AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Cord Blood Stem Cell TransplantationFetal BloodTransplantation ConditioningHematologic NeoplasmsGraft vs Host DiseaseHistocompatibility TestingTransplantation, HomologousHematopoietic Stem Cell TransplantationBlood BanksTransplantation ChimeraGraft SurvivalHistocompatibilityTissue DonorsSpinal CordAllograftsTransplantsMyeloablative AgonistsImmunogenetic PhenomenaHLA AntigensLiver TransplantationChimerismLeukemiaBone Marrow TransplantationTreatment OutcomeUnrelated DonorsSpinal Cord InjuriesInfant, NewbornHematologic DiseasesGraft vs Leukemia EffectVolvariellaHematopoietic Stem CellsKidney TransplantationVidarabineWhole-Body IrradiationCytomegalovirus InfectionsLeukodystrophy, Globoid CellBlood DonorsImmunosuppressive AgentsGraft RejectionAntilymphocyte SerumRetrospective StudiesUmbilical CordAnemia, AplasticRecurrenceColony-Forming Units AssayAntigens, CD34Transplantation, AutologousHeart TransplantationPrecursor Cell Lymphoblastic Leukemia-LymphomaDisease-Free SurvivalHematopoiesisSurvival AnalysisTime FactorsLung TransplantationStem Cell TransplantationMyelodysplastic SyndromesImmunophenotypingAcute DiseaseLeukemia, Myeloid, AcuteSurvival RateEpstein-Barr Virus InfectionsCytomegalovirusInfectionLeukocyte CountOrgan TransplantationPeripheral Blood Stem Cell TransplantationCell TransplantationPregnancyFollow-Up StudiesPancreas TransplantationNeutrophilsTransplantation ImmunologyIslets of Langerhans TransplantationKiller Cells, NaturalTransplantationRisk FactorsIncidenceMaternal-Fetal ExchangeSpinal Cord DiseasesCell DifferentiationCells, CulturedLiving DonorsTransplantation, IsogeneicFetal Tissue TransplantationTransplantation, HeterologousTransplantation, HeterotopicSpinal Cord CompressionHeart-Lung TransplantationMice, SCIDDonor SelectionCell SeparationSpermatic CordFlow CytometryImmunosuppressionBone Marrow CellsCell Culture TechniquesStem CellsTissue and Organ ProcurementMice, Inbred NODTransplantation Tolerance
Autologous stem cell transHematopoietic cellTransplantDonorsHSCTUCBTAllogeneic Hematopoietic Stem CBoneProgenitor cellsTransplantsKidney TransplantationMultiple myelomaHuman leukocyOutcomesHematologyHaploidenticalGraftEngraftmentLeukemiaGraftsMyeloablativeAdults2017AllogenicPediatricDonor stem cellsUmbilical cord bloodBaby's umbilical cordCollected from the umbilical cordOutcomeOrgans and tissuesAdult patientsMycosis fungoidesClinical2021DonationPatientsTissue2020PlacentaAplastic AnemiaGVHDPublic cord blooTissuesRemissionMultipotentCryopreservationDiseasesDisordersOncology
Autologous stem cell trans1
Hematopoietic cell2
  • The specific medications administered for aplastic anemia depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation (HCT). (medscape.com)
  • For patients in whom hematopoietic cell transplantation (HCT) may be attempted, transfusions should be used judiciously because minimally transfused subjects have achieved superior therapeutic outcomes. (medscape.com)
Transplant31
  • When needed for a transplant, the cord blood unit can be shipped to the transplant center. (schoolandyouth.org)
  • BMT InfoNet is dedicated to providing transplant patients, survivors and their loved ones with emotional support and high quality, easy-to-understand information about bone marrow, peripheral blood stem cell and cord blood transplants. (schoolandyouth.org)
  • Provides free cord blood banking for a full family member with a need for transplant. (schoolandyouth.org)
  • Our retrospective cohort study consisted of 885 adults and children (612 whites, 145 blacks, and 128 Hispanics) who received unrelated single UCBT for leukemia and myelodysplastic syndromes between 1995 and 2006 and were reported to the Center for International Blood and Marrow Transplant Research. (duke.edu)
  • Biol Blood Marrow Transplant , 18 (6), 903-912. (duke.edu)
  • Biol Blood Marrow Transplant 18, no. 6 (June 2012): 903-12. (duke.edu)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • Gannamani V, Varma A, Nathan S, Ustun C. Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. (jefferson.edu)
  • Blood from each cord is frozen (cryopreservervation) as an individual cord blood unit that is available to transplant. (bonemarrowtest.com)
  • The first successful cord blood transplant (CBT) was done in 1988 in a child with Fanconi anemia. (wikipedia.org)
  • Unrelated cord blood Transplant. (uab.cat)
  • Group for Blood and Marrow Transplant. (uab.cat)
  • Cord blood banks store frozen cord blood until someone who is a genetic match requires a transplant. (medicalnewstoday.com)
  • Hematopoietic stem cells are the same type of blood-forming stem cells present in a bone marrow transplant. (medicalnewstoday.com)
  • This is because the cord blood does not have to match that of the person receiving the transplant as closely as with a bone marrow transplant. (medicalnewstoday.com)
  • Cord blood does not contain many stem cells, which means that adults needing a transplant will require cord blood stem cells from multiple donors. (medicalnewstoday.com)
  • Privately banking cord blood may not be any more effective than undergoing a transplant of stem cells from a stranger. (medicalnewstoday.com)
  • An autologous transplant procedure uses the person's own cord blood stem cells for their transplant. (medicalnewstoday.com)
  • Stem cells found in your baby's umbilical cord are less likely than other stem cells, including those from bone marrow, to lead to complications following transplant. (lifebankusa.com)
  • 1,2 Two of the most frequent complications of stem cell transplantation are transplant rejection and graft versus host disease, or GvHD. (lifebankusa.com)
  • Not only does cord blood widen the pool of potential donations, it also requires a less precise match than a transplant using adult donor stem cells. (blood.ca)
  • By donating cord blood or joining the stem cell registry, donors help transplant centres provide better matches for patients - and help reduce their risk of life-threatening complications. (blood.ca)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
  • In February 2021, the company presented details of the results of the omidubicel Phase 3 study at the Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy and Center for International Blood & Marrow Transplant Research. (biospace.com)
  • IU researchers aided doctors in France in the first cord blood transplant in 1989. (ibj.com)
  • A cord blood transplant in the future might be indicated, so we're going to save the blood just in case," said Dr. Scott Goebel, who is part of the pediatric stem cell transplantation program at the children's hospital. (ibj.com)
  • Bone marrow/stem cell transplantation , including traditional and reduced-intensity transplant, using related, unrelated or umbilical cord blood cells for transplant. (dana-farber.org)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Donors12
  • To investigate cord blood as a possible solution to a critical public health need: finding appropriate hematopoietic transplants for patients who have no matched bone marrow donors. (schoolandyouth.org)
  • Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) and potential alternative for bone marrow transplantation for patients who lack human leukocyte antigen (HLA)-matched donors. (wjgnet.com)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • A cord blood bank may be private (i.e. the blood is stored for and the costs paid by donor families) or public (i.e. stored and made available for use by unrelated donors). (wikipedia.org)
  • Abstract Background In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). (uab.cat)
  • Twelve years after cord blood donors saved her life, Lourdess Sumners is making the most of the gift she's been given. (blood.ca)
  • For Lourdess, the stem cells came from the umbilical cord blood of two anonymous donors on opposite sides of the world. (blood.ca)
  • Stem cells are found in the bone marrow and circulating blood of adult donors, as well as in umbilical cord blood. (blood.ca)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
HSCT9
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
  • There is a lower incidence with cord blood compared with traditional HSCT, despite less stringent HLA match requirements. (wikipedia.org)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
UCBT3
Allogeneic Hematopoietic Stem C1
Bone18
Progenitor cells8
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
  • Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
  • However, the interest in cord blood is mostly driven by the observation that cord blood also contains various types of stem and progenitor cells, mostly hematopoietic stem cells. (wikipedia.org)
  • Endothelial progenitor cells and multipotent unrestricted adult stem cells can also be found in cord blood. (wikipedia.org)
  • BACKGROUND:Umbilical cord blood has become an important source of hematopoietic stem and progenitor cells for therapeutic applications. (duke.edu)
  • HCT/Ps such as amnion/chorion hematopoietic stem/progenitor cells from cord blood and peripheral blood, and reproductive tissues such as semen and oocytes, have the potential for harboring Zika virus. (cdc.gov)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
Transplants10
  • Website provides basic information about cord blood transplants. (schoolandyouth.org)
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • Cord blood banks recruit expectant mothers who donate their baby's umbilical cord blood for stem cell transplants. (bonemarrowtest.com)
  • Gluckman E, Rocha V. Donor selection for unrelated cord blood transplants. (lifebankusa.com)
  • This study will assess the safety and effectiveness of certain cord blood transplants. (nih.gov)
  • The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. (nih.gov)
  • The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
  • Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA approval was based on phase 3 testing that pitted the use of omidubicel in 62 patients against standard unmanipulated cord blood transplants in 63 patients following myeloablative conditioning. (medscape.com)
Kidney Transplantation1
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Multiple myeloma1
Human leukocy1
  • Analysis according to human leukocyte antigen (HLA) disparity revealed that tacrolimus-based GVHD prophylaxis resulted in higher OS and lower relapse rate and nonrelapse mortality (NRM) than cyclosporine-based GVHD prophylaxis in patients transplanted with 6/6 and ≤4/6 HLA-matched umbilical cord blood. (elsevierpure.com)
Outcomes3
Hematology2
  • Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood and birthing tissues in the emerging fields of cellular therapies and regenerative medicine. (duke.edu)
  • Learn about the advances in blood cancer care and research presented by Dana-Farber physicians and scientists at the Annual Meeting of the American Society of Hematology (ASH). (dana-farber.org)
Haploidentical1
Graft7
  • Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease if the cord blood is from a genetically different person, and the risk of severe infection while the immune system is reconstituted. (wikipedia.org)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
  • In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
  • Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation. (duke.edu)
  • The blood products should, if possible, undergo leukocyte reduction to prevent alloimmunization and CMV transmission and should be irradiated to prevent transfusion-associated graft versus host disease (GVHD) in HCT candidates. (medscape.com)
Engraftment2
  • In many cases, the engraftment time depends on the cell dose, or the amount of stem cells obtained in the sample of blood. (wikipedia.org)
  • CD34+ cell dose is critical for cord blood (CB) engraftment. (duke.edu)
Leukemia10
Grafts1
  • The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). (duke.edu)
Myeloablative1
Adults4
  • Ooi J. Cord blood transplantation in adults. (lifebankusa.com)
  • While adults in Canada donate stem cells by joining Canadian Blood Services Stem Cell Registry, umbilical cord blood is donated directly by new mothers. (blood.ca)
  • Older adults with cancers of the blood often have different needs from younger adults, for example, a higher risk for heart disease, diabetes, or kidney problems, which may limit treatment options. (dana-farber.org)
  • However, babies are small and umbilical cords even smaller, so it is very hard to get enough stem cells to treat adults with. (lu.se)
20171
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Allogenic2
  • There is growing interest from cell therapeutics companies in developing genetically modified allogenic natural killer cells from umbilical cord blood as an alternative to CAR T cell therapies for rare diseases. (wikipedia.org)
  • These receptors allow NK cells to spare autologous normal cells and to kill cells in which MHC class I expression is down-regulated (eg, by tumor transformation or viral infection) or cells expressing non-self MHC class I alleles unable to engage these receptors (eg, allogenic transplantation settings). (ashpublications.org)
Pediatric1
  • As a pediatric hematologist at Cook Children's, Dr. Donald Beam understands how blood functions in the body, and when things don't work like they should, he's here to help make them better. (cookchildrens.org)
Donor stem cells1
Umbilical cord blood1
Baby's umbilical cord1
Collected from the umbilical cord1
Outcome1
  • Correction of NK cell defects in CHS should improve the outcome of hematopoietic stem-cell transplantation, proposed as therapy. (torvergata.it)
Organs and tissues5
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
Adult patients2
Mycosis fungoides2
Clinical1
  • The method most commonly used in clinical practice is the "closed technique", which is similar to standard blood collection techniques. (wikipedia.org)
20212
  • Blood Adv 2021. (harvard.edu)
  • BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)
Donation5
Patients11
  • Double-unit unrelated cord blood transplantation (DUCBT) is an option in patients for whom a single unit is not sufficient to provide an adequate number of cells . (bvsalud.org)
  • Indeed, in a group of patients, a relevant fraction of NK cells expressed a mature phenotype characterized by the KIR + NKG2A − signature 3-6 months after transplantation. (ashpublications.org)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • COHORT II: Patients that do not have cancer-associated DNA-repair gene mutations undergo blood sample collection at baseline. (bcan.org)
  • The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
  • Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
  • Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
  • Frequent outpatient follow-up for patients with aplastic anemia is needed to monitor blood counts and any adverse effects of various drugs. (medscape.com)
  • The British Committee for Standards in Haematology also recommends irradiated blood products for all patients receiving antithymocyte globulin (ATG) therapy. (medscape.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
Tissue5
  • Newborn Possibilities Program® offers free cord blood and tissue processing and five years of storage to qualifying families in the U.S. (schoolandyouth.org)
  • The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
  • 1,2 GvHD develops when blood cells from the donor's stem cells attack the recipient's cells and tissue. (lifebankusa.com)
  • Many believe that someday they'll be able to develop stem cells into other organs, muscles and nerves and use them to rebuild cardiac tissue, repair damage caused by stroke or spinal cord injuries, and reverse the effects of diseases such as Parkinson's and multiple sclerosis. (ibj.com)
  • The use of gametes, embryonic and fetal tissue as well as blood and blood products raises additional questions that need to be separately addressed. (who.int)
20202
Placenta6
Aplastic Anemia1
GVHD1
Public cord bloo3
  • it is a public cord blood bank and part of the NHS. (wikipedia.org)
  • People can store cord blood in a private cord blood bank or donate to a public cord blood bank. (medicalnewstoday.com)
  • The COVID-19 pandemic has created challenges for many parts of Canada's health system, including the national public cord blood bank. (blood.ca)
Tissues1
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
Remission1
Multipotent2
Cryopreservation1
  • Cord blood collection is typically depleted of red blood cells before cryopreservation to ensure high rates of stem cell recovery. (wikipedia.org)
Diseases2
Disorders5
Oncology1
  • 21 University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg, Germany. (nih.gov)