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Myocardial InfarctionCoronary OcclusionCoronary VesselsCold IschemiaCoronary CirculationCoronary AngiographyWarm IschemiaIschemiaMyocardial IschemiaAngioplasty, Balloon, CoronaryCoronary DiseaseTime FactorsCoronary Artery DiseaseMyocardial ReperfusionElectrocardiographyCollateral CirculationMyocardiumDogsMyocardial Reperfusion InjuryTreatment OutcomeBrain IschemiaInfarctionCoronary StenosisRisk FactorsCerebral InfarctionCoronary Artery BypassHemodynamicsCoronary ThrombosisIschemic Preconditioning, MyocardialOrgan PreservationProspective StudiesThrombolytic TherapyHeartDelayed Graft FunctionFollow-Up StudiesReperfusion InjuryVentricular Function, LeftCreatine KinaseStentsDisease Models, AnimalRetrospective StudiesVentricular RemodelingTissue DonorsGraft SurvivalCoronary Care UnitsAnterior Wall Myocardial InfarctionNephrectomyDeathMyocardial StunningPercutaneous Coronary InterventionStreptokinasePredictive Value of TestsEchocardiographyKidney TransplantationArterial Occlusive DiseasesArrhythmias, CardiacAngina PectorisMyocardial RevascularizationCoronary VasospasmHeart VentriclesRecurrenceBalloon OcclusionAcute DiseaseLiver TransplantationRisk AssessmentMyocardial ContractionTissue and Organ HarvestingPrognosisCoronary RestenosisAngina, UnstablePlatelet Aggregation InhibitorsFibrinolytic AgentsBlood PressureStroke VolumeCardiac CatheterizationVentricular Dysfunction, LeftTissue and Organ ProcurementCardiotonic AgentsConstrictionCoronary AneurysmBiological MarkersSwineCadaverHeart RatePostoperative ComplicationsVentricular FibrillationLiving DonorsRats, Sprague-DawleyChest PainAdenosineStrokeBlood Flow VelocityLigationAspirinMultivariate AnalysisVasodilator AgentsBiliary TractRats, WistarOrgan Preservation SolutionsTomography, Emission-Computed, Single-Photon
PercutaneousElevationArteriesSTEMIThrombosisNecrosisIschemic strokeSymptomsMinutes after coronary occlusionReperfusionVascularAngiographyStenosisPulmonaryPerfusionAtherosclerosisTransmuralClinicalUnstableMiddle cerebrAtherosclerotic plaquesBypassCardiovascularThrombolytic therapyRestoration of coronary blood flowDecrease myocardialCardiac ischemiaOutcomesCABGRuptureEmbolismChestRevascularizationInfarctSymptomPatients with coronary disease2023Morbidity and mortaArterial occlusionRecurrent ischemiaCardiomyocyteSuggestiveStrokeThromboticVentricularOxygen consumptionArrhythmiasHeartAnginaMortality
Percutaneous15
Elevation21
Arteries11
  • An occlusion of arteries disrupts oxygen and blood supply to tissues, leading to ischemia. (wikipedia.org)
  • Coronary Artery Disease (CAD) results from the stenosis of coronary arteries by an atherosclerotic plaque. (wikipedia.org)
  • The coronary arteries perfuse the cardiomyocytes located within the myocardium. (wikipedia.org)
  • The Promus ELITE Everolimus-Eluting Platinum Chromium Coronary Stent System is indicated for improving luminal diameter in patients, including those with diabetes mellitus, with symptomatic heart disease or documented silent ischemia due to de novo lesions in native coronary arteries ≥2.25 mm to ≤4.00 mm in diameter in lesions ≤34 mm in length. (bostonscientific.com)
  • However, transmural and non-transmural myocardial infarction are estimations of assumed injury to the myocardium, whereas acute coronary syndromes attempt to describe the spectrum of physiologic events occurring in coronary arteries during an acute ischemic event. (biomedcentral.com)
  • Figure 1: Coronary arteries. (lacounty.gov)
  • Overview of Coronary Artery Disease Coronary artery disease (CAD) involves impairment of blood flow through the coronary arteries, most commonly by atheromas. (msdmanuals.com)
  • Just as impurities in the water turn into scales that can block pipelines, coronary arteries can also become blocked due to plaque rupture and thrombus formation. (medicaltrend.org)
  • The purpose of placing a stent is to open the narrowed or occluded blood vessels, restore the blood flow of the coronary arteries, and restore the blood supply to the heart. (medicaltrend.org)
  • With some exceptions due to genetic variation, coronary arteries exhibit unique and diagnostic territorial distributions. (statpearls.com)
  • Coronary angiography showed normal development of the left and right coronary arteries without significant stenosis in the coronary trunk or branches. (biomedcentral.com)
STEMI6
  • We found a significant 18% increase in the risk of STEMI associated with each 7.1 μg/m 3 increase in PM 2.5 concentration in the previous hour prior to acute coronary syndrome onset, with smaller, non-significantly increased risks associated with increased fine particle concentrations in the previous 3, 12, and 24 hours. (biomedcentral.com)
  • Increased fine particle concentrations in the hour prior to acute coronary syndrome onset were associated with an increased risk of STEMI, but not NSTEMI. (biomedcentral.com)
  • Further investigation into mechanisms by which PM can preferentially trigger STEMI over NSTEMI within this rapid time scale is needed. (biomedcentral.com)
  • We conducted our prospective observational study in the Cardiology department from-August 2018 to August 2019 on patients who are presented by STEMI with the duration from onset of symptoms to first medical contact were 12 hours or less we included 199 patients in our study. (researchsquare.com)
  • The preclinical work focuses on animal models of myocardial ischemia-reperfusion injury, which is an experimental model for STEMI, as well as ex-vivo models of myocardial ischemia. (gu.se)
  • STEMI (ACCF/AHA [O'Gara 2013]): Ischemic symptoms within 12 hours of treatment or evidence of ongoing ischemia 12 to 24 hours after symptom onset with a large area of myocardium at risk or hemodynamic instability. (medicine.com)
Thrombosis10
Necrosis7
Ischemic stroke7
  • Without proper prevention or management, these diseases can progress into life-threatening complications of myocardial infarction, gangrene, ischemic stroke, and in severe cases, terminate in brain death or cardiac arrest. (wikipedia.org)
  • Thus, clinical conditions (such as ischemic stroke and myocardial infarction) occur (5). (istanbulmedicaljournal.org)
  • Recent studies have confirmed that the PLR can be used for myocardial infarction, ischemic stroke, pulmonary embolism, and peripheral ischemia (9-11). (istanbulmedicaljournal.org)
  • AF occurs in 6-21% of patients with acute coronary syndrome (ACS), which unfavorably affects their prognosis due to an increased risk of ischemic stroke, as well as in-hospital and long-term mortality [9]. (scardio.ru)
  • Atrial fibrillation (AF) is a major risk factor for ischemic stroke, contributing to an incremental risk of more than five times [ 1 ]. (e-jnc.org)
  • Acute ischemic stroke: Treatment of acute ischemic stroke (AIS) as soon as possible but within 3 hours of symptom onset. (medicine.com)
  • Data from a multicenter, randomized, double-blind, placebo-controlled trial in patients with acute ischemic stroke (AIS) presenting during the time period of 3 to 4.5 hours after symptom onset who were treated with IV alteplase supports the use of alteplase for the treatment of patients presenting during this time period Hacke 2008. (medicine.com)
Symptoms13
  • Depending on the extent of ischemia, symptoms of arterial occlusion range from simple soreness and pain that can be relieved with rest, to a lack of sensation or paralysis that could require amputation. (wikipedia.org)
  • Signs and symptoms of arterial occlusion depend on several factors, including the location, extent, and onset of blockage. (wikipedia.org)
  • Symptoms can be less severe during gradual narrowing, as this allows time for the widening of existing vessels and the formation of new ones (collateral vessels), allowing blood to still reach the area. (wikipedia.org)
  • For severe symptoms, the signs are usually visible and lead to ischemia. (wikipedia.org)
  • Patients who present early and who receive treatment within two hours after onset of symptoms benefit the most (fig 1). (bmj.com)
  • Diagnosis is by symptoms, electrocardiography, and myocardial imaging. (msdmanuals.com)
  • Admit patients who have symptoms or who have concomitant acute myocardial ischemia or myocardial infarction (MI). (medscape.com)
  • Cetirizine was added to the therapy, suspecting coronary ischemia secondary to allergic reaction (Kounis syndrome), without any effect on symptoms. (ceemjournal.org)
  • PCI completely relieved ischemia when measured on stress testing, but this improvement in blood flow did not lead to the large differences in angina symptoms between the two treatment groups that PCI proponents had expected. (medscape.com)
  • Initial symptoms, comorbidities, and localization of cerebral ischemia were recorded. (istanbulmedicaljournal.org)
  • The generally accepted definition of sudden death is a sudden loss of consciousness from a cardiovascular event within an hour of the onset of symptoms. (la12.org)
  • 6 hours from the onset of symptoms, is influenced by additional variables that may shift the balance toward good or bad clinical outcomes. (ajnr.org)
  • Inclusion criteria for thrombolytic therapy were 18 years of age or older, presenting within 6 hours of stroke symptoms onset with initial National Institute of Health Stroke Scale (NIHSS) of 8 or more, except for aphasia and visual field deficit, and normal initial head CT scan. (ajnr.org)
Minutes after coronary occlusion1
  • The pathophysiological basis for using endocardial extent of infarction as a measure of MaR is that previous experimental studies have shown that the endocardial extent of infarction is established approximately 40 minutes after coronary occlusion[ 11 ]. (biomedcentral.com)
Reperfusion18
  • This study demonstrated that the endocardial extent of infarction as assessed by LGE CMR underestimates MaR in comparison to T2-weighted imaging, especially in patients with early reperfusion and aborted myocardial infarction. (biomedcentral.com)
  • Thus, time to reperfusion is thought to limit the transmural infarct progression rather than the endocardial extent of infarction. (biomedcentral.com)
  • At present, this can only be obtained by re-establishing coronary flow, although coronary reperfusion does not necessarily imply myocardial perfusion. (bmj.com)
  • Although rapid restoration of blood flow and reperfusion is the main measure in the treatment of myocardial infarction, myocardial cells that are ischemic for a specific period of time may suffer progressive damage or even death when their blood supply is restored. (nmn-bio.com)
  • Another endogenous form of cardioprotection, similar to PC but applicable at the time of reperfusion, termed postconditioning (PostC), has been recently described. (eurekaselect.com)
  • Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)
  • The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
  • One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
  • The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
  • Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
  • This figure outlines the time course for normoxic (A) and ischemia-reperfusion (B) experiments. (justia.com)
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
  • Ischemia/reperfusion (I/R) injury is a multifactorial process by which cellular damage is initiated in organs during hypoxia, after which cells are then stressed by restoration of oxygen delivery and rebalancing of pH. (beccajcampbell.com)
  • Benefits of reperfusion therapy are time-dependent. (thoracickey.com)
  • As time from symptom onset (artery occlusion) to reperfusion increases, the myocardium available to salvage decreases, which raises the risk of mortality ( 1 , 2 , 3 , 4 and 5 ). (thoracickey.com)
  • So the greatest myocardial salvage and mortality benefit from reperfusion therapy comes within the first few hours of therapy ( Fig. 17-1 ). (thoracickey.com)
  • A number of variables may influence the total time of reperfusion with primary PCI. (thoracickey.com)
Vascular5
  • Avoid vigorous suction during attempts to determine catheter occlusion to prevent damage to the vascular wall or collapse of soft-walled catheters. (pdr.net)
  • 4 On this basis, the need is felt for new therapeutic approaches effective in inhibiting thrombus formation and preventing vascular occlusion with a targeted action at the site of vascular injury and a negligible effect on the systemic physiological hemostasis. (lww.com)
  • The fifth-generation heart stent magnesium alloy soluble heart stent is made of magnesium alloy, which takes into account the solubility of the fourth-generation stent and the supporting capacity of the metal stent, and has potential advantages in restoring coronary vascular motion. (medicaltrend.org)
  • The response of thrombolysis at different vascular occlusion sites may well be related to the thrombus burden. (ajnr.org)
  • In cerebral regions affected by ischemia, intrinsic vascular autoregulation is often lost. (westjem.com)
Angiography5
  • Arterial occlusion is diagnosed by exercise testing, ultrasonic duplex testing, and multi-detector coronary tomography angiography. (wikipedia.org)
  • High-risk coronary angiography was done 2 h later because he had worsening persistent chest pain and started to develop signs of heart failure. (heartviews.org)
  • The coexistence of MI and TS is life-threatening, and it makes acute management more challenging because both diseases might be associated with hemodynamic instability, and acute MI requires immediate coronary angiography (CAG) that needs iodinated contrast media. (heartviews.org)
  • The patient received emergent coronary angiography, which demonstrated no evidence of coronary atherosclerotic disease but did show occlusion of a marginal vessel secondary to a pellet. (westjem.com)
  • Here we describe the case of a 43-year-old man who presented with AMI and chest distress despite the normal appearance of his coronary artery during coronary angiography. (biomedcentral.com)
Stenosis5
  • Chronic myocardial ischemia resulting from progressive coronary artery stenosis leads to hibernating myocardium (HIB), defined as myocardium that adapts to reduced oxygen availability by reducing metabolic activity, thereby preventing irreversible cardiomyocyte injury and infarction. (bvsalud.org)
  • Once the stenosis reaches 80%, the myocardial flow and function are impaired, creating HIB. (bvsalud.org)
  • An ICA was performed, showing a good angiographic result of the recent angioplasty and no other coronary stenosis. (ceemjournal.org)
  • Chen LChester MRRedwood SHuang JLeatham EKaski JC Angiographic stenosis progression and coronary events in patients with "stabilized" unstable angina. (jamanetwork.com)
  • Imbalance between the myocardial oxygen need and the availability of oxygen, and consequently myocardial ischaemia may also be caused, in the absence of an acute coronary stenosis (plaque rupture), by tachycardia and bradycardia, coronary spasm, hypotension, anaemia, respiratory insufficiency or other severe disease. (unboundmedicine.com)
Pulmonary4
Perfusion4
  • Currently, the most widely used method to determine myocardial perfusion defects is myocardial perfusion single photon emission computed tomography (SPECT). (biomedcentral.com)
  • Thus, using myocardial perfusion SPECT for determination of MaR in patients with acute coronary occlusion is a major logistic challenge not possible at many hospitals[ 6 ]. (biomedcentral.com)
  • Myocardial salvage depends on the prompt, complete, and sustained restoration of myocardial perfusion. (bmj.com)
  • These disorders can also decrease relative myocardial perfusion because myocardial mass is increased (causing decreased diastolic flow). (msdmanuals.com)
Atherosclerosis2
  • The death certificate and autopsy report listed "hypertensive cardiovascular disease" as the cause of death with "coronary atherosclerosis" as a contributing factor. (cdc.gov)
  • Cardiovascular disease, including atherosclerosis, myocardial infarction, heart failure and stroke, is the leading cause of morbidity and mortality in developed nations. (frontiersin.org)
Transmural3
  • Thereafter, the infarcted area will increase by transmural progression from the endocardium to the epicardium with increasing duration of ischemia, referred to as the wavefront phenomenon[ 11 ]. (biomedcentral.com)
  • Recently, using hospital admissions data (without symptom onset time data), we reported that myocardial infarction/PM 2.5 associations may be limited to transmural infarctions [ 6 ]. (biomedcentral.com)
  • Left ventricular pseudoaneurysm is an uncommon complication after transmural acute myocardial infarction (AMI). (biomedcentral.com)
Clinical10
  • In the situation of acute coronary occlusion, the myocardium supplied by the occluded vessel is subject to ischemia and is referred to as the myocardium at risk (MaR). Single photon emission computed tomography has previously been used for quantitative assessment of the MaR. It is, however, associated with considerable logistic challenges for employment in clinical routine. (biomedcentral.com)
  • Acute myocardial infarction (AMI) is a frequent clinical condition associated with a high immediate and short term mortality and long term morbidity. (bmj.com)
  • However, unstable angina was not included in this study since symptom onset times were not available, and the diagnosis is typically based on clinical judgment without objective criteria. (biomedcentral.com)
  • Angina pectoris is a clinical syndrome of precordial discomfort or pressure due to transient myocardial ischemia without infarction. (msdmanuals.com)
  • Clinical presentations include silent ischemia, angina pectoris, acute. (msdmanuals.com)
  • The degree of recanalization was directly related to time to therapy and associated with good clinical outcome without an increase in the rate of adverse effect. (ajnr.org)
  • Time to achieving vessel patency has been shown to be crucial in achieving a better clinical outcome ( 2 - 4 ). (ajnr.org)
  • Top-of-carotid occlusion is associated with poor clinical outcome and low rate of recanalization when compared with middle cerebral artery (MCA) occlusion ( 7 , 8 ). (ajnr.org)
  • A prospective, randomized, controlled clinical trial in patients with AIS due to middle cerebral artery occlusion administered intra-arterial alteplase within 6 hours of symptom onset suggested benefit as compared to IV anticoagulation alone Poncyljusz 2007. (medicine.com)
  • Compared with fibrinolytic therapy, primary PCI is able to achieve higher rates of TIMI grade 3 flow and infarct artery patency, and lower rates of reinfarction, recurrent ischemia, intracranial hemorrhage, and death in randomized clinical trials ( 5 ). (thoracickey.com)
Unstable5
Middle cerebr2
Atherosclerotic plaques2
  • Ardissino DMerlini PAAriens RCoppola RBramucci EMannucci PM Tissue-factor antigen and activity in human coronary atherosclerotic plaques. (jamanetwork.com)
  • Approximately 70% of fatal AMI cases are attributed to occlusion caused by atherosclerotic plaques. (statpearls.com)
Bypass4
  • The standard surgical intervention for severe CAD is coronary artery bypass graft surgery (CABG), but it has been shown to be an imperfect therapy, yet no adjunctive therapies exist to recover myocytes adapted to chronic ischemia. (bvsalud.org)
  • OBJECTIVE: This study aimed to investigate whether or not the application of a stem cell-derived exosome-laden collagen patch (EXP) during coronary artery bypass grafting (CABG) can recover cardiac function by modulating mitochondrial bioenergetics and myocardial inflammation in hibernating myocardium (HIB), which is defined as myocardium with reduced blood flow and function that retains viability and variable contractile reserve. (bvsalud.org)
  • We aim to evaluate the association between syntax score and extracellular matrix histological characteristics of aortic punch tissue obtained during coronary artery bypass surgery (CABG). (opencardiovascularmedicinejournal.com)
  • This analysis compares coronary artery bypass surgery patients with High and Low syntax score which were followed up for one year period. (opencardiovascularmedicinejournal.com)
Cardiovascular4
  • At 1 year, EMACCE (Sum of cardiovascular death, stroke, congestive cardiac failure, and limb, gut and myocardial ischemia) was significantly elevated in the High syntax group (P=0.022). (opencardiovascularmedicinejournal.com)
  • In the United States, it is estimated that 200-300 young people die each year from cardiovascular events during physical exercise.1 [http://] While this number is relatively low compared with other causes of death in similar age groups and considering how many athletic events take place annually, several times a year, television media report an athlete's death. (la12.org)
  • As a member of neurotrophins with pro-survival effect on cardiovascular system buy real cytotec NGF was found to be crucial in maintaining normal myocardial performance [16]. (beccajcampbell.com)
  • More cardiovascular events, including myocardial ischemia and/or infarction, were observed in treatment-experienced subjects who received maraviroc. (drugs.com)
Thrombolytic therapy3
Restoration of coronary blood flow1
  • Early and definitive restoration of coronary blood flow (ie, early revascularization) is the most important intervention for achieving an improved survival rate. (medscape.com)
Decrease myocardial1
  • 4] disclose in Cardiovasc Drugs Ther (2007) 21:253-256, that GLP-1 alone did not decrease myocardial infarction but in combination with the GLP-1 breakdown inhibitor valine pyrrolidide (VP) a significant reduction in myocardial infarction occurred. (justia.com)
Cardiac ischemia2
Outcomes2
CABG2
  • An early revascularization strategy with either PCI or CABG, in collaboration between cardiologists and surgeons, is recommended for appropriate patients with suspected cardiogenic shock related to acute coronary syndrome (eg, those with uncertain neurologic status, those who received previous fibrinolysis), regardless of the time delay from MI onset. (medscape.com)
  • Currently, CABG-related MI is defined as (1) biomarker level elevations more than 5 times the upper reference limit plus either new pathological Q waves or new left bundle branch block (LBBB), (2) angiographically documented new graft or native coronary artery occlusion, or (3) imaging evidence of new loss of viable myocardium. (medscape.com)
Rupture3
  • In almost all patients, AMI is caused by an acute thrombotic coronary occlusion following the rupture of the cap of an atherosclerotic plaque. (bmj.com)
  • This is often caused by a sudden rupture of an atherosclerotic plaque and the subsequent thrombus formation, which results in an abrupt reduction, or complete cessation, of blood flow within the coronary artery. (unboundmedicine.com)
  • Left ventricular free wall rupture in myocardial infarction (MI) is often fatal, and only a few patients undergo operation. (biomedcentral.com)
Embolism2
Chest4
Revascularization3
  • This is distinct from myocardial infarction, as HIB has the potential for recovery with revascularization. (bvsalud.org)
  • This regenerative therapy can stimulate myocardial recovery that does not respond to revascularization alone. (bvsalud.org)
  • Cardiogenic shock may be prevented with early revascularization in patients with myocardial infarction (MI) and with required intervention in patients with structural heart disease. (medscape.com)
Infarct2
  • Myocardial infarct size was assessed by triphenyltetrazolium staining. (silverchair.com)
  • Time-independent benefits of opening the artery have also been suggested to exist, and include improving infarct healing, electrical stability, and reducing in reinfarction. (thoracickey.com)
Symptom6
  • The commonest symptom of arterial occlusion is intermittent claudication, which consists of a painful, aching sensation in the affected muscle. (wikipedia.org)
  • Early treatment within 6 hours of symptom onset significantly improves prognosis. (statpearls.com)
  • UA is suggested by angina pain that occurs for the first time and is then experienced with increasing frequency or that is a known symptom of previously diagnosed stable angina which is rapidly worsening (over days - in less than 2 weeks). (unboundmedicine.com)
  • 12 hours from the symptom onset are reconstructed according to the data of scintigraphic studies in patients with acute myocardial infarction. (thoracickey.com)
  • These include prehospital variables (symptom onset to first medical contact, prehospital transport, prehospital notification, EMS-administered therapies) and in-hospital factors (diagnosis time, patient variables, cath lab staffing, and procedural time). (thoracickey.com)
  • Symptom-onset-toballoon time and door-to-balloon time are significantly correlated with mortality following primary PCI ( 6 , 7 and 8 ). (thoracickey.com)
Patients with coronary disease1
20231
  • In 2023, a study published by Nanjing Medical University in 'Stem Cell Reviews and Reports' proved that NMN can improve myocardial infarction and promote angiogenesis. (nmn-bio.com)
Morbidity and morta1
  • Despite current optimal treatment, the morbidity and mortality of coronary heart disease remain significant worldwide and open the way for the development of novel cardioprotective therapies. (eurekaselect.com)
Arterial occlusion2
  • Arterial occlusion is a condition involving partial or complete blockage of blood flow through an artery. (wikipedia.org)
  • The pathophysiology of diseases of arterial occlusion depends on the type of occlusion, the severity of blockage, and the location of the occluded artery. (wikipedia.org)
Recurrent ischemia1
  • In these scenarios, timely and effective platelet and coagulation cascade inhibition is of utmost importance to treat thrombotic events, prevent recurrent ischemia, and improve short-term prognosis. (lww.com)
Cardiomyocyte2
  • The major components of this syndrome include cardiomyocyte death, myocardial stunning, arrhythmias and no-reflow [1]. (justia.com)
  • However, later studies found the role of endogenous NGF in several other pathological processes, including angiogenesis, endothelial cells and cardiomyocyte survival, cardiac repair following myocardial infarction [4, 18, 19]. (beccajcampbell.com)
Suggestive3
  • Computerized QTc is 435 ms. There is abnormal T-wave inversion in leads V2-V5, suggestive of ischemia. (blogspot.com)
  • Is strongly suggestive of left main coronary artery (LMCA) occlusion or severe multi-vessel disease . (litfl.com)
  • Pain suggestive of myocardial infarction is prolonged, persisting for over 20 minutes, and usually has constant intensity. (unboundmedicine.com)
Stroke3
  • Antiplatelet Trialists' Collaboration, Collaborative overview of randomised trials of antiplatelet therapy I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. (jamanetwork.com)
  • Thrombolysis reduces major disability or death when given within 3 hours (or perhaps even 6 hours) of ischaemic stroke onset when there are no contraindications to treatment. (wikimili.com)
  • Uncertainty about time of stroke onset (e.g. patients awakening from sleep). (wikimili.com)
Thrombotic1
  • An urgent invasive coronary angiogram (ICA) was performed, showing a complete thrombotic left main occlusion, which was treated with angioplasty and two drug-eluting stents ( Fig. 1 ). (ceemjournal.org)
Ventricular4
  • Additional autopsy findings included coronary artery disease, cardiomegaly (enlarged heart), and left ventricular hypertrophy (LVH). (cdc.gov)
  • As the myocardium becomes ischemic, coronary sinus blood pH falls, cellular potassium is lost, lactate accumulates, ECG abnormalities appear, and ventricular function (both systolic and diastolic) deteriorates. (msdmanuals.com)
  • However, atropine should be administered with caution in patients with suspected myocardial ischemia, as ventricular dysrhythmias can occur in this situation. (medscape.com)
  • Echocardiography, and cardiac computed tomography showed a ventricular pseudoaneurysm, and direct visualization at the time of surgery showed that it had ruptured in the mediastinum instead of the pericardium. (biomedcentral.com)
Oxygen consumption1
  • Many modifying factors may influence the absolute time periods of salvage ability (collaterals, intermittent occlusion, myocardial oxygen consumption, ischemic preconditioning, persistence of residual blood flow, recruitment of collaterals, hibernating). (thoracickey.com)
Arrhythmias1
  • From understanding basic ECG patterns to unraveling the various arrhythmias, coronary heart disease, and heart attacks, this comprehensive guide will enlighten you on the importance of ECG pattern recognition and differential diagnosis in modern medicine. (ecgedu.com)
Heart21
  • Patients with significant coronary artery disease (CAD) experience chronic ischemia, which puts them at risk for heart failure and sudden death. (bvsalud.org)
  • Conduct exercise stress tests into the fire department medical evaluation program for fire fighters at increased risk for coronary heart disease (CHD). (cdc.gov)
  • The onset of this heart disease, which leads to the death of heart muscle cells, is one of the causes. (nmn-bio.com)
  • Researchers used surgery to induce coronary artery occlusion in rats, causing heart tissue damage and simulating a heart attack. (nmn-bio.com)
  • This patient presented with an atypical presentation of myocardial ischemia complicated by a third-degree AV heart block. (lacounty.gov)
  • Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. (eurekaselect.com)
  • Because myocardial oxygen demand is determined mainly by heart rate, systolic wall tension, and contractility, narrowing of a coronary artery typically results in angina that occurs during exertion and is relieved by rest. (msdmanuals.com)
  • Following the treatment for an occlusion of a coronary artery branch (an artery supplying the heart muscle), a damage to heart muscle occurs. (justia.com)
  • 1999 Update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). (jamanetwork.com)
  • Myocardial infarction (MI), commonly called heart attack, remains a leading cause of mortality and morbidity worldwide, raising an urgent need for novel therapies. (debuglies.com)
  • Coronary heart disease (CHD) is the leading cause of mortality worldwide, and ranks among the top six causes of morbidity. (debuglies.com)
  • and China, with a population of 4-5 times that of the United States, performed 750,000 heart stent operations in 2017. (medicaltrend.org)
  • The consequences may be insufficient blood supply to the heart, myocardial infarction, or even sudden death. (medicaltrend.org)
  • At present, heart stent implantation is still one of the main ways for cardiologists to treat coronary heart disease worldwide. (medicaltrend.org)
  • Upon autopsy, he was found to have 90% occlusion of three heart vessels. (la12.org)
  • Myocardial infarction (MI) causes permanent damage to the heart muscle due to inadequate oxygen supply. (statpearls.com)
  • As a non-invasive diagnostic tool, an ECG records the heart's electrical activity, providing valuable information about heart rate, heart rhythm, and the timing of electrical impulses as they travel through the heart's various chambers. (ecgedu.com)
  • If the myocardial infarction affects the full thickness of the heart muscle then Q waves develop. (ecgedu.com)
  • Although the frequency of acute heart failure due to myocardial ischemia after an acetazolamide challenge may be low, its occurrence in patients with severe arteriosclerotic disease should be routinely considered. (journalmc.org)
  • It worsens heart failure and increases mortality in patients with myocardial infarction, and is an independent risk factor for death. (aafp.org)
  • In an in vivo dog model with left anterior descending coronary occlusion, Abe and his colleagues observed that both exogenous and endogenous NGF may protect the heart from neural stunning [17]. (beccajcampbell.com)
Angina5
Mortality3
  • Pre-hospital initiation of treatment may save one hour in comparison to the in-hospital administration and is associated with a fourfold higher incidence of aborted infarction (17.1% v 4.5%) and an absolute reduction of 2.0% (relative 17%) in hospital mortality. (bmj.com)
  • This study investigated whether continuative use of antidepressants (ADs), considered as a proxy of a state of depression, prior to acute myocardial infarction (AMI) is associated with a higher mortality afterwards. (debuglies.com)
  • In high-income countries, acute myocardial infarction (AMI) is the CHD carrying the highest mortality and morbidity rates [ 1 , 2 , 3 , 4 ]. (debuglies.com)