• Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
  • In mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) that received a high fat diet equivalent of fried food in humans, the transplanted heart was rejected after 21 days. (pharmacytimes.com)
  • Meanwhile, mice with hyperlipidemia caused by a genetic mutation of ApoE who were fed a lower fat diet had their transplanted hearts last 61 days and healthy mice fed a lower fat diet had transplanted hearts that lasted more than 100 days. (pharmacytimes.com)
  • Possible associations were analyzed by fitting logistic regression models with AD as outcome, controlling for centre, age, sex and presence of apolipoprotein ε4 allele (APOEε4). (ox.ac.uk)
  • Apolipoprotein E (ApoE) a protein component of bloodstream lipid particles has an important function in lipid transportation. (careersfromscience.org)
  • Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. (jci.org)
  • Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of the genetically polymorphic apo(a). (jci.org)
  • We have determined the phenotype, concentration, and distribution of apo(a) in plasma from patients with lipoprotein lipase (LPL) deficiency (type I hyperlipoproteinemia, n = 14), in apo E 2/2 homozygotes with type III hyperlipoproteinemia (n = 12) and in controls (n = 16). (jci.org)
  • Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
  • These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
  • Supportive secondary endpoints (not multiplicity controlled) were percent change in apolipoprotein B-100 (ApoB) and in non-high-density lipoprotein-C (non-HDL-C) from baseline to week 8, and the proportion of participants who achieved protocol-defined LDL-C goals at week 8. (ridgwayrecord.com)
  • Assessment of BMI, HOMA-IR, and circulating lipid (total cholesterol, low-density lipoprotein, high-density lipoprotein, non-esterified fatty acids, triacylglycerol, apolipoprotein-A1 and apolipoprotein-B) concentrations, was made when fasted before (V1) and after a 12-week intervention (V2), during which participants consumed 250 ml per d of OJ or an energy and sugars-matched orange-flavoured drink (control). (nottingham.ac.uk)
  • Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)
  • We assessed the effects of 2 y of weight loss achieved with various diet regimens on phytosterols (markers of intestinal cholesterol absorption), lanosterol (marker of de novo cholesterol synthesis), and changes in apolipoprotein concentrations. (nih.gov)
  • We assessed circulating phytosterol and lanosterol concentrations and their ratios to cholesterol and apolipoproteins A-I and B-100 in 90 DIRECT participants at 0, 6, and 24 mo. (nih.gov)
  • Long-term weight loss is related to a characteristic response suggestive of altered cholesterol and apolipoprotein metabolism. (nih.gov)
  • In the present study Golden Syrian hamsters were fed on isoenergetic, low cholesterol (0·05 g/kg) diets containing 100, 150 or 200 g added fat/kg. (cambridge.org)
  • More impressively, the mice getting onion extract had total cholesterol and apolipoprotein B levels that were markedly lower (as much as 60% lower for each) than controls on the high fat diet. (naturalnews.com)
  • Onions are known to have the ability to decrease blood fats, and in a recent placebo-controlled clinical trial, onion skin extract significantly lowered total cholesterol, LDL cholesterol and the atherogenic index in healthy young women after just two weeks. (naturalnews.com)
  • Individuals from two population-based cohorts, the Copenhagen General Population Study (2003-2015, N = 107 341), and the Copenhagen City Heart Study (1991-1994, N = 9387) were followed prospectively until end of 2016 to assess low plasma HDL cholesterol and apolipoprotein A1 as risk factors for cancer using Cox proportional hazard regression. (biomedcentral.com)
  • Among 27 cancer types, low HDL cholesterol and/or apolipoprotein A1 were associated with increased risk of multiple myeloma, myeloproliferative neoplasm, non-Hodgkin lymphoma, breast cancer, lung cancer, and nervous system cancer. (biomedcentral.com)
  • For this purpose, we used measured HDL cholesterol and apolipoprotein A1 in 116,728 individuals from two independent Danish population-based cohorts recruited during different time periods. (biomedcentral.com)
  • In the present study, we included 107,341 individuals with information on measured HDL cholesterol and apolipoprotein A1. (biomedcentral.com)
  • Familial defective apolipoprotein B-100: High total cholesterol. (upmc.com)
  • Evaluation of the Non-HDL Cholesterol to Apolipoprotein B Ratio as a Screening Test for Dysbetalipoproteinemia. (legehandboka.no)
  • Everyone should avoid meat and dairy products two days per week, in order to help keep animal fats and related cholesterol problems under control. (johnsanidopoulos.com)
  • High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
  • The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. (lu.se)
  • Methods and Results-A peptide comprising amino acids 3136 to 3155 of apoB-100 (p210) was fused to the B subunit of cholera toxin (CTB), which binds to a ganglioside on mucosal epithelia. (lu.se)
  • This effect was accompanied by induction of regulatory T cells that markedly suppressed effector T cells rechallenged with apoB-100 and increased numbers of interleukin (IL)-10(+) CD4(+) T cells. (lu.se)
  • Conclusion-Nasal administration of an apoB-100 peptide fused to CTB attenuates atherosclerosis and induces regulatory Tr1 cells that inhibit T effector responses to apoB-100. (lu.se)
  • Buy Human Apolipoprotein B-100 (ApoB-100) from Lee Biosolutions. (leebio.com)
  • There was a significant decrease in ApoB-100 and malondialdehyde compared to baseline values and compared to the control group. (who.int)
  • The effect of nasal administration of the p210-CTB fusion protein on atherogenesis was compared with that of an ovalbumin peptide fused to CTB and with untreated controls. (lu.se)
  • D) Consultant sequence (peptide) insurance coverage from the IgD recognized in the microdissected test displaying 62 total spectra, 26 exclusive spectra, and 20 exclusive peptides for 53% insurance coverage of IgD proteins with 100% possibility. (isct-eu2018.com)
  • Hepatic LDL-receptor mRNA concentrations were significantly decreased in animals fed on TP, while apolipoprotein B mRNA concentrations were significantly increased. (cambridge.org)
  • Four hundred and eighty-six subjects, aged 33 to 78 years (56.1 ± 8.4), were recruited to participate in a study examining plasma lipid and apolipoprotein concentrations. (biomedcentral.com)
  • Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
  • Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. (humanconnectome.org)
  • In this report, we conducted mass spectrometric analysis of the N-glycosylation profiles of recombinant spike proteins derived from four common SARS-CoV-2 variants classified as Variant of Concern, including Alpha, Beta, Gamma, and Delta along with D614G variant spike as a control. (cdc.gov)
  • The FH case-control study was associated with the E4 allele in the Saudi population. (edu.pl)
  • Several case-control studies have reported an association between schizophrenia and the epsilon 4 allele of Apolipoprotein E gene. (elsevierpure.com)
  • This meta-analysis has evaluated the collective evidence for an association between the e4 allele of Apolipoprotein E gene and schizophrenia. (elsevierpure.com)
  • We analyzed published data sequentially first considering epsilon 4 allele itself, and then epsilon 4 carrier status as risk factors for schizophrenia using a sample of 17 population-based case-control studies, of which 6 were from Asian and 11 from Caucasian populations. (elsevierpure.com)
  • After allowing for sensitivity analysis of the studies and assessment of publication bias, we conclude that the epsilon 4 allele of Apolipoprotein E does not play a major role in risk of schizophrenia in Caucasian populations. (elsevierpure.com)
  • The Centers for Disease Control and Prevention (CDC) recognize diabetes as the 7th leading cause of death in the U.S. (adam.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Additionally, the Centers for Disease Control and Prevention (CDC) has selected reducing SSB intake as a target behavior for preventing and controlling obesity and supports states in working on state-level data to prioritize subgroups that may need more targeted interventions for SSB reduction. (cdc.gov)
  • Introduction The National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC) collects, analyzes, and disseminates data on the health status of U.S. residents. (cdc.gov)
  • Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
  • However, there have been reports in the media claiming detrimental consequences of 100% juice consumption, including weight-gain and adverse effects on insulin sensitivity and blood lipid profile. (nottingham.ac.uk)
  • Lipid profiles of the brand new and Qatari York R145C were in comparison to controls. (careersfromscience.org)
  • Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
  • In the two genetic conditions, there is grossly impaired catabolic conversion of apo B-100-containing precursor lipoproteins to low-density lipoproteins. (jci.org)
  • Their combined effects do not explain 100% of the risk, genetic interactions may contribute. (ox.ac.uk)
  • Low apoB levels may indicate Bassen-Kornzweig syndrome (abetalipoproteinemia), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)
  • High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. (ucdenver.edu)
  • In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
  • ABSTRACT In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double- blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
  • MK-0616-008 ( NCT05261126 ) was a randomized, double-blind, placebo-controlled, multi-center Phase 2b trial designed to evaluate the efficacy and safety of MK-0616 administered daily compared to placebo in adult participants with hypercholesterolemia and a broad spectrum of ASCVD risk. (ridgwayrecord.com)
  • The effect of daily OJ consumption was assessed using a randomised, placebo-controlled, single-blinded, parallel group design. (nottingham.ac.uk)
  • My latest control hereby to administration is placebo-controlled at going the choroidal sequela and help that I was through all of these new titles with the Prognosis of including the control( herein taken to often ' the flow of full-frame-rate ') that spotlights guiding Off-Pump procedures in card with those of 4000-fold test. (ebl-motoparts.de)
  • Here we report that nonglycosylated full-length and C-terminal truncated amyloid precursor protein (APP) accumulates exclusively in the protein import channels of mitochondria of human AD brains but not in age-matched controls. (jneurosci.org)
  • Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
  • Arbuscular mycorrhizal fungi (AMF) can control soilborne diseases such as Fusarium oxysporum f.sp. (thrombin-inhibitor.com)
  • Although triacylglycerol concentration was similar between the groups at both visits, a trend for the change in this variable to differ between groups was observed (P = 0.060), with those in control exhibiting a significant increase in triacylglycerol at V2, compared with V1. (nottingham.ac.uk)
  • Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis Distinguishing Between Particle Concentration, Type, and Content. (legehandboka.no)
  • The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
  • In this study, researchers fed three different doses of flavonoids extracted from onion, an oral chemo drug, or saline (as control) to mice, along with a high-fat diet. (naturalnews.com)
  • Figure 3: Arteriolar vasoactivity and endothelium-dependent vasodilation in 1- to 2-month-old pericyte-deficient Pdgfrb +/− mice and age-matched littermate controls. (nature.com)
  • Figure 6: Cortical neuronal activity, neuronal number, neuritic density and behavior in pericyte-deficient Pdgfrb +/− mice 1-2 and 6-8 months old, along with age-matched littermate controls. (nature.com)
  • Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice. (cdc.gov)
  • Trastorno familiar que se caracteriza por incremento de la concentración del colesterol transportado por las lipoproteínas de baja densidad (LDL) y por déficit de un receptor en la superficie celular que regula la degradación de las LDL y la síntesis del colesterol. (bvsalud.org)
  • Although serum IgD amounts weren't examined at the proper period of analysis, the serum IgD was within regular limitations (76 kIU/L, regular 100) after two cycles of treatment. (isct-eu2018.com)
  • RESULTS: The expression levels of microRNAs and inflammatory factors were found to be significantly higher in the CSF of MS patients compared to controls (P (bvsalud.org)
  • Odds for drinking SSBs 1 or more times per day were significantly lower among adults with 100% fruit juice intake of less than 1 time per day versus 1 or more times per day and among adults who drank alcohol versus those who did not drink alcohol. (cdc.gov)
  • Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab. (ucdenver.edu)
  • Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. (nsjbio.com)
  • We conducted the 2-y Dietary Intervention Randomized Controlled Trial (DIRECT-a study of low-fat, Mediterranean, and low-carbohydrate diets). (nih.gov)
  • Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
  • Some evidence has shown that the capacity of the apoB/apoA-I ratio in assessing cardiovascular risk is strong and may be better than the use of apolipoprotein B alone. (medscape.com)
  • The overall Pearl Index (statistical estimation of the number of unintended pregnancies in 100 woman-years of exposure) was 2.65 per 100 woman-years of use. (uspharmacist.com)
  • They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals. (sysy.com)
  • Glial and neuronal control of brain blood flow. (nature.com)
  • For some patients with higher T stage (ie, T2, some T3), en bloc resections of the gallbladder and portal lymph nodes may be recommended, although this may carry a high morbidity and mortality (similar to bile duct carcinoma). (medscape.com)
  • The main problem for patients is rejection, so if organ rejection can be controlled, survival increases. (pharmacytimes.com)
  • To this end, we measured electromagnetic spontaneous activity with MEG in 39 healthy control elders, 41 elders with SCD and 51 MCI patients. (humanconnectome.org)
  • Control Intervention1: Placebo (Tris buffer solution (containing Arginine hydrochloride, and polysorbate 80)): In Double blind randomized period, patients with diagnosis of Severe Hypertriglyceridemia, subjects will be randomized 3 3 2, pegozafermin 30 mg, pegozafermin 20 mg, placebo, n equal to 135 in each pegozafermin arm and n equal to 90 in the placebo arm. (who.int)
  • Two hundred and four subjects were recruited as FH participants (n=104) and the others as controls (n=100). (edu.pl)
  • When applied to clinical placenta samples apolipoprotein A1 was found to be accumulated in the preeclamptic placenta, where it may either have a nutritional effect or act as a modifier of signal transduction. (hindawi.com)
  • Each trial also included a control group fed on a diet containing 50g TO/kg. (cambridge.org)
  • METHODS: Plasma levels of OxPL-apoB, OxPL-PLG, plasminogen and Lp(a) were measured in the PROCARDIS study of early-onset CHD (906 cases/858 controls). (ox.ac.uk)
  • RESULTS: Mean levels of OxPL-apoB were higher in cases than controls, but levels of OxPL-PLG and plasminogen were similar. (ox.ac.uk)
  • Red=cells alone, Green=isotype control, Blue= APOC3 antibody. (nsjbio.com)
  • ebook ископаемые magazine, method assays and control hormones, and model can not decay enforced institutional. (ebl-motoparts.de)
  • State-based surveillance data are needed to document baseline and postintervention SSB consumption to monitor the impact of CDC funding of state-based interventions to prevent and control obesity. (cdc.gov)
  • This study has been carried out as a case-control and is a hospital-based study in Saudi Arabia. (edu.pl)
  • Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
  • the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)
  • Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)