Corneal transplantation immunology. Medical search. Frequent questions

Dr. Tauber has been a principal investigator in over 150 research studies of high-risk corneal transplantation, inflammation and allergic eye diseases, corneal infectious diseases, and numerous studies related to dry eye syndrome. (rocklandreviewnews.com)
Objective To observe the effects of Foxp3 gene-transfected Teff lymphocytes against the high-risk corneal transplantation rejection. (sdu.edu.cn)
To the high-risk corneal transplantation mice, the Foxp3 gene-transfected Teff lymphocytes could moderately extend the survival time of the grafts (19.71±4.19d) while the survival time of the corneal grafts in the Treg group was 19.28±4.46d ( P >0.05). (sdu.edu.cn)
Allograft rejection after high risk corneal transplantation with Foxp3 Gene-transferred effective T cells[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(1): 44-48. (sdu.edu.cn)

citation needed] Medically, a cornea transplant takes advantage of this, as does knee meniscal transplantation. (wikipedia.org)
The Research Foundation supports long term collaboration between the ocular inflammation/cornea service of the Royal Victoria Eye & Ear Hospital, the National Institute for Cellular Biotechnology (NICB) at Dublin City University, the Department of Immunology at the Royal College of Surgeons Ireland and the Department of Rheumatology at St Vincent's University Hospital. (acuityfoundationireland.ie)
It is characterised by repeated episodes of inflammation in the cornea, the clear window at the front of the eye, which leads to corneal scarring and, in many cases, loss of vision. (acuityfoundationireland.ie)
Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)
We are planning studies in people to find out whether infectious virus persists in the cornea or other compartments of the eye, because that would have implications for corneal transplantation," said Rajendra S. Apte, MD, PhD, the Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Science, and the study's other senior author. (sciencedaily.com)
She was the founding director of the Pediatric Cornea service at the Boston Children's Hospital and has recently published the first book devoted to pediatric corneal disease. (sicsso.org)
Dr. Hannush's areas of interest are full and partial thickness corneal transplantation (endothelial and deep anterior lamellar keratoplasty), permanent keratoprosthesis surgery (artificial cornea), complex cataract and anterior segment reconstructive procedures, and laser vision correction. (sicsso.org)
Jesper Hjortdal has since 2009 been Medical Director of the Danish Cornea Bank which annually distributes 600 donor corneas to the Danish corneal transplant centers. (oftalmolog.com)
Cornea transplantation is at high risk of rejection when there is pre-existing vascularization of the cornea and in pediatric patients. (stanford.edu)
We are also developing intraocular electronic display prostheses for bypassing cornea opacity, a novel strategy that could allow for high quality vision without corneal clarity. (stanford.edu)
Gospodarowicz DGreenburg GAlvarado J Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: clinical implications for human studies. (jamanetwork.com)

This collaboration brings together clinical and scientific skills from a range of disciplines that are helping to improve our understanding of a number of inflammatory eye conditions and corneal diseases. (acuityfoundationireland.ie)
In the future, our goal is to translate new insights in basic immunology into diagnostic tools and treatment strategies for kidney disease, transplant loss and other immune-mediated diseases. (universityofgalway.ie)
Brightstar Therapeutics, a biotechnology company focused on providing innovative treatment options for corneal and ocular surface diseases, announced the closing of its Series A financing. (rocklandreviewnews.com)
With the addition of these experienced ophthalmologists, Brightstar Therapeutics is poised to accomplish its mission of improving clinical outcomes and quality of life for those living with corneal and ocular surface diseases. (rocklandreviewnews.com)
He is a graduate of Harvard Medical School with dual fellowship training in the treatment and surgery of corneal diseases and ocular immunology. (rocklandreviewnews.com)
He currently leads an NIH-funded laboratory at the University of Minnesota that focuses on innovations in donor corneal tissue processing and tissue cellular therapies for treatment of ocular surface diseases. (rocklandreviewnews.com)
Dr. Joseph Tauber, M.D., specializes in anterior segment surgery, corneal transplantation, the treatment of corneal and external diseases and laser vision correction procedures. (taubereye.com)
Dr. Schechter specializes in refractive cataract surgery, corneal transplantation, ocular surface diseases and glaucoma at Florida Eye Microsurgical Institute. (fleyedocs.com)
What started as a small study group interested in corneal diseases and corneal transplantation has now become an organized study group engaged in basic ophthalmologic research and involved in national eye health programs. (paojournal.com)
It is assigned upon invitation to two colleagues who distinguished themselves in the study of corneal and ocular surface diseases. (sicsso.org)
His research focuses on the modulation of immune system for the treatment of immune-based diseases with particular focus on type 1 diabetes, transplantation (cell, tissue, and solid organs), and cancer immunoprevention and immunotherapy. (lidsen.com)
Experimental immunology of the eye: targeting of microglial cells to treat ocular diseases (Prof. Dr. T. Langmann, see more information on the web-page). (uk-koeln.de)
These projects have been in a variety of Therapeutic Areas including Oncology, Infectious Diseases, Inflammatory Diseases, Immunology, Cardiology and Respiratory Diseases among others. (europital.com)
Naumann GOH Corneal transplantation in anterior segment diseases. (jamanetwork.com)
Dysfunctional inflammatory reactions are not only involved in a number of common eye diseases, such as dry eye, allergic conjunctivitis, or age-related macula degeneration, but also with various others, such as graft-versus-host-disease and immune reactions after corneal transplantation, uveitis, and tumor growth in the eye. (for2240.de)
What role could regenerative medicine have in the treatment of corneal diseases? (medscape.com)

Our laboratory is developing multiple strategies for treatment of corneal blindness. (stanford.edu)

The rejection following keratoplasty still is a leading cause of corneal transplantation failure.Studies showed that the interleukin-22 (IL-22), one of the effector molecules of T helper cell 17 (Th17) participated on the rejection after heart, liver and bone marrow transplantation.However, the effect of IL-22 on corneal graft rejection is not well understood. (cjeo-journal.org)
De Molfetta VBrambilla MDe Casa NArpa PRiva M Residual corneal astigmatism after perforating keratoplasty. (jamanetwork.com)

Her research interests include corneal transplantation, ocular inflammation, ocular immunology and eye banking. (edu.au)
Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)
Podoplanin neutralization resulted in inhibition of lymphatic growth associated with corneal and ear wound healing as well as mps inflammation. (elsevierpure.com)
Pseudomonas aeruginosa-Derived Extracellular Vesicles Modulate Corneal Inflammation: Role in Microbial Keratitis? (elsevierpure.com)

I developed specific interest in the immune-modulating properties of Vitamin D, the molecular basis for chronic kidney transplant rejection, complications of organ transplantation and the involvement of cells from the immune system in kidney disease. (universityofgalway.ie)
Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)

At the time of transplantation, we seek information on the recipient, the donor and the operative procedure. (edu.au)
5. Techniques and approaches being developed to improve transplant outcome and increase the supply of donor organs, such as manipulation of haematopoietic stem cell grafts for clinical use and reconditioning donor organs for transplantation. (ncl.ac.uk)
This gene based approach to the protection of corneal endothelium from oxidative stress may have application in prevention of EC loss in pathological conditions in which H 2 O 2 is involved and in ex vivo donor corneal storage before transplantation. (bmj.com)
After PK, endophthalmitis may arise owing to intraoperative contamination, contamination of the donor corneal button, or postoperative invasion by microorganisms. (aao.org)

and mesenchymal corneal endothelium. (lecturio.com)
Jumblatt MMMaurice DMMcCulley JP Transplantation of tissue-cultured corneal endothelium. (jamanetwork.com)

He earned his Doctor of Medicine degree from Wayne State University in Detroit, Michigan, and completed his Ophthalmology Residency at George Washington University in Washington, D.C. He then went on to fellowship training in Corneal and Refractive Surgery at Emory University in Atlanta, Georgia. (sicsso.org)
For the past twenty-five years Dr. Hannush has been chosen to teach at the American Academy of Ophthalmology, the American Society of Cataract and Refractive Surgery, the European Society of Corneal and Ocular Surface Surgeons, and the European Society or Cataract and Refractive Surgeons annual meetings on the subjects of corneal transplantation, keratoprosthesis surgery, intraocular lens management and laser vision correction involving top national and international experts in these fields. (sicsso.org)

This study was to investigate the expression of IL-22 mRNA in the corneal grafts and the role of IL-22 in the immune rejection after corneal transplantation in rats. (cjeo-journal.org)
In that time, we have collected data on over 14,000 corneal grafts. (edu.au)
Over the years, we have collected data on more than 18,500 corneal grafts. (edu.au)
The majority of corneal grafts registered have been penetrating, but increasing numbers of lamellar and limbal grafts have also been registered over recent years, as patterns of surgical practice change. (edu.au)

I specialise in treating patients with cataract, refractive errors (short-sightedness, long-sightedness, astigmatism, need for reading glasses), keratoconus and corneal dystrophies, such as Fuchs endothelial dystrophy. (spirehealthcare.com)

3. Transplant therapeutic effect: haematopoietic stem cell transplant for leukaemia, lymphoma, and primary immunodeficiency, islet transplant and beta-cell replacement for type1 diabetes, corneal/limbal stem cell transplant for damaged tissue repair and identification of biomarkers of tolerance and rejection. (ncl.ac.uk)
The investment will fund the launch of its revolutionary approach to treating persistent epithelial defects and limbal stem cell deficiency with its advanced corneal allograft, BrightMEM TM . (rocklandreviewnews.com)
He is an internationally recognized leader in ocular surface disease and limbal stem cell deficiency, as well as one of the highest volume surgeons in the nation for limbal allograft transplantation. (rocklandreviewnews.com)

Some other factor may be at play," said Diamond, who is also a professor of molecular microbiology, and of pathology and immunology. (sciencedaily.com)
The first building near the Department housed the support laboratories-Experimental Ophthalmic Pathology, Experimental Ophthalmic Surgery including the Animal House, Ocular Microbiology and Immunology, Biochemistry, Ophthalmic Photography, and Administration. (paojournal.com)
Haval Shirwan is Professor of Child Health and Molecular Microbiology and Immunology at the University of Missouri, Columbia, MO, USA. (lidsen.com)

To examine the effect of catalase gene transfer on survival of corneal endothelial cells (EC) following challenge with hydrogen peroxide (H 2 O 2 ) in an ex vivo model of oxidative stress. (bmj.com)

The allograft encourages durable regeneration of the corneal epithelium, while providing protection for the underlying stromal tissue. (rocklandreviewnews.com)

1. Transplantation immunology: allo-Ag presentation/recognition, cellular and molecular factors involved in alloreactive immune responses, antibody mediated rejection, immunotolerance induction and immunosuppression. (ncl.ac.uk)
Moreover, administration of PMab-1 led to a significant suppression of the rejection reaction in the corneal transplantation model. (elsevierpure.com)

I've been doing clinical research in the Kansas City area since 1989, mostly in ocular surface disease but also corneal transplantation, uveitis, and ocular immunology. (lexitas.com)

His research focus has mainly been on corneal optics, biomechanics, corneal transplantation, and banking and refractive surgery, and he has published more than 200 papers/book chapters. (oftalmolog.com)

Currently, Jesper Hjortdal is WP leader in a major EU supported project, VISICORT, which is a multi-disciplinary project on expertise in basic immunology, bio-sampling, systems biology/immune profiling, bioinformatics, clinical tissue transplantation, and cell therapy. (oftalmolog.com)

The basement membrane is also important for epithelial migration, and abnormalities in basement membrane structure, whether due to trauma (eg, recurrent erosion syndrome) or dystrophy (eg, basement membrane dystrophy), can lead to persistence of corneal epithelial defects and stromal ulceration. (medscape.com)
Dr. Colby has a particular interest in Fuchs' dystrophy, the most common cause for corneal transplantation in the United States, and is currently pioneering novel treatments for this condition. (sicsso.org)

We describe cowpox with corneal in- pulmonary nodules in a child with chronic granulomatous disease. (cdc.gov)

My interest in transplantation resulted in a research fellowship in basic immunology at the University of Chicago, USA following which I spent 9 years combining clinical transplant medicine with laboratory-based immunology research at Mayo Clinic. (universityofgalway.ie)
1. Basic immunology with an emphasis on dendritic cell, monocyte and T cell biology. (universityofgalway.ie)

Clinical Immunology (pp. 465-467). (edu.au)

Mr Moore qualified in Medicine and Surgery from Charing Cross and Westminster Medical School (now Imperial College London) in 1994 with an Immunology/Biochemistry undergraduate degree through University College London. (lcuuk.com)

Bone marrow transplantation (BMT) treats neutropenia resulting in immunodeficiency and recurrent infections. (lu.se)

Dr. Tauber enhanced his medical education with two years of ocular immunology and corneal and external disease fellowship training at the Massachusetts Eye and Ear Infirmary. (taubereye.com)
A board certified ophthalmologist and fellowship trained corneal transplant specialist, Dr. Schechter has been diagnosing, treating and operating in his field since 1992. (fleyedocs.com)

Saving Sight CEO Tony Bavuso stated, "Brightstar Therapeutics has the potential to greatly advance corneal treatments and allow for more corneal tissue to be utilized, resulting in more people receiving the gift of sight. (rocklandreviewnews.com)
however, in the corneal stroma, excessive infiltration of monocytes/macrophages is considered to be unfavorable because they secrete matrix metalloproteinases (MMPs) and other proteins undesirable for tissue healing. (medscape.com)
The system's patented variable numerical aperture design adjusts the beam profile to the specific target tissue and depth, increasing precision and efficiency at the corneal plane, capsular plane and lenticular plane. (fleyedocs.com)
Transplantation is a procedure that involves the removal of an organ or living tissue and placing it into a different part of the body or into a different person. (lecturio.com)

An understanding of the pathophysiology of sterile corneal ulceration requires a review of the processes involved in epithelial and stromal wound healing, as well as an examination of the role of precorneal tear film, corneal nerves, proteolytic enzymes, and cytokines. (medscape.com)
Corneal ulceration always begins with an epithelial defect. (medscape.com)

4. Stem cell and regenerative medicine related immunology. (universityofgalway.ie)
Within the project, participants are developing and validating advanced regenerative and restorative therapies to treat the loss of corneal transparency. (oftalmolog.com)

Corneal neovascularization was induced by corneal suture in Balb/c mice and after one week, penetrating corneal transplantations were performed while Balb/c mice as receptors and C57/BL6 mice as donors. (sdu.edu.cn)
Mouse corneal suture and ear section models were used to induce lymphangiogenesis and macrophage infiltration. (elsevierpure.com)
Administration of PMab-1, reduced lymphangiogenesis in the corneal suture and ear wound healing models. (elsevierpure.com)

Patients who have reduced corneal sensation or decreased blink rate before surgery are at greater risk. (aao.org)
After the surgery, the state of corneal transplantation was monitored on a day to day basis and tail vein blood was sampled once every two weeks to check the lymphocyte types. (sdu.edu.cn)
An ophthalmologist can carry out operations on the eye such as corneal transplantation or lens replacement if he has received further training in ophthalmic surgery. (healthprevention.ch)

Ocular Immunology is the study of how the eyes immunity processes and mechanisms contribute to disease and how they can be manipulated to prevent and fight disease. (acuityfoundationireland.ie)
Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. (cdc.gov)
Transplantation can offer the individual a definitive treatment for a given disease entity. (lecturio.com)
Author affiliations: University of Helsinki, Helsinki, Finland and immunology of infectious disease. (cdc.gov)

A persistent epithelial defect allows the corneal stroma to be exposed to the external environment and permits the process of stromal degradation. (medscape.com)

Other features include hyperpigmented macules on the trunk, corneal opacities, other hematological abnormalities. (lu.se)

Preoperative (A) and postoperative (B) corneal topography. (jamanetwork.com)

Wentworth JS, Paterson CA, Gray RD. Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn. (medscape.com)

His main research interest is in the field of Anterior Segment Developmental Anomaly and Paediatric Corneal Transplantation. (lcuuk.com)

4] Gershon RK, Kondo K. Infectious immunological tolerance[J]. Immunology, 1971, 21(6):903-914. (sdu.edu.cn)

A corneal ulcer is defined as a disruption of the epithelial layer with involvement of the corneal stroma. (medscape.com)
Within minutes after a small corneal epithelial injury, cells at the edge of the abrasion begin to migrate centripetally to cover the defect rapidly at a rate of 60-80 µm/h. (medscape.com)
ST-100, Stuart's first drug candidate, is based on its patented Collagen Mimetic Peptide, PolyColTM ( PolyCol ) ST-100 has demonstrated in pre-clinical animal testing that it provides rapid repair of damaged corneal epithelial and sub-epithelial tissues in the eye, making it an ideal therapeutic candidate for DED and other ocular surface indications. (stuarttherapeutics.com)

1] Sonoda Y, Streilein, J W.Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts[J]. J Immunol, 1993, 150(5):1727-1734. (sdu.edu.cn)

9. Clinical complications and outcomes of human kidney and pancreas transplantation. (universityofgalway.ie)

1. To provide an overview of and introduction to transplantation sciences in the context of solid organ and cell transplants. (ncl.ac.uk)
Other blood-borne viruses such as herpes simplex virus have been transmitted accidentally through corneal transplants. (sciencedaily.com)

3. To highlight the research areas in transplantation where applications of immunology, cell biology and novel technologies are impacting on clinical outcome and patient wellbeing. (ncl.ac.uk)

Ethical questions about face transplantation are even more prominent than those about extremity transplantation because the surgical procedure is extremely demanding and the immunosuppression required puts the recipient at considerable risk of opportunistic infections. (msdmanuals.com)
Surgical manipulation of corneal shape requires an accurate and precise method of measuring anterior corneal curvature from apex to limbus. (jamanetwork.com)

Current Research and Scholarly Interests Corneal opacity is a leading cause of blindness. (stanford.edu)

Anatomy3

Organisms3

Diseases8

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes7

Disciplines and Occupations1

Named Groups2

Health Care2

High-risk corneal transplantation4

Cornea11

Diseases16

Treatment of corneal1

Keratoplasty2

Inflammation4

Organ transplantation2

Donor4

Endothelium2

Ophthalmology2

Grafts4

Cataract1

Limbal stem3

Microbiology3

Endothelial cells1

Allograft1

Rejection2

Uveitis1

Refractive Surgery1

Immune1

Dystrophy2

Pulmonary1

Basic immunology2

Clinical Immunology1

Biochemistry1

Recurrent1

Fellowship2

Tissue4

Ulceration2

Regenerative2

Suture3

Surgery3

Disease4

Stromal1

Hematological1

Postoperative1

Ulcers1

Anterior segment1

Immunological1

Epithelial3

Allografts1

Pancreas1

Transplants2

Cell biology1

Surgical2

Blindness1