• Many factors including cyclins, cyclin-dependent kinases (CDKs), ubiquitin ligases, inhibitors of cyclin-dependent kinases, and reversible phosphorylations regulate mitotic exit to ensure that cell cycle events occur in correct order with fewest errors. (wikipedia.org)
  • Proteolytic degradation of cell cycle regulators and corresponding effects on the levels of cyclin-dependent kinases were proposed as a mechanism that promotes eukaryotic cell cycle and metaphase-to-anaphase transition in particular. (wikipedia.org)
  • Discoveries were made which indicated the importance of the level of the inhibitors of cyclin-dependent kinases in regulating eukaryotic cell cycle. (wikipedia.org)
  • Cyclins function as regulators of CDK kinases. (novusbio.com)
  • A relatively well understood example is the network that controls progression of the cell cycle, where cyclin-dependent kinases (CDKs) couple with various cyclins over the cell cycle to regulate critical processes [ 2 - 4 ]. (biomedcentral.com)
  • Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. (nature.com)
  • Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (nature.com)
  • Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g. (molcells.org)
  • Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
  • Increasing numbers of sequence and biochemical data show the involvement of cyclin-dependent kinases (CDKs) and cyclins in regulation of the cell cycle progression in higher plants. (bibbase.org)
  • The present yeast two-hybrid analyses showed differential interaction between defined D-type cyclins and Cdc2Ms kinases functioning in G2/M phases. (bibbase.org)
  • article{meszaros_multiple_2000, title = {Multiple cyclin-dependent kinase complexes and phosphatases control {G2}/{M} progression in alfalfa cells}, volume = {43}, issn = {1573-5028}, url = {https://doi.org/10.1023/A:1006412413671}, doi = {10/cb64mn}, abstract = {Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
  • Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
  • Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. (lookformedical.com)
  • Development through mitosis depends upon three major regulatory systems, each involving several serine/threonine kinases, referred to as mitotic kinases. (survivinpathway.com)
  • Current research suggests that mitotic kinases have a key role in regulating the cell cycle. (survivinpathway.com)
  • Right chromosome segregation is closely controlled by mitotic kinases such as cyclin dependent NIMA related kinase 2, Pololike kinase, kinase 1 and Aurora kinases. (survivinpathway.com)
  • Cyclin-dependent kinase 2 (CDK2), a member of Cyclin-dependent kinases (CDKs), plays an important role in cell division and DNA replication. (mdpi.com)
  • Cell cycle progression is largely controlled by the activity of cyclin dependent kinases (CDKs) and their cyclin binding partners. (lancs.ac.uk)
  • Since that time several RASSF1A kinases are also discovered including cyclin-dependent kinase-4 (18) PKC (19) MST1 (macrophage stimulating-1) (20) and Aurora-B (21) that have different results on RASSF1A function. (healthandwellnesssource.org)
  • Despite different thresholds of Sic1 level that are required to trigger mitotic exit compared to G1-S transition, the level of Sic1 was shown to play a key role in regulating eukaryotic cell cycle by inhibiting the activity of CDKs. (wikipedia.org)
  • The complexity represented by different types of CDKs and cyclins in a single species such as alfalfa, indicates that multicomponent regulatory pathways control G2/M transition. (bibbase.org)
  • Paradoxically, progression deeper into cell cycle arrest was accompanied by increases in proliferative effectors such as CDKs and cyclins, which can drive cell cycle re-entry by overcoming p21 induction. (bvsalud.org)
  • We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. (biomedcentral.com)
  • Targets of the cyclin-dependent kinase Cdk1. (nature.com)
  • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)
  • Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (nature.com)
  • In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
  • Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
  • Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)
  • The company's seliciclib is an orally available, cyclin dependent kinase inhibitor. (pharmaceutical-technology.com)
  • Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. (arigobio.cn)
  • We found Sid1p is additionally controlled by Cyclin Dependent Kinase activity, uncovering an important link between mitotic events and initiation of cytokinesis. (umassmed.edu)
  • Multiple rounds of centrosome reproduction were blocked by selective inactivation of cyclin-dependent kinase 2-cyclin E (Cdk2-E) and were restored by addition of purified Cdk2-E. Confocal immunomicroscopy revealed that cyclin E was localized at the centrosome. (umassmed.edu)
  • Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. (crick.ac.uk)
  • Here we show that cells transactivate the mitotic gene network as they exit the S phase through a CDK1 (cyclin-dependent kinase 1)-directed FOXM1 phosphorylation switch. (elsevierpure.com)
  • Without Cdk1-Clb2 complexes to phosphorylate proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, spindle elongation and chromosomal segregation are promoted, facilitating mitotic exit. (wikipedia.org)
  • Clb2 degradation did shorten the Cdk1-inhibition period required for triggering irreversible mitotic exit indicating that cyclin proteolysis contributes to the dynamic nature of the eukaryotic cell cycle due to slower timescale of its action but is unlikely to be the major determining factor in triggering irreversible cell cycle transitions. (wikipedia.org)
  • Cdk1-inhibitors could induce mitotic exit even when degradation of B-type cyclins was blocked by expression of non-degradable Clbs or proteasome inhibitors. (wikipedia.org)
  • The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. (ebi.ac.uk)
  • The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic cyclins that reflects some of the current literature. (ebi.ac.uk)
  • Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)
  • Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)
  • CDK1, also named as CDC2, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily.CDC2 plays a key role in the control of the eukaryotic cell cycle. (caslab.com)
  • This is in contrast to control cells where cyclin B 1 appears at the centrosomes in early prophase based on cell cycle-specific localization of CENP-F. Furthermore, cyclin B/Cdk1 kinase activity in early G 2 is aberrantly high in BubR1-depleted cells. (ewha.ac.kr)
  • Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. (arigobio.cn)
  • Cdk1 also contributes to the control of DNA replication. (arigobio.cn)
  • CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. (arigobio.cn)
  • During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. (arigobio.cn)
  • Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding. (nih.gov)
  • Cdk1) which provide temporal and spatial control. (monbug.ca)
  • β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by casein kinase II. (ox.ac.uk)
  • The model is based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. (ebi.ac.uk)
  • The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. (fcgportal.org)
  • These "LP" type docking motifs determine cyclin specificity, promote phosphorylation of suboptimal CDK sites and multi-site phosphorylation of substrates both in vivo and in vitro. (umassmed.edu)
  • This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis. (ox.ac.uk)
  • Mitotic exit is an important transition point that signifies the end of mitosis and the onset of new G1 phase for a cell, and the cell needs to rely on specific control mechanisms to ensure that once it exits mitosis, it never returns to mitosis until it has gone through G1, S, and G2 phases and passed all the necessary checkpoints. (wikipedia.org)
  • However, sister chromatids failed to segregate, and cells reverted to mitosis once the inhibitors were washed away, indicating that a threshold level of the inhibitors needs to be achieved to trigger irreversible mitotic exit independently of cyclin degradations. (wikipedia.org)
  • We introduced autocatalytic transcription of E2F, E2F regulated transcription of cyclin B, Cdc20/Cdh1 mediated E2F degradation, enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis. (ebi.ac.uk)
  • The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
  • Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. (wikidata.org)
  • Stern, B. & Nurse, P. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. (nature.com)
  • Fisher, D. L. & Nurse, P. A single fission yeast mitotic cyclin B p34 cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. (nature.com)
  • The role of BubR1 has been established mainly in mitosis as an essential mitotic checkpoint protein although it is expressed throughout the cell cycle. (ewha.ac.kr)
  • An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
  • We additional display that CUL4A-mediated RASSF1A degradation takes place during depletion and mitosis of CUL4A markedly reverses mitotic-phase-stimulated RASSF1A degradation. (healthandwellnesssource.org)
  • Miller, M. E. & Cross, F. R. Cyclin specificity: how many wheels do you need on a unicycle? (nature.com)
  • A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. (nature.com)
  • Tissue specificity of cyclin B expression in D. melanogaster]. (nih.gov)
  • Our results suggest that budding yeast has become dependent on G1 cyclin specificity to couple cell cycle progression to essential morphogenetic events. (crick.ac.uk)
  • In animals, CDK inhibitors are tightly regulated, especially by posttranslational mechanisms of which control of nuclear access and regulation of protein turnover are particularly important. (uni-bielefeld.de)
  • Polo-like kinase (PLK) inhibitors targets the mitotic phase of the cell cycle. (pharmaceutical-technology.com)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • In this theory, anaphase promoting complex (APC), a class of ubiquitin ligase, facilitates degradation of mitotic cyclins (Clb2) and anaphase-inhibiting factors (PDS1, CUT2) to promote mitotic exit. (wikipedia.org)
  • In budding yeast, the phosphatase Cdc14 is released from nucleolus to promote mitotic exit (ME). (rockefeller.edu)
  • Here, we observe that cyclin F is regulated by proteolysis through β-TrCP. (ox.ac.uk)
  • The anaphase promoter complex (APC) is a multiprotein complex - an ubiquitin E3 ubiquitin ligase - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the metaphase-anaphase transition. (fapesp.br)
  • The identification of the complete set of genes encoding the APC subunits in Arabidopsis, suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. (fapesp.br)
  • The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. (ox.ac.uk)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
  • Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
  • Despite a decade-long analysis building RASSF1A as a significant tumor suppressor that has a crucial function in cell development control and apoptosis small is well known about its legislation at the proteins level. (healthandwellnesssource.org)
  • This study is the first to suggest a role of hBubR1 in controlling centrosome targeting of cyclin B 1 and timing of mitotic entry. (ewha.ac.kr)
  • To facilitate investigation of the mechanisms that control centrosome reproduction, a frog egg extract arrested in S phase of the cell cycle that supported repeated assembly of daughter centrosomes was developed. (umassmed.edu)
  • Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. (caslab.com)
  • Many speculations were made with regard to the control mechanisms employed by a cell to promote the irreversibility of mitotic exit in a eukaryotic model organism, the budding yeast Saccharomyces cerevisiae. (wikipedia.org)
  • However, experiments using budding yeast cells with cdc28-as1, an INM-PP1 (ATP analog)-sensitive Cdk allele, proved that destruction of B-type cyclins (Clb) is not necessary for triggering irreversible mitotic exit. (wikipedia.org)
  • Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant with B-type cylins in budding yeast. (umassmed.edu)
  • In this dissertation, I have presented evidence that some G1 cyclins in budding yeast, Cln1/2, specifically identify substrates by interacting with a leucine-proline rich sequence different from the ones used by B-type cyclins. (umassmed.edu)
  • Finally, by studying many fungal cyclins exogenously expressed in budding yeast, we discovered that some have the ability to make the CDK hyper-potent, which suggests that these cyclins confer special properties to the CDK. (umassmed.edu)
  • This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
  • Several cell cycle events require specific forms of the cyclin-CDK complexes. (umassmed.edu)
  • however, the mechanisms underlying the regulation of cyclin F are poorly understood. (ox.ac.uk)
  • They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. (novusbio.com)
  • Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
  • Our results reveal a conserved signaling network, termed the Septation Initiation Network (SIN), of which Sid1p is an intermediate component, that controls temporal and spatial regulation of cytokinesis. (umassmed.edu)
  • Its mechanism and regulation of its frequency by Clb2-Cdk, suggest the hypothesis that intrinsically autonomous Cdc14 release cycles are locked at once per cell cycle through entrainment by the cyclin-Cdk oscillator. (rockefeller.edu)
  • Here using an in vitro cell-free DNA replication system we analyse the interplay between Ciz1 and cyclin A/CDK2 in regulation of the initiation phase of DNA replication. (lancs.ac.uk)
  • Previous evidence points to numerous components of the spindle assembly checkpoint and mitotic regulation playing a major role in several cancers [ 11 , 12 ]. (biomedcentral.com)
  • These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
  • in particular how the APC/C is controlled by the Spindle Assembly Checkpoint. (embo.org)
  • cdc25+ functions as an inducer in the mitotic control of fission yeast. (wikidata.org)
  • A fission yeast general translation factor reveals links between protein synthesis and cell cycle controls. (ox.ac.uk)
  • In two independent screens we isolated fission yeast mutations with phenotypes suggesting defects in B-cyclin function or expression. (ox.ac.uk)
  • β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. (ox.ac.uk)
  • Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. (ebi.ac.uk)
  • Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. (molcells.org)
  • These may offer new insight into the biomedical function of G1 cyclins in breast cancer progression. (mesvetmed.ir)
  • This autonomous Cdc14 release oscillator functions at constant cyclin-Cdk levels by titrated introduction of undegradable Clb2, and at cell-cycle-average Clb2 levels given a block of cell cycle progression by actin depolymerization. (rockefeller.edu)
  • A single cyclin can also replace all G1 cyclins to support ordered cell cycle progression, fulfilling key predictions of the quantitative model. (crick.ac.uk)
  • Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. (nih.gov)
  • Cdc20 and Cdh1, which are the activators of APC, recruit substrates such as securin and B-type cyclins(Clb) for ubiquitination. (wikipedia.org)
  • It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. (umassmed.edu)
  • There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. (umassmed.edu)
  • Interestingly, this region is close to but not same as the one implicated in B-type cyclins to binding substrates. (umassmed.edu)
  • The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition. (ox.ac.uk)
  • As expected, BubR1 depletion leads to degradation of cyclin B 1 in the G 2 phase. (ewha.ac.kr)
  • Sic1 level was shown to play a major role in triggering irreversible mitotic exit (M-G1 transition) as well as in G1-S transition. (wikipedia.org)
  • Maternal to zygotic transition (MZT) is the key event during embryogenesis marked by the switch of control from the maternal and possibly paternal transcripts to the newly synthesized embryonic gene products [ 9 - 11 ]. (biomedcentral.com)
  • promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. (arigobio.cn)
  • Much is known about the control of the G 1 /S, G 2 /M, and metaphase/anaphase transitions, but thus far, no control mechanism has been identified for the S/G 2 transition. (elsevierpure.com)
  • Much is known about the control of the G1/S, G2/M, and metaphase/anaphase transitions, but thus far, no control mechanism has been identified for the S/G2 transition. (elsevierpure.com)
  • APC in association with Cdc20 (APC-Cdc20) ubiquitinates and targets mitotic cyclins (Clb2) for degradation at initial phase. (wikipedia.org)
  • Donaldson, A. D. The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing. (nature.com)
  • Reducing mitotic cyclin-Cdk activity is critical for ME, but Cdc14 release and resequestration is not blocked by endogenous undegradable mitotic cyclin Clb2. (rockefeller.edu)
  • Released and active separase cleaves cohesin that held sister chromatids together, facilitating separation of sister chromatids and initiates mitotic exit by promoting release of Cdc14 from nucleolus. (wikipedia.org)
  • Levels of the B-cyclins Cig2 and Cdc13 are dramatically reduced upon inactivation of Ded1, and this reduction is independent of degradation by the anaphase promoting complex. (ox.ac.uk)
  • We show that B-cyclin translation is specifically inhibited upon nitrogen starvation of wild-type cells, when B-cyclin/Cdc2 inactivation is a prerequisite for G(1) arrest and subsequent mating. (ox.ac.uk)
  • Our data suggest that translational inhibition of B-cyclin expression represents a third mechanism, in addition to cyclin degradation and Rum1 inhibition, that contributes to Cdc2 inactivation as cells exit from the mitotic cell cycle and prepare for meiosis. (ox.ac.uk)
  • A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
  • Enables cyclin-dependent protein serine/threonine kinase regulator activity. (nih.gov)
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • Together, our results indicate that hBubR1 depletion triggers premature centrosomal localization of cyclin B 1 probably leading to premature mitotic entry. (ewha.ac.kr)
  • by CG0009 resulted in slight upregulation from the -catenin focus on genes, c-Myc and c-Jun, however, not cyclin D1, indicating that CG0009-mediated cyclin D1 depletion overwhelms the pro-survival sign of -catenin, leading to cell loss of life. (globaltechbiz.com)
  • Our findings claim that the book GSK3 inhibitor, Tauroursodeoxycholate CG0009, inhibits breasts cancers cell development through cyclin D1 p53 and depletion activation, and may hence offer a forward thinking healing approach for breasts malignancies resistant to hormone-based therapy. (globaltechbiz.com)
  • The results suggest ways to arrest the mitotic oscillator by altering the maximum rates of the converter enzymes. (ebi.ac.uk)
  • Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. (vt.edu)
  • The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. (vt.edu)
  • Several recent research including ours show that RASSF1A induces cell routine arrest in both G1/S- and mitotic (M)-stages (8 11 -16). (healthandwellnesssource.org)
  • Several mechanisms have already been identified because of its actions on cell routine control for instance RASSF1A-mediated G1/S cell routine arrest continues to be from the inhibition of cyclin D1 accumulating in the nucleus (15) and M-phase of cell routine legislation is certainly from the capability of RASSF1A to modulate the experience of anaphase-promoting complicated (16) and microtubule dynamics (8 11 -14). (healthandwellnesssource.org)
  • Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
  • Considering the conservation of cell cycle regulators in the eukaryotic kingdom, it is likely that similar mechanisms to control cytokinesis exist in humans. (umassmed.edu)
  • For a normal eukaryotic cell, mitotic exit is irreversible. (wikipedia.org)
  • This concept incorporates autonomous cell cycle oscillators previously reported into a coherent cell cycle control by cyclin-Cdk oscillation, therefore, may have broad implications for the structure and evolution of eukaryotic cell cycle. (rockefeller.edu)
  • The mitotic spindle performs this function in eukaryotic cells. (monbug.ca)
  • Finally, we examine co-clustering of the CDK consensus motifs with the 'cy' or RXL motif [ 17 ], which is known to be important in determining which CDK-cyclin complex will phosphorylate a given substrate. (biomedcentral.com)
  • Subsequently, we have discovered the substrate-binding region in Cln2 and further showed that this region is highly conserved amongst a variety of fungal G1 cyclins from budding yeasts to molds and mushrooms, thus suggesting a conserved function across fungal evolution. (umassmed.edu)
  • APC ubiquitinates nine-amino acid motif known as the destruction box (D box) in the NH2-terminal domain of mitotic cyclins for degradation by proteasome. (wikipedia.org)
  • The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. (fcgportal.org)
  • Localization of Cdc2Ms F kinase to the preprophase band (PPB), the perinuclear ring in early prophase, the mitotic spindle and the phragmoplast indicated a pivotal role for this kinase in mitotic plant cells. (bibbase.org)
  • In the qualitative model, cell cycle events are ordered by distinct substrate specificities of successive cyclin waves. (crick.ac.uk)
  • The abnormally high number of centrosomes found in many human tumor cells can lead directly to aneuploidy and genomic instability through the formation of multipolar mitotic spindles. (umassmed.edu)
  • Cdc14 release and ME is controlled by mitotic cyclin-Cdk oscillation, the FEAR network including a non-proteolytic function of separase (Esp1), and the Mitotic Exit Network (MEN) indirectly activated by spindle elongation through cohesin cleavage by the proteolytic function of Esp1. (rockefeller.edu)
  • Tumor weight and volume were significantly lower in the bipSUR treated mice than untreated tumor-bearing mice and control. (mesvetmed.ir)
  • Histopathological observations revealed more apoptotic foci and lower mitotic cells in tumor sections in the treated mice than in control groups. (mesvetmed.ir)
  • During these mitotic cycles, there are barely detectable oscillations in the total level of B-type cyclins. (vt.edu)
  • Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. (vt.edu)
  • Further research is demanded to identify the protein partners of G1 cyclins involved in the cancer pathways. (mesvetmed.ir)
  • We show that ICK1/KRP1 exerts its function in the nucleus and its presence in the nucleus is controlled by multiple nuclear localization signals as well as by nuclear export. (uni-bielefeld.de)
  • While degradation of Sic1 to a certain low level triggered the onset of S phase, accumulation of Sic1 to a certain high level was required to trigger irreversible mitotic exit. (wikipedia.org)
  • The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. (wikidata.org)
  • Here, we demonstrate that reducing BubR1 levels during the G 2 phase causes accelerated mitotic entry. (ewha.ac.kr)
  • Intriguingly, cyclin B 1 is prematurely targeted to centrosomes appearing at early G 2 phase in BubR1-depleted cells despite its low levels. (ewha.ac.kr)
  • Here, we study the relative contributions of qualitative and quantitative Cdk control in Saccharomyces cerevisiae All S phase and mitotic cyclins can be replaced by a single mitotic cyclin, albeit at the cost of reduced fitness. (crick.ac.uk)
  • Control mechanisms establish this order by dictating when a cell transitions from one phase to the next. (elsevierpure.com)
  • We consider a minimal cascade model previously proposed for the mitotic oscillator driving the embryonic cell division cycle. (ebi.ac.uk)
  • From published experimental evidence, we propose a molecular mechanism for control of the cell division cycle in Caulobacter crescentus. (ebi.ac.uk)
  • The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. (ebi.ac.uk)
  • The company develops small molecule drugs that target various phases of cell cycle control for the treatment of cancer and other serious diseases. (pharmaceutical-technology.com)
  • Using quantitative time-lapse microscopy, we demonstrate an intrinsic oscillatory module controlling Cdc14 localization. (rockefeller.edu)
  • Using a diverse set of quantitative tools, based in single cell and population measurements, we show that g-tubulin plays an unexpected role in orchestrating the formation of anti-parallel microtubules during the assembly of mitotic spindle. (monbug.ca)
  • Localization to the chromocenters is mediated by an N-terminal domain, in addition we find that this domain may be involved in cyclin binding. (uni-bielefeld.de)