Grosberg is expected to provide new and synergistic expertise in applying multiscale computational modeling and tissue engineering to stem cell-derived cardiomyocytes (heartmuscle cells), cardiac morphogenesis (development of structure), and cardiac function. (constantcontact.com)
Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations of human cells are being developed to address the formidable pharmacological and physiological gaps between monolayer cell cultures, animal models, and humans that severely limit the speed and efficiency of drug development. (rsc.org)
Allometric scaling that describes inter-species variation of organ size and properties provides some guidance, but given the desire to utilize these systems to extend and validate human pharmacokinetic and pharmacodynamic (PK/ PD ) models in support of drug discovery and development, it is more appropriate to scale each organ functionally to ensure that it makes the suitable physiological contribution to the coupled system. (rsc.org)
At Vanderbilt he works on the development of novel biomaterials to enhance the intracellular delivery of biomacromolecular therapeutics for applications ranging from cardiovascular disease to cancer therapy. (rsc.org)