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  • cancers
  • Lung cancers harboring mutations in the epidermal growth factor receptor ( EGFR ) respond to EGFR tyrosine kinase inhibitors, but drug resistance invariably emerges. (sciencemag.org)
  • To elucidate mechanisms of acquired drug resistance, we performed systematic genetic and histological analyses of tumor biopsies from 37 patients with drug-resistant non-small cell lung cancers (NSCLCs) carrying EGFR mutations. (sciencemag.org)
  • In three patients, serial biopsies revealed that genetic mechanisms of resistance were lost in the absence of the continued selective pressure of EGFR inhibitor treatment, and such cancers were sensitive to a second round of treatment with EGFR inhibitors. (sciencemag.org)
  • This course will provide a comprehensive, multidisciplinary introduction to state of the art approaches in the care of patients with thoracic malignancies, including various types of lung cancers and esophageal cancers. (coursera.org)
  • In oncology in general, it is observed that tumour size is often strongly predictive of the clinical behaviour and, thus, a number of cancers (e.g. adenocarcinoma of the lung, papillary renal cell carcinoma) are defined, in part, on the basis of a minimum size. (wikipedia.org)
  • Symptoms and signs are as for other lung cancers. (wikipedia.org)
  • hilar
  • just finished 4th round and next plan is to do open chest Left lung resection and removal of hilar lymph nodes. (cancergrace.org)
  • The most frequent site of failure was the hilar nodes and contiguous lung. (biomedsearch.com)
  • Analysis of the dosimetry in the mediastinal, hilar nodes and contiguous lung failures revealed three factors which may have contributed to a low dose. (biomedsearch.com)
  • chest
  • A, the first patient (Case 1) exhibited multiple nodules of varying sizes scattered throughout both lungs based on chest radiography. (aacrjournals.org)
  • invasive
  • In addition, excisional biopsies are invasive, can't be used repeatedly, and are ineffective in understanding the dynamics of tumor progression and metastasis. (wikipedia.org)
  • diagnostic
  • 1 , 2 , 3 Its immunohistochemical detection has been used in diagnostic surgical pathology to distinguish thyroid and lung tumours from those of other organs. (pubmedcentralcanada.ca)
  • commonly
  • A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. (wikipedia.org)
  • Biopsies are most commonly performed for insight into possible cancerous and inflammatory conditions. (wikipedia.org)
  • suspicious
  • It usually comes to medical attention on a screening mammogram, as a non-specific suspicious abnormality that requires a biopsy. (wikipedia.org)