ProteinPolymeraseProteinsRegulatorySmall subunitInitiationTranscription FactorsMRNAGENESSpecificityMolecularAlphaSynthaseChromatinNuclearZincHistoneInterproscanWD40RUNX2InterleukinPhosphorylationSequenceTranscriptionalRelated to genetic changesSigmaCatalysisCytokineInhibitorDissociationUndergoReceptorInteractionOxidoreductaseSubfamilyDomainPromoterRUNX1EnzymeKappaMembraneAffinity
Protein40
- This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
- This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
- Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
- Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. (wikipedia.org)
- The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g. (wikipedia.org)
- The role of the regulatory T cell transcription factor Foxp3 in shaping the transcriptosomes of natural and induced regulatory T cells was analyzed using mice expressing a mutant FOXP3-EGFP fusion protein (Foxp3deltaEGFP). (gsea-msigdb.org)
- formin binding protein 4 [Source:H. (gsea-msigdb.org)
- guanylate binding protein 4 [Sourc. (gsea-msigdb.org)
- Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
- Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
- Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
- Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
- The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
- Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
- This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
- A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
- 6097 beta-lactamase domain protein CP001857 CDS Arcpr_0005 complement(6094. (go.jp)
- 30270 beta-lactamase domain protein CP001857 CDS Arcpr_0037 complement(30271. (go.jp)
- 40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
- 47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
- Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
- In the budding yeast Saccharomyces cerevisiae , the minimal transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. (tcdb.org)
- protein_coding" "Cz03g40300.t1","No alias","Chromochloris zofingiensis","Pre-mRNA processing factor 4 (PRP4)-like [Interproscan]. (ntu.edu.sg)
- protein_coding" "Cz05g30030.t1","No alias","Chromochloris zofingiensis","mRNA splicing factor Cwf21 domain [Interproscan]. (ntu.edu.sg)
- Transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
- Interacts with hcv core protein. (lu.se)
- The Inhibitor of DNA binding 3 ( ID3 ) is a member of the ID protein family, consisting of four members ( ID1 to ID4 ). (nature.com)
- Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. (embl-heidelberg.de)
- They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl-heidelberg.de)
- The LIN-14 transcription factor likely directly represses dma-1 gene expression through a transcriptional means, whereas the LIN-41 tripartite motif protein likely indirectly promotes dma-1 gene expression through a posttranscriptional means. (stanford.edu)
- This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
- A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
- The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
- A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
- Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
- The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
- A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
- It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
- Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
- NICD1, which not is a skeletal focus, can be controlled by docking to the hormone-bound addition 1-alpha( HIF1A) which serves in the protein when amine homodimers are progressive. (evakoch.com)
Polymerase5
- RNA polymerase I (RNAP I) synthesizes pre-rRNA 45S, which matures into the ribosome 's 28S, 18S, and 5.8S subunits. (sciencefacts.net)
- The sigma (σ) factor of the RNA polymerase is encoded by nuclear genes. (sciencefacts.net)
- All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)
- Cheng A, Wan D, Ghatak A, Wang C , Feng D, Fondell JD, Ebright RH , Fan H. Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria. (academictree.org)
- RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding. (academictree.org)
Proteins15
- 3%). The organic phase is mainly formed by collagen type I fibers, which provide elasticity and flexibility to bone, but also non-collagenous proteins as well, such as cytokines, growth factors, and proteoglycans. (biomedcentral.com)
- The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
- Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
- Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
- Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
- The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
- The membrane bound docking subcomplex includes several Pex proteins, Pex13p, 14p and 17p. (tcdb.org)
- All Cbl cells bind a psychomotor CourseExplore that fails sterile entry buildings on linked proteins. (erik-mill.de)
- proteins are 6 caused download rarefied receptors that in starts 1, 4A and 103( factor) have carefully cross-presented to obtain certain 1-5, 2-4, 3-6. (erik-mill.de)
- The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
- While mRNA of alfa subunits (HIFs- α) are not altered by exposure to hypoxia, alfa, but not beta, proteins are stabilized by hypoxia. (biomedcentral.com)
- Proteins which bind to DNA. (lookformedical.com)
- The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
- This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
- high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)
Regulatory2
- pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
- α subunit also contains elements for interaction with the regulatory factors. (sciencefacts.net)
Small subunit1
- UTP25 small subunit processome com. (gsea-msigdb.org)
Initiation7
- This transcription initiation-factor structural module preorganizes template-strand ssDNA to engage the RNAP active center, thereby facilitating binding of initiating nucleotides and enabling transcription initiation from initiating mononucleotides. (osti.gov)
- However, this transcription initiation-factor structural module occupies the path of nascent RNA and thus presumably must be displaced before or during initial transcription. (osti.gov)
- In this paper, we report four sets of crystal structures of bacterial initially transcribing complexes that demonstrate and define details of stepwise, RNA-extension-driven displacement of the "σ-finger" of the bacterial transcription initiation factor σ. (osti.gov)
- 39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)
- 54053) translation initiation factor eIF-1A CP001857 CDS Arcpr_0064 complement(54088. (go.jp)
- Transcription initiation at a consensus bacterial promoter proceeds via a 'bind-unwind-load-and-lock' mechanism. (academictree.org)
- 1999), binding in the estrogen of the fatty proteoglycan of NOTCH2, NICD2, into the initiation. (evakoch.com)
Transcription Factors3
- Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
- We will also describe evidence about the ability of semaphorins to affect the expression and activity of transcription factors activated by hypoxia, such as hypoxia-inducible factor-1. (biomedcentral.com)
- These transcription factors are composed of an alpha subunit (HIF-1α, HIF-2α and HIF-3α), and a beta subunit (HIF-1β) [ 20 ]. (biomedcentral.com)
MRNA1
- evm.model.tig00001501.4","tig00001501_g9219.t1","Cyanophora paradoxa","Pre-mRNA-processing factor 19 OS=Oryza sativa subsp. (ntu.edu.sg)
GENES5
- It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (wakehealth.edu)
- The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
- The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (hmdb.ca)
- p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. (hmdb.ca)
- Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
Specificity1
- Cleavage/polyadenylation specificity factor, A subunit, C-terminal [Interproscan]. (ntu.edu.sg)
Molecular2
- Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
- It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. (lookformedical.com)
Alpha6
- it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. (wikipedia.org)
- integrin subunit alpha 6 [Source:H. (gsea-msigdb.org)
- A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. (lookformedical.com)
- The core enzyme (ββ′α 2 ω) consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (sciencefacts.net)
- 7524) oxaloacetate decarboxylase alpha subunit CP001857 CDS Arcpr_0006 complement(7556. (go.jp)
- Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Synthase1
- 18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)
Chromatin1
- Chromatin assembly factor 1. (lookformedical.com)
Nuclear3
- Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
- Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
- Antígeno nuclear que juega un papel en la síntesis y reparación del ADN, y en la progresión del ciclo celular. (bvsalud.org)
Zinc4
- In this study, we identified zinc finger transcription factor 148 ( ZNF148 , also called Zfp148 and ZBP-89) as a direct target of MYC. (nature.com)
- The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger . (embl-heidelberg.de)
- Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl-heidelberg.de)
- In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)
Histone2
- The bromodomain has been shown to bind acetylated lysine residues on histone tails. (embl-heidelberg.de)
- When cells enter senescence the binding to RD of both PRC1 and PRC2 complexes is lost leading to a decreased level of histone H3K27 trimethylation (H3K27me3). (plos.org)
Interproscan10
- ARID DNA-binding domain [Interproscan]. (ntu.edu.sg)
- FAD/NAD(P)-binding domain [Interproscan]. (ntu.edu.sg)
- ATPase, AAA-type, core [Interproscan]. (ntu.edu.sg)
- Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)
- Probable molybdopterin binding domain [Interproscan]. (ntu.edu.sg)
- tRNA synthetase class II core domain (G, Seryl-tRNA synthetase N-terminal domain [Interproscan]. (ntu.edu.sg)
- Molydopterin dinucleotide binding domain, Molybdopterin oxidoreductase Fe4S4 domain [Interproscan]. (ntu.edu.sg)
- 4Fe-4S binding domain, 4Fe-4S dicluster domain [Interproscan]. (ntu.edu.sg)
- DMSO reductase anchor subunit (DmsC) [Interproscan]. (ntu.edu.sg)
- Nitrate reductase delta subunit [Interproscan]. (ntu.edu.sg)
WD401
- The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)
RUNX21
- Pre-osteoblasts, a heterogeneous population of cells, including those transitioning from MSCs to mature osteoblasts, which express the transcription factor runt related transcription factor 2 (RUNX2) , a key player in the osteogenesis process. (biomedcentral.com)
Interleukin1
- interleukin 3 receptor subunit alp. (gsea-msigdb.org)
Phosphorylation2
- Bortezomib is significantly beneficial for de novo pediatric AML patients with low phosphorylation of the NF-?B subunit RelA. (childrensmercy.org)
- ITCH Phosphorylation p39 loss-of-function MAP2K1( visually activated as MEK1) is a single proneurotrophin and size concept binding that is and appears MAPK3( ERK1)( Ohren et al. (evakoch.com)
Sequence2
- Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)
- The consensus core of HRE sequence is 5′-RCGTG-3′ (where R is A or G). (biomedcentral.com)
Transcriptional3
- Mechanistically, we identified the Inhibitor of DNA binding 1 and 3 ( ID1, ID3 ), drivers of cancer stemness and plasticity, as previously uncharacterized targets of transcriptional repression by ZNF148. (nature.com)
- Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300. (embl-heidelberg.de)
- Hypoxia-inducible factors (HIFs) are responsible for the transcriptional responses to hypoxic stress. (biomedcentral.com)
Related to genetic changes1
- Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. (wikipedia.org)
Sigma2
- When the sigma (σ) factor binds to the core, it forms the holoenzyme. (sciencefacts.net)
- To bind to the promoter, the core RNAP binds to the sigma (σ), forming the holoenzyme (ββ′α2ω σ) with 6 subunits. (sciencefacts.net)
Catalysis1
- Manganese can substitute for magnesium as an essential co-factor for PNPase catalysis, and our crystal structure of the enzyme in complex with manganese suggests how the metal is positioned to stabilise the transition state. (port.ac.uk)
Cytokine1
- cytokine receptor like factor 3 [S. (gsea-msigdb.org)
Inhibitor1
- inhibitor of DNA binding 3 [Source. (gsea-msigdb.org)
Dissociation1
- junction oligosaccharide( VLDL) ligates a subunits recognized by the dissociation and plays the I of disabilities from the course to the glass of the platelet( Gibbons et al. (erik-mill.de)
Undergo2
- VLDL binds undergo defined by cell reaction microdomains and created in receptors been nationally. (erik-mill.de)
- e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)
Receptor1
- Pex5p, the PTS1 receptor, is known to bind to the integral Pex13p and/or Pex17p and the peripheral Pex14p. (tcdb.org)
Interaction1
- A similar interaction pattern occurs in the structurally homologous human exosome between the Rrp45 and Rrp46 subunits. (port.ac.uk)
Oxidoreductase1
- neighboring Expression represses to underlie identified by the oxidoreductase of Rev with importin-beta and B23 and signaling at the Syndecan transcription through proteases between acts and hours. (evakoch.com)
Subfamily1
- ATP binding cassette subfamily A m. (gsea-msigdb.org)
Domain2
- Each α subunit has an N-terminal αNTD domain and a C-terminal αCTD domain. (sciencefacts.net)
- The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect. (embl.de)
Promoter1
- The σ factor reduces the core enzyme's affinity for binding to non-specific DNA sequences while binding to the promoter. (sciencefacts.net)
RUNX11
- Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
Enzyme1
- ω is the smallest of all subunits that helps assemble and provide stability to the core enzyme. (sciencefacts.net)
Kappa1
- NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
Membrane1
- It binds CHOLESTEROL and is involved in LIPIDS transport, membrane traffic, and SIGNAL TRANSDUCTION. (lookformedical.com)
Affinity1
- Thus, the core translocon includes Pex13p, and Pex14p recognizes the receptors, Pex5p and Pex7p with nanomolar affinity. (tcdb.org)