AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Cord Blood Stem Cell TransplantationFetal BloodTransplantation, AutologousHematopoietic Stem Cell TransplantationTransplantation ConditioningTransplantation, HomologousGraft vs Host DiseaseHematologic NeoplasmsHistocompatibility TestingBone Marrow TransplantationGraft SurvivalBlood BanksTransplantation ChimeraTransplantsTissue DonorsHistocompatibilityTreatment OutcomeSpinal CordAllograftsRecurrenceMyeloablative AgonistsKidney TransplantationHLA AntigensImmunogenetic PhenomenaLiver TransplantationRetrospective StudiesChimerismLeukemiaSurvival AnalysisGraft RejectionSpinal Cord InjuriesUnrelated DonorsHematologic DiseasesHematopoietic Stem Cell MobilizationInfant, NewbornImmunosuppressive AgentsGraft vs Leukemia EffectHematopoietic Stem CellsVolvariellaHodgkin DiseaseWhole-Body IrradiationCytomegalovirus InfectionsMultiple MyelomaVidarabineHeart TransplantationAntilymphocyte SerumBlood DonorsLeukodystrophy, Globoid CellLung TransplantationTime FactorsAnemia, AplasticAntigens, CD34Stem Cell TransplantationUmbilical CordColony-Forming Units AssayDisease-Free SurvivalPrecursor Cell Lymphoblastic Leukemia-LymphomaHematopoiesisAcute DiseaseSurvival RateMyelodysplastic SyndromesImmunophenotypingLeukemia, Myeloid, AcuteTransplantationPeripheral Blood Stem Cell TransplantationCytomegalovirusEpstein-Barr Virus InfectionsInfectionFollow-Up StudiesLeukocyte CountCell TransplantationTransplantation ImmunologyBlood Transfusion, AutologousOrgan TransplantationIslets of Langerhans TransplantationRisk FactorsKiller Cells, NaturalPregnancyNeutrophilsLiving DonorsIncidencePancreas TransplantationFetal Tissue TransplantationTissue and Organ ProcurementImmunosuppressionCells, CulturedPostoperative ComplicationsTransplantation, IsogeneicTransplantation, HeterotopicHeart-Lung TransplantationCell DifferentiationCyclosporineTacrolimusMaternal-Fetal ExchangeTransplantation, HeterologousWaiting ListsLiver FailureCell SeparationT-LymphocytesFlow Cytometry
Stem cellDonorMesenchymal stemAllogenicPeripheral blood stemHSCTAdult autologous and allogeneicCentersMultiple myelomaHaploidenticalProgenitorChemotherapyOutcomesProcedureSyngeneicImmune systemDonorsPBSCTTherapiesType of transplantApheresisComplicationsDiseasesDonor'sCancersPediatric bloodAcute myeloidPatients undergoingCells1987HematologyDisordersLaboratoryHospitalHSCsClinicalSolid tumorsMycosis fungoidesCellular
Stem cell85
Donor33
  • The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • Private cord blood banks store cord blood solely for potential use by the donor or donor's family. (wikipedia.org)
  • On the possibility that cord blood stem cells could be used for other purposes, the World Marrow Donor Association and European Group on Ethics in Science and New Technologies states "The possibility of using one's own cord blood stem cells for regenerative medicine is currently purely hypothetical. (wikipedia.org)
  • With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
  • Identification of the appropriate type of transplantation - autologous (from the patient), syngeneic (from an identical twin), or allogeneic (from a related, unrelated or cord blood donor). (uchicagomedicine.org)
  • As a blood donor, you are a vital part of a team of individuals working together to save the lives of patients in our area's hospitals. (lifesouth.org)
  • As you relax in the donor chair, the phlebotomist will check your veins, swab your arm with iodine and prepare the bag and other materials needed to collect your blood donation. (lifesouth.org)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • Cellular therapy products for transplantation are obtained from a patient's own stem cells, a related donor, or an unrelated donor. (bethematch.org)
  • Most of these therapies require allogeneic transplants, where the patient must use a genetically-matched cord blood donor. (bioinformant.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (yashfiin.com)
  • A new cell therapy, donor lymphocyte infusion, emerged in the 1990s to ensure that the donor stem cells remain engrafted whereby lymphocytes from the blood of a donor are given to a patient who has already received a hematopoietic stem cells from the same donor. (mastercellbank.com)
  • Stem cells from a donor whose tissue is comparable to yours are used in the most popular allogeneic transplant. (bonemarrowtransplantations.com)
  • The International Bone Marrow Transplant Registry , the National Marrow Donor Program (NMDP) and U.S. News & World Report recognize Children's Colorado as meeting the highest standards of 100-day and one-year post-BMT survival compared to other U.S. pediatric BMT programs. (childrenscolorado.org)
  • Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)
  • First, the donor is provided numerous days of shots to help stem cells move from the bone marrow into the blood. (iytmed.com)
  • During leukapheresis, blood is removed from the donor through an IV line. (iytmed.com)
  • The red blood cells are returned to the donor. (iytmed.com)
  • Allogeneic transplant- The transplantation involves infusing stem cells, extracted from a donor who is genetically matched with the patient. (stemcelline.com)
  • Usually, the donor may be a sibling or any blood-related person, just in case no one is available then, the nearest genetically equivalent person can also donate to the patient. (stemcelline.com)
  • Though this transplant is quite preferable around the world, still there might occur many complications in case the donor is mismatched. (stemcelline.com)
  • The collaboration supports NiCord ® , Gamida Cell's investigational cell therapy, which has the potential to serve as a universal bone marrow donor source for patients with hematologic malignancies, or blood cancers, and bone marrow failure disorders requiring bone marrow transplantation. (bethematchbiotherapies.com)
  • Despite the curative potential of bone marrow transplants, it is estimated that more than 40 percent of eligible patients in the U.S. do not receive one for various reasons, including difficulty in finding a matched donor. (bethematchbiotherapies.com)
  • 1 NiCord is designed to potentially serve as a universal alternative to existing donor sources for bone marrow transplant. (bethematchbiotherapies.com)
  • Backed by the industry-leading experience of the National Marrow Donor Program/Be The Match , and a research partnership with the CIBMTR ® (Center for International Blood and Marrow Transplant Research ® ), the organization designs solutions that advance cell and gene therapies in any stage of development. (bethematchbiotherapies.com)
  • Studies of donor cord blood cells in adults with stroke and children with cerebral palsy and autism are also underway. (duke.edu)
  • When healthy stem cells used in a transplant come from a donor, it is called an allogeneic transplant. (fredhutch.org)
Mesenchymal stem6
  • Cord blood is also a source of mesenchymal stem cells, which can further be differentiated to form connective tissues, bones and cartilage. (wikipedia.org)
  • The ambitious Xcellerate proposal plans to raise USD 20 million over five years to cover cerebral palsy research using three types of cells: umbilical cord blood stem cells, mesenchymal stem cells, and induced neural progenitor stem cells. (parentsguidecordblood.org)
  • While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
  • There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
  • Among these, umbilical cord-derived mesenchymal stem cells (UC-MSCs), commonly referred to as Wharton's Jelly, have garnered attention for their promising applications in regenerative medicine. (innatehealthcare.org)
  • In contrast to autologous mesenchymal stem cells, which are harvested from an individual's bone marrow or fat tissue, UC-MSCs have a greater youthful potency and a higher capacity to self-replicate. (innatehealthcare.org)
Allogenic5
  • HIAE is accredited for autologous and allogenic transplantation. (factglobal.org)
  • allogenic natural killer cells (NK-cells) generated ex vivo from umbilical cord blood progenitor cells in cancer immunotherapy. (mastercellbank.com)
  • This BMT unit is at par with the best in the world, and performs both Allogenic, and Autologous BMT's. (mediescapes.com)
  • The average cost of an Autologous transplant is $10,000 to $39,796 and for an Allogenic transplant, it lies between $10,832 to $44,701. (stemcelline.com)
  • this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
Peripheral blood stem1
  • The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)
HSCT10
  • Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
  • Although outcomes after HSCT have improved markedly since transplants were first utilized, infection remains an important source of morbidity. (medscape.com)
  • With her expertise in T-cell depleted transplant and haploidentical HSCT, along with her several certifications and training, Dr. Smitha is a highly sought-after specialist. (hcgoncology.com)
  • Dr. Smitha's special interest lies in T cell-depleted transplant and haploidentical HSCT. (hcgoncology.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Adult autologous and allogeneic1
  • The Baptist Cancer Center Malignant Hematology and Transplant Program is a FACT-accredited program that performs adult autologous and allogeneic transplantation. (bethematch.org)
Centers7
  • It might be helpful to look at centers that have done transplants for a specific disease and centers that have done transplants for any corresponding broad disease categories . (bethematch.org)
  • Centers are not required to report autologous transplants so the numbers might be incomplete. (bethematch.org)
  • With FACT accreditation, it is possible to open this path to other transplantation centers that also take good care of Brazilian and Latin American patients. (factglobal.org)
  • 99% of transplantation centers in Japan. (apbmt.org)
  • The Japanese Society of Hematopoietic Cell Transplantation (JSHCT) has been conducting a nationwide survey on HCT since 1993, in which HCTs performed at participating centers are registered with the JSHCT every year. (apbmt.org)
  • 300 transplantation centers nationwide, with a penetration rate exceeding 99% 1 . (apbmt.org)
  • Before joining MC3 with her 20+ years of experience, Dr. Shaz was most recently the Executive Vice President, Chief Medical and Scientific Officer of the New York Blood Center, one of the largest independent, community-based, nonprofit blood centers in the United States. (duke.edu)
Multiple myeloma4
Haploidentical5
Progenitor6
  • These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
  • Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Cord blood is now being enriched with functional stem and progenitor cells and also immune modulatory cells. (mastercellbank.com)
  • Stored blood from umbilical cords is also a promising source of haematopoietic progenitor cells - the type of stem cells found in bone marrow and peripheral blood. (planer.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Chemotherapy14
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Conditioning treatment - administration of chemotherapy and/or radiation to the patient in order to destroy all of the diseased cells in the body and to create space in the bone marrow for the transplanted stem cells to populate. (uchicagomedicine.org)
  • Post-transplant care - including regular examinations to monitor allogeneic transplant patients for signs of graft vs. host disease (GVHD) and to watch autologous and allogeneic patients for immune system recovery, complications related to chemotherapy or radiation and cancer recurrence (relapse). (uchicagomedicine.org)
  • Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. (biomedcentral.com)
  • The autologous HCT cohort had a higher proportion of chemotherapy-sensitive disease, peripheral blood grafts, and HCT in first complete remission (CR1). (elsevierpure.com)
  • AHSCT aims to stop the damage caused by MS to the brain and spinal cord by 'wiping out' the faulty immune system with a high dose of chemotherapy. (sheffield.ac.uk)
  • Once destroyed, the immune system is then rebuilt using blood and bone marrow stem cells which would have been collected from the patient's own blood prior to chemotherapy. (sheffield.ac.uk)
  • People get lower doses of chemotherapy and radiation prior to a transplant. (iytmed.com)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (iytmed.com)
  • A bone marrow transplant replaces bone marrow that is either not working effectively or has been damaged (ablated) by chemotherapy or radiation. (iytmed.com)
  • Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
Outcomes4
  • Cytogenetics and Blast Count Determine Transplant Outcomes in Patients with Active Acute Myeloid Leukemia. (mdanderson.org)
  • We conduct research to improve transplant outcomes provide support and resources for patients, and partner with a global network. (bethematch.org)
  • For help with understanding these statistics, please see Understanding Transplant Outcomes . (bethematch.org)
  • Trends in utilization and outcomes after autologous or allogeneic hematopoietic cell transplantation (HCT) for Burkitt lymphoma were analyzed in 241 recipients reported to the Center for International Blood and Marrow Transplant Research between 1985 and 2007. (elsevierpure.com)
Procedure4
  • Donating blood is usually a simple and pleasant procedure. (lifesouth.org)
  • In 1996, the hospital performed the first transplantation procedure in an autoimmune disease patient (refractory autoimmune hemolytic anemia) in Brazil and, since 1999, encouraged by Julio Voltarelli, has been performing transplants for autoimmune diseases with special focus on multiple sclerosis. (factglobal.org)
  • A bone marrow transplant is a procedure to replace damaged or damaged bone marrow with healthy bone marrow stem cells. (iytmed.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Syngeneic1
Immune system11
  • Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
  • This is why cord blood cells are currently used to treat blood and immune system related genetic diseases, cancers, and blood disorders. (wikipedia.org)
  • It will take 6 to 12 months or more for your child's blood counts and immune system to fully recover. (medlineplus.gov)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Hematopoietic stem cells (HSCs) are defined as stem cells that have a preference for becoming cells of the blood and immune system, such as white blood cells, red blood cells, and platelets. (bioinformant.com)
  • Hematopoietic stem cells (HSCs) are the stem cells that repopulate the blood and immune system within humans, via a process known as haematopoiesis. (bioinformant.com)
  • Five years later in 1988, the first successful cord blood transplant to restore a patient's blood and immune system cells took place in France. (bioinformant.com)
  • For this type of cellular therapy, we draw blood from a patient to collect circulating T cells, which are an important part of the body's immune system. (childrenscolorado.org)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • These treatments require further medication to improve the immune system deteriorated during the period and sometimes even end up with destroying the healthy blood cells. (stemcelline.com)
  • The cord blood is tested for antigens, unique immune system markers, and is then controlled rate frozen prior to cryo storage at -196 C. Transplanted cord blood stem cells theoretically pose a lower risk of graft versus host problems because cord blood stem cells will not yet have fully developed antigen markers. (planer.com)
Donors9
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • That means the blood supply collected from our donors directly serves the needs of patients in our local community. (lifesouth.org)
  • Blood cannot be manufactured, and local hospitals rely on LifeSouth blood donors to make sure blood is on the shelf to help patients in their moment of need. (lifesouth.org)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • In 1997, the transplantation program from unrelated donors began with two procedures using cells from umbilical cords obtained from the New York Blood Center. (factglobal.org)
PBSCT1
  • In cases of unrelated HCT, PBSC transplantation (PBSCT) still comprises only a very small percentage, which reflects the fact that unrelated PBSCT did not come into use in Japan until 2010. (apbmt.org)
Therapies7
  • We have performed more than 1,100 bone marrow transplants and have a growing cellular therapy program offering new, effective and less toxic therapies for a variety of diseases. (childrenscolorado.org)
  • Gamida Cell's work to bring a new therapeutic option to patients in need of a bone marrow transplant aligns with our core mission to help organizations deliver cellular therapies that save more lives and improve the quality of life for patients," said Amy Ronneberg, President of Be The Match BioTherapies. (bethematchbiotherapies.com)
  • A systematic review of directly applied biologic therapies for acute spinal cord injury. (elearnsci.org)
  • Salewski RPF, Eftekharpour E, Fehlings MG. Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury? (elearnsci.org)
  • A systematic review of cellular transplantation therapies for spinal cord injury. (elearnsci.org)
  • Dr. Kurtzberg is an internationally renowned expert in pediatric hematology/oncology, pediatric blood and marrow transplantation, umbilical cord blood banking and transplantation, and novel applications of cord blood in the emerging fields of cellular therapies and regenerative medicine. (duke.edu)
  • Dr. Kurtzberg's lab has developed novel assays enumerating ALDH bright cells to predict cord blood potency from segments attached to cryopreserved cord blood units, and is performing translational research testing cord blood expansion, cellular targeted therapies and tissue repair and regeneration. (duke.edu)
Type of transplant2
Apheresis4
  • Blood stem cells are taken through a painless process called apheresis. (uchicagomedicine.org)
  • The stem cells are collected by passing all the blood through an apheresis machine that draws out stem cells from the blood and returns the rest of the blood. (stemcelline.com)
  • Prior to joining the New York Blood Center, Dr. Shaz was an Associate Professor at Emory University and directed the transfusion service at Grady Memorial Hospital, and before that, she was an Instructor at Harvard Medical School and Assistant Medical Director of the transfusion service and Medical Director of the transfusion/apheresis unit at Beth Israel Deaconess Medical Center in Boston. (duke.edu)
  • Dr. Shaz is President of AABB, a member of the Board of Directors of the Cord Blood Association, active member of the College of American Pathologists, and has been a board member, committee chair and active committee member of the American Society for Apheresis. (duke.edu)
Complications2
  • Early diagnosis and early implementation of bone marrow transplantation (BMT) are crucial to minimize neurodevelopmental complications and ensure productive adult life in patients with PNP deficiency. (medscape.com)
  • Our depth and breadth of knowledge allows us to treat both common and very rare blood diseases, and help manage any complications that might arise, helping you get better faster. (fredhutch.org)
Diseases7
  • Both private and public cord blood banks have developed in response to the potential for cord blood in treating diseases of the blood and immune systems. (wikipedia.org)
  • You will answer questions about your medical history, as well as questions required by the FDA to determine if you practice high-risk activities for contracting HIV, hepatitis and other diseases that are harmful to the community blood supply. (lifesouth.org)
  • For the past thirty years, cord blood has been used within transplant medicine, including for the treatment of leukemia and other blood diseases. (bioinformant.com)
  • Our top-ranked hematology, oncology, blood and marrow transplant and cellular therapy programs are national leaders in new and advanced treatments for pediatric cancers and blood diseases. (childrenscolorado.org)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • Our radiologists report on your imaging studies and our hematopathologists (pathologists who specialize in blood diseases) review the results of your biopsy. (bidmc.org)
  • Recent areas of investigation, which are funded by the Marcus Foundation, include the use of autologous cord blood in children with neonatal brain injury, cerebral palsy, and autism, as well as preclinical studies manufacturing microglial oligodendrocyte-like cells from cord blood to treat patients with acquired and genetic brain diseases. (duke.edu)
Donor's1
  • Physicians believe that for many cancers, the donor's white blood cells might attack any staying cancer cells, much like when white blood cells attack bacteria or viruses when fighting an infection. (iytmed.com)
Cancers4
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
  • Under the terms of the collaboration agreement, Gamida Cell and Be The Match BioTherapies will explore opportunities to work together across Gamida Cell's ongoing clinical development program for NiCord, including the Phase 3 clinical study in patients with high-risk blood cancers. (bethematchbiotherapies.com)
  • Blood and marrow transplant (BMT) is often the best therapy for blood cancers. (fredhutch.org)
Pediatric blood3
  • That's why our Pediatric Blood and Marrow Transplant and Cellular Therapy Program team is committed to the highest standards of quality, the latest and most proven treatments, and the overall care and well-being of your child and family. (childrenscolorado.org)
  • Our team is the region's most experienced pediatric blood and marrow transplant and cellular therapy (BMT) program. (childrenscolorado.org)
  • Our providers specialize in pediatric blood and marrow transplants and cellular therapy, so you can trust that your child is in good hands. (childrenscolorado.org)
Acute myeloid4
Patients undergoing1
  • 1,000 new AML patients undergoing allogeneic or autologous HCT. (apbmt.org)
Cells60
19871
Hematology1
  • Patients to be bone marrow transplanted are referred to BONE MARROW TRANSPLANT Council after their preliminary investigation by the related departments in the hospital such as Hematology, Oncology, Immunology and Metabolism or the related departments of the other hospitals. (saglik.gov.tr)
Disorders4
  • c)chronic myeloproliferative disorders, in which increased production of one or more terminally differentiated myeloid elements usually leads to elevated peripheral blood counts. (fdocuments.net)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • Corneal transplantation is currently the only therapy for severe corneal disorders. (lww.com)
  • HLBS-PopOmics: an online knowledge base to accelerate dissemination and implementation of research advances in population genomics to reduce the burden of heart, lung, blood, and sleep disorders. (cdc.gov)
Laboratory4
  • In 1996 and 1997, the institution was accredited by ISO 9001 in the areas of Laboratory, Blood Bank and Intensive Care Unit (ICU), which later spread to other areas. (factglobal.org)
  • The standards indicate that our transplant team has been consistently recognized through national peer review for high-quality patient care and laboratory performance for bone marrow transplant. (childrenscolorado.org)
  • Following various inspections by the Swissmedic Agency, acting autonomously (prerogative Standardised Transplant / Tissue from umbilical cord - autologous and allogeneic) as well as by delegation on behalf of the Federal Office of Public Health- FOPH (umbilical-cord blood - related allogeneic), the CORDSAVINGS laboratory has had its various operating licences extended. (cordsavings.com)
  • CordSavings laboratory meets the legal requirements for the storage of umbilical cord blood. (cordsavings.com)
Hospital7
HSCs2
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
Clinical9
  • Parent's Guide to Cord Blood Foundation reported in their March 2016 newsletter that CP Alliance is partnering with Cell Care , the largest family cord blood bank in Australia, on a clinical trial that offers sibling cord blood therapy at the Murdoch Childrens Research Institute to cerebral palsy patients in Australia. (parentsguidecordblood.org)
  • Therefore, we performed a phase 1/2a, single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs (UMSCs) in the treatment of psoriasis and to preliminarily explore the possible mechanisms. (nature.com)
  • While most of the existing clinical research has been on smaller numbers of patients receiving therapy, the lack of reported adverse events from UC-MSC transplantations is encouraging. (innatehealthcare.org)
  • NiCord, Gamida Cell's lead clinical program, is under development as a universal bone marrow transplant solution for patients with high-risk hematologic malignancies. (bethematchbiotherapies.com)
  • Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. (elearnsci.org)
  • Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. (elearnsci.org)
  • Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. (elearnsci.org)
  • Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. (elearnsci.org)
  • The world's first bone marrow transplant took place in the 1970s, when one of our physician-researchers, E. Donnall Thomas, MD , and his team developed the clinical use of transplants - and won a Nobel Prize for this work. (fredhutch.org)
Solid tumors1
  • The only exceptions to this are patients who are transplanted for solid tumors or acquired anemias. (bioinformant.com)
Mycosis fungoides1
Cellular4
  • Both public and private cord blood banks are also eligible for voluntary accreditation with either the Association for the Advancement of Blood & Biotherapies (AABB) or the Foundation for the Accreditation of Cellular Therapy (FACT). (wikipedia.org)
  • When your child needs a blood or bone marrow transplant or cellular therapy treatment, you want to find the best care possible. (childrenscolorado.org)
  • Our program is also an approved transplant site of the NMDP, the Children's Oncology Group (COG) and the Pediatric Transplantation and Cellular Therapy Consortium . (childrenscolorado.org)
  • In addition to advancing new pharmacological and cellular immunotherapies in support of these goals, we also are developing mobile health technologies (mHealth) to monitor patients at home, both as part of our innovative home transplant program as well as to improve follow up care of all our patients when they return home after transplant. (dukecancerinstitute.org)