• Airway basal cells are found deep in the respiratory epithelium, attached to, and lining the basement membrane. (wikipedia.org)
  • Basal cells are the stem cells or progenitors of the airway epithelium and can differentiate to replenish all of the epithelial cells including the ciliated cells, and secretory goblet cells. (wikipedia.org)
  • Basal cells are the stem cells, or progenitors of all the cells in the respiratory epithelium. (wikipedia.org)
  • Typically the airway epithelium turns over fairly slowly with the basal cells in a quiescent state, and just a few intermediate cells being seen. (wikipedia.org)
  • Following injury to airway epithelium, the basal cells can become infected by the respiratory syncytial virus. (wikipedia.org)
  • Studies have shown that the initial development of emphysema is centred on the early changes in the airway epithelium of the small airways. (wikipedia.org)
  • Here we report that the flavoring chemicals induce transcriptomic changes and perturb cilia function in the airway epithelium. (nature.com)
  • Our study indicates that the two widely used e-cig flavoring chemicals impair the cilia function in airway epithelium and likely contribute to the adverse effects of e-cig in the lung. (nature.com)
  • it is also not known whether the flavoring chemicals similarly damage human airway epithelium. (nature.com)
  • Interactions of oxygen radicals with airway epithelium. (duke.edu)
  • The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. (duke.edu)
  • We present an in-depth single-cell atlas of in vitro multiculture systems on human primary airway epithelium derived from normal and diseased lungs of 27 individual donors. (stanford.edu)
  • In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. (cdc.gov)
  • In the lung of COPD patients, alveolar type II epithelial cells and endothelial cells [31] and small airway bronchiolar epithelium [32] express decreased PCNA levels compared with related non-COPD control groups. (islamophobiacon.com)
  • In the new study, researchers used novel lab techniques that allowed them to examine the impact of both diacetyl and 2,3-pentanedione on epithelial cells in a system that closely mimicked the human airway epithelium in vivo. (newswise.com)
  • To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. (atsjournals.org)
  • In subjects with severe asthma, as compared with subjects with mild asthma, normal subjects, and diseased control subjects, we found novel evidence of increased cellular proliferation in the airway contributing to a thickened epithelium and LR. (atsjournals.org)
  • In severe asthma, there is increased cellular proliferation in the airway contributing to a thickened epithelium and lamina reticularis. (atsjournals.org)
  • The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining the airways ≥ 6th generations. (biomedcentral.com)
  • The primary functions of the respiratory epithelium, depending on their origin, is to moisten, protect the airway tract from potential pathogens, infections and tissue injury, and facilitate gas exchange. (lonza.com)
  • The respiratory epithelium in trachea and bronchi is pseudostratified and primarily consists of three main cell types - cilia cells, goblet cells, and basal cells. (lonza.com)
  • Basal cells are progenitor cells that differentiate into cells types found within the epithelium. (lonza.com)
  • In asthma the epithelium appears to be more fragile than that of COPD, the epithelial reticular basement membrane (RBM) is significantly thicker, there is marked enlargement of the mass of bronchial smooth muscle, and emphysema does not occur in the asthmatic nonsmoker. (nih.gov)
  • Despite progress in animal studies, the genes and their expression pattern involved in mucus production and secretion in human airway epithelium are not well understood. (biomedcentral.com)
  • We hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, the major macromolecular component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production/secretion. (biomedcentral.com)
  • Flexible bronchoscopy and brushing were used to obtain small airway epithelium (10th to 12th order bronchi) from healthy nonsmokers (n=60) and healthy smokers (n=72). (biomedcentral.com)
  • Massive parallel sequencing (RNA-Seq) was used to verify gene expression of small airway epithelium from 5 nonsmokers and 6 smokers. (biomedcentral.com)
  • As a validation cohort, we assessed the MUC5AC-associated core gene list in the small airway epithelium of an independent set of healthy smokers (n = 72). (biomedcentral.com)
  • Little is known about the gene networks associated with the synthesis and secretion of mucins in the human small airway epithelium. (biomedcentral.com)
  • Deep sequencing of small airway epithelium RNA confirmed these observations. (biomedcentral.com)
  • Optimal MCC depends on airway surface liquid (ASL) lining the airway epithelium that facilitates ciliary beating to clear the mucus. (fiu.edu)
  • Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
  • The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
  • Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells1. (stanford.edu)
  • And many authors have shown that this human lung also in adulthood retains a significant regenerative potential from your large to the small airways and in terminal and respiratory bronchioles [17] and that tissue regeneration is usually achieved in two ways, by proliferation of common differentiated cells and/or by deployment of specialized stem/progenitor cells [18, 19]. (islamophobiacon.com)
  • The basal cells (BC) are the stem/progenitor cells of the SAE, responsible for the differentiation into intermediate cells and ciliated, club and mucous cells. (biomedcentral.com)
  • Scientists grew progenitor cells in a lab using original cells and reintroduced the cells back into COPD patients' lungs. (interestingengineering.com)
  • During their study, the researchers discovered that P63+ progenitor cells could be the key to reversing lung damage. (interestingengineering.com)
  • They took out some P63+ progenitor cells from the lungs of the patients, cultured those in a lab until these cells turned into millions in number, and finally placed the cells back into the patient's airways. (interestingengineering.com)
  • When Zuo and his team examined the patients 24 weeks after the experiment, they noticed that various parameters indicating lung health improved in all the participants who received the cultured P63+ progenitor cells. (interestingengineering.com)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • To find new treatments for COPD, researchers have been investigating stem cells, which are capable of differentiating into any cell in the body, and progenitor cells, which are descendants of stem cells and can only differentiate into the cells that belong to the same tissue or organ and are normally used by the body to repair and replace damaged tissue. (breathinglabs.com)
  • Professor Wei Zuo, of the School of Medicine, Tongji University, Shanghai, China, and chief scientist at Regend Therapeutics Ltd in China, and his colleagues have been investigating whether a type of cell called P63+ lung progenitor cells might be able to regenerate lung tissue damaged by COPD. (breathinglabs.com)
  • P63+ progenitor cells are known for their ability to regenerate the tissues of the airways, and previously we and other scientists have shown in animal experiments that they can repair the damaged epithelial tissue in the alveoli - the tiny air sacs in the lungs that play a crucial role in the exchange of gases between air breathed in and the blood supply to the lungs. (breathinglabs.com)
  • In this first phase I clinical trial, the researchers set out to investigate the efficacy and safety of taking P63+ progenitor cells from the lungs of 20 COPD patients, using them to grow millions more in the laboratory, before transplanting them back into the patients' lungs. (breathinglabs.com)
  • We used a tiny catheter that contains a brush to collect the progenitor cells from the patients' own airways. (breathinglabs.com)
  • Researchers have successfully used patients' own P63+ lung progenitor cells to repair damaged lung tissue in COPD patients, improving their quality of life. (earth-news.info)
  • Human lung progenitor cells like the ones shown here were collected from patients' airways, cloned, and then transplanted back into the patients' lungs to repair damage from emphysema, in a recent pilot trial. (tiatira.com)
  • In 17 patients with emphysema, doctors used a small brush to collect so-called P63+ progenitor cells from the airways. (tiatira.com)
  • Zuo's team cloned the progenitor cells to create millions more and then transplanted them back into the patients' lungs to repair the damaged lung tissue. (tiatira.com)
  • The persistent activation of the innate immune response in basal cells, may contribute to the characteristic chronic inflammation seen in these disorders. (wikipedia.org)
  • In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the "spill-over" of inflammatory mediators into the circulation may result in important systemic manifestations of the disease, such as skeletal muscle wasting and cachexia. (ersjournals.com)
  • Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities. (ersjournals.com)
  • Chronic obstructive pulmonary disease (COPD) is primarily characterised by the presence of airflow limitation resulting from airways inflammation and remodelling often associated with parenchymal destruction and the development of emphysema. (ersjournals.com)
  • NF-κB and AP-1 are responsible for the coordinated expression of several genes that control inflammation, cell proliferation and apoptosis. (biomedcentral.com)
  • Ongoing inflammation, airway injury, and healing are part of the remodeling process in asthma and perhaps lead to disordered repair and fibrosis as a consequence. (atsjournals.org)
  • Further, it has been reported that liraglutide attenuated bleomycin-induced pulmonary fibrosis and OVA-induced chronic airway inflammation. (justia.com)
  • COPD is characterised by tissue destruction and inflammation. (bmj.com)
  • In COPD, there is epithelial mucous metaplasia, airway wall fibrosis, and inflammation associated with loss of surrounding alveolar attachments to the outer wall of small airways: bronchiolar smooth muscle is increased also. (nih.gov)
  • Smoking cessation is the only intervention of proven value in early-stage COPD, however, even with cessation, the destructive process initiated by cigarette smoking continues (COPD Fact Sheet, 2014) emphasizing the need for therapies targeted towards smoke induced inflammation and lung destruction. (justia.com)
  • Inflammation of the bronchi in COPD can be permanent, compared with asthma, where it is temporary. (zesttwellness.com)
  • Whilst many studies have shown that RV-infected airway epithelial cells secrete many proinflammatory cytokines that may exacerbate airway inflammation, limited studies have sought to investigate the potential role of airway fibroblasts in mediating RV-induced inflammation in airway diseases. (whiterose.ac.uk)
  • Subsequent experiments performed using a panel of broad and class I-selective PI3K small-molecule inhibitors demonstrated functional redundancy of class I PI3K isoforms in modulating the RV-induced inflammation. (whiterose.ac.uk)
  • In conclusion, the work outlined in this thesis demonstrates two major findings: (i) a potential role for lung fibroblasts in mediating airway inflammation following RV infection and (ii) the involvement of PI3Ks and mTOR in induction of proinflammatory cytokines in response to RV infection, and that autophagy plays a limited role in the cytokine response to RV infection or control of RV replication. (whiterose.ac.uk)
  • In this project, we study innate host defense, with a focus on roles for chemokines and innate antibiotics during airway inflammation. (lu.se)
  • These molecules are important both in the context of the prolonged and dysregulated inflammation as well as during the exacerbations seen COPD, asthma, and CF. (lu.se)
  • Basal cell dysfunction causes the overproduction and secretion of mucus, and decreased mucus clearance that leads to the characteristic features of mucus hypersecretion, and productive cough of chronic bronchitis and chronic obstructive pulmonary disease (COPD). (wikipedia.org)
  • Cigarette smoke (CS) is well known to be a risk factor for pulmonary diseases including chronic obstructive pulmonary disease (COPD), lung cancer, asthma, pulmonary hypertension, and vascular diseases such as atherosclerosis [ 1 ]. (hindawi.com)
  • Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow obstruction. (ersjournals.com)
  • For many, they are the result of a systemic "spill-over" of the inflammatory and reparatory events occurring in the lungs of patients with COPD, with the disease remaining at the centre of the process (fig. 1 ⇓ ), whereas for others the pulmonary manifestations of COPD are one more form of expression of a "systemic" inflammatory state with multiple organ compromise 3 , 4 . (ersjournals.com)
  • Systemic effects and comorbidities of chronic obstructive pulmonary disease (COPD). (ersjournals.com)
  • Cigarette smoke exposure causes various diseases involving changes in miRNA expressions in the pathogenesis of atherosclerosis, chronic obstructive pulmonary disease (COPD) and lung cancer (12-15). (researchsquare.com)
  • The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. (duke.edu)
  • Additionally, SAECs derived from chronic obstructive pulmonary disease (COPD) patients (COPD-SAECs) were investigated. (bvsalud.org)
  • Proteomics and genomics studies have contributed to understanding the pathogenesis of chronic obstructive pulmonary disease (COPD), but previous studies have limitations. (stanford.edu)
  • Chronic obstructive pulmonary disease (COPD) is marked by airspace enlargement (emphysema) and small airway fibrosis, leading to airflow obstruction and eventual respiratory failure. (molcells.org)
  • Unlike traditional immortalized pulmonary cell lines and primary cells, lung organoids contain various differentiated cell types with complex tissue architecture that more closely resemble in vivo tissues and functionality. (sigmaaldrich.com)
  • Expert Summary: This article shows that ACE-2, the SARS-Cov2 binding target receptor expressed in epithelial cells, in lower air way is increased in current smokers and patients with chronic obstructive pulmonary disease (COPD) compared with non-smokers. (lux-covid19.lu)
  • Impaired cilia function has been linked with lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma. (newswise.com)
  • Therefore, the cellular/tissue injury triggered by the oxidant burden generated by air pollutants in association with cigarette smoking plays a pivotal role in the pathogenesis of several inflammatory and proliferative lung disorders, including chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), cystic fibrosis, and also lung cancer. (biomedcentral.com)
  • In particular, inhaled oxidants such as ozone and nitrogen dioxide cause sequestration of inflammatory cells into the pulmonary microcirculation, thus leading to their accumulation within air spaces. (biomedcentral.com)
  • Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally and the sixth leading cause in the US. (interestingengineering.com)
  • Select cell types are complemented with diseased cells isolated from donors diagnosed with asthma, COPD, Cystic Fibrosis or Idiopathic Pulmonary Fibrosis (IPF). (lonza.com)
  • Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
  • Pulmonary vasculature is remodeled in COPD. (nih.gov)
  • The present invention provides methods and compositions of prophylaxis for, or for treating, chronic obstructive pulmonary disease (COPD), cancer, arthritis, skin damage, or atherosclerotic plaque rupture in a subject in need thereof, which comprise i) a statin or ii) selective serotonin reuptake inhibitor (SSRI). (justia.com)
  • Chronic obstructive pulmonary disease (COPD) is an enormous unmet medical need. (justia.com)
  • Milan, Italy: For the first time, researchers have shown it is possible to repair damaged lung tissue in patients with chronic obstructive pulmonary disease (COPD) using the patients' own lung cells. (breathinglabs.com)
  • Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways. (biomedcentral.com)
  • Researchers have demonstrated the potential to heal injured lung tissue in chronic obstructive pulmonary disease (COPD) patients using their own lung cells for the first time. (earth-news.info)
  • Transplanting patients' own lung cells helped repair tissue damage from chronic obstructive pulmonary disease (COPD) in a small preliminary trial, researchers reported on Tuesday at the European Respiratory Society International Congress in Milan. (tiatira.com)
  • The number of patients with asthma and chronic obstructive pulmonary disease (COPD) in case series from hospitals in China and Italy were much lower than expected for the prevalence of these diseases. (archbronconeumol.org)
  • Chronic Respiratory diseases like chronic obstructive pulmonary disease (COPD), pulmonary hypertension, asthma, and pneumonia are emerging as significant comorbidities in people living with HIV in the combination antiretroviral therapy (cART) era. (fiu.edu)
  • We interact with a lot of people who suffer from Chronic Obstructive Pulmonary Disease (COPD) which is an umbrella term for diseases such as emphysema (weakened and ruptured alveoli) and chronic bronchitis, where the bronchi stay inflamed and over-produce mucus, causing constant breathing challenges. (zesttwellness.com)
  • The parameters for the model are obtained for the mucus in healthy, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) conditions by fitting the rheological model to the experimental data. (ensam.eu)
  • Airway closure is a surface-tension-driven phenomenon that occurs when the ratio of the pulmonary liquid layer thickness to the airway radius exceeds a certain threshold. (ensam.eu)
  • The ERR contains state-of-the-art review articles, editorials and correspondence, in addition to summaries of the most important recent research findings and published studies in topics such as COPD, asthma, pulmonary hypertension, interstitial lung disease, lung cancer, tuberculosis and pulmonary infections. (ers-education.org)
  • This pulmonary exposure to alcohol can damage the bronchial epithelial layer of the lung [ 6 , 7 ], while impairing the lung's ability to repair epithelial wounding via inhibition of the PKA pathway [ 8 ]. (cdc.gov)
  • An emerging hazard is respiratory disease, including: occupation-related chronic bronchitis, chronic obstructive pulmonary disease (COPD), and exacerbation of asthma due to the inhalation of dust associated with swine husbandry [ 13 ]. (cdc.gov)
  • Symptoms most commonly range from mild cough and mucous membrane irritation to severe exacerbations of underlying pulmonary diseases like COPD or asthma and, in extreme cases, death. (medscape.com)
  • The largest pulmonary arteries have small yellow atherosclerotic plaques in pulmonary arterial hypertension. (medscape.com)
  • Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. (msdmanuals.com)
  • Lung organoids are useful three-dimensional (3D) cell culture models for studying human lung development and respiratory diseases including viral infections (SARS-CoV, H1N1, MERS), cystic fibrosis, asthma/COPD, exposure to air pollution and the effects of smoking. (sigmaaldrich.com)
  • Oxidant-induced phenotypic changes may thus significantly contribute to the key pathogenic role played by bronchial epithelial cells in inflammatory airway disorders such as asthma and COPD. (biomedcentral.com)
  • Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. (atsjournals.org)
  • In bronchial biopsies from 21 normal subjects, 11 subjects with chronic bronchitis, 9 subjects with mild asthma, and 31 subjects with severe asthma, we evaluated epithelial cell morphology: epithelial thickness, lamina reticularis (LR) thickness, and epithelial desquamation. (atsjournals.org)
  • Airway epithelial and LR thickness was greater in subjects with severe asthma compared with those with mild asthma, normal subjects, and diseased control subjects (p = 0.009 and 0.033, respectively). (atsjournals.org)
  • There was a greater level of apoptotic activity in the airway biopsy in subjects with severe asthma as compared with the normal subjects using the TUNEL assay (p = 0.002), suggesting increased cell death. (atsjournals.org)
  • These changes may contribute to the progressive decline in lung function and airway remodeling in patients with severe asthma. (atsjournals.org)
  • Airway remodeling in asthma refers to structural changes in the airway, including subepithelial fibrosis, smooth muscle hypertrophy, and blood vessel hyperplasia. (atsjournals.org)
  • Limited knowledge exists on airway remodeling in severe asthma. (atsjournals.org)
  • The inventors found that GLP-1R agonists inhibited IL-33 expression and release from the lungs of mice in response to an airway challenge the allergen extract of the aeroallergen Alternaria alternata , an aeroallergen which has protease activity and which is associated with severe asthma exacerbations. (justia.com)
  • Our application sections, further down on this page, are packed with data, white papers, posters and other useful tools, giving you an overview on how Lonza's airway cells are being used to study diseases like asthma, COPD, lung cancer and more. (lonza.com)
  • Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. (nih.gov)
  • The clinically observed distinctions between asthma and COPD are reflected by differences in the remodeling process, the patterns of inflammatory cells and cytokines, and also the predominant anatomic site at which these alterations occur. (nih.gov)
  • The hypertrophy of submucosal mucus-secreting glands is similar in extent in asthma and COPD. (nih.gov)
  • The number of bronchial vessels and the area of the wall occupied by them increase in severe corticosteroid-dependent asthma: it is likely that these increases also occur in severe COPD as they do in bronchiectasis. (nih.gov)
  • In COPD the changes begin later in life and the associated inflammatory response differs from that in asthma. (nih.gov)
  • Profiling type 2 and non-type 2 asthma should follow the concept of complex endotypes/subendotypes in parallel with addition of new targets such as ASM, epithelial components of asthma and epigenetic modifications together with integration of systems medicine and advances in HIT. (koreamed.org)
  • Evidence that long-term exposure to atmospheric particulates decreases the body's defences against bacterial and viral pathogens appear sufficient, particularly by altering the response of bronchial epithelial cells via inflammatory processes and endothelial dysfunction, and exacerbating the conditions of chronically ill patients, particularly those with COPD and asthma [8-14], and children with acute respiratory infections [15]. (bmj.com)
  • Patients diagnosed with asthma and COPD. (archbronconeumol.org)
  • In a series of 140 SARS-CoV-2 patients hospitalized in Wuhan, no cases of asthma were described, and only 1.4% had COPD. (archbronconeumol.org)
  • 1 In another multicenter series from the same country that included 476 patients with COVID-19, 4.6% had COPD, but asthma was not mentioned among the comorbidities. (archbronconeumol.org)
  • Human rhinoviral (RV) infection is a major trigger of exacerbations of airway diseases such as asthma and COPD. (whiterose.ac.uk)
  • COPD, asthma, and cystic fibrosis (CF) together affect a large number of individuals and no curative treatments are available. (lu.se)
  • In addition, antibacterial chemokines can serve as both biomarkers and templates to develop new treatment strategies against inflammatory bouts of COPD, asthma, and CF. (lu.se)
  • Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
  • In this study, we utilized primary normal human bronchial epithelial (NHBE) cells that are cultured at an air-liquid interface (ALI) to mimic the in vivo airway characteristics 30 . (nature.com)
  • They exposed normal human bronchial epithelial (NHBE) cells to the chemicals for 24 hours. (newswise.com)
  • We found that HIV Tat protein and cigarette smoke individually and additively inhibit CFTR biogenesis and function in normal human bronchial epithelial cells via a common TGF-β signaling pathway. (fiu.edu)
  • There is no doubt that comorbidities increase the risk of hospitalisation and mortality in COPD patients, especially as the airway obstruction becomes more severe 1 . (ersjournals.com)
  • The researchers wanted to examine the relationship between goblet cell hyperplasia and smoking to find out if people with chronic bronchitis and current smokers would have more GCD, whether or not they had any airflow obstruction. (hcplive.com)
  • The findings of this study suggest that "large airway epithelial mucin stores increase initially before the onset of mild airflow obstruction and then decrease as more severe disease develops. (hcplive.com)
  • Another possible conclusion of this study is that "goblet cell hyperplasia does not contribute to airflow obstruction but rather that active smoking is its primary determinant. (hcplive.com)
  • Despite the possible weaknesses, the researchers "were able to demonstrate in this small sample that current smoking and chronic bronchitis, and not airflow obstruction, were independent factors associated with goblet cell hyperplasia. (hcplive.com)
  • It has been suggested that the subepithelial fibrosis in asthmatic lungs may contribute to thickening of the airway wall, which in turn may result in physiologic alterations, such as chronic airflow obstruction and airway hyperresponsiveness ( 1 ). (atsjournals.org)
  • The physiologic hallmark of COPD is fixed airway obstruction with a progressive decline in the forced expiratory volume in one second (FEV1). (justia.com)
  • These cells are vulnerable to damage and the basal cells can replace damaged cells by differentiation. (wikipedia.org)
  • When activated the basal cells acquire damage-associated phenotypes to enable differentiation to the particular cell type that has been damaged. (wikipedia.org)
  • When this happens the basal cell can be skewed to favour the differentiation of mucous-producing (secretory goblet cells) over that of ciliated cells. (wikipedia.org)
  • The release of antimicrobials may occur as a second-line defence with cell differentiation. (wikipedia.org)
  • Our large-scale single-cell profiling identified new cell states and differentiation trajectories of rare airway epithelial cell types in human distal lungs. (stanford.edu)
  • The 3dGRO™ Human Lung Organoid Culture System is a serum-free, multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids that structurally resemble the in vivo branching airway and early alveolar structures. (sigmaaldrich.com)
  • ESW in combination with tenogenic medium improved the differentiation of human adipose-derived stem cells (hASCs) into tenoblast-like cells [21]. (islamophobiacon.com)
  • ESW combined with Rabbit Polyclonal to CACNG7 osteogenic Gabazine medium increased the osteogenic differentiation of treated hASCs [22], while stem cell differentiation into myofibroblasts was partially reduced by ESW treatment [23]. (islamophobiacon.com)
  • A third marker of cell proliferation is usually CD90 (Thy1, thymocyte differentiation antigen-1), a glycophosphatidylinositol cell surface protein expressed by thymocytes, CD34+ cells, mesenchymal stem cells, endothelial cells, and cardiac fibroblasts. (islamophobiacon.com)
  • Promotes Th17 differentiation of T-cells. (cusabio.com)
  • The resulting cell line (hSABCi-NS1.1) was characterized by RNAseq, TaqMan PCR, protein immunofluorescence, differentiation capacity on an air-liquid interface (ALI) culture, transepithelial electrical resistance (TEER), airway region-associated features and response to genetic modification with SPDEF. (biomedcentral.com)
  • The immortalized hSABCi-NS1.1 cell line has diverse differentiation capacities and retains SAE features, which will be useful for understanding the biology of SAE, the pathogenesis of SAE-related diseases, and testing new pharmacologic agents. (biomedcentral.com)
  • Lonza's BulletKit TM Media for growth and air-liquid interface studies is optimized to support consistent growth or differentiation of primary airway cells while maintaining the tissue-specific characteristics. (lonza.com)
  • Our BulletKit TM Media is formulated with growth factors and hormones necessary to optimally support consistent growth or differentiation of primary cells while maintaining the tissue-specific characteristics. (lonza.com)
  • The combination of these factors can increase the inflammatory burden in the lower airways, overwhelming the protective anti-inflammatory defence mechanisms, leading to tissue damage. (zesttwellness.com)
  • A respiratory viral infection targets the epithelial cells of the lungs, which can lead to desquamation (shedding or peeling of that layer of cells), microvascular dilatation (swelling of micro blood vessels), edema (fluid-swelling), and inflammatory cell infiltrate (the body's production of inflammatory molecules to fight infection). (zesttwellness.com)
  • initiation of inflammatory immune responses, activation of immune cells and releases of many cytokines, chemokines and other inflammatory molecules with variable pathologic effects on lung to cause different respiratory diseases[8-11]. (heraldopenaccess.us)
  • 1 We have shown previously that acute exposure to 2 ppm NO 2 can induce an acute inflammatory response in healthy human airways. (bmj.com)
  • Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)
  • A few of these inflammatory responses, such as inflammatory cell recruitment, can be modulated by alcohol exposure [ 1 , 2 , 3 , 4 ]. (cdc.gov)
  • These diseases have in common that they start at the airway mucosal surfaces and inflammatory bouts (exacerbations) are to a large extent triggered by infections. (lu.se)
  • Lonza offers a comprehensive range of normal human respiratory epithelial, smooth muscle, fibroblast and endothelial cells with a broad donor variety. (lonza.com)
  • E-cig use can cause oxidative stress and endothelial cell dysfunction (8, 9), and compromised innate immune response in lungs (10). (researchsquare.com)
  • By integrating single-cell datasets of human lung tissues, we discovered immune-primed subsets enriched in lungs and organoids derived from patients with chronic respiratory disease. (stanford.edu)
  • It is the first to look at the impact of flavoring chemicals in human epithelial cells, which are the type that line the lungs. (newswise.com)
  • We and other scientists have shown in animal experiments that they can repair the damaged epithelial tissue in the alveoli - the tiny air sacs in the lungs that play a crucial role in the exchange of gases between air breathed in and the blood supply to the lungs," said Wei Zuo, one of the study authors and a professor at Tongji University School of Medicine. (interestingengineering.com)
  • We cloned the cells to create up to a thousand million more, and then we transplanted them back into the patients' lungs via bronchoscopy in order to repair the damaged lung tissue. (breathinglabs.com)
  • Twelve weeks later, the body's ability to transfer oxygen from air sacs in the lungs to the red blood cells in the lungs' blood vessels had on average increased to 40%, from a baseline of 30%, the researchers found. (tiatira.com)
  • We want to enable the basal cells to survive and grow in such a difficult situation, to enhance the recovery of the lungs. (longfonds.nl)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Subsequent exposure and ingestion of silica by alveolar macrophages leads to cell necrosis, autophagy, and the release of nondegraded intracellular silica. (medscape.com)
  • SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. (cdc.gov)
  • Cigarette smoke, which contains many oxidants and free radicals in both its gaseous and particulate phases [ 1 ], significantly contributes to recruit macrophages into the airways, as well as to increase neutrophil numbers within lung microvessels. (biomedcentral.com)
  • The EPCs seem to be impaired and thus lead to the repair of capacity of the lung tissue reduced in patients with COPD. (hindawi.com)
  • Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models. (duke.edu)
  • For instance, GLP-1R agonist administration decreased TNFα and IL-6 production by peripheral blood mononuclear cells (PBMC) of obese patients with T2D and diabetic mouse adipose tissue. (justia.com)
  • Partner with Lonza and choose from a broad donor variety of airway cells from normal, asthmatic, COPD, Cystic Fibrosis or iPF lung tissue. (lonza.com)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • The affected tissue cannot be repaired with current treatments, only alleviated with medicines that widen the airways to improve airflow, known as bronchodilators. (breathinglabs.com)
  • These are put on a medium that specifically stimulates growth of basal cells and creates organoids: small versions of airway lining tissue. (longfonds.nl)
  • Furthermore, it was demonstrated that in the presence of monocytes, RV and bacterial-derived LPS coinfections could act in synergy to augment the proinflammatory responses of airway tissue cells. (whiterose.ac.uk)
  • The trial involved 20 patients, out of which nine patients suffered from extremely severe COPD, six had severe COPD, two were diagnosed with mild emphysema, and three acted as a control group. (interestingengineering.com)
  • In this trial, we found that P63+ progenitor cell transplantation could repair mild emphysema, making the lung damage disappear. (interestingengineering.com)
  • Emphysema is a feature of severe COPD: in spite of the destructive process, alveolar wall thickening and focal fibrosis may be detected. (nih.gov)
  • For the first time in people, doctors have used patients' own lung cells to repair damage from emphysema, as we report below. (tiatira.com)
  • COPD, often caused by smoking, includes emphysema and chronic bronchitis. (tiatira.com)
  • Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. (duke.edu)
  • Cystic fibrosis transmembrane conductance regulator (CFTR) plays a pivotal role in airway MCC by virtue of its ability to regulate ASL levels, ASL pH, and consequently mucus viscosity. (fiu.edu)
  • 10 μm in diameter) are deposited within the distal airways and alveoli following inhalation. (medscape.com)
  • The child should have or pelotas viagra fewer squamous epithelial cells distal to the diagnosis, although papillary thyroid carcinoma, adrenal insufficiency may have a history of copd is the process of toilet phobia, a young child, a dislocated lens, past surgery, or thoracotomy if needed dry assess color a provide warmth position clear airway if upper airway patency cannot be met. (albionfoundation.org)
  • For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug which blocks the airway, halting distal gas exchange. (ensam.eu)
  • Although the group of participants in this study was small, the researchers contend that excluding people who may have conditions linked to lower airway goblet cell hyperplasia such as upper airway disease or recent exacerbations, adds strength to the findings. (hcplive.com)
  • Recently, Roflumilast, a phosphodiesterase type 4 (PDE-4) inhibitor was approved as a new therapeutic for COPD exacerbations with sales progressively growing since release (Fabbri et al. (justia.com)
  • Atrovent®, Spiriva®) and β-adrenergic agonists (e.g., albuterol, Opened®), relax airway smooth muscle and appear to decrease dyspnea, increase FEV1, and decrease the frequency of reported exacerbations in certain populations (Hanania and Marciniuk, 2011). (justia.com)
  • In a half to two thirds of COPD exacerbations, a viral infection is the cause. (zesttwellness.com)
  • The goblet cells produce and secrete mucous to trap pathogens and debris within the airway tract. (lonza.com)
  • Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
  • Our data showed that diacetyl and 2,3-pentanedione induced significant transcriptomic changes, including those related to ciliogenesis, in the primary NHBE cells. (nature.com)
  • They play a key role in keeping the human airway clear of mucus and dirt and allow people to breathe easily and without irritation. (newswise.com)
  • The ciliated cells are located across the apical surface and facilitate the movement of mucus across the airway tract. (lonza.com)
  • The identification of the genes associated with increased airway mucin production in humans should be useful in understanding the pathogenesis of airway mucus hypersecretion and identifying therapeutic targets. (biomedcentral.com)
  • This finding will be useful in identifying therapeutic targets to treat small airway mucus hypersecretion. (biomedcentral.com)
  • The process of mucus production and secretion is central to the normal defense of the lung, with mucus an important component of the airway mucociliary escalator that continuously cleanses the lung of inhaled particulates, pathogens and xenobiotics [ 1 ]. (biomedcentral.com)
  • These changes can be "dysregulated" or greater in people with COPD which can make the lower airways more vulnerable to a secondary bacterial infection, because the changes can interfere with mucus clearance and reduce bacterial clearance. (zesttwellness.com)
  • GROTBERG, J. B. Airway mucus is a complex material with both viscoelastic and viscoplastic properties that vary with healthy and pathological conditions of the lung. (ensam.eu)
  • In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
  • Furthermore, comparing COPD-SAECs to SAECs without COPD in PG exposure, cell proliferation, cell viability, DNA damage and apoptosis were significantly greater in COPD-SAECs. (bvsalud.org)
  • We find that AT1 and AT2 cells act as distinct cells of origin and manifest divergent responses to concomitant WNT activation and KRAS(G12D) induction, which accelerates AT2-derived but inhibits AT1-derived adenoma proliferation. (stanford.edu)
  • Cell growth (WST-1 test) was assessed, and proliferation markers were analyzed by qRT-PCR in cell lysates and by ELISA assessments in cell supernatants and cell lysates. (islamophobiacon.com)
  • After ESW treatment, we observed a significant increase of cell proliferation in all cell types. (islamophobiacon.com)
  • Markers of cell proliferation include CD117 (c-Kit or SCFR), a receptor Gabazine tyrosine kinase protein that binds to stem cell factor (SCF), expressed on hematopoietic stem cells. (islamophobiacon.com)
  • Another marker Gabazine of cell proliferation is usually proliferating cell nuclear antigen (PCNA). (islamophobiacon.com)
  • Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. (cusabio.com)
  • Cell counting was performed after trypan blue staining, cell proliferation was assessed using MTT assay, and apoptosis was evaluated through caspase-3 activation and Tunel assay. (biomedcentral.com)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • Short term exposure to 0.4-2 ppm NO 2 can also induce modest bronchoconstriction and non-specific bronchial hyperresponsiveness (BHR) in healthy and asthmatic airways. (bmj.com)
  • In addition to adding to the existing literature and knowledge of airway pathology and clinical phenotype, this study highlights the importance of smoking cessation programs. (hcplive.com)
  • The current knowledge about COVID-19 pathogenesis and pathology in fatalities is based on a small number of described cases and extrapolations from what is known about other similar coronaviruses, such as SARS-CoV and MERS-CoV ( 10 - 18 ). (cdc.gov)
  • Compared to the large airway cell line BCi-NS1.1, differentiated of hSABCi-NS1.1 cells on ALI were enriched with small airway epithelial genes, including surfactant protein genes, LTF and small airway development relevant transcription factors NKX2-1, GATA6, SOX9, HOPX, ID2 and ETV5. (biomedcentral.com)
  • This is followed by shortened cilia, loss of ciliated cells, mucous cell hyperplasia, and loss of cell junctions giving a leaky epithelial barrier. (wikipedia.org)
  • Comorbid diseases potentiate the morbidity of COPD, leading to increased hospitalisations, mortality and healthcare costs. (ersjournals.com)
  • Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. (ersjournals.com)
  • Cigarette smoke exposure causes various diseases including COPD, atherosclerosis, and lung cancer. (researchsquare.com)
  • Extracorporeal shock wave therapy (ESWT) is usually applied in many musculoskeletal diseases and in regenerative medicine based on its capability to induce neoangiogenesis, osteogenesis, regeneration, and remodeling through stem cell activation [20]. (islamophobiacon.com)
  • Pharmacological management of airway obstructive diseases is a fast-evolving field. (ersjournals.com)
  • These properties of MSCs provided a rationale to investigate their potential for treatment of a variety of diseases, including COPD. (bmj.com)
  • Modulation of the NALP3 protein inflammasomes induces regulatory T cells to express cytotoxic T-lymphocyte antigen 4, IL-10, and transforming growth factor-beta (TGF-β). (medscape.com)
  • Owing to a bifrontal plug growth, this airway closure flow induces high stress levels on the wall, which is the location of airway epithelial cells. (ensam.eu)
  • The topological change during coalescence induces a high level of stress and stress gradients on the epithelial cells, which are large enough to damage them, causing sublethal or lethal responses. (ensam.eu)
  • Here, using a machine learning (ML) algorithm, we attempted to identify pathways in cultured bronchial epithelial cells of COPD patients that were significantly affected when the cells were exposed to a cigarette smoke extract (CSE).Small airway epithelial cells were collected from patients with COPD and those without COPD who underwent bronchoscopy. (stanford.edu)
  • What signalling pathways of the cell do they effect? (longfonds.nl)
  • Furthermore, the signalling pathways involved in the regulation of cytokine responses of structural airway cells to RV infection remain unclear, particularly with regard to signalling via PI3K, and the PI3K-dependent pathway, autophagy. (whiterose.ac.uk)
  • IL-33 activates group 2 innate lymphoid cells (ILC2) to produce the type 2 cytokines IL-5 and IL-13 that initiate innate immunity-driven allergic responses. (justia.com)
  • In comparison to airway epithelial cells, the lack of viral-detecting PRRs TLR3, RIG-I, MDA5 and virally-induced transcription factors IRF1 and IRF7 in fibroblasts may be a potential explanation as to why the fibroblasts do not secrete the IFN-stimulated cytokines CCL5 and CXCL10 (indicating that the RV-infected fibroblasts do not produce IFNs), therefore providing no antiviral response to limit viral replication, with concomitant cell death. (whiterose.ac.uk)
  • But, to our knowledge, no data are available on ESW treatment of main bronchial fibroblasts of patients with COPD and control healthy smokers or bronchial epithelial cells (16HBE). (islamophobiacon.com)
  • We aimed in this study to analyze the proliferative effect of shock waves when applied as an external challenge to main bronchial fibroblasts of COPD patients and control smokers, and to immortalized bronchial epithelial cells (16HBE). (islamophobiacon.com)
  • The first aim of this thesis was to investigate the innate immune responses of human airway fibroblasts to RV infection, and to compare those responses with those of airway epithelial cells. (whiterose.ac.uk)
  • It was found that RV infection induced differential responses in normal human airway fibroblasts and epithelial cells. (whiterose.ac.uk)
  • However, the EPCs were greatly reduced in patients with severe COPD and the reduction was correlated with COPD severity [ 8 ]. (hindawi.com)
  • The study included 12 healthy smokers, 15 patients with moderate to severe COPD, and 11 healthy nonsmokers. (hcplive.com)
  • The study authors recently conducted a phase one trial involving severe COPD patients who were likely to die from the disease. (interestingengineering.com)
  • In our trial, 35% of the patients had severe COPD and 53% had extremely severe COPD. (breathinglabs.com)
  • Usually, many patients with such severe COPD will die quite quickly if their disease progresses. (breathinglabs.com)
  • Roughly a third of the study participants had severe COPD and more than half had extremely severe COPD, Zuo said. (tiatira.com)
  • Taking N-acetyl cysteine by mouth for at least 6 months seems to decrease flare-ups by about 40% in people with moderate to severe COPD. (medlineplus.gov)
  • In this context, if it is possible to immortalize normal human SAE BC that retain the capacity to differentiate to ciliated, secretory, and other differentiated cell types in vitro on air-liquid interface (ALI) culture, it would be very useful to the investigation of SAE biology in health and disease, and the assessment of pharmacologic agents targeted to modify dysregulated BC biology relevant to the pathogenesis of human lung disease. (biomedcentral.com)
  • It was found that the PI3K pharmacological inhibitor 3-MA, typically used to inhibit autophagy, suppressed RV-induced cytokine production in airway epithelial cells. (whiterose.ac.uk)
  • The ciliated cells and secretory cells that form the epithelial barrier, and function in mucociliary clearance, are terminally differentiated meaning that they cannot self-renew. (wikipedia.org)
  • and into secretory cells under the control of Notch signalling, and the transcription factors SPDEF and FOXA3. (wikipedia.org)
  • The normal ratio of ciliated cells to secretory cells is 10 to 1, and this is highly controlled throughout most of the respiratory tree. (wikipedia.org)
  • RNA in situ hybridization showed that it was mainly expressed in the secretory epithelial cells surrounding the lumen of the mammary gland alveoli. (molcells.org)
  • Lentivirus-mediated expression of SPDEF in hSABCi-NS1.1 cells induced secretory cell metaplasia, accompanied with characteristic COPD-associated SAE secretory cell changes, including up-regulation of MSMB, CEACAM5 and down-regulation of LTF. (biomedcentral.com)
  • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. (duke.edu)
  • And which of those are particularly relevant for basal (stem) cell growth? (longfonds.nl)
  • pp. 558-572) demonstrate that recombinant human hyaluronan and proteoglycan link protein 1 (rhHAPLN1) significantly reduces the extended airspaces of the emphysematous alveoli by increasing the levels of TGF-β receptor I and SIRT1/6, as a previously unrecognized mechanism in human alveolar epithelial cells, and consequently mitigates COPD. (molcells.org)
  • With COPD, the alveoli (air sacs) become less efficient at bringing oxygen into the body and sending carbon dioxide out. (zesttwellness.com)
  • The hyperplasia of airway basal cells is the earliest indication of smoking-related abnormality in the lung. (wikipedia.org)
  • Cilia are antennae-like protuberances that are present on 50-75% of the cells that line human airways. (newswise.com)
  • Janes' lab receives biopsies from human airways, taken during procedures that patients undergo. (longfonds.nl)
  • KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming. (stanford.edu)
  • Here we demonstrate a different scenario: expression of KRAS(G12D) in differentiated AT1 cells reprograms them slowly and asynchronously back into AT2 stem cells that go on to generate indolent tumours. (stanford.edu)
  • Additionally, lung organoids can be derived from small amounts of patient tissues or pluripotent stem cells to create living biobanks that facilitate personalized biomedical research. (sigmaaldrich.com)
  • Human pluripotent stem cells are differentiated into definitive endoderm cells using a 4-day induction medium. (sigmaaldrich.com)
  • It is also considered a marker of multipotent mesenchymal stem cells when expressed in association with other markers (CD29, CD44, CD73, CD105) [33, 34]. (islamophobiacon.com)
  • These are particular types of stem cells found in various tissues of the skin, breast, digestive tracts, and airways. (interestingengineering.com)
  • Stem cell and progenitor cell-based regenerative medicine may be the biggest, if not the only, hope to cure COPD," he told the congress. (breathinglabs.com)
  • Leading respiratory scientist Professor Sam Janes developed a rapid method to identify the needles in a haystack of drugs that stimulate growth of airway stem cells. (longfonds.nl)
  • Some of them are also stem cells: these produce other types of cells that also make up the airways. (longfonds.nl)
  • Janes: "My research for the Consortium aims to find drugs that make the basal cells grow and control their stem cell behaviour. (longfonds.nl)
  • Using RNA-Seq, we performed global transcriptomic profiling in primary NHBE cells exposed to diacetyl or 2,3-pentanedione. (nature.com)
  • Newswise - Boston, MA - Two chemicals widely used to flavor electronic cigarettes may be impairing the function of cilia in the human airway, according to a new study led by Harvard T.H. Chan School of Public Health. (newswise.com)
  • Basal cells are the first cells to be affected by exposure to cigarette smoke. (wikipedia.org)
  • Healthy smokers had a greater GCD than nonsmokers, but also, notably, a greater GCD than the participants with COPD. (hcplive.com)
  • The regeneration of cells can be normal or in the case of smokers the regeneration may be of altered histologic phenotypes. (wikipedia.org)
  • Smokers are ten times more likely than non-smokers to die of COPD. (justia.com)
  • Basal cells can also provide a defence function upregulating innate immune mediators such as RNase7, an antimicrobial protein. (wikipedia.org)
  • When cultured on ALI, hSABCi-NS1.1 cells consistently formed tight junctions and differentiated into ciliated, club (SCGB1A1 + ), mucous (MUC5AC + , MUC5B + ), neuroendocrine (CHGA + ), ionocyte (FOXI1 + ) and surfactant protein positive cells (SFTPA + , SFTPB + , SFTPD + ), observations confirmed by RNAseq and TaqMan PCR. (biomedcentral.com)
  • Machine Learning-Based Proteomics Reveals Ferroptosis in COPD Patient-Derived Airway Epithelial Cells Upon Smoking Exposure. (stanford.edu)
  • ML-based feature selection was used to determine the most distinctive patterns in the proteomes of COPD and non-COPD cells after exposure to smoke extract. (stanford.edu)
  • Ferroptosis was enriched in both COPD and non-COPD epithelial cells after their exposure to smoke extract. (stanford.edu)
  • Single-cell RNA sequencing data showed that in cells from COPD patients, ferroptosis is enriched in basal, goblet, and club cells in COPD but not in other cell types.Our ML-based feature selection from proteomic data reveals ferroptosis to be the most distinctive feature of cultured COPD epithelial cells compared to non-COPD epithelial cells upon exposure to smoke extract. (stanford.edu)
  • COPD is one of the chronic non communicable disease occurred associated with work related condition including exposure to wood dust [12-14]. (heraldopenaccess.us)
  • 1- 3 The precise mechanisms underlying this latter biological link are not well understood but studies in animal models have shown that NO 2 exposure could impair some local defence mechanisms in the airways. (bmj.com)
  • Agricultural worker co-exposure to alcohol and organic dust has been established, although little research has been conducted on the combination effects of alcohol and organic dusts on the lung. (cdc.gov)