Coronary angiography technetium 99m sestamibi. Medical search. Frequent questions

Comparison with technetium-99m sestamibi single-photon emission computed tomography and quantitative coronary angiography. (bvsalud.org)
In nondiabetic patients, a number of factors may be used to stratify the level of risk of coronary disease, including clinical history, resting ventricular function, exercise capacity, the presence and extent of ischemia at single-photon emission-computed tomography (SPECT), or stress echo. (diabetesjournals.org)
Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)

Conclusion: This study compared computed tomography (CT) versus invasive coronary angiography (ICA) for guiding the treatment of patients with stable angina with intermediate probability for coronary artery disease (CAD). (allenpress.com)

Preoperative non-invasive testing aims to provide information primarily about coronary artery disease (myocardial ischemia or reduced blood supply to the heart muscle), left ventricular (LV) dysfunction, and heart valve abnormalities in selected patients. (cadth.ca)
Table Biological and Effective ClearanceRESTSTRESSHeart LiverHeart LiverTimeBiologicalEffectiveBiologicalEffectiveBiologicalEffectiveBiologicalEffective5 min.1.21.219.619.41.51.55.95.830 min.1.11.012.211.51.41.34.54.21 hour1.00.95.65.01.41.22.42.12 hours1.00.82.21.71.21.00.90.74 hours0.80.50.70.41.00.60.30.2A study in dog myocardial ischemia model reported that Technetium Tc 99m Sestamibi undergoes myocardial distribution (redistribution), although more slowly and less completely than thallous chloride Tl-201. (drugcentral.org)

Attenuation is more likely with technetium-99m ( 99m Tc) than with radioactive thallium 201 (Tl-201). (msdmanuals.com)
The usual isotopes for such studies are either thallium-201 or technetium-99m. (wikipedia.org)

In this study, cardiac CT was used to evaluate the prevalence of atherosclerotic lesions and the severity of coronary artery stenosis in patients with TID of the left ventricle with or without associated myocardial perfusion defects on SPECT MPI. (snmjournals.org)
When compared with the TID-negative control cohort, TID-positive patients had no significant differences in the presence and extent of atherosclerosis, the degree of coronary artery stenosis, or the calcium score at cardiac CT. (snmjournals.org)
The presence of TID with an otherwise normal SPECT MPI study does not translate into a greater extent of coronary artery disease as assessed by cardiac CT or increased risk for future major adverse cardiac events. (snmjournals.org)
We investigated the role of technetium-99m (99mTc) sestamibi cardiac imaging and dobutamine echocardiography in detecting myocardial viability early after acute myocardial infarction. (cnr.it)
4 Because of the high prevalence of symptomatic and asymptomatic coronary artery disease (CAD) in this patient population, the clinical assessment aims to identify patients at increased risk of cardiac complications and apply strategies to reduce this risk. (cadth.ca)
Patients with a confirmed acute coronary syndrome should be admitted to a cardiac care unit or high dependency unit with continuous ECG rhythm monitoring. (bmj.com)
Patients who have had ischaemic ECG changes, or cardiac troponin release or raised CK-MB enzyme demonstrated at any time during admission, have a confirmed acute coronary syndrome. (bmj.com)
Those patients with unstable angina or non-Q wave myocardial infarction whose condition has stabilised, but who are at high risk of death or further cardiac events , should be referred for coronary angiography. (bmj.com)
As all underwriters "should" know, coronary heart disease (CHD) is the leading cause of mortality globally, and patients who have chronic forms of CHD experience substantial morbidity, including high rates of recurrent cardiac events and eventual onset of heart failure. (allenpress.com)
If the study is being done for the primary diagnosis of coronary artery disease, then sensitivity will be maximized if certain cardiac medications are withheld ( 2 ), though this should be done only if approved by the referring physician. (snmjournals.org)
By 1963, Dr. William Bruce, aware of the tendency of people with coronary artery disease to experience angina (cardiac chest discomfort) during exercise, developed the first standardized method of "stressing" the heart, where serial measurements of changes in blood pressure, heart rate and electrocardiographic (ECG/EKG) changes could be measured under "stress-stress" conditions. (wikipedia.org)
CLINICAL TRIALS:MYOCARDIAL IMAGING: In trial of rest and stress Technetium Tc 99m Sestamibi imaging, the relationship of normal or abnormal perfusion scans and long term cardiac events was evaluated in 521 patients (511 men, 10 women) with stable chest pain. (drugcentral.org)

A population of 135 patients who had undergone both myocardial technetium-99m-sestamibi rest-stress scintigraphy and coronary angiography within 3 months was studied. (lu.se)

By the late 1980s, two different compounds containing technetium-99m were introduced: teboroxime and sestamibi. (wikipedia.org)

Coronary CT angiography was used to evaluate each coronary segment for the presence and composition of atherosclerotic plaque and the degree of coronary stenosis. (snmjournals.org)

Assessment of the physiologic significance of coronary disease with dipyridamole real-time myocardial contrast echocardiography. (bvsalud.org)

Nineteen patients (mean age 52 ± 10 years) underwent coronary angiography, low-dose dobutamine echocardiography and rest 99mTc sestamibi imaging within 10 days of myocardial infarction. (cnr.it)

Previous studies have suggested that TID in the context of reversible myocardial perfusion defects is associated with increased risk of severe, extensive multivessel coronary artery disease (CAD) ( 1 , 6 , 7 ). (snmjournals.org)
The purpose of the present study was to develop a computer-based method for automatic detection and localization of coronary artery disease in myocardial bull's-eye scintigrams. (lu.se)
The networks were trained to detect coronary artery disease in two vascular territories using coronary angiography as gold standard. (lu.se)
Artificial neural networks can detect coronary artery disease in myocardial bull\u2019s-eye scintigrams with such a high accuracy that the application of neural networks as clinical decision support tools appears to have significant potential. (lu.se)
Approximately 50% of mortality in diabetic patients is related to coronary disease ( 1 ), and diabetes has a significant impact on outcome in patients with established coronary disease ( 2 ). (diabetesjournals.org)
A further strategy would be to screen patients for existing evidence of coronary disease, with the intent of myocardial revascularization in those at greatest risk. (diabetesjournals.org)
However, resting ST segment changes may be false positive responses for epicardial coronary disease ( 5 ), and false positive ST segment changes and poor exercise capacity may reduce the utility of standard exercise electrocardiogram testing. (diabetesjournals.org)
Coronary artery disease (CAD) is a complex disease that causes reduced or absent blood flow in one or more of the arteries that encircle and supply the heart. (medscape.com)
Also, visit eMedicineHealth's patient education articles Chest Pain , Coronary Heart Disease , and Heart Attack . (medscape.com)
This study enrolled 3561 patients (56.2% female) with stable chest pain and an intermediate pretest probability of obstructive coronary artery disease (CAD) who were referred for invasive coronary angiography (ICA) at one of 26 European centers in 16 European countries. (allenpress.com)
Coronary artery disease is thecommonest cause of heart failure, followed by other causes such ashypertension, valvular heart disease and cardiomyopathy. (dokumen.tips)
It evaluates many heart conditions, such as coronary artery disease (CAD), hypertrophic cardiomyopathy and heart wall motion abnormalities. (wikipedia.org)
If one is to evaluate ischemia (reductions in coronary blood flow resulting from coronary artery disease) then individuals must be studied under "stress" conditions and comparisons require "stress-stress" comparisons. (wikipedia.org)
For coronary artery disease, heart valve disease, peripheral vascular disease, and congenital heart defects, our interventional cardiologists have very specialized training that enables them to utilize catheters to clear the path for your blood to flow the way it should. (statesborocardiologyga.com)

Although studies of subcellular fractionation and electron micrographic analysis of heart cell aggregates suggest that Tc 99m Sestamibi cellular retention occurs specifically within the mitochondria as result of electrostatic interactions, the clinical relevance of these findings has not been determined.The mechanism of Tc 99m Sestamibi localization in various types of breast tissue (e.g., benign, inflammatory, malignant, fibrous) has not been established. (drugcentral.org)

The term coronary is derived from crown, referring to the way these arteries sit on the heart. (medscape.com)
See the images below depicting the coronary arteries and CAD. (medscape.com)
Selective injection image of the left coronary arteries. (medscape.com)
Lesions that cause blockages in the coronary arteries may be stable or unstable. (medscape.com)

Stress is induced by either exercise or a pharmaceutical agent (dobutamine, dipyridamole, or adenosine), which increases coronary blood flow to the myocardium. (cadth.ca)

7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
Compared with radionuclide images of blood delivery, MRIs and CT scans improve resolution, depiction of the functional effect and the relationship to the coronary supply, and identification of the area at risk without stress. (medscape.com)
Table illustrates the biological clearance as well as effective clearance (which includes biological clearance and radionuclide decay) of Tc 99m Sestamibi from the heart and liver. (drugcentral.org)

However, sestamibi imaging is useful to identify patients with dysfunctional segments without contractile reserve which may benefit by revascularization. (cnr.it)
Patients with a suspected acute coronary syndrome should be observed, with repeat 12 lead ECG recording, during symptoms if the opportunity arises. (bmj.com)
In patients with documented myocardial infarction, imaging revealed the infarct up to four hours post dose.MetabolismThe agent is excreted without any evidence of metabolism.EliminationThe major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. (drugcentral.org)
All patients had baseline rest and exercise Technetium Tc 99m Sestamibi scan and were followed for 13.2 +- 4.9 months (range: to 24 months). (drugcentral.org)

The ideal imaging time reflects the best compromise between heart count rate and surrounding organ uptake.Myocardial uptake which is coronary flow dependent is 1.2% of the injected dose at rest and 1.5% of the injected dose at exercise. (drugcentral.org)

12.1 Mechanism of Action Technetium Tc 99m Sestamibi is cationic Tc 99m complex which has been found to accumulate in viable myocardial tissue in manner analogous to that of thallous chloride Tl-201. (drugcentral.org)

stress testing for risk assessment is unnecessary if the patient is already in a high risk category for which coronary angiography is indicated. (bmj.com)

There is less than 1% protein binding of technetium Tc 99m Sestamibi in plasma. (drugcentral.org)

D1 = first diagonal, LAD = left anterior descending artery, LCX = left circumflex, LM = left main coronary artery, and OM1= first obtuse marginal. (medscape.com)

To examine the hypothesis that glyceryl trinitrate (GTN) may cause headache in patients with normal coronary arteries more often than in patients with obstructive coronary artery disease (CAD). (bmj.com)
It is often difficult to determine whether chest pain is from obstructive coronary artery disease (CAD) or is of non-cardiac origin. (bmj.com)

Within 7 days after STEMI onset, laboratory tests, two-dimensional ECHO, ECG Holter, gated 99 m Technetium Sestamibi single-photon emission computed tomography (SPECT), and cardiac magnetic resonance imaging (MRI) were performed by experts who were blinded to treatment allocation and clinical information. (medscape.com)
Patients with known or suspected CAD referred for dipyridamole stress technetium-99m sestamibi single-photon emission computed tomographic (SPECT) studies were enrolled. (elsevierpure.com)
In 15 of the 43 patients, coronary angiography was performed within 30 days of the MCE/SPECT tests. (elsevierpure.com)
When false-negative SPECT scans were corrected for results of angiography, concordance increased to 93% (κ = 0.82). (elsevierpure.com)
For territorial analysis, concordance between MCE and SPECT for location of perfusion defects was 65% (κ = 0.41) and 74% (κ = 0.61) after SPECT was corrected by angiography. (elsevierpure.com)
In conclusion, visual assessment of regional differences in MBF velocity using PB127 allows detection of CAD with good concordance compared with technetium-99m sestamibi SPECT. (elsevierpure.com)
BACKGROUND: We measured myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) by a dynamic low-dose CZT-SPECT protocol in patients with suspected or known coronary artery disease (CAD) and investigated the capability of dynamic data in predicting obstructive CAD. (cnr.it)
A total of 173 patients with suspected or known CAD underwent dynamic CZT-SPECT after the injection of 155 MBq and 370 MBq of (99m)Tc-sestamibi for rest and stress imaging, respectively. (cnr.it)
Assessment of Diastolic Function Using 16-Frame 99mTc-Sestamibi Gated Myocardial Perfusion SPECT: Normal Values. (thecardiacsuite.com)
Combined Supine and Prone Quantitative Myocardial Perfusion SPECT: Method Development and Clinical Validation in Patients with no Known Coronary Artery Disease. (thecardiacsuite.com)
Heller GV, Kapetanopoulos A. Use of Adenosine Technetium-99m Sestamibi Gated- SPECT to Differentiate Between Ischemic and Non-ischemic Dilated Cardiomyopathy in a Diabetic Woman. (cardioepemvasis.gr)

Coronary artery bypass grafting (CABG) is the most effective revascularization approach for stenotic coronary arteries. (medscape.com)
During exercise, the magnitude of the increase in blood flow to the non-ischemic myocardial zones is greater than to the zones supplied by stenotic coronary arteries. (wikidoc.org)

Newer technologies such as CT fractional flow reserve, CT angiography with perfusion, and whole-heart coronary magnetic resonance angiography with perfusion, which can provide both anatomic and functional information in the same test, obviate the need for multiple diagnostic tests to obtain a comprehensive assessment of both plaque burden and downstream ischemia. (medscape.com)
Technetium-99m is used as a marker of myocardial perfusion. (wikidoc.org)
Automatic Quantitation of Regional Myocardial Wall Motion and Thickening From Gated Technetium-99m Sestamibi Myocardial Perfusion Single-Photon Emission Computed Tomography. (thecardiacsuite.com)

If one is to evaluate ischemia (reductions in coronary blood flow resulting from coronary artery disease) then individuals must be studied under "stress" conditions and comparisons require "stress-stress" comparisons. (wikipedia.org)
Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease: The ISCHEMIA Trial. (bu.edu)

OBJECTIVE@#To evaluate the effect of Danhong Injection (, DH) on the index of microcirculatory resistance (IMR) and myocardial injury in patients with unstable angina undergoing elective percutaneous coronary intervention (PCI). (bvsalud.org)
Percutaneous coronary intervention (PCI) has become the most frequently performed procedure. (medscape.com)

Patients were also excluded from the study if one of the following adverse events occurred following the G-CSF injection: new acute coronary syndrome requiring urgent surgical revascularization, any other adverse life-threatening clinical event, or withdrawal of patient consent. (medscape.com)
Coronary revascularization is the most important treatment strategy for CAD. (medscape.com)
Multidisciplinary decision-making should analyze current evidence, consider the clinical condition of the patient, and determine the safety of and necessity for coronary revascularization with either PCI or CABG. (medscape.com)
Defining the optimal approach to revascularization in chronic coronary syndrome patients with diabetes and multivessel disease: Is our equipoise evidence-based? (bu.edu)

We hypothesized that assessment of hyperemic myocardial blood flow (MBF) velocity using myocardial contrast echocardiography (MCE) can detect coronary artery disease (CAD). (elsevierpure.com)
Myocardial markers, including myoglobin, creatine kinase (CK), creatine kinase MB (CK-MB), and coronary troponin T (cTnT) values were measured at baseline and 24 h after PCI. (bvsalud.org)

In patients with angina despite pharmacotherapy or who have symptomatic ventricular arrhythmias, invasive coronary angiography is recommended. (medscape.com)

D1 = first diagonal, LAD = left anterior descending artery, LCX = left circumflex, LM = left main coronary artery, and OM1= first obtuse marginal. (medscape.com)

In general, nuclear medicine studies involve the use of a radioactive source, usually technetium ( 99m Tc), which has a short half life (six hours). (bmj.com)

Multi-detector row CT angiography of lower extremity arterial inflow and runoff: initial experience. (rsna.org)
Moving beyond binary grading of coronary arterial stenoses on coronary computed tomographic angiography: insights for the imager and referring clinician. (curehunter.com)

Patient had severe multivessel coronary artery disease, with echocardiogram showing septal dyskinesis and apical akinesis. (basicmedicalkey.com)

My principal research interests include studies in stable ischemic heart disease, post-MI secondary prevention, acute coronary syndromes, and preventive cardiology. (bu.edu)

For example, 99m Tc-methylene diposphonate (MDP) binds to bone while 99m Tc-iminodiacetic acid (IDA) is taken up and excreted by the hepatocytes, and labelled macroaggregates of human serum albumin ( 99m Tc-MAA) are trapped in the terminal pulmonary arterioles due to their relatively large size. (bmj.com)
CT angiography of pulmonary embolism in patients with underlying respiratory disease: impact of multislice CT on image quality and negative predictive values. (rsna.org)

Technetium-99m, a calcium analog with a higher photon energy and a shorter half life than thallium chloride, can be linked to a variety of agents. (wikidoc.org)

The technique of radionuclide bone scintigraphy is performed by the intravenous injection of 99m Tc-MDP, which is taken up by actively remodelling bone. (bmj.com)

It evaluates many heart conditions, such as coronary artery disease (CAD), hypertrophic cardiomyopathy and heart wall motion abnormalities. (wikipedia.org)

Patients were excluded from the study if they had a history of chronic headache, long term nitrates use, or any coronary artery procedures. (bmj.com)

GTN is highly effective in coronary vasodilatation and in relieving angina in patients with obstructive CAD. (bmj.com)
By 1963, Dr. William Bruce, aware of the tendency of people with coronary artery disease to experience angina (cardiac chest discomfort) during exercise, developed the first standardized method of "stressing" the heart, where serial measurements of changes in blood pressure, heart rate and electrocardiographic (ECG/EKG) changes could be measured under "stress-stress" conditions. (wikipedia.org)

Technetium-99m-sestamibi is an isonitrile compound that, like thallium, is taken up by the myocardium proportional to blood flow but in contrast to thallium does not undergo redistribution. (wikidoc.org)

Compared with radionuclide images of blood delivery, MRIs and CT scans improve resolution, depiction of the functional effect and the relationship to the coronary supply, and identification of the area at risk without stress. (medscape.com)

Coronary angiography was performed within one month of GTN administration with the usual clinical indications such as recurrent chest pain, abnormal ECG, or abnormal results of stress tests. (bmj.com)

Patients with a normal thallium scan are at low risk for CAD and subsequent coronary angiography is indicated only if the patient has a high probabilty Duke treadmill score . (wikidoc.org)

Anatomy16

Organisms2

Diseases50

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment94

Phenomena and Processes19

Disciplines and Occupations1

Information Science8

Health Care31

Single-photon emi3

Tomography1

Myocardial ischemia2

Thallium-2012

Cardiac12

Scintigraphy1

Teboroxime1

Stenosis1

Significance of coronary1

Echocardiography1

Disease14

Localization1

Arteries4

Dipyridamole1

Radionuclide3

Patients4

Heart1

Viable1

Stress1

Plasma1

Left1

Obstructive coronary artery2

SPECT11

Stenotic coronary arteries2

Perfusion3

Ischemia2

Percutaneous2

Revascularization4

Myocardial2

Arrhythmias1

Circumflex1

Radioactive1

Arterial2

Multivessel1

Acute1

Pulmonary2

Calcium1

Injection1

Wall motion1

Chronic1

Angina2

Myocardium1

Functional1

Results1

Patient1