Loading...
  • clinical
  • The method most commonly used in clinical practice is the "closed technique", which is similar to standard blood collection techniques. (wikipedia.org)
  • Gamida Cell is a clinical-stage biopharmaceutical company leveraging its proprietary technology to develop cell therapies that are designed to cure cancer and rare, serious hematologic diseases. (businesswire.com)
  • To learn more about Gamida Cell, including current clinical studies, please visit www.gamida-cell.com and on Twitter , LinkedIn and Facebook . (businesswire.com)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Antibodies are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. (wikipedia.org)
  • In 1995, Hackensack was part of a large clinical study sponsored by National Cancer Institute to study the use of bone marrow transplantation to treat women with advanced breast cancer. (wikipedia.org)
  • This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression. (wikipedia.org)
  • cytokines
  • The T cells produce an excess of cytokines, including TNF-α and interferon-gamma (IFNγ). (wikipedia.org)
  • showed that human dermal fibroblast-derived Muse cells were efficiently differentiated into melanin-producing functional melanocytes by a cocktail of cytokines. (wikipedia.org)
  • TGFβ The TGFβ family of cytokines regulate the stemness of both normal and cancer stem cells. (wikipedia.org)
  • myeloid
  • Using the ratio ρ = L / M {\displaystyle \rho =L/M} of lymphoid (L) to myeloid (M) cells in blood as a quantitative marker, the stem cell compartment can be split into three categories of HSC. (wikipedia.org)
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • mononuclear cells
  • Other tests are performed depending on the suspected disorder: Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T lymphocytes (dependent on their cell surface markers, e.g. (wikipedia.org)
  • spinal cord i
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • Research has shown that CD34+ cells are relatively more in men than in women in the reproductive age among Spinal Cord Injury victims. (wikipedia.org)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • aplastic anemia
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • The USFDA has conferred orphan drug status on Pluristem's PLX cells for the treatment of Buerger's disease (2011) and aplastic anemia (2013). (wikipedia.org)
  • Antibodies
  • The basic tests performed when an immunodeficiency is suspected should include a full blood count (including accurate lymphocyte and granulocyte counts) and immunoglobulin levels (the three most important types of antibodies: IgG, IgA and IgM). (wikipedia.org)
  • Tests for T cell function: skin tests for delayed-type hypersensitivity, cell responses to mitogens and allogeneic cells, cytokine production by cells Tests for B cell function: antibodies to routine immunisations and commonly acquired infections, quantification of IgG subclasses Tests for phagocyte function: reduction of nitro blue tetrazolium chloride, assays of chemotaxis, bactericidal activity. (wikipedia.org)
  • commonly
  • Unlike ES and iPS cells, transplanted Muse cells in testes of immunodeficient mice -a commonly used experiment to test the tumorigenicity of stem cells- have not been reported to form teratomas, even after six months. (wikipedia.org)
  • somatic
  • Hela cells and human fibroblast-derived iPS cells showed high telomerase activity while Muse was at nearly the same level as that in somatic cells such as fibroblasts (these data are shown without running control for the telomerase activity, the comparison is not scientific thought). (wikipedia.org)
  • In contrast, genes related to cell cycle progression and tumorigenicity in Muse cells were at the same level as those in somatic cells, while the same genes were very high in ES and iPS cells. (wikipedia.org)
  • 2002
  • This view was first challenged by the 2002 discovery by the Muller-Sieburg group in San Diego, who illustrated that different stem cells can show distinct repopulation patterns that are epigenetically predetermined intrinsic properties of clonal Thy-1lo Sca-1+ lin− c-kit+ HSC. (wikipedia.org)
  • In 2002, Pecora was an investigator in a study of PV701, a virus that selectively attacks cancer cells. (wikipedia.org)
  • adult stem
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation. (wikipedia.org)
  • As BLSC's and VSEL cells are present in virtually all adult tissues, including lung, brain, kidneys, muscles, and pancreas Co-purification of BLSC's and VSEL cells with other populations of adult stem cells may explain the apparent pluripotency of adult stem cell populations. (wikipedia.org)
  • 2016
  • In August 2016, Europe's Horizon 2020 Program awarded Pluristem an $8 million grant to cover a portion of its expenses in Europe for Pluristem's Phase III study of PLX-PAD cells in the treatment of critical limb ischemia. (wikipedia.org)
  • tissues
  • Pluripotent stem cells can be directly obtained from normal human mesenchymal tissues without using artificial manipulations such as gene introduction. (wikipedia.org)
  • More recent findings suggest that pluripotent stem cells may reside in blood and adult tissues in a dormant state. (wikipedia.org)