect compared to PCS at one month after stenting in a porcine coronary restenosis model. (e-ceth.org)
  • To evaluate their in vitro biological responses, we conducted experiments involving porcine coronary artery endothelial cells (PCAECs) and smooth muscle cells (PCASMCs). (programmaster.org)
  • Percutaneous coronary interventional strategies for treatment of in-stent restenosis: a network meta-analysis. (ox.ac.uk)
  • The place of rotablator for treatment of in-stent restenosis. (nih.gov)
  • As a rule, percutaneous coronary intervention (PCI) with drug-eluting stent implantation for every intermediate lesion could increase the risk of stent thrombosis or restenosis, whereas deferral revascularization of high-risk intermediate lesions might be associated with a higher risk of long-term events [ 5 , 6 ]. (hindawi.com)
  • In coronary stenting procedures, in-stent restenosis and thrombosis pose ongoing challenges. (programmaster.org)
  • These findings underscore the potential of TMS+NH3/O2 nanocoatings to mitigate both restenosis and thrombosis in coronary stent applications. (programmaster.org)
  • My research explores how blood flow perturbations caused by the stent design contribute to in-stent restenosis and thrombosis, studying the impact of the fluid forces on blood components and endothelial cells. (umass.edu)
  • However, there are important histological differences between these secondary lesions and primary coronary atheroma. (bmj.com)
  • Treatment of coronary intermediate lesions remains a controversy, and the role of arterial remodeling patterns determined by intravascular ultrasound in intermediate lesion is still not well known. (hindawi.com)
  • The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
  • Intravascular ultrasound (IVUS) is superior to coronary angiography in terms of accurate assessment of lumen area and plaque burden and thus is commonly applied to evaluate intermediate stenotic lesions and guide the decision about revascularization in real-world practice [ 4 , 7 ]. (hindawi.com)
  • The number of lesions treated with DES to prevent one restenosis ranged from 11 to 47 in various subgroups. (lu.se)
  • Wolverine (3.5*10mm) cutting balloon was used to dilate the lesions in the left main coronary artery, and Bingo (3.5*20mm) drug balloon was used to expand and release drugs. (salesandmarketingnetwork.com)
  • Uses of balloon catheters or BMS for the treatment of coronary artery lesions shows good short-term results but long-term follow up revealed restenosis in up to 20%-30% of patients. (scirp.org)
  • To understand why, we will compare the function of individual human right atrial and left ventricular cardiac cells (cardiomyocytes) from coronary bypass patients who have diabetes and those who do not. (otago.ac.nz)
  • Lipid peroxidation and changes in vitamin E levels during coronary artery bypass grafting. (vitalraadet.dk)
  • In 2012, Boston Scientific acquired BridgePoint Medical to integrate BridgePoint s first-of-its-kind crossing and re-entry systems for the treatment of coronary chronic total occlusions (CTOs).The drug-eluting stent segment also gainedsignificant attention from leading players inthe North American interventional cardiology and peripheral devices market. (marketsandmarkets.com)
  • However, data regarding the long-term clinical outcomes of IVUS-guided deferral of coronary revascularization are limited. (hindawi.com)
  • Patients who will experience little benefit from coronary revascularization are also excluded. (medscape.com)
  • In August 1994, the FDA approved the second coronary stent, the Palmaz-Schatz stent. (medscape.com)
  • Exercise tolerance tests were performed at two weeks, and six months post-procedure to determine if there was any evidence of restenosis. (usask.ca)
  • In-stent restenosis is clinically challenging and accounts for about 10% of all percutaneous coronary interventions. (medscape.com)
  • 8 Cytomegalovirus seropositivity was not independently related to coronary atherosclerosis in 314 hearts removed at transplantation, although a stronger and statistically significant association emerged in younger subjects. (bmj.com)
  • These results extend the benefit of c7E3 bolus/c7E3 infusion from reducing abrupt closure and acute-phase adverse outcomes to a diminished need for subsequent coronary revascularisation procedures. (duke.edu)
  • Acute coronary syndrome is one of many primary causes of mortality and morbidity in the world. (ijisrt.com)
  • Objective: The objective of this study was to determine whether the incidence of ISR in patients with acute coronary syndrome undergoing percutaneous coronary intervention at Haji Adam Malik General Hospital Medan was correlated with the CHA2DS2-VASc score. (ijisrt.com)
  • CHA2DS2-VASc Score, In-Stent Restenosis, Acute Coronary Syndrome. (ijisrt.com)
  • [ 6 ] Julio C Palmaz, an interventional vascular radiologist, and Richard Schatz, an interventional cardiologist, designed this bare-metal coronary stent, which was manufactured and sold by Cordis. (medscape.com)
  • Neointimal hyperplasia after vascular injury plays a critical role in the process of vascular restenosis, but the mechanism has not been fully elucidated yet [ 3 ]. (hindawi.com)
  • The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. (usask.ca)
  • However, the post-PCI six-month levels of both homocysteine and MDA are predictors of restenosis. (usask.ca)
  • Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months than the rise in homocysteine levels at the same time interval. (usask.ca)
  • Drug-coated balloons (DCB), also referred to as drug-eluting balloons (DEB), were created as a way to reduce very high restenosis rates in peripheral vessels. (researchandmarkets.com)
  • Notable product launches in the North American interventional cardiology and peripheral devices market include Abbott s XIENCE Xpedition Everolimus Eluting Coronary Stent Systemand Covidien s Viance crossing catheter and Enteer Re-entry System. (marketsandmarkets.com)
  • A guiding catheter is inserted into a large peripheral artery and threaded to the appropriate coronary ostium. (msdmanuals.com)
  • In-stent restenosis was positively associated with mean plasma glucose levels as well as oxidative stress and inflammatory markers during the insulin infusion period.Conclusions:In hyperglycemic patients with STEMI, optimal peri-procedural glycemic control by reducing oxidative stress and inflammation may improve the outcome after PCI. (unisa.it)
  • The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine- xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis. (usask.ca)
  • The primary endpoint was target lesion failure at 1 year, a composite of target lesion restenosis, target vessel-related MI, or cardiac death. (medscape.com)
  • History of diabetes mellitus and greater stent length were major risk factors in developing In-Stent Restenosis in our study. (pafmj.org)
  • They also have been investigated in clinical trials to prevent coronary artery in-stent restenosis. (researchandmarkets.com)
  • Interventional therapy has been known to cause complications, which is in-stent restenosis (ISR). (ijisrt.com)
  • [ 5 ] Cesar Gianturco, a radiologist, and Gary Roubin, an interventional cardiologist, designed this bare-metal coronary stent, which was manufactured and sold by Cook Inc. The Gianturco-Roubin stent was a balloon-expandable and coil-type stent manufactured using a flat 316 L stainless steel wire coil attached to a single longitudinal strut. (medscape.com)