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  • acute
  • Core Binding Factor (CBF) Acute Myeloid Leukemia (AML) is cytogenetically characterized by either the t(8;21) or the inv(16)/t(16;16) chromosomal abnormalities, which, although being pathognomonic, are not sufficient per se to induce overt leukemia but rather determine a preclinical phase of disease when preleukemic subclones compete until the acquisition of clonal dominance by one of them. (hindawi.com)
  • PEBP2
  • Our data indicate that CBF/PEBP2 plays primarily a structural role as it induces a conformational change in the enhanceosome that is associated with augmented binding of c-Myb. (duke.edu)
  • In contrast, c-Myb has no apparent affect on CBF/PEBP2 binding, but is critical for transcriptional activation. (duke.edu)
  • CBFbeta
  • Here, we present the crystal structures of the AML1/Runx-1/CBFalpha(Runt domain)-CBFbeta(core domain)-C/EBPbeta(bZip)-DNA, AML1/Runx-1/CBFalpha(Runt domain)-C/EBPbeta(bZip)-DNA, and AML1/Runx-1/CBFalpha(Runt domain)-DNA complexes. (rcsb.org)
  • The hydrogen bonding network formed among CBFalpha(Runt domain) and CBFbeta, and CBFalpha(Runt domain) and DNA revealed the allosteric regulation mechanism of CBFalpha(Runt domain)-DNA binding by CBFbeta. (rcsb.org)
  • affinity
  • subunit that increases the binding affinity of CBFα for DNA . (dartmouth.edu)
  • Although MTX includes a lower Significantly affinity, its make use of being a ligand continues to be effective for Significantly concentrating on if a multivalent style AST-1306 strategy [28,29,is certainly applied that may offer very tight binding in comparison to a weak monovalent binding interaction. (healthandwellnesssource.org)
  • chromatin
  • To understand the molecular mechanisms for synergy between these transcription factors in the context of chromatin, we used in vivo footprinting to study the requirements for protein binding to Edelta within wild-type and mutant versions of a human TCR delta minilocus in stably transfected Jurkat cells. (duke.edu)
  • 2002). An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experiments. (core.ac.uk)
  • genetic
  • Because some people with a 16p12.2 microdeletion have no obvious signs or symptoms (a situation called incomplete penetrance), researchers believe that other genetic or environmental factors may also be involved. (nih.gov)
  • length
  • In addition our method recovered a novel generalised version of an existing PWM for Sp1 that allows for variable length binding. (core.ac.uk)