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  • cells
  • The lamellæ are produced by keratocytes (corneal connective tissue cells), which occupy about 10% of the substantia propria. (wikipedia.org)
  • During development of the embryo, the corneal stroma is derived from the neural crest (a source of mesenchyme in the head and neck ) which has been shown to contain mesenchymal stem cells . (wikipedia.org)
  • collagen
  • Keratocytes within standard collagen matrices (which are highly compliant) maintained a dendritic phenotype following culture in serum-free media, PDGF, IGF and FGF, but developed stress fibers in TGFβ1. (mdpi.com)
  • Keratocytes within compressed collagen (which has high stiffness and low porosity) maintained a dendritic phenotype following culture in serum-free media, PDGF and IGF, but developed stress fibers in both FGF and TGFβ1. (mdpi.com)
  • Keratocytes phenotypical changes were morphologically assessed and gene expression of aldehyde dehydrogenase (ALDH), collagen type 1 and lumican were determined through RT-PCR. (biomedcentral.com)
  • 4 - 9 Keratocan knockout mice have a thinner corneal stroma with irregular collagen fibril organization compared with the normal mice, 8 and lumican knockout mice have increased collagen fibril diameter and develop opaque corneas. (arvojournals.org)
  • Keratocytes isolated from human corneas were encapsulated within compressed collagen gels to constitute a 3D model of the cornea's stroma. (arvojournals.org)
  • Lumican regulates collagen fibril structure such that gene targeted mice deficient in lumican manifest Ehlers Danlos Syndrome-like skin fragility, tendon weaknesses and corneal opacity. (hopkinsmedicine.org)
  • 2 7 8 Transparency and biomechanical stability are dependent on the precise organization of collagen fibrils within the corneal stroma. (arvojournals.org)
  • Wound Healing
  • There has been no effective treatment or agent that is available for corneal injury in promoting corneal wound healing. (biomedcentral.com)
  • Downregulation of lumican and keratocan expression is an undesirable phenotypic change that occurs during corneal wound healing. (arvojournals.org)
  • Acacia honey is a natural product which has proven to have therapeutic effects on skin wound healing, but its potential healing effects in corneal wound healing have not been studied. (blogspot.com)
  • The results of the present study show promising role of AH role in accelerating the initial stage of corneal wound healing. (blogspot.com)
  • Understanding the role of PDGFRα in TGF-β3's ability to stimulate SMA may potentially help in understanding the differential functions of TGF-β1 and TGF-β3 in corneal wound healing. (arvojournals.org)
  • One such growth factor, transforming growth factor β (TGFβ), has emerged as a key component of the corneal wound-healing response. (arvojournals.org)
  • Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. (bu.edu)
  • Tissue
  • These findings contribute to our understanding of corneal stromal biology in health and disease, and will prove useful in optimizing keratocyte cultures for tissue engineering, cell biology, and clinical applications. (arvojournals.org)
  • embryonic
  • The objective of this study is to examine the potential of human fetal keratocytes (HFKs) to differentiate into neural crest-derived tissues when challenged in an embryonic environment. (rice.edu)
  • The novel Dox inducible Kera RT driver mouse line is a useful genetic tool for gene manipulation and elucidating gene functions in corneal stroma and tendons of limbs and tail during embryonic development, homeostasis and pathogenesis. (arvojournals.org)
  • reepithelialization
  • Minns MS, Teicher G, Rich CB, Trinkaus-Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. (bu.edu)
  • regulate
  • Keratocan and lumican, the major KSPGs in the corneal stroma, regulate both fibril diameter and interfibrillar spacing as evident from the phenotype of lumican and keratocan knockout mice. (arvojournals.org)