AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Coronary AngiographyMyocardial InfarctionCoronary VesselsCoronary Artery DiseaseCoronary CirculationArteriesAngioplasty, Balloon, CoronaryCoronary Artery BypassCoronary StenosisCoronary DiseaseCoronary ThrombosisPulmonary ArteryUltrasonography, InterventionalCoronary VasospasmAngina, UnstableCarotid ArteriesCoronary OcclusionFemoral ArteryPercutaneous Coronary InterventionRupture, SpontaneousRenal ArteryCerebral ArteriesAngioscopyMesenteric ArteriesCoronary AneurysmPlaque, AtheroscleroticTreatment OutcomeStentsRisk FactorsElectrocardiographyBasilar ArteryRadial ArteryProspective StudiesMammary ArteriesCoronary RestenosisTime FactorsNo-Reflow PhenomenonIliac ArteryCalcinosisPredictive Value of TestsVertebral ArteryFollow-Up StudiesAngina, StableTomography, X-Ray ComputedMyocardial IschemiaAngina PectorisVasodilationCarotid Artery DiseasesCarotid Artery, InternalSubclavian ArteryAcute Coronary SyndromeBrachial ArteryHemodynamicsCardiac CatheterizationRisk AssessmentVasodilator AgentsDogsMyocardial RevascularizationCoronary Care UnitsCoronary Artery Bypass, Off-PumpRetrospective StudiesSeverity of Illness IndexThermographyCarotid Artery, CommonEndothelium, VascularSplenic ArteryHepatic ArteryPlatelet Aggregation InhibitorsThoracic ArteriesVascular CalcificationVasoconstrictionMuscle, Smooth, VascularCeliac ArteryRecurrenceMyocardial ReperfusionBlood PressureInferior Wall Myocardial InfarctionOphthalmic ArteryBiological MarkersMyocardiumMesenteric Artery, SuperiorSensitivity and SpecificitySwineEchocardiographyAngiographyRenal Artery ObstructionRuptureUmbilical ArteriesVascular PatencyMiddle Cerebral ArteryChi-Square DistributionUlnar ArteryPrognosisBronchial ArteriesHeartAcute DiseaseNitroglycerinTemporal ArteriesAtherosclerosisPopliteal Artery
Right coronAtherosclerosisDiseasePrimary percutaneous coronary intPlaquesPercutaneous coronary interventionMajor culpritElevationPost-percutaneous coronary intLesion in the leftOutcomesAngiography was performedStenosisAngiographicPatientsRevascularizationEpicardialProximalAngioplastyAcute coronaryCABGAngiogramVesselSpasmPossible culpritThrombosisReperfusionCalcificationCardiacBlockageClinicalCholesterolPrognostic significanceSurgeryMyocardial perfusionBloodLipoproteinHeartMortality
Right coron3
  • The odds of death for left versus right dominance among those with left circumflex or left main culprit lesions was 1.25 (95% CI, 1.02-1.53), for right coronary artery lesions was 1.19 (95% CI, 0.83-1.71), and for left anterior descending artery lesions was 1.09 (95% CI, 0.93-1.28). (duke.edu)
  • The severity of ST segment elevation in acute inferior myocardial infarction: Does it predict the presence of a proximal culprit lesion along the right coronary artery course? (cumhuriyet.edu.tr)
  • The right ventricle (RV) is frequently involved in ST-segment elevation myocardial infarction (STEMI) when the culprit or concurrent chronic total occlusion (CTO) is located in the right coronary artery (RCA). (ru.nl)
Atherosclerosis14
  • The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
  • Large, multicenter randomized trials of various pharmacologic modalities have recently achieved great success in the treatment of patients with coronary artery atherosclerosis. (medscape.com)
  • A recent computer tomography coronary angiography demonstrated normal coronary arteries with no atherosclerosis. (tidsskriftet.no)
  • Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success of interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction and peripheral artery diseases). (karger.com)
  • Cholesterol is the main culprit in the development of atherosclerosis (plaques that form on the inside of blood vessels) thereby, resulting in heart attacks. (home-remedies-for-you.com)
  • It forms plaque, a thick, hard deposit that congest the arteries resulting in atherosclerosis. (home-remedies-for-you.com)
  • How accurate is atherosclerosis imaging by coronary computed tomography angiography? (escholarship.org)
  • Invasive coronary plaque imaging such as intravascular ultrasound and optical coherence tomography has been widely used to observe culprit or non-culprit coronary atherosclerosis, as well as optimize stent sizing, apposition and deployment. (escholarship.org)
  • This review article aims to focus on various evidence in coronary plaque imaging by coronary CTA and describes how accurate coronary CTA can classify coronary atherosclerosis. (escholarship.org)
  • few studies have looked at the relationship between CRP and large artery atherosclerosis- (LAA-) type AIS. (hindawi.com)
  • AIS has different subtypes, and large artery atherosclerosis (LAA) is a key subtype of the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system. (hindawi.com)
  • These results demonstrate the novel information that TRPC1/TRPC3 channels mediate lysoPC-induced Ca 2+ influx and apoptosis via activating the pro-apoptotic proteins Bax and cleaved caspase-3 and inhibiting the anti-apoptotic protein Bcl-2 and the survival kinase pAkt in human coronary artery SMCs, which implies that TRPC1/TRC3 channels may be the therapeutic target of lysoPC-induced disorders such as atherosclerosis. (oncotarget.com)
  • Imaging tests can detect subclinical coronary atherosclerosis and aid initiation of targeted preventative efforts based on patient risk. (bvsalud.org)
  • This condition is known as atherosclerosis or "hardening of the arteries. (medlineplus.gov)
Disease40
Primary percutaneous coronary int3
Plaques6
  • Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients with Acute Coronary and Cerebrovascular Syndromes. (wikipedia.org)
  • It is assessing whether the positron emission tomography (PET) tracer 18F-sodium fluoride is as a marker of coronary plaque vulnerability and can detect culprit and non-culprit unstable coronary plaques in patients with recent myocardial infarction. (ed.ac.uk)
  • 18F-Fluoride positron emission tomography identifies ruptured and high-risk coronary atherosclerotic plaques. (ed.ac.uk)
  • Conclusions: High short-term risk for acute cardiac events in asymptomatic middle-aged male runners is shown by stratification of validated biomarkers, which may render non-obstructive coronary atherosclerotic plaques vulnerable to rupture during marathons. (scirp.org)
  • The EDTA solution is injected into the patient's body and it binds with the calcium plaques that cause blockage of the coronary arteries, hence improving the blood flow. (cordisheartinstitute.com)
  • If you have high levels of LDL particles, cholesterol can build up in your arteries and form blockages called plaques. (medlineplus.gov)
Percutaneous coronary intervention1
Major culprit1
  • Dr. Kaplan says he does not know why obesity leads to sexual and urinary dysfunction, but he hypothesizes that vascular or blood flow changes to the pelvis, along with alterations in hormone levels due to obesity, may be the major culprit. (newswise.com)
Elevation11
  • The goal of the trial was to compare the safety and efficacy of emergent coronary angiography with percutaneous coronary intervention (PCI) if indicated compared with delayed angiography among patients presenting with out-of-hospital cardiac arrest who did not have ST-segment elevation on electrocardiogram (ECG) post-return of spontaneous circulation (ROSC). (acc.org)
  • Coronary Angiography After Cardiac Arrest Without ST Segment Elevation: One-Year Outcomes of the COACT Randomized Clinical Trial. (acc.org)
  • Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation. (acc.org)
  • Due to ST elevation, invasive coronary angiography was performed, revealing a suspected culprit lesion in the left anterior descending artery, treated with percutaneous coronary intervention (PCI). (tidsskriftet.no)
  • We examined the reasons for CCL X , clinical characteristics, and outcomes of patients presenting as ST-segment-elevation myocardial infarction activations who receive emergent coronary angiography (EA) compared with CCL X . (ahajournals.org)
  • Primary PCI is defined as the performance of percutaneous coronary intervention (PCI) (either conventional balloon angioplasty or coronary stent placement) in the setting of ST elevation MI (STEMI) without antecedent treatment with a fibrinolytic agent. (wikidoc.org)
  • The goal of facilitated PCI is to improve coronary patency before the procedure for the treatment of ST elevation myocardial infarction . (wikidoc.org)
  • CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)
  • In this study, we aim to define the role of endothelin in regulating coronary microvascular blood flow and myocardial perfusion following PCI in patients with non-ST elevation acute coronary syndromes (NSTACS), by assessing whether adjunctive therapy with a selective endothelin A (ET A ) receptor antagonist acutely improves postprocedural coronary microvascular blood flow. (bmj.com)
  • This analysis included ACS patients with either ST- or Non-ST-Segment Elevation (STE-ACS or NSTE-ACS) subtype, who had angiographic evidence of coronary occlusion (≥50% narrowing in at least one main coronary artery). (pitt.edu)
  • Identification of Coronary Culprit Lesion in ST Elevation Myocardial Infarction by Using Deep Learning. (cdc.gov)
Post-percutaneous coronary int2
Lesion in the left1
  • We hypothesized that LA function would be further decreased in AMI patients with a culprit lesion in the left circumflex branch (LCX). (bvsalud.org)
Outcomes3
  • However, it remains unknown whether outcomes are better when patients undergo a single procedure to place stents in both culprit and no culprit arteries (immediate) or two procedures days or weeks apart (staged). (consultantlive.com)
  • But a large randomized trial, the COMPLETE trial, including more than 4000 patients with acute heart attack showed that opening up both the culprit artery and the non-culprit artery provided significantly better clinical outcomes than treating the culprit vessel alone. (deepaknatarajan.com)
  • A novel 6-metabolite signature for prediction of clinical outcomes in type 2 diabetic patients undergoing percutaneous coronary intervention. (cdc.gov)
Angiography was performed1
  • In the delayed arm, coronary angiography was performed after neurological recovery, in general after the patient was moved out of the intensive care unit. (acc.org)
Stenosis4
  • Given recent technologies, semi-automated plaque software is available to identify coronary plaque stenosis, volume and characteristics and potentially allows to be used for the assessment of more details of plaque information, progression and future risk as a surrogate tool of the invasive imaging modalities. (escholarship.org)
  • Based on haemodynamic and functional considerations it is less reasonable to identify coronary left main stenosis as a special risk factor for OPCAB surgery. (ecrjournal.com)
  • Multivariable analysis revealed that culprit was associated with age, abnormal angiography per site, and diabetes, but not with troponin or angiographic stenosis severity. (medicom-publishers.com)
  • Multivariable analysis showed abnormal CMR to be associated with higher peak troponin, creatinine, and diastolic blood pressure, but not with OCT culprit lesion or angiographic stenosis severity. (medicom-publishers.com)
Angiographic1
  • Confirmation of these findings with angiographic core laboratory verification of coronary dominance and longer term follow-up will be desirable. (duke.edu)
Patients18
  • Coronary Angiography After Cardiac Arrest - The Right Timing or the Right Patients? (acc.org)
  • All patients will undergo a combined CT coronary angiogram (CTCA) and PET scan using 18F-NaF as a tracer. (ed.ac.uk)
  • Despite several randomized controlled trials (RCTs) comparing complete revascularization (CR) and culprit-only revascularization (COR), the optimal PCI strategy for STEMI patients with MVD remains unsettled. (illinois.edu)
  • Okuya, Y, Gohil, K & Moussa, ID 2022, ' Angiography versus FFR guided complete revascularization versus culprit-only revascularization for patients presenting with STEMI: Network meta-analysis ', Catheterization and Cardiovascular Interventions , vol. 100, no. 3, pp. 340-350. (illinois.edu)
  • Left atrial function assessed by left atrial strain in patients with left circumflex branch culprit acute myocardial infarction. (bvsalud.org)
  • Sixty-eight AMI patients treated with emergent or urgent percutaneous coronary intervention were enrolled. (bvsalud.org)
  • Global LAS strain was lower in AMI patients with a culprit lesion in the LCX than those with culprit lesions in other vessels, without any significant difference in LA volume index. (bvsalud.org)
  • In patients referred for CABG, aspirin should be continued up to the time of surgery, especially in those who present with an acute coronary syndrome. (medscape.com)
  • Patients who will experience little benefit from coronary revascularization are also excluded. (medscape.com)
  • Diagnostic capacity of 64-slice multidetector computed tomography for acute coronary syndrome in patients presenting with acute chest pain. (wustl.edu)
  • In some patients another coronary artery may also be blocked, this is the non-culprit artery. (deepaknatarajan.com)
  • This year another big randomized trial from France that included more than 1100 acute heart patients documented that using FFR for a non-culprit vessel having a 50% to 69% did not provide a clinical advantage over visual appearance during coronary angiography. (deepaknatarajan.com)
  • But in case the non-culprit vessel has a block of 50% to 69% the patients should be assessed for ischemia by FFR after a month of the index procedure. (deepaknatarajan.com)
  • In EXPLORE, STEMI-patients with concurrent CTO were randomized to CTO percutaneous coronary intervention (PCI) or no CTO-PCI. (ru.nl)
  • Data Modeling Using Vital Sign Dynamics for In-hospital Mortality Classification in Patients with Acute Coronary Syndrome. (cdc.gov)
  • Machine Learning Identifies New Predictors on Restenosis Risk after Coronary Artery Stenting in 10,004 Patients with Surveillance Angiography. (cdc.gov)
  • Machine learning for prediction of bleeding in acute myocardial infarction patients after percutaneous coronary intervention. (cdc.gov)
  • Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing. (cdc.gov)
Revascularization3
  • The research, presented at the American College of Cardiology (ACC) 2023 Scientific Sessions in New Orleans, Louisiana, suggested immediate stenting, or percutaneous coronary intervention (PCI), was also associated with a reduction in myocardial infarction and unplanned ischemic-driven revascularization. (consultantlive.com)
  • The blocked artery is referred to as the "culprit lesion" and the other at-risk arteries as "non-culprit lesions", while the placement of stents in both lesions is referred to as completed revascularization. (consultantlive.com)
  • Performance of machine learning-based coronary computed tomography angiography for selecting revascularization candidates. (cdc.gov)
Epicardial3
  • Despite advancements in restoring epicardial artery patency via reperfusion therapy, microvascular obstruction (MVO) limits cardiovascular recovery at the tissue level and results in poorer prognosis, including death. (hhs.gov)
  • We performed subgroup analyses and formally tested for effect modification by the epicardial coronary artery containing the culprit lesion. (duke.edu)
  • Objectives Percutaneous coronary intervention (PCI) for acute coronary syndromes frequently fails to restore myocardial perfusion despite establishing epicardial vessel patency. (bmj.com)
Proximal1
  • His coronary angiogram showed a culprit proximal LAD lesion, as well as other non-stentable lesions in his two other main vessels. (emergucate.com)
Angioplasty3
  • The two methods to achieve this goal are thrombolytic treatment and immediate coronary angiography followed by primary angioplasty if appropriate. (bmj.com)
  • Facilitated PCI is defined as the intent to perform a PCI (either conventional balloon angioplasty or coronary stent placement) in the setting of STEMI following treatment with either a full dose or half dose of a fibrinolytic agent. (wikidoc.org)
  • The blocked artery needs treatment with coronary angioplasty and stenting to restore blood flow to the dying cells in the after heart. (deepaknatarajan.com)
Acute coronary2
  • METHODS AND RESULTS: We related left and codominance, relative to right dominance, with in-hospital mortality in 207 926 percutaneous coronary interventions (PCI) for acute coronary syndromes from July 1, 2009 through June 30, 2010 in the National Cardiovascular Data Registry Cath Percutaneous Coronary Intervention (CathPCI) Registry database version 4. (duke.edu)
  • Following percutaneous coronary intervention (PCI) for acute coronary syndromes, rise in endothelin-1 (ET-1) levels, a potent vasoconstrictor produced by the vascular endothelium, has been proposed as a potential mediator of reperfusion injury and 'no reflow' phenomenon. (bmj.com)
CABG3
  • [ 53 ] The risk for MI was reduced after percutaneous coronary intervention and noncardiac surgical procedures, but not for coronary artery bypass grafting (CABG). (medscape.com)
  • Before coronary artery bypass grafting (CABG), the patient's medical history should be carefully examined for factors that might predispose to complications. (medscape.com)
  • Despite these initial positive results, the European Coronary Surgery Study conducted in the 1970s indicated that the significant improvement in 5-year survival rates with CABG was not apparent in the subsequent 5 years. (medscape.com)
Angiogram1
  • These findings demonstrate that even if the angiogram does not show substantial artery blockage, women with symptoms and blood test findings consistent with a heart attack likely do have a heart attack and not heart inflammation, Prof. Reynolds concluded. (medicom-publishers.com)
Vessel7
  • There was no statistical evidence for effect modification by culprit lesion vessel (P=0.8). (duke.edu)
  • CONCLUSION: We demonstrated the basic feasibility of motion-corrected targeted PET/CT imaging of CXCR4 expression in coronary artery lesions, which was triggered by vessel wall inflammation but also by stent-induced injury. (tum.de)
  • It was believed earlier that the union culprit vessel is best left alone during the index procedure. (deepaknatarajan.com)
  • The decision to stent the non-culprit vessel was taken if it was blocked 70% or more, and if the blockage ranged between 50% to 69% stenting was done when the fractional flow reserve (FFR) was below 0.80. (deepaknatarajan.com)
  • Usage of FFR in the cath lab confirms whether a 50% to 69% block is actually producing schema in the heart muscle being supplied by the non-culprit vessel. (deepaknatarajan.com)
  • Hence currently the take-home message should be that stenting of both the culprit vessel and the non-culprit vessel should be done either in the same hospital setting or within one and a half months of the heart attack if the non-culprit artery is 70% or more blocked regardless of ischemia. (deepaknatarajan.com)
  • An independent reviewer abstracted clinical data on location of the culprit vessel(s) and severity of coronary occlusion reports. (pitt.edu)
Spasm2
  • Coronary artery spasm or thromboembolism likely caused MI/regional ischaemic injury in cases without OCT culprit. (medicom-publishers.com)
  • Mechanisms of MINOCA in women were often similar to mechanisms of MI-CAD: atherothrombosis with possible contribution or coronary artery spasm. (medicom-publishers.com)
Possible culprit1
Thrombosis2
Reperfusion3
  • If there are clinical signs and symptoms of failure of the fibrinolytic agent to achieve reperfusion, then rescue PCI is performed to open the totally occluded artery. (wikidoc.org)
  • If there are clinical signs and symptoms of incomplete reperfusion, then adjunctive PCI is performed to further open a patent artery (one with TIMI grade 2 or 3 flow). (wikidoc.org)
  • This treatment strategy refers to the pre-PCI administration of pharmacologic reperfusion followed by planned diagnostic catheterization and immediate Percutaneous Coronary Intervention. (wikidoc.org)
Calcification1
  • Mice deficient in MGP alone (MGP −/− OPN +/+ ) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 ± 0.01 mmol/g dry weight), and the expression of OPN in the calcified arteries was greatly up-regulated compared with MGP wild-types. (silverchair.com)
Cardiac6
  • The past 4 decades have witnessed tremendous progress in the areas of acute cardiac care, coronary care unit expansion, thrombolytic usage, and PCI. (medscape.com)
  • What Is the Rationale for Utilizing Bilateral Internal Thoracic Arteries in Concomitant Cardiac Operations? (go.jp)
  • Adverse clinical consequences associated with conventional coronary artery bypass surgery (CCAB) have largely been attributed to cardiopulmonary bypass circuit (CPB), hypothermic cardiac arrest, aortic cannulation and cross-clamping. (ecrjournal.com)
  • Post-PCI coronary microvascular blood flow and myocardial perfusion were assessed by measuring Doppler-derived average peak velocity (APV), and cardiac biomarker levels were quantified. (bmj.com)
  • Multi-modality imaging with optical coherence tomography (OCT) and cardiac magnetic resonance (CMR) identified an underlying cause in 84.5% of women with myocardial infarction with non-obstructive coronary arteries (MINOCA), according to findings from the HARP-MINOCA study. (medicom-publishers.com)
  • Coronary OCT and Cardiac MRI to Determine Underlying Causes of Minoca in Women. (medicom-publishers.com)
Blockage1
  • Heart attack - This happens at the terminal stages when there is a complete blockage of the coronary artery. (cordisheartinstitute.com)
Clinical3
  • Incidence and Prognostic Significance of Thrombocytopenia Developed During Acute Coronary Syndrome in Contemporary Clinical Practice. (wustl.edu)
  • This novel methodology may serve as a platform for future diagnostic and therapeutic clinical studies targeting the biology of coronary atherosclerotic plaque. (tum.de)
  • Prediction of 3-year all-cause and cardiovascular cause mortality in a prospective percutaneous coronary intervention registry: Machine learning model outperforms conventional clinical risk scores. (cdc.gov)
Cholesterol4
Prognostic significance1
  • The primary endpoint of the trial is to determine the prognostic significance of coronary 18F-NaF uptake. (ed.ac.uk)
Surgery3
  • These drugs should be continued until the point of surgery because sudden withdrawal of the medications may cause tachycardia, rebound hypertension, and a loss of coronary vasodilatation. (medscape.com)
  • This is a surgery that involves creating a bypassed way around the blocked artery to facilitate the blood flow to the heart. (cordisheartinstitute.com)
  • The open-heart surgery is the traditional form of surgery which is performed in cases where a wide incision needs to be made to gain access to the blocked artery. (cordisheartinstitute.com)
Myocardial perfusion1
  • BACKGROUND: Left or codominant coronary arterial circulation may represent less well-balanced myocardial perfusion and thus confer worse prognosis in acute coronary syndrome, especially for culprit lesions arising from the left coronary artery. (duke.edu)
Blood4
  • 1 Most attention, however, has been focused on treatments that may restore antegrade coronary blood flow in the culprit artery of the patient with evolving acute myocardial infarction. (bmj.com)
  • A few conditions like infection of the lungs, inflammation of the covering layer of the lungs, block in the artery supplying blood to the lungs and high blood pressure in the blood vessels carrying blood to the lungs can cause chest pain. (cardiacwellnessinstitute.com)
  • There are usually 3 coronary arteries supplying blood supply to the heart. (deepaknatarajan.com)
  • Lipoprotein (a) particles are stickier than other types of LDL particles, so they may be more likely to cause blockages and blood clots in your arteries. (medlineplus.gov)
Lipoprotein1
  • Oxidized low-density lipoprotein (ox-LDL) is a well-known culprit of atherogenesis, which causes a series of aberrant initial changes in vascular smooth muscle cells (SMCs) including lipid homeostasis and deposition, dysfunction of Ca 2+ homeostasis, and apoptosis [ 1 , 2 ]. (oncotarget.com)
Heart5
  • In the United Kingdom (UK), coronary heart diseases (CHD) are responsible for a high number of the deaths in the country each year. (worldatlas.com)
  • Almost half of these CVD related deaths are due to coronary heart diseases. (worldatlas.com)
  • According to WHO data from 2014, coronary heart diseases was responsible for 34.04% of total deaths in the country. (worldatlas.com)
  • However, the presence of CT-measured right heart and pulmonary artery dilatation in COVID-19 is likely attributable to this process and may be a possible surrogate for its detection. (researchgate.net)
  • The reason may be that in the setting of an acute heart attack FFR may be underestimating the physiological ramifications of a blocked artery. (deepaknatarajan.com)
Mortality1
  • Left coronary dominance was associated with higher in-hospital mortality in unadjusted (odds ratio=1.29, 95% confidence interval [CI], 1.17-1.42) and adjusted models (1.19, 95% CI, 1.06-1.34). (duke.edu)