SerumMaternalUmbilical cordIntestinal iron absorptionSpinal cord compreDevelopmentalLiverPreventiveIronPregnancyLevelsCellsMedicationOccurring during dPatientGroupsSamplesIncludeErythropoietinFerritinPregnancyAbsorption2022Concentrations2019DetectionSickle cell diHematopoieticClinicalLevelsPatientsRelationshipDevelopmentEarly childhoodStatusRoleGrowthBirthHigherTransferWeeksResponseWomenTherapy
Serum1
- 2009). Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients . (up.pt)
Maternal5
- 2009). Erythrocyte changes in preeclampsia: Relationship between maternal and cord blood erythrocyte damage . (up.pt)
- 2009). Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy . (up.pt)
- Pregnancy, delivery, and the puerperium are associated with increased rates of iron deficiency and anemia, which correlates with worse maternal and fetal outcomes and places pregnant women at increased risk of obstetric hemorrhage. (karger.com)
- They found that maternal fat metabolism as early as the 5th month of pregnancy, and the growth of the fetal abdomen growth patterns of fetal abdominal growth associated with maternal lipid metabolites that track newborn growth, adiposity and development into childhood. (ox.ac.uk)
- These fetal growth patterns are also associated with blood flow and nutrient transfer by the placenta, demonstrating a complex interaction between maternal and fetal nutrition early in pregnancy that influences postnatal weight and eventually adult health. (ox.ac.uk)
Umbilical cord4
- The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
- The youngest and most primitive MSCs may be obtained from umbilical cord tissue, namely Wharton's jelly and the umbilical cord blood. (wikipedia.org)
- The umbilical cord is available after a birth. (wikipedia.org)
- Supported by a grant from the Bill & Melinda Gates Foundation, the INTERBIO-21st Study monitored the growth inside the womb of over 3,500 babies in six countries (Brazil, Kenya, Pakistan, South Africa, Thailand, and the United Kingdom) using serial fetal ultrasound scans throughout pregnancy, and analysed blood samples taken from the women early in pregnancy and from the umbilical cord at birth. (ox.ac.uk)
Intestinal iron absorption2
- The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. (bvsalud.org)
- Hypoxia downregulates the expression of hepcidin, which leads to both increased intestinal iron absorption and increased release of recycled iron from the reticuloendothelial system [ 21 , 22 ]. (hindawi.com)
Spinal cord compre2
- As a result, males may be more likely to have extramedullary hematopoiesis and thus more likely to require splenectomy or to develop spinal cord compression, an uncommon but serious complication of paraspinal extramedullary hematopoiesis. (medscape.com)
- Yathiraj PH, Singh A, Vidyasagar S, Varma M, Mamidipudi V. Excellent and durable response to radiotherapy in a rare case of spinal cord compression due to extra-medullary hematopoiesis in β-thalassemia intermedia: case report and clinicoradiological correlation. (medscape.com)
Developmental1
- The paper complements work published by the same groups in 2021 that identified fetal head growth trajectories that are associated with different developmental, behavioural, visual and growth outcomes at 2 years of age. (ox.ac.uk)
Liver1
- The master regulator of iron balance in humans is hepcidin, a peptide produced by the liver [ 20 ]. (hindawi.com)
Preventive1
- Bleeding complications should be anticipated and blood loss reduced by interdisciplinary preventive measures and individually tailored care. (karger.com)
Iron1
- Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. (frontiersin.org)
Pregnancy2
- Aims: We aimed to determine the prevalence of antidiabetic drug use (insulins and blood glucose-lowering drugs) before and during pregnancy in Switzerland and the changes therein during pregnancy and over time. (bvsalud.org)
- Very importantly, in both studies, the same critical time period close to the 5th month of pregnancy is the starting point for accelerated or decelerated fetal growth that is sustained into early childhood. (ox.ac.uk)
Levels1
- Therefore, we aimed (1) to provide the first data on cord blood hepcidin levels in a Belgian cohort and (2) to determine variables associated with cord blood hepcidin concentrations. (bvsalud.org)
Cells3
- These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
- However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
- Transfusion of washed, leukocyte-poor red blood cells (RBCs) at approximately 8-15 mL RBCs per kilogram (kg) of body weight over 1-2 hours is recommended. (medscape.com)
Medication1
- We identified claims for any antidiabetic medication (ADM), insulins, blood glucose-lowering drugs, and individual substances within each class. (bvsalud.org)
Occurring during d1
- Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? (gu.se)
Patient1
- Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic transfusions. (karger.com)
Groups1
- ABO and Rh blood groups, demographics, and comorbidities in COVID-19 related deaths: A retrospective study in Split-Dalmatia County, Croatia. (kbsplit.hr)
Samples1
- Cord blood samples were analyzed using a combination of weak cation exchange chromatography and time-of-flight mass spectrometry. (bvsalud.org)
Include1
- Blood banking considerations for these patients include completely typing their erythrocytes for Rh and ABO antigens prior to the first transfusion. (medscape.com)
Erythropoietin4
- 13. Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. (nih.gov)
- 2009). Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients . (up.pt)
- During pregnancy, adaptations to iron homeostasis occur due to increased maternal, neonatal and placental iron demands, Maternal iron absorption and release from stores is regulated in response to iron demands via regulatory hormones erythropoietin, hepcidin and erythroferrone. (cornell.edu)
- While data on erythropoietin and hepcidin during pregnancy exist, no data on erythroferrone in human pregnancies exist due to previous lack of validated human assay. (cornell.edu)
Ferritin3
- 12. Depleted iron stores and iron deficiency anemia associated with reduced ferritin and hepcidin and elevated soluble transferrin receptors in a multiethnic group of preschool-age children. (nih.gov)
- 17. Threshold Ferritin Concentrations Reflecting Early Iron Deficiency Based on Hepcidin and Soluble Transferrin Receptor Serum Levels in Patients with Absolute Iron Deficiency. (nih.gov)
- Secondary objectives were to investigate the development of hepcidin, plasma ferritin and inflammatory markers over the course of pregnancy dependent on weight status. (cambridge.org)
Pregnancy4
- Aims: We aimed to determine the prevalence of antidiabetic drug use (insulins and blood glucose-lowering drugs) before and during pregnancy in Switzerland and the changes therein during pregnancy and over time. (bvsalud.org)
- This is consistent with elevated hepcidin in the 3 rd trimester and higher inflammation throughout pregnancy. (cambridge.org)
- Supported by a grant from the Bill & Melinda Gates Foundation, the INTERBIO-21st Study monitored the growth inside the womb of over 3,500 babies in six countries (Brazil, Kenya, Pakistan, South Africa, Thailand, and the United Kingdom) using serial fetal ultrasound scans throughout pregnancy, and analysed blood samples taken from the women early in pregnancy and from the umbilical cord at birth. (ox.ac.uk)
- Very importantly, in both studies, the same critical time period close to the 5th month of pregnancy is the starting point for accelerated or decelerated fetal growth that is sustained into early childhood. (ox.ac.uk)
Absorption3
- 5. A Prolonged Bout of Running Increases Hepcidin and Decreases Dietary Iron Absorption in Trained Female and Male Runners. (nih.gov)
- The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. (bvsalud.org)
- Overweight/obesity (owob) causes low-grad systemic inflammation and thereby an up-regulation of hepcidin and a reduction in fractional iron absorption (FIA) even with low iron stores. (cambridge.org)
20221
- Blood (2022 Nov 24) 140:2276-2289. (nih.gov)
Concentrations2
- 14. The effects of 8 weeks of endurance running on hepcidin concentrations, inflammatory parameters, and iron status in female runners. (nih.gov)
- Therefore, we aimed (1) to provide the first data on cord blood hepcidin levels in a Belgian cohort and (2) to determine variables associated with cord blood hepcidin concentrations. (bvsalud.org)
20192
Detection1
Sickle cell di2
- Association of haemolysis markers, blood viscosity and microcirculation function with organ damage in sickle cell disease in sub-Saharan Africa (the BIOCADRE study). (amedeo.com)
- Comparison of CD34(+) cells isolated from frozen cord blood and fresh adult peripheral blood of sickle cell disease patients in gene correction of the sickle mutation at late-stage erythroid differentiation. (nih.gov)
Hematopoietic3
- These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
- However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
- For β-thalassemia major, hematopoietic stem cell transplantation (HSCT), cord blood transplantation from a related donor, or autologous HSCT with gene therapy . (nih.gov)
Clinical1
Levels3
- 3. Hepcidin and other indicators of iron status, by alpha-1 acid glycoprotein levels, in a cohort of Mexican infants. (nih.gov)
- Cord blood iron levels were measured in 217 control infants. (nih.gov)
- The genotypes expected to increase fetal iron levels correlated with birth weight in males and their association with ALL was stronger in females who, we postulate, could not offset iron excess by increasing their weight. (nih.gov)
Patients1
- Blood banking considerations for these patients include completely typing their erythrocytes for Rh and ABO antigens prior to the first transfusion. (medscape.com)
Relationship1
- Is there a relationship between fetal brain function and the fetal behavioral state? (uni-tuebingen.de)
Development2
- Through its effect on cell proliferation, iron is involved in both fetal development and cancer. (nih.gov)
- Treatment with regular red blood cell transfusions and iron chelation therapy allows for normal growth and development and improves prognosis. (nih.gov)
Early childhood1
Status2
- 11. The value of soluble transferrin receptor and hepcidin in the assessment of iron status in children with cystic fibrosis. (nih.gov)
- Cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery, but are not available for the Belgian population. (bvsalud.org)
Role1
- Role of MFHAS1 in regulating hepcidin expression via the BMP/SMAD and MAPK/ERK1/2 signalling pathways. (nih.gov)
Growth2
- The paper complements work published by the same groups in 2021 that identified fetal head growth trajectories that are associated with different developmental, behavioural, visual and growth outcomes at 2 years of age. (ox.ac.uk)
- Variation in the SITAR size parameter was ≥90% explained by the combination of average length within the first 60 days of birth (as a proxy for fetal growth) and intensity, regardless of sex, with much greater contribution by postnatal intensity (r≥0.89 between size and intensity). (ox.ac.uk)
Birth2
- The umbilical cord is available after a birth. (wikipedia.org)
- Certain materno-fetal genotype combinations that increase fetal iron exposure showed associations with higher birth weight in males and somewhat higher ALL risk in females. (nih.gov)
Higher1
- Hepcidin was still significantly higher in the owob women in the 3 rd trimester. (cambridge.org)
Transfer1
- Iron transfer to the fetus was determined as iron stable isotope concentration in cord blood. (cambridge.org)
Weeks1
- For β-thalassemia major, complete blood count every three to four weeks and with illnesses. (nih.gov)
Response1
- 15. Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? (nih.gov)
Women2
- 4. Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection. (nih.gov)
- More than a third (36%) of those women with a preoperative hematocrit of 25% or less required a postoperative blood transfusion. (glowm.com)