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  • tissue
  • Preimplantation genetic diagnosis (PGD) has been used to enable families to have a child that is a tissue match for an existing sick sibling in need of an allogeneic haematopoietic stem cell (HSC) transplantation. (bmj.com)
  • Preimplantantion genetic diagnosis for HLA testing has been proposed as a superior method for creating a tissue matched child that can donate stem cells to its sick sibling. (bmj.com)
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood cell production. (wikipedia.org)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • Unlike for embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than human embryos designated for scientific research. (wikipedia.org)
  • Adipose tissue (lipid cells), which requires extraction by liposuction. (wikipedia.org)
  • In practice, stem cells are identified by whether they can regenerate tissue. (wikipedia.org)
  • Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. (wikipedia.org)
  • mononuclear cells
  • Other tests are performed depending on the suspected disorder: Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T lymphocytes (dependent on their cell surface markers, e.g. (wikipedia.org)
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • GVHD
  • GvHD can also occur after a blood transfusion if the blood products used have not been irradiated or treated with an approved pathogen reduction system. (wikipedia.org)
  • Antibodies
  • The basic tests performed when an immunodeficiency is suspected should include a full blood count (including accurate lymphocyte and granulocyte counts) and immunoglobulin levels (the three most important types of antibodies: IgG, IgA and IgM). (wikipedia.org)
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • Antibodies are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. (wikipedia.org)
  • differentiation
  • Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation. (wikipedia.org)
  • Stochastic differentiation: when one stem cell develops into two differentiated daughter cells, another stem cell undergoes mitosis and produces two stem cells identical to the original. (wikipedia.org)
  • The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes and neurons. (wikipedia.org)
  • tissues
  • Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. (wikipedia.org)
  • As BLSC's and VSEL cells are present in virtually all adult tissues, including lung, brain, kidneys, muscles, and pancreas Co-purification of BLSC's and VSEL cells with other populations of adult stem cells may explain the apparent pluripotency of adult stem cell populations. (wikipedia.org)
  • In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. (wikipedia.org)
  • Stem cells can now be artificially grown and transformed (differentiated) into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. (wikipedia.org)
  • clinical
  • The method most commonly used in clinical practice is the "closed technique", which is similar to standard blood collection techniques. (wikipedia.org)
  • This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • precursor
  • In 1924, Russian-born morphologist Alexander A. Maximow used extensive histological findings to identify a singular type of precursor cell within mesenchyme that develops into different types of blood cells. (wikipedia.org)
  • severe
  • Since more than one type of immune cell is affected, this disease is classified as a severe combined immunodeficiency disease (SCID). (wikipedia.org)
  • In 2014, the European Medicines Agency recommended approval of limbal stem cells for people with severe limbal stem cell deficiency due to burns in the eye. (wikipedia.org)
  • Stems cells are being studied in those with severe heart disease. (wikipedia.org)