Copper azides. Medical search. Frequent questions

More particularly, the invention relates to a copper catalyzed regioselective click chemistry ligation of azides and terminal alkynes to form triazoles. (justia.com)
The second chapter describes a method for the preparation of 5-iodo-1,2,3-triazoles directly from organic azides and terminal alkynes. (fsu.edu)
Through these improvements the method became more synthetically practical and increased the reaction substrate scope to include unreactive azides and alkynes. (fsu.edu)
The method described in Chapter 3 is a simple and rapid process for the synthesis of bistriazoles from organic azides and terminal alkynes under oxidative conditions ( oxygen atmosphere) with a broad substrate scope. (fsu.edu)
N-substituted glycine oligomers, or peptoids, can be used in conjunction with the copper-catalyzed [3 + 2] cycloaddition of azides and alkynes to generate branched polymer networks. (nyu.edu)
By incorporating both azides and alkynes as side chain functionalities on the oligomer scaffolds, peptoids are able to form cross-linked macromolecular products. (nyu.edu)
It Ciproxifan is definitely known that alkynes could be triggered toward uncatalyzed [3+2] cycloaddition by conjugating the alkyne device with electron-withdrawing ester organizations because of a lowering from the LUMO energy from the alkyne.13 14 Thus it really is reasonable to check the theory that propiolate derivatives ethynyl ketones and ethynyl aldehydes could possibly be more reactive inside a copper-catalyzed AAC aswell. (healthy-nutrition-plan.com)
Fmoc- protected for solid phase synthesis), propargyl amino acids, PEG azide and alkynes (Maleimide-PEG3-Azide and acetylene PEG maleimide for pegylation), alkyne and azide containing chemical modification reagents (propargyl amine, 1-(2-nitrophenyl) propargyl alcohol, succinidyl-hex-5-ynoate, succinimidyl-4-azovalerate, pentynoic acid, 2-azido-3-methyl propanoic acid) and Diazo transfer reagents (imidazole-1-sulfonyl azide). (genengnews.com)
The copper-catalyzed Huisgen 1,3-dipolar cycloaddition of organic azides and terminal alkynes is an important click reaction for such processes. (chemistryviews.org)

This dissertation describes the development of alternative products from the copper-catalyzed azide-alkyne cycloaddition (CuAAC). (fsu.edu)
Chapter 5 summarizes the work conducted on modifying the conditions applied to the copper catalyzed azide alkyne cycloaddition (CuAAC). (fsu.edu)
We assumed from limited anecdotal info that CuAAC response rates are even more sensitive to the type from the alkyne component compared to the azide. (healthy-nutrition-plan.com)
The electron-poor character of propiolamides may provide well for the introduction of turn-on fluorogenic substrates for CuAAC as illustrated from the dequenching of pyrene-propiolamide (PyrPRA) substrate upon response with an azide. (healthy-nutrition-plan.com)
AZDye™ 800 Picolyl Azide is an advanced fluorescent probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boost the efficiency of the CuAAC reaction, resulting in a faster and more biocompatible CuAAC labeling. (vectorlabs.com)
The copper-catalyzed variant of Huisgen azide-alkyne cycloaddition (CuAAC) fits the concept well and is one of the most popular prototype click reactions to date. (genengnews.com)
CuAAC click reaction between an azide and alkyne takes place in presence of a Cu (I) catalyst under mild conditions, resulting in the formation of a triazole link connecting the two molecules. (genengnews.com)
In peptide chemistry the increasing popularity of the CuAAC is largely a result of the unique properties of both azides and the resulting triazoles. (genengnews.com)
This article describes the first observation of crystallization-induced microphase separation in thin film and bulk cellulose triacetate- block -poly(γ-benzyl- l -glutamate) (PBLG) [cellulose triacetate (CTA)- b -PBLG] via copper-catalyzed azide-alkyne cycloaddition (CuAAC) between azido-functionalized CTA at the reducing end and alkyne-functionalized PBLG at the C-terminus. (springer.com)
Copper-catalysed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) is the predominantly used bioconjugation method in the field of activity-based protein profiling (ABPP). (cipsm.de)

Although azide chemistry can be hazardous, the hazard of working with these reagents may be minimized by employing appropriate safety precautions. (justia.com)
The uniqueness of azides for click chemistry purposes arises from the extraordinary stability of these reagents toward H 2 O, O 2 , and the majority of organic synthesis conditions. (justia.com)
Reagents contain sodium azide. (avivasysbio.com)
Use of plumbing free of lead or copper or of reagents that do not contain azides are recommended. (cdc.gov)
Sodium azide has been added to some reagents as a preservative. (lincoresearch.com)

Sodium azide exists as an odorless white solid. (cdc.gov)
Persons who work on automobiles regularly are at an increased risk of exposure to sodium azide, which is used as a propellant in airbags. (cdc.gov)
Exposure to sodium azide can be fatal. (cdc.gov)
Indoor Air: Sodium azide can be released into indoor air as fine particles (aerosol). (cdc.gov)
Water: Sodium azide can be used to contaminate water. (cdc.gov)
Agricultural: If sodium azide is released into the air as fine particles (aerosol), it has the potential to contaminate agricultural products. (cdc.gov)
Sodium azide can be absorbed into the body by inhalation, ingestion, skin contact, or eye contact. (cdc.gov)
Ingestion is an important route of exposure to solid sodium azide. (cdc.gov)
Contains sodium azide. (fishersci.com)
Sodium azide may react with lead and copper plumbing to form highly explosive metal azide. (fishersci.com)
Sodium azide is very toxic if ingested or inhaled. (avivasysbio.com)
Sodium azide yields toxichydrazoic acid under acidic conditions. (avivasysbio.com)
This Current Intelligence Bulletin briefly discusses the explosive hazard associated with sodium-azide (26628228). (cdc.gov)
Sodium-azide, a common preservative used in automatic blood counters in over 15000 hospitals and clinical laboratories in the United States, was associated with a number of violent explosions at hospitals in the United States and Canada. (cdc.gov)
After completing the blood count procedure, the waste (containing azide) was usually flushed into a drain, bathing the drain with solutions of sodium-azide. (cdc.gov)
Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. (cdc.gov)
When it is mixed with water or an acid, sodium azide changes rapidly to a toxic gas with a pungent (sharp) odor. (cdc.gov)
Sodium azide is best known as the chemical found in automobile airbags. (cdc.gov)
An electrical charge triggered by automobile impact causes sodium azide to explode and convert to nitrogen gas inside the airbag. (cdc.gov)
Sodium azide is used as a chemical preservative in hospitals and laboratories. (cdc.gov)
In one case, sodium azide was poured into a drain, where it exploded and the toxic gas was inhaled (breathed in). (cdc.gov)
Sodium azide is used in agriculture (farming) for pest control. (cdc.gov)
Sodium azide is also used in detonators and other explosives. (cdc.gov)
Following release of sodium azide into water, you could be exposed to sodium azide by drinking the contaminated water. (cdc.gov)
Following contamination of food with sodium azide, you could be exposed to sodium azide by eating the contaminated food. (cdc.gov)
Following release of sodium azide into the air, you could be exposed by breathing in the dust or the gas that is formed. (cdc.gov)
Sodium azide can also enter the body and cause symptoms through skin contact. (cdc.gov)
An explosion involving sodium azide may cause burn injury as well as expose people to the toxic gas, hydrozoic acid. (cdc.gov)
The seriousness of poisoning caused by sodium azide depends on the amount, route, and length of time of exposure, as well as the age and preexisting medical condition of the person exposed. (cdc.gov)
Breathing the gas that is formed from sodium azide causes the most harm, but ingesting (swallowing) sodium azide can be toxic as well. (cdc.gov)
The gas formed from sodium azide is most dangerous in enclosed places where the gas will be trapped. (cdc.gov)
The gas formed from sodium azide is less dense (lighter) than air, so it will rise. (cdc.gov)
Sodium azide prevents the cells of the body from using oxygen. (cdc.gov)
Sodium azide is more harmful to the heart and the brain than to other organs, because the heart and the brain use a lot of oxygen. (cdc.gov)
Showing these signs and symptoms does not necessarily mean that a person has been exposed to sodium azide. (cdc.gov)
Survivors of serious sodium azide poisoning may have heart and brain damage. (cdc.gov)
First, get fresh air by leaving the area where the sodium azide was released. (cdc.gov)
Moving to an area with fresh air is a good way to reduce the possibility of death from exposure to sodium azide. (cdc.gov)
If the sodium azide release was outside, move away from the area where the sodium azide was released. (cdc.gov)
If the sodium azide release was indoors, get out of the building. (cdc.gov)
If leaving the area that was exposed to sodium azide is not an option, stay as low to the ground as possible, because sodium azide fumes rise. (cdc.gov)
If you are near a release of sodium azide, emergency coordinators may tell you to either evacuate the area or to " shelter in place " inside a building to avoid being exposed to the chemical. (cdc.gov)
If you think you may have been exposed to sodium azide, you should remove your clothing, rapidly wash your entire body with soap and water, and get medical care as quickly as possible. (cdc.gov)
Sodium azide is highly toxic. (illinois.edu)
Sodium azide in solution is rapidly absorbed through the skin. (illinois.edu)
Sodium azide rapidly hydrolyzes in water and acids, forming hydrazoic acid (HN 3 ), a highly toxic and volatile liquid solution that poses a serious inhalation hazard. (illinois.edu)
Sodium azide decomposes violently when heated to 275⁰C. (illinois.edu)
When sodium azide or its solutions come into contact with metal surfaces such as lead, copper, zinc, silver, or brass, heavy metal azides, which are highly shock-sensitive explosives, are formed. (illinois.edu)
Mixing sodium azide solutions with heavy metal salts including mercuric chloride can lead to explosions. (illinois.edu)
Due to the hazards associated with solid sodium azide, buying dilute solutions of 5% or less sodium azide is recommended. (illinois.edu)
Wear standard laboratory attire i.e., closed-toe shoes, long pants, a lab coat, eye protection, and nitrile gloves when handling sodium azide powder or solution. (illinois.edu)
Clearly label all equipment and instruments that come into contact with sodium azide, and thoroughly flush them with water to avoid the build-up of azide salts. (illinois.edu)
Be careful servicing metal parts that have come into contact with sodium azide. (illinois.edu)
Sweep up spills of solid sodium azide carefully, and try to avoid dust formation. (illinois.edu)
Store sodium azide in a cool, dry area away from heat and open flames. (illinois.edu)
Under no circumstances should you pour sodium azide solutions down the drain. (illinois.edu)

The organic azides and heavy metal azides are explosive. (ihcworld.com)

Copper azide can be prepared by a metathesis reaction between water-soluble sources of Cu2+ and azide ions. (wikipedia.org)
In many instances, the reaction sequence regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles. (justia.com)
The reaction is mediated by in-situ generated copper(I) catalyst and iodinating agents. (fsu.edu)
The 2nd-order price constant from the conjugate addition of the model cysteine-containing peptide to possess recently described the usage of 2-picolyl azides for bioconjugation.44 The chelating impact allows the a reaction to proceed at low micromolar concentration of reactants without accelerating ligands but with benefits using their use. (healthy-nutrition-plan.com)
Through these experiments , he found that copper ions had controlled the reaction to only form one product, leading him to discover the copper catalyzed azide-alkyne cycloaddition. (popsci.com)
W]e developed the copper-free SPAAC-NAD-seq, which utilizes the strain-promoted azide-alkyne cycloaddition reaction to capture NAD-RNAs followed by high-throughput sequencing," the authors write. (genomeweb.com)
The great development in synthetic strategies, from click polymerization ( i.e. , copper-catalyzed azide-alkyne cycloaddition, metal-free azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, thiol-ene/yne addition, Diels-Alder cycloaddition, Menschutkin reaction, and aza-Michael addition) to recently reported multicomponent reactions, gives rise to diverse HPs with desirable functional/hetero-functional groups and topologies such as segmented or sequential ones. (rsc.org)
Reaction with lead or copper pipes can build up highly explosive azide salts. (illinois.edu)
Dibenzocyclooctyne (DBCO, ADIBO) is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (spAAC), a copper-free click chemistry reaction. (sysy.com)

A metal catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to give triazoles. (justia.com)

Azide reacts with cyclooctyne including DBCO through catalyst-free strain-promoted azide-alkyne cycloaddition (SPAAC). (creativepegworks.com)

However, probably because of concerns about the safety of working with organic azides, synthetic chemists, in both pure and applied fields, have not given this transformation the special attention it deserves. (justia.com)
Azides make only a fleeting appearances in organic synthesis, serving as one of the most reliable means to introduce a nitrogen substituent -R-X→[R-N 3 ]→R-NH 2 . (justia.com)
Indeed, organic azides, particularly in the aliphatic series, are exceptionally stable toward the common reactive chemicals, ranging from dioxygen and water to the aqueous solutions of highly-functionalized organic molecules which make up living cells. (justia.com)
Researchers found a new way to reduce carbon dioxide (CO 2 ) emissions by wrapping copper nanocubes with an organic layer, solving instability and selectivity problems with copper nanocubes in catalysis, and improving how this electrocatalyst converts CO 2 into organic molecules. (hiroshima-u.ac.jp)
While bulk copper metal has known to convert carbon dioxide into various organic molecules, these small pieces of copper can further improve catalytic activity not only by the increase of its surface area but also by the unique electronic structure of copper emerged from nanosizing. (hiroshima-u.ac.jp)
These monomers were tethered by the chemistry on copper oxide and an even organic layer grew on the surface of the cubes. (hiroshima-u.ac.jp)
The wrapping improved carbon dioxide reduction of the copper beneath this organic layer by suppressing hydrogen evolution, and also maintained the cubic structure throughout the catalyst operation," said Kume. (hiroshima-u.ac.jp)
It reacts with halogenated organics (e.g., dichloromethane), forming explosive organic azides. (illinois.edu)

Copper(II) azide is a medium density explosive with the molecular formula Cu(N3)2. (wikipedia.org)
Copper azide is very explosive and is too sensitive for any practical use unless handled in solution. (wikipedia.org)
Cu2+ + 2 N−3 → Cu(N3)2 It can be destroyed by concentrated nitric acid to form non-explosive products, these being nitrogen, nitrogen oxides and copper(II) nitrate. (wikipedia.org)
Dilute azide- containing compounds in running water before discardingto avoid accumulation of potentially explosive deposits in lead or copper plumbing. (avivasysbio.com)
Current intelligence bulletin 13 - explosive azide hazard. (cdc.gov)
Procedures for decontaminating plumbing that currently contain explosive azides are given. (cdc.gov)

Shah, NH & Kirshenbaum, K 2008, ' Direct generation of polymer films on copper surfaces through azide-alkyne cycloaddition reactions between peptidomimetic oligomers ', Macromolecular Rapid Communications , vol. 29, no. 12-13, pp. 1134-1139. (nyu.edu)
Click chemistry is a versatile tool to conjugate PEG to various substrates through copper-free or copper-catalyzed azide-alkyne cycloaddition reactions. (creativepegworks.com)

Reacts with silver, copper forming compounds sensitive to mechanical shock, concussion, friction or sparks. (ihcworld.com)
Azide reacts with alkyne in the presence of copper catalyst to form a stable 1,2,3-triazole ring linkage. (creativepegworks.com)
Cholesterol-PEG-DBCO reacts with azide in a copper-free click chemistry. (creativepegworks.com)

The reactions are mediated by copper(II) acetate, and completed within 3 hours, with ≥ 50% isolated yields. (fsu.edu)
Peptides can also be made by inter- and intramolecular click reactions using azide or alkyne containing amino acids or building blocks during peptide synthesis. (genengnews.com)

The invention relates to a stepwise Huisgen cycloaddition process catalyzed by copper(l). (justia.com)
It is called Azide-Alkyne Huisgen Cycloaddition. (creativepegworks.com)

The SPAAC-NAD sequencing (SPAAC-NAD-seq) approach is designed to capture and characterize NAD-RNAs using a scheme that avoids a copper catalyzed enzymatic conversion step used in a conventional NAD captureSeq method, the team says, noting that the copper ions can contribute to RNA fragmentation that dials down sensitivity of that approach. (genomeweb.com)

Alkali and alkaline earth azides are not considered explosives under normal laboratory conditions. (ihcworld.com)

It also changes into a toxic gas (hydrazoic acid) when it comes in contact with solid metals (for example, when it is poured into a drain pipe containing lead or copper). (cdc.gov)

Azides are chemically important as a crucial functional group for click chemistry (H. C. Kolb, et al. (justia.com)
I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
Just as Sharpless was working on click chemistry in the early 2000's, Morten Meldal from the University of Copenhagen and Sharpless separately presented what considered to be the crown jewel of click chemistry: the copper catalyzed azide-alkyne cycloaddition . (popsci.com)

The functional group such as DBCO is used to conjugate azide-containing moieties including protein, antibody and dyes on the micelle or liposome surface. (creativepegworks.com)

Even dilute solutions can accumulate enough azide salts over time to cause a serious explosion. (illinois.edu)

The azide intermediate is shown in brackets because it is generally reduced straightaway to the amine. (justia.com)

Azide groups are easy to introduce, stable to water and oxidative conditions, and orthogonal to many functional groups in peptide synthesis. (genengnews.com)

Over a period of time, the azide reacted with copper, lead, brass, or solder in the plumbing system to form an accumulation of lead- azide (13424469) or copper-azide (14215306). (cdc.gov)

Introduction of azide and alkyne moieties into structurally diverse peptide side chains, combined with on-resin macrocyclization conditions, is used to design structurally constrained peptides. (genengnews.com)

Although the actual cycloaddition step may be faster and/or more regioselective for 1,3-dipoles other than azide, the latter is by far the most convenient to introduce and to carry hidden through many synthetic steps. (justia.com)

Recent developments in carbon dioxide reduction using copper electrocatalysts can convert the gas into hydrocarbons and alcohol, but the selectivity of various copper-related electrocatalysts developed so far is still elusive, because they tend to lose activity through structural reorganization during the catalysis," said Shoko Kume , associate professor at the Graduate School of Advanced Science and Engineering at Hiroshima University in Japan. (hiroshima-u.ac.jp)

Up to 40-fold increase of signal intensity, compared to conventional azides, was reported (see Selected References). (vectorlabs.com)

Mild and catalytic copper-induced cleavage of Ynoc carbamate could be useful when traditional safeguarding organizations for an amino group can't be used because of senstitivity from the substrtate towards the cleavage protocols. (healthy-nutrition-plan.com)

On disposal, flush with a large volume of water to prevent azide buildup. (fishersci.com)

In a paper published in Chemical Communications on June 23, researchers explain a process for improving the way the copper nanocubes convert carbon dioxide, by improving their selectivity. (hiroshima-u.ac.jp)

Currently, copper nanocubes are not widely adopted as a method for carbon dioxide reduction because they are unstable and do not have the level of selectivity needed to effectively recycle the carbon dioxide into other chemical products. (hiroshima-u.ac.jp)

Applications which leverage the unique reactivity offered by the azide group itself are disclosed by the following references from the laboratories of Aube, Banert, and Stoddart (a) P. Desal, et al. (justia.com)

Do not discard solutions containing azides down domestic sinks. (ihcworld.com)

The oligomer starting materials are readily associated onto copper metal sheets, allowing for localized cross-link proliferation which in turn generates thin film polymer coatings. (nyu.edu)

Anatomy1

Diseases4

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes10

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Alkynes9

CuAAC10

Reagents5

Sodium56

Heavy metal azides1

Reaction9

Triazoles1

Strain-promoted1

Organic8

Explosive6

Cycloaddition reactions2

Reacts3

Reactions2

Huisgen2

Ions1

Explosives1

Hydrazoic acid1

Chemistry3

Conjugate1

Dilute1

Amine1

Synthesis1

Accumulation1

Moieties1

Synthetic1

Catalysis1

Conventional1

Catalytic1

Water1

Convert1

Chemical1

References1

Solutions1

Metal1