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  • SCAD
  • Adults with SCAD will be identified both retrospectively and prospectively.Confirmation of the diagnosis by review of coronary angiography will be required before proceeding with the informed consent process and blood or saliva sample procurement. (clinicaltrials.gov)
  • In spontaneous (carotid or coronary) artery dissection (SCAD), the layers separate and blood seeps in between the layers. (clevelandclinic.org)
  • ischemic heart d
  • Although the SYNTAX score was not conceived as a method to predict outcomes related to anatomic characteristics, some reports have demonstrated that it may be an effective tool for predicting the risk of major ischemic events in patients undergoing PCI with stable ischemic heart disease and multivessel or left main disease, Palmerini and colleagues wrote. (medpagetoday.com)
  • Most ruptures and clotting events are too small to produce symptoms, though they still produce heart muscle damage, a slow progressive process resulting in ischemic heart disease, the most common basis for congestive heart failure. (wikipedia.org)
  • severity
  • As judged by exercise performance, the presence of left main disease did not correlate with the severity of the patient's symptomatology. (bmj.com)
  • ischaemic heart d
  • As per the World Health Organization (WHO) June 2011 statistics for the 10 most common causes of death worldwide, ischaemic heart disease tops the list, accounting for 12.8% of deaths or 7.25 million lives worldwide. (bewellbuzz.com)
  • lesions
  • Optical imaging technology from Wasatch Photonics Inc. creates images of coronary artery walls in vivo to show where lesions and plaques have formed. (purdue.edu)
  • chest pain
  • Exercise-induced ischaemia (chest pain and/or greater than 1 mm ST segment change) occurred in 100 per cent of left main, 69 per cent of three-vessel, and 45 per cent of two-vessel disease patients. (bmj.com)
  • SNPs
  • The LDLR gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. (wikipedia.org)
  • GWASs typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major human diseases, but can equally be applied to any other organism. (wikipedia.org)
  • The associated SNPs are then considered to mark a region of the human genome that may influence the risk of disease. (wikipedia.org)
  • GWA studies identify SNPs and other variants in DNA associated with a disease, but they cannot on their own specify which genes are causal. (wikipedia.org)
  • genetic
  • Genome-wide association studies have identified around 60 genetic susceptibility loci for coronary artery disease. (wikipedia.org)
  • not in citation given] However, for common and complex diseases the results of genetic linkage studies proved hard to reproduce. (wikipedia.org)
  • This study type asks if the allele of a genetic variant is found more often than expected in individuals with the phenotype of interest (e.g. with the disease being studied). (wikipedia.org)
  • blood
  • If it grows large enough, it can block the flow of blood through a main coronary artery or a smaller branch artery and trigger a heart attack. (diagnose-me.com)
  • These participants may be people with a disease (cases) and similar people without the disease (controls), or they may be people with different phenotypes for a particular trait, for example blood pressure. (wikipedia.org)
  • participants
  • When applied to human data, GWA studies compare the DNA of participants having varying phenotypes for a particular trait or disease. (wikipedia.org)