APOELipoproteinCholesterolApoB-100PeptideConcentrationsGenotypeProteinsAlleleCenters for DiseasAlzheimer'sLipidPolymorphismsGeneticCoronary heart dImmune complexesPlacebo-controlledAmyloidProtein componentDiseasesConcentrationMiceReceptorSerumSignificantlyAcuteGeneDietsCardiovascularExposureStructuralNeuronalPatientsParticipantsClinicalDietLevelsAntibodyAssaysObesityStudy
APOE7
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
- The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
- Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
- In mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) that received a high fat diet equivalent of fried food in humans, the transplanted heart was rejected after 21 days. (pharmacytimes.com)
- Meanwhile, mice with hyperlipidemia caused by a genetic mutation of ApoE who were fed a lower fat diet had their transplanted hearts last 61 days and healthy mice fed a lower fat diet had transplanted hearts that lasted more than 100 days. (pharmacytimes.com)
- Possible associations were analyzed by fitting logistic regression models with AD as outcome, controlling for centre, age, sex and presence of apolipoprotein ε4 allele (APOEε4). (ox.ac.uk)
- Apolipoprotein E (ApoE) a protein component of bloodstream lipid particles has an important function in lipid transportation. (careersfromscience.org)
Lipoprotein8
- Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. (jci.org)
- Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of the genetically polymorphic apo(a). (jci.org)
- We have determined the phenotype, concentration, and distribution of apo(a) in plasma from patients with lipoprotein lipase (LPL) deficiency (type I hyperlipoproteinemia, n = 14), in apo E 2/2 homozygotes with type III hyperlipoproteinemia (n = 12) and in controls (n = 16). (jci.org)
- Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
- These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
- Supportive secondary endpoints (not multiplicity controlled) were percent change in apolipoprotein B-100 (ApoB) and in non-high-density lipoprotein-C (non-HDL-C) from baseline to week 8, and the proportion of participants who achieved protocol-defined LDL-C goals at week 8. (ridgwayrecord.com)
- Assessment of BMI, HOMA-IR, and circulating lipid (total cholesterol, low-density lipoprotein, high-density lipoprotein, non-esterified fatty acids, triacylglycerol, apolipoprotein-A1 and apolipoprotein-B) concentrations, was made when fasted before (V1) and after a 12-week intervention (V2), during which participants consumed 250 ml per d of OJ or an energy and sugars-matched orange-flavoured drink (control). (nottingham.ac.uk)
- Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)
Cholesterol14
- We assessed the effects of 2 y of weight loss achieved with various diet regimens on phytosterols (markers of intestinal cholesterol absorption), lanosterol (marker of de novo cholesterol synthesis), and changes in apolipoprotein concentrations. (nih.gov)
- We assessed circulating phytosterol and lanosterol concentrations and their ratios to cholesterol and apolipoproteins A-I and B-100 in 90 DIRECT participants at 0, 6, and 24 mo. (nih.gov)
- Long-term weight loss is related to a characteristic response suggestive of altered cholesterol and apolipoprotein metabolism. (nih.gov)
- In the present study Golden Syrian hamsters were fed on isoenergetic, low cholesterol (0·05 g/kg) diets containing 100, 150 or 200 g added fat/kg. (cambridge.org)
- More impressively, the mice getting onion extract had total cholesterol and apolipoprotein B levels that were markedly lower (as much as 60% lower for each) than controls on the high fat diet. (naturalnews.com)
- Onions are known to have the ability to decrease blood fats, and in a recent placebo-controlled clinical trial, onion skin extract significantly lowered total cholesterol, LDL cholesterol and the atherogenic index in healthy young women after just two weeks. (naturalnews.com)
- Individuals from two population-based cohorts, the Copenhagen General Population Study (2003-2015, N = 107 341), and the Copenhagen City Heart Study (1991-1994, N = 9387) were followed prospectively until end of 2016 to assess low plasma HDL cholesterol and apolipoprotein A1 as risk factors for cancer using Cox proportional hazard regression. (biomedcentral.com)
- Among 27 cancer types, low HDL cholesterol and/or apolipoprotein A1 were associated with increased risk of multiple myeloma, myeloproliferative neoplasm, non-Hodgkin lymphoma, breast cancer, lung cancer, and nervous system cancer. (biomedcentral.com)
- For this purpose, we used measured HDL cholesterol and apolipoprotein A1 in 116,728 individuals from two independent Danish population-based cohorts recruited during different time periods. (biomedcentral.com)
- In the present study, we included 107,341 individuals with information on measured HDL cholesterol and apolipoprotein A1. (biomedcentral.com)
- Familial defective apolipoprotein B-100: High total cholesterol. (upmc.com)
- Evaluation of the Non-HDL Cholesterol to Apolipoprotein B Ratio as a Screening Test for Dysbetalipoproteinemia. (legehandboka.no)
- Everyone should avoid meat and dairy products two days per week, in order to help keep animal fats and related cholesterol problems under control. (johnsanidopoulos.com)
- High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
ApoB-1006
- The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. (lu.se)
- Methods and Results-A peptide comprising amino acids 3136 to 3155 of apoB-100 (p210) was fused to the B subunit of cholera toxin (CTB), which binds to a ganglioside on mucosal epithelia. (lu.se)
- This effect was accompanied by induction of regulatory T cells that markedly suppressed effector T cells rechallenged with apoB-100 and increased numbers of interleukin (IL)-10(+) CD4(+) T cells. (lu.se)
- Conclusion-Nasal administration of an apoB-100 peptide fused to CTB attenuates atherosclerosis and induces regulatory Tr1 cells that inhibit T effector responses to apoB-100. (lu.se)
- Buy Human Apolipoprotein B-100 (ApoB-100) from Lee Biosolutions. (leebio.com)
- There was a significant decrease in ApoB-100 and malondialdehyde compared to baseline values and compared to the control group. (who.int)
Peptide2
- The effect of nasal administration of the p210-CTB fusion protein on atherogenesis was compared with that of an ovalbumin peptide fused to CTB and with untreated controls. (lu.se)
- D) Consultant sequence (peptide) insurance coverage from the IgD recognized in the microdissected test displaying 62 total spectra, 26 exclusive spectra, and 20 exclusive peptides for 53% insurance coverage of IgD proteins with 100% possibility. (isct-eu2018.com)
Concentrations2
- Hepatic LDL-receptor mRNA concentrations were significantly decreased in animals fed on TP, while apolipoprotein B mRNA concentrations were significantly increased. (cambridge.org)
- Four hundred and eighty-six subjects, aged 33 to 78 years (56.1 ± 8.4), were recruited to participate in a study examining plasma lipid and apolipoprotein concentrations. (biomedcentral.com)
Genotype2
- Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
- Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. (humanconnectome.org)
Proteins1
- In this report, we conducted mass spectrometric analysis of the N-glycosylation profiles of recombinant spike proteins derived from four common SARS-CoV-2 variants classified as Variant of Concern, including Alpha, Beta, Gamma, and Delta along with D614G variant spike as a control. (cdc.gov)
Allele5
- The FH case-control study was associated with the E4 allele in the Saudi population. (edu.pl)
- Several case-control studies have reported an association between schizophrenia and the epsilon 4 allele of Apolipoprotein E gene. (elsevierpure.com)
- This meta-analysis has evaluated the collective evidence for an association between the e4 allele of Apolipoprotein E gene and schizophrenia. (elsevierpure.com)
- We analyzed published data sequentially first considering epsilon 4 allele itself, and then epsilon 4 carrier status as risk factors for schizophrenia using a sample of 17 population-based case-control studies, of which 6 were from Asian and 11 from Caucasian populations. (elsevierpure.com)
- After allowing for sensitivity analysis of the studies and assessment of publication bias, we conclude that the epsilon 4 allele of Apolipoprotein E does not play a major role in risk of schizophrenia in Caucasian populations. (elsevierpure.com)
Centers for Diseas5
- The Centers for Disease Control and Prevention (CDC) recognize diabetes as the 7th leading cause of death in the U.S. (adam.com)
- Centers for Disease Control and Prevention. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Additionally, the Centers for Disease Control and Prevention (CDC) has selected reducing SSB intake as a target behavior for preventing and controlling obesity and supports states in working on state-level data to prioritize subgroups that may need more targeted interventions for SSB reduction. (cdc.gov)
- Introduction The National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC) collects, analyzes, and disseminates data on the health status of U.S. residents. (cdc.gov)
Alzheimer's1
- Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
Lipid2
- However, there have been reports in the media claiming detrimental consequences of 100% juice consumption, including weight-gain and adverse effects on insulin sensitivity and blood lipid profile. (nottingham.ac.uk)
- Lipid profiles of the brand new and Qatari York R145C were in comparison to controls. (careersfromscience.org)
Polymorphisms1
- Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
Genetic3
- In the two genetic conditions, there is grossly impaired catabolic conversion of apo B-100-containing precursor lipoproteins to low-density lipoproteins. (jci.org)
- Their combined effects do not explain 100% of the risk, genetic interactions may contribute. (ox.ac.uk)
- Low apoB levels may indicate Bassen-Kornzweig syndrome (abetalipoproteinemia), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)
Coronary heart d3
- Oxidized phospholipids on apolipoprotein B-100 versus plasminogen and risk of coronary heart disease in the PROCARDIS study. (ox.ac.uk)
- BACKGROUND AND AIMS: Oxidized phospholipids carried on the apolipoprotein B-100 (OxPL-apoB) component of Lp(a) are predictive of coronary heart disease (CHD), but the role of oxidized phospholipids carried on plasminogen (OxPL-PLG) is unknown. (ox.ac.uk)
- Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterolemia and a high risk of coronary heart disease: a randomized, controlled trial. (ucdenver.edu)
Immune complexes2
- High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. (ucdenver.edu)
- In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
Placebo-controlled4
- ABSTRACT In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double- blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
- MK-0616-008 ( NCT05261126 ) was a randomized, double-blind, placebo-controlled, multi-center Phase 2b trial designed to evaluate the efficacy and safety of MK-0616 administered daily compared to placebo in adult participants with hypercholesterolemia and a broad spectrum of ASCVD risk. (ridgwayrecord.com)
- The effect of daily OJ consumption was assessed using a randomised, placebo-controlled, single-blinded, parallel group design. (nottingham.ac.uk)
- My latest control hereby to administration is placebo-controlled at going the choroidal sequela and help that I was through all of these new titles with the Prognosis of including the control( herein taken to often ' the flow of full-frame-rate ') that spotlights guiding Off-Pump procedures in card with those of 4000-fold test. (ebl-motoparts.de)
Amyloid1
- Here we report that nonglycosylated full-length and C-terminal truncated amyloid precursor protein (APP) accumulates exclusively in the protein import channels of mitochondria of human AD brains but not in age-matched controls. (jneurosci.org)
Protein component1
- Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
Diseases1
- Arbuscular mycorrhizal fungi (AMF) can control soilborne diseases such as Fusarium oxysporum f.sp. (thrombin-inhibitor.com)
Concentration3
- Although triacylglycerol concentration was similar between the groups at both visits, a trend for the change in this variable to differ between groups was observed (P = 0.060), with those in control exhibiting a significant increase in triacylglycerol at V2, compared with V1. (nottingham.ac.uk)
- Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis Distinguishing Between Particle Concentration, Type, and Content. (legehandboka.no)
- The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
Mice4
- In this study, researchers fed three different doses of flavonoids extracted from onion, an oral chemo drug, or saline (as control) to mice, along with a high-fat diet. (naturalnews.com)
- Figure 3: Arteriolar vasoactivity and endothelium-dependent vasodilation in 1- to 2-month-old pericyte-deficient Pdgfrb +/− mice and age-matched littermate controls. (nature.com)
- Figure 6: Cortical neuronal activity, neuronal number, neuritic density and behavior in pericyte-deficient Pdgfrb +/− mice 1-2 and 6-8 months old, along with age-matched littermate controls. (nature.com)
- Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice. (cdc.gov)
Receptor1
- Trastorno familiar que se caracteriza por incremento de la concentración del colesterol transportado por las lipoproteínas de baja densidad (LDL) y por déficit de un receptor en la superficie celular que regula la degradación de las LDL y la síntesis del colesterol. (bvsalud.org)
Serum1
- Although serum IgD amounts weren't examined at the proper period of analysis, the serum IgD was within regular limitations (76 kIU/L, regular 100) after two cycles of treatment. (isct-eu2018.com)
Significantly2
- RESULTS: The expression levels of microRNAs and inflammatory factors were found to be significantly higher in the CSF of MS patients compared to controls (P (bvsalud.org)
- Odds for drinking SSBs 1 or more times per day were significantly lower among adults with 100% fruit juice intake of less than 1 time per day versus 1 or more times per day and among adults who drank alcohol versus those who did not drink alcohol. (cdc.gov)
Acute1
- Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab. (ucdenver.edu)
Gene1
- Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. (nsjbio.com)
Diets1
- We conducted the 2-y Dietary Intervention Randomized Controlled Trial (DIRECT-a study of low-fat, Mediterranean, and low-carbohydrate diets). (nih.gov)
Cardiovascular2
- Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
- Some evidence has shown that the capacity of the apoB/apoA-I ratio in assessing cardiovascular risk is strong and may be better than the use of apolipoprotein B alone. (medscape.com)
Exposure1
- The overall Pearl Index (statistical estimation of the number of unintended pregnancies in 100 woman-years of exposure) was 2.65 per 100 woman-years of use. (uspharmacist.com)
Structural1
- They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals. (sysy.com)
Neuronal1
- Glial and neuronal control of brain blood flow. (nature.com)
Patients4
- For some patients with higher T stage (ie, T2, some T3), en bloc resections of the gallbladder and portal lymph nodes may be recommended, although this may carry a high morbidity and mortality (similar to bile duct carcinoma). (medscape.com)
- The main problem for patients is rejection, so if organ rejection can be controlled, survival increases. (pharmacytimes.com)
- To this end, we measured electromagnetic spontaneous activity with MEG in 39 healthy control elders, 41 elders with SCD and 51 MCI patients. (humanconnectome.org)
- Control Intervention1: Placebo (Tris buffer solution (containing Arginine hydrochloride, and polysorbate 80)): In Double blind randomized period, patients with diagnosis of Severe Hypertriglyceridemia, subjects will be randomized 3 3 2, pegozafermin 30 mg, pegozafermin 20 mg, placebo, n equal to 135 in each pegozafermin arm and n equal to 90 in the placebo arm. (who.int)
Participants1
- Two hundred and four subjects were recruited as FH participants (n=104) and the others as controls (n=100). (edu.pl)
Clinical1
- When applied to clinical placenta samples apolipoprotein A1 was found to be accumulated in the preeclamptic placenta, where it may either have a nutritional effect or act as a modifier of signal transduction. (hindawi.com)
Diet1
- Each trial also included a control group fed on a diet containing 50g TO/kg. (cambridge.org)
Levels2
Antibody1
- Red=cells alone, Green=isotype control, Blue= APOC3 antibody. (nsjbio.com)
Assays1
- ebook ископаемые magazine, method assays and control hormones, and model can not decay enforced institutional. (ebl-motoparts.de)
Obesity1
- State-based surveillance data are needed to document baseline and postintervention SSB consumption to monitor the impact of CDC funding of state-based interventions to prevent and control obesity. (cdc.gov)
Study4
- This study has been carried out as a case-control and is a hospital-based study in Saudi Arabia. (edu.pl)
- Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
- the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)
- Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)