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Core Binding FactorsCore Binding Factor beta SubunitCore Binding Factor alpha SubunitsGA-Binding Protein Transcription FactorCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 1 SubunitTranscription Factor AP-2Molecular Sequence DataTranscription FactorsSmooth Muscle MyosinsDNA-Binding ProteinsBase SequenceBinding SitesAmino Acid SequenceProtein BindingChromosomes, Human, Pair 16Chromosome InversionPromoter Regions, GeneticLeukemia, Myeloid, AcuteOncogene Proteins, FusionProtein SubunitsTranscription, GeneticMutationProto-Oncogene Proteins c-etsChromosomes, Human, Pair 21Enhancer Elements, GeneticGABA Plasma Membrane Transport ProteinsNeoplasm ProteinsCell LineProto-Oncogene ProteinsOsteoblastsMacromolecular SubstancesModels, MolecularMutagenesis, Site-DirectedProtein Structure, TertiaryDNATransfectionTranslocation, GeneticViral Core ProteinsOsteocalcinOsteogenesisRNA, MessengerTranscriptional ActivationNuclear ProteinsGene Expression RegulationRecombinant Fusion ProteinsOrganic Anion TransportersSigma FactorAlkaline PhosphataseEscherichia coliLeukemia, MyeloidCell DifferentiationCells, CulturedSequence Homology, Amino AcidCloning, MolecularHematopoiesisKineticsMembrane Transport ModulatorsCore Binding Factor Alpha 3 SubunitMolecular WeightElectrophoresis, Polyacrylamide GelProto-Oncogene Protein c-ets-1Recombinant ProteinsProton-Translocating ATPasesProtein Conformation
ProteinProteinsNuclear respiratoryAnkyrin repeatMotifsCTCFHelix-loop-DomainExpressionCAMPSiteTranscription factorPromoter
Protein10
  • This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
  • This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
  • Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
  • GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene. (wikipedia.org)
  • GABP is a multimeric protein consisting of GABPA and GABPB with its isoforms GABPB1, GABPB1-L, GABPB1-S, GABPB2. (oncotarget.com)
  • PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
  • Binding-protein-dependent transport system inner membrane component [Interproscan]. (ntu.edu.sg)
  • Rod binding protein, Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [Interproscan]. (ntu.edu.sg)
  • HAMP domain, Tar ligand binding domain homologue, Methyl-accepting chemotaxis protein (MCP) signalling domain [Interproscan]. (ntu.edu.sg)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
Proteins6
  • GA-binding proteins selectively bind at these positions, respectively, causing an activation of the promoter and overexpression of TERT. (oncotarget.com)
  • All GA-binding proteins progress through the glioma grades and have the highest expression levels in secondary glioblastomas. (oncotarget.com)
  • The present study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas. (oncotarget.com)
  • Further investigations must be made to elucidate the relation between TERT and all GABP proteins as it may play a key role in the gliomagenesis. (oncotarget.com)
  • ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
  • Like Ras, ARFs are active in their GTP-bound form, and their duration of activity is controlled by GTPase-activating proteins (GAPs), which assist ARFs in hydrolyzing GTP to GDP. (embl.de)
Nuclear respiratory1
  • Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
Ankyrin repeat1
  • The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. (embl.de)
Motifs1
  • The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
CTCF3
  • Gained loop anchors were enriched for AP-1 occupancy and were characterized by large increases in histone H3K27ac (over 11-fold) but relatively small increases in CTCF and RAD21 binding (1.26- and 1.23-fold, respectively). (bvsalud.org)
  • Linear modeling revealed that changes in histone H3K27ac, chromatin accessibility, and JUN binding were better correlated with changes in looping than RAD21 and almost as well correlated as CTCF. (bvsalud.org)
  • Together these data suggest that although CTCF and RAD21 may be the core machinery dictating where loops form, other features (both at the anchors and within the loop boundaries) may play a larger role than previously anticipated in determining the relative loop strength across cell types and conditions. (bvsalud.org)
Helix-loop-1
  • The core of the repeat seems to be an helix-loop-helix structure. (embl.de)
Domain2
  • Cold-shock' DNA-binding domain [Interproscan]. (ntu.edu.sg)
  • Putative sugar-binding domain [Interproscan]. (ntu.edu.sg)
Expression1
  • However, before we can gain a proper understanding of their role in mice that are missing these ion channel subunits, we need to know their developmental expression profile in the developing mouse. (edu.au)
CAMP1
Site1
  • The motif does not match any known transcription factor binding site. (gsea-msigdb.org)
Transcription factor4
  • This gene encodes the GA-binding protein transcription factor, beta subunit. (wikipedia.org)
  • May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. (nih.gov)
  • This matches the NFE2L1 [GeneSymbol=NFE2L1] , MAFG [GeneSymbol=MAFG] transcription factor binding site V$TCF11MAFG_01 (v7.4 TRANSFAC). (gsea-msigdb.org)
  • The promoter analysis yields 174 candidate motifs, including most previously known transcription-factor binding sites and 105 new motifs. (gsea-msigdb.org)
Promoter3
  • Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. (nih.gov)
  • In addition to its chemotactic properties, IL-16 has also been shown to suppress HIV-1 replication in vitro and appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. (novoprolabs.com)
  • Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 (71%) melanomas examined. (nih.gov)