Core binding factors. Medical search. Frequent questions

Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
Genetic, biochemical and structural studies have implicated Argonaute proteins as the catalytic core of the RNAi effector complex, RISC. (rcsb.org)
Splicing is a complex, multistep process involving hundreds of proteins: some are responsible for recognising the splice sites, while others stabilise the binding of the spliceosome to the mRNA or cut out the introns and join the exons. (imb.de)
First, FUBP1 stabilises the binding of other splicing proteins to the 3' splice site, helping the cell to recognise the correct exon-intron boundary. (imb.de)
The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
Sigma factors are a class of proteins constituting essential dissociable subunits that confer sequence-specific DNA binding properties to RNA polymerase (RNAP). (hindawi.com)
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. (fishersci.com)
H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. (fishersci.com)

Core binding factors are composed of: a non-DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). (wikipedia.org)
The protein produced from the normal CBFB gene interacts with another protein called RUNX1 to form a complex called core binding factor (CBF). (medlineplus.gov)
This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)

The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
Matrix protein p17 has two main functions: in infected cell, it targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (proteopedia.org)
It binds in the cytoplasm the human BAF protein which prevent autointegration of the viral genome, and might be included in virions at the ration of zero to 3 BAF dimer per virion. (proteopedia.org)
Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (proteopedia.org)
The core is constituted by capsid protein hexamer subunits. (proteopedia.org)
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (atlasgeneticsoncology.org)
To better understand how mRNAs are spliced in normal cells and how this is disrupted in cancer, Julian and his colleagues Katja and Michael set out to study FUBP1 (far upstream binding protein 1), which is known to be frequently mutated in gliomas, and to determine whether it has a role in splicing. (imb.de)
First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
Transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
Interacts with hcv core protein. (lu.se)

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)

CmABF1 and CmCBF4 were selected as candidate TFs that could directly bind to promoter fragments of CmADC in vitro and in planta to promote its transcription. (eurekalert.org)
CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
Within the RNAP holoenzyme, sigma factors provide promoter recognition specificity to the polymerase and contribute to DNA strand separation, then they dissociate from RNAP core enzyme and transcription initiation follows [ 1 ]. (hindawi.com)
Besides the vegetative sigma factor, which recognizes the "standard" promoter, many bacteria possess alternative sigma factors that confer altered promoter specificity upon RNAP [ 2 ]. (hindawi.com)
Within this core promoter region we recognized functional binding sites for TFAP2 transcription factors and identified TFAP2 as repressors of the TBX20 gene in vitro and in vivo. (nih.gov)
C promoter binding factor/ Suppressor of Hairless/ lag- 1). (bvsalud.org)

POL_HV1Z2 ] Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. (proteopedia.org)
A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. (yeastgenome.org)
By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
Using CIS-ANALYST, the distribution of Bcd, Cad, Hb, Kr, and Kni binding sites were examined in a 1-Mb genomic region surrounding the well-characterized eve locus at a site_p value of 0.0003. (sdbonline.org)

The head region interacts with actin and includes a segment that attaches (binds) to ATP. (medlineplus.gov)

Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)

The spectrum of genes harboring germline variants in pediatric MDS has also recently begun to expand beyond transcription factors, including ANKRD26 17 and SRP72 18 . (nature.com)
They can bind directly to DRE/CRT (dehydration-responsive element/C repeat) cis -acting elements in the promoters of cold-regulated (COR) genes and trigger their expression to help plants withstand the bitter cold. (eurekalert.org)
Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
In addition, many of the remaining clusters are adjacent to genes expressed in a pattern characteristic of genes regulated by these factors. (sdbonline.org)
Sequences of previously described binding sites were collected for these five factors present in the cis-regulatory regions of known target genes. (sdbonline.org)
A model based which contains the Oct4/Sox2/Nanog core as well its interaction upon regulatory mechanisms inferred from ChIP-on-chip and with a few other key genes. (lu.se)

To understand the DNA recognition mechanism of zinc finger motifs of transcription factor Sp1, we have determined the solution structure of DNA-binding domain of the Sp1 by solution NMR techniques. (rcsb.org)
The DNA-binding domain of Sp1 consists of three Cys(2)His(2)-type zinc finger motifs. (rcsb.org)

The presence of CBFβ-MYH11 may block binding of CBF to DNA, impairing its ability to control gene activity. (medlineplus.gov)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
In this study, a gene encoding for an rpoS -like sigma factor, rpoX , has been cloned and characterized. (hindawi.com)

Exceptions are acute promyelocytic leukemia (APL) and core binding factor AML (i.e. (cap.org)
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia. (cdc.gov)

C-repeat binding factors (CBFs) act at the crossroads of the transcriptional regulatory network that underlies cold stress response. (eurekalert.org)
Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
The precise etiology is unknown, but immunogenetic, immunologic, and environmental factors contribute to its pathogenesis. (medscape.com)

From DNA-binding analysis performed by NMR and comparison between structures determined here and previously reported structures of other zinc fingers, it was assumed that DNA recognition modes of fingers 2 and 3 would be similar to those of fingers of Zif268, in which each finger recognizes four base pairs strictly by using residues at positions -1, 2, 3, and 6 of the recognition helix. (rcsb.org)
Binds these RNAs through its zinc fingers. (proteopedia.org)

Desmoglein 1 is a glycoprotein that belongs to the cadherin superfamily (ie, calcium adhesion molecules present in the desmosomal core). (medscape.com)

The research groups of Julian König and Katja Luck (Institute of Molecular Biology, IMB, Mainz, Germany), together with the group of Michael Sattler (Institute of Structural Biology and Technical University of Munich, Germany) have discovered that the proto-oncogene FUBP1 has a previously unknown function as a core splicing component at long introns. (imb.de)

To investigate whether binding site clustering could help to explain the specificity of these factors for eve , a simple notion of binding site clustering was incorporated into CIS-ANALYST, allowing searches for segments of a specified length containing a minimum number of predicted binding sites. (sdbonline.org)

The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)

Their roles in intracellular signalling pathways suggest factors such as STAT3 might be involved in ageing and/or age-related disease [ 266 ]. (senescence.info)

Epidermal exposure to UV light may enhance autoantibody epidermal binding and preferential neutrophil adhesion, which can contribute to acantholysis in endemic pemphigus foliaceus. (medscape.com)

This capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species (By similarity). (proteopedia.org)

It is proposed that this relaxed property of finger 1 allows transcription factor Sp1 to bind various DNA sequences with high affinity. (rcsb.org)
The binding sequences for each factor were aligned by using the motif-assembly program, and the binding specificities of each factor were modeled with position weight matrices (PWMs). (sdbonline.org)
PWMs are a useful way to represent binding specificities and provide a statistical framework for searching for novel instances of the motif in genome sequences (Berman, 2002). (sdbonline.org)
Recently, genome sequences revealed that in addition to rpoS , an rpoS -like sigma factor was found in V. alginolyticus 12G01. (hindawi.com)

1979. Transition and heavy metal inhibition of ligand binding to muscarinic acetylcholine receptors from rat brain. (cdc.gov)

Activity of these inhibitors depends on their mechanism of receptor binding (active vs inactive conformation) and efficacy against the FLT3-ITD and -TKD mutations (type 1 inhibitors are active both on FLT3 -ITD and TKD, whereas type 2 inhibitors are active only on FLT3 -ITD). (dovepress.com)
Indeed, when the researchers analysed sequencing data from glioma patients, they found that patients with FUBP1 loss-of-function mutations had more skipping of exons with long adjacent introns than patients with mutations in other splicing factors. (imb.de)

Mutation and in vitro DNA binding studies completed on a subset of the CRMs provide evidence for a direct regulatory relationship. (sdbonline.org)

Transcription factors like those of the STAT family are activated by growth factors and cytokines. (senescence.info)
The T-box family of transcription factors has been shown to have major impact on human development and disease. (nih.gov)

We estimated SARS-CoV-2 seroprevalence among residents of Hillsborough County, Florida, USA, to determine factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
The goals of this study were to estimate SARS-CoV-2 seroprevalence among Hillsborough County residents and to determine the demographic and behavioral factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
Particle-enhanced assays were based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)

pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
A common feature of these cis-regulatory modules is the presence of multiple binding sites for multiple transcription factors. (sdbonline.org)

Whether this cluster of binding sites might be the gt posterior enhancer was evaluated. (sdbonline.org)

The FH domain is a winged helix DNA-binding domain. (nih.gov)

By comparing the complete genomes from cancerous and normal cells for about 800 patients, we have successfully pinpointed the genetic factors behind some of the toughest pediatric cancers. (stjude.org)
At the core of the network reside Oct4, Sox2 and Nanog, into embryonic stem cells [1,2,3,4,5], have made major inroads which form a self-organized core of the TFs maintaining into stem cell biology. (lu.se)

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute , National Institute of Allergy and Infectious Diseases , and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198. (rcsb.org)

While this article focuses on specific VR issues, most of the origins are core optimization areas such as poly counts, common performance mistakes, and knowing the more efficient but relative quality solution to apply. (intel.com)
Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. (fishersci.com)

A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. (proteopedia.org)
They find that FUBP1 is responsible for stabilising the binding of other splicing factors to the 3' splice site. (imb.de)
A significant fraction of these binding site clusters overlap known CRMs that are regulated by these factors. (sdbonline.org)

Alternative sigma factors are synthesized or activated in response to certain environmental conditions. (hindawi.com)
These alternative sigma factors are further classified by the physiological processes that they control, for example, stress response and flagella biosynthesis [ 3 , 4 ]. (hindawi.com)

You need to determine the STD-related risk factors among target populations. (cdc.gov)
Questions cover behavioral risk factors (e.g., alcohol and tobacco use), preventive health measures, health status, limitation of activity, and health care access and utilization. (cdc.gov)

To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. (fluoridealert.org)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

The study included 153 patients who were newly diagnosed with core-binding factor AML and treated with FLAG-based regimens between 2017 and 2018. (ascopost.com)

ABA-responsive element (ABRE)-binding factors (ABFs) are core components in ABA signaling and are broadly involved in plant growth and development, as well as responses to biotic and abiotic stresses such as cold. (eurekalert.org)

are quantifiable measurements, agreed to beforehand, that reflect the critical success factors of an organisation. (who.int)

It shows no stimulation by ATP, suggesting that factors promoting product release are missing from the recombinant enzyme. (rcsb.org)

For each component, a set of core indicators has been agreed. (who.int)
We are currently assessing the capacity of each country in generating reliable data for the 68 core indicators of the framework. (who.int)

Because this genetic change affects CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)

The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)

A growing body of evidence has identified fibrinogen as an important risk factor for cardiovascular disease, the major cause of death in the U.S. The objective of including this measure was to provide data on laboratory, clinical, and socio-demographic correlates of fibrinogen levels. (cdc.gov)

To the extent that [ 11 C]DASB binding provides an index of the integrity of serotonin neurons, our findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans. (cambridge.org)

The same clustering criteria that were successful for identifying CRMs in eve (700-bp regions with at least 13 predicted binding sites) identified clusters overlapping 14 of these 19 known CRMs (Berman, 2002). (sdbonline.org)

This article is about why Ambedkar took so long time to decide to convert, the various inherent factors involved in it and its after effects. (buddhismtoday.com)

Anatomy4

Diseases4

Chemicals and Drugs18

Phenomena and Processes13

Information Science2

Proteins8

CBFB3

Protein14

RUNX11

Promoter6

Genomic4

Attaches1

Subunit1

Genes7

Motifs2

Gene3

Acute2

Transcriptional2

Pathogenesis2

Zinc2

Superfamily1

Molecular1

Specificity1

Embryo1

STAT31

Epidermal1

Similarity1

Sequences4

Ligand1

Mutations2

Vitro1

Family2

Antibody3

Regulatory2

Enhancer1

Domain1

Cells2

RCSB PDB1

Specific2

Site3

Sigma factors2

Risk factors2

Expression2

Newly1

Signaling1

Organisation1

Enzyme1

Indicators2

Genetic1

Environmental1

Evidence1

Extent1

Sites1

Convert1