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Suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation, indicative of JAK2 inhibition, was observed at 3 hours post-dose for subjects in the 300, 500, and 680 mg groups, with the level of suppression increasing with dose. (nih.gov)
The relationship between fedratinib exposure and suppression of STAT3 phosphorylation was described using an inhibitory effect sigmoid Emax model, with an EC50 of 1,210 ng/mL in healthy subjects. (nih.gov)
Cells transfected with mimic of the put-miR-34 showed significant decrease in expression of Signal Transducers and Activators of Transcription 3 (STAT3), and the inhibitor of put-miR-34 showed significant increase in STAT3 expression and its phosphorylation. (cdc.gov)
Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). (drugbank.com)
Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. (drugbank.com)
Most directly relevant to our recent and future work is the characterization of latent cytoplasmic transcription factors of the STAT family (Stat 1 through 6 and variants thereof) that are activated by phosphorylation involving cell surface receptors for growth factors or cytokines and the JAK family of tyrosine protein kinases (recently reviewed in 23,24). (nih.gov)
Significantly the regenerating epithelium across the DUM proven heightened STAT3 phosphorylation and cell proliferation that was suppressed in uteri of conditional knockout mice. (biobender.com)
Phosphorylation of STAT3 at Tyr-705 and Ser-727 was reduced by DIM in a concentration-dependent manner. (biomedcentral.com)
Interleukin (IL)-6-induced phosphorylation of STAT3 at Tyr-705 was significantly blocked by DIM. (biomedcentral.com)
Beside RES potentiated sorafenib induced inhibitory effect on constitutive STAT3 and STAT5 phosphorylation apoptotic effects in 786-O cells and this correlated with down-regulation of various oncogenic gene products. (biospraysehatalami.com)
Our data indicate a direct role for TEL-AML1, via increasing the activity of RAC1, in regulating the phosphorylation of signal transducer and activator of transcription 3 (STAT3), which results in transcriptional induction of MYC. (ashpublications.org)
Aug 2022 Chk1 Inhibition Potently Inhibits Phosphorylation and Activation of the STAT3 Transcription Factor in Human Multiple Myeloma Cells. (vcu.edu)
Indeed, SK-BR-3 cells exposed to nidogen-1-depleted endothelial supernatants showed increased promigratory STAT3 phosphorylation along with increased cell migration. (biomedcentral.com)
View more applications data using this product to stain Veri-Cells™ lyophilized control cells and to study phosphorylation kinetics in our Scientific Poster Library. (biolegend.com)
IL-10 signals via IL-10RA/IL-10RB [ 9 ] and results in the phosphorylation of Stat3, a critical transcription factor for the immunosuppressive effect of IL-10 [ 10 ]. (ijbs.com)

Background: The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of xenobiotic detoxification genes and is a critical mediator of gene-environment interactions. (nih.gov)
Global expression analysis of AHR-positive cells showed that activation of the AHR/TCDD axis disrupted the concerted expression of genes that regulate multiple signaling pathways involved in cardiac and neural morphogenesis and differentiation, including dozens of genes encoding homeobox transcription factors and Polycomb and trithorax group proteins. (nih.gov)
The STAT3 gene is part of a family known as the STAT genes. (medlineplus.gov)
The STAT proteins bind to regulatory regions near genes, which allows the proteins to control whether these genes are turned on or off. (medlineplus.gov)
Changes in the STAT3 gene that cause AD-HIES alter the structure and function of the STAT3 protein, impairing its ability to control the activity of other genes. (medlineplus.gov)
We identified 131 genes (including 6 transcription factors) that were commonly regulated in mouse kidney disease models and in CKD patients. (asn-online.org)
Once it had been found that genes were sequentially activated by serum or purified growth factors (1), the emphasis of the research was the identification and characterization of induced genes and proteins and their possible roles in determining the cellular response. (nih.gov)
The experimental approach we and others took to identify genes and proteins was the isolation and analysis of cDNAs derived from mRNAs that appeared at different times after cultured fibroblastic cells were stimulated with serum or purified growth factors (PDGF, FGF) (1-4). (nih.gov)
The largest class of immediate early response genes encoded transcription factors, including members of the AP1 basic-leucine zipper family (c-Jun, JunB, c-Fos, Fra-1 FosB), the Egr1/Zif268 family of zinc finger proteins (8,9), c-Myc, and Id proteins. (nih.gov)
Because of their ubiquity we assumed that Jun/Fos and Zif268 transcription factors in particular are partially responsible for activating delayed early response genes, but our experiments were primarily directed at understanding more general properties of these proteins, e.g. (nih.gov)
DNA binding properties of Jun and Jun/Fos dimers (13,14) and Zif268 (15), defining growth factor response elements involved in activation of the Zif268 (16) and JunB genes (17), identifying proteins that functionally interact with Jun and Fos (see below), and structural characterization of the novel metal-binding domain of Nup475 (see below). (nih.gov)
In addition, we have studied the HMG-I delayed early proteins, which were identified in our cDNA screen, both from the point of view of their DNA- binding properties and the role of immediate early transcription factors in the activation of delayed early genes (see below). (nih.gov)
While our research on growth factor-induced proteins was being pursued, a great deal of progress has been made in understanding transmembrane signaling by growth factors and cytokines, the link between transmembrane signaling and the activation of immediate early genes, regulation of the cell cycle, and the biochemistry of transcription factors. (nih.gov)
4Tran provides new insight into the manner in which transposons contribute to chromosome architecture and identifies target genes that transposable elements can potentially control. (biomedcentral.com)
RES-induced an increased manifestation of PTPε and SHP-2 and the deletion of these two genes by small interfering RNA abolished the ability of RES to inhibit STAT3 activation suggesting the critical part of both PTPε and SHP-2 in its possible mechanism of action. (biospraysehatalami.com)
Cytokines exert their biological activities through the activation and translocation of transcription factors into the nucleus whether they drive the expression of specific cytokine-responsive genes. (hindawi.com)
Genes down-regulated in T cells: control (0h) versus IL21 [GeneID=59067] treatment for 6h. (gsea-msigdb.org)
Comparing genome-wide expression array data to binding sites revealed that most IL-21-regulated genes were associated with combined STAT3-IRF4 sites rather than pure STAT3 sites. (gsea-msigdb.org)
Expression of the Sonic hedgehog ( Shh ) and the downstream transcriptional factor Gli-1 genes, implicated in the pathogenesis of medulloblastoma, was found to be significantly increased and cotranscribed in cerebellar granule neurons of the GIFN/STAT2 -/- mice. (jci.org)

14. Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. (nih.gov)
At present, the master regulators of Th lineages that have been identified include T-bet/Stat4 (Th1), GATA-3/Stat5 (Th2), RORγt/Stat3 (Th17), Foxp3/Stat5 (Treg) and Bcl-6/Stat3 (Tfh), respectively. (nih.gov)
Earlier reports show high rate of recurrence of improved STATs activation in CHR2797 (Tosedostat) RCC cells and individual specimens [4 34 35 Because of the pivotal part of STATs in tumor cell survival proliferation and angiogenesis we hypothesized that STAT3 and STAT5 could be a novel restorative target for RCC. (biospraysehatalami.com)
5'-biotinylated STAT3 and STAT5 was from Bioneer Corporation (Daejeon Korea). (biospraysehatalami.com)
An immune response also induced in the brain of the GIFN/STAT2 -/- mice was associated with IFN-γ gene expression by CD3 + T cells and the activation of the STAT1, STAT3, STAT4, and STAT5 molecules. (jci.org)

mice, metformin attenuated irritation in kidney and liver organ tissue and inhibited B cell differentiation into plasma cells and the forming of germinal centers in colaboration with enhanced AMPK appearance as well as the inhibition of mTOR-STAT3 signaling [40]. (exposed-skin-care.net)
mice, metformin attenuated inflammation in kidney and liver tissues and inhibited B cell differentiation into plasma cells and the formation of germinal centers in association with enhanced AMPK expression and the inhibition of mTOR-STAT3 signaling [40]. (exposed-skin-care.net)
Stat3 inhibition or shRNA-knockdown also significantly increases DSG3 mRNA and protein levels. (jci.org)
Our data indicate that glucocorticoids and rapamycin upregulate DSG3 transcription through inhibition of Stat3. (jci.org)
We find that glucocorticoids and rapamycin upregulate DSG3 transcription through inhibition of the transcription factor Stat3. (jci.org)
Chemical inhibition and siRNA knockdown experiments demonstrated that STAT-3 activation is dependent on the activation of nonreceptor tyrosine-protein kinase 2 (TYK2) and epidermal growth factor receptor (EGFR) tyrosine kinases. (cdc.gov)
Thus, STAT3 inhibition represents a promising possible therapeutic strategy for the treatment of TEL-AML1 leukemia. (ashpublications.org)
Sept 2021 Pharmacological Inhibition of the Nucleosome Remodeling Factor (NURF) with Bromodomain Inhibitors Controls TNBC Cancer Growth. (vcu.edu)

Nfil3 transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock. (researcher-app.com)

IL-24 carries its functions through two types of membrane receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) with simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their cytoplasmic domains. (wikipedia.org)
Through these two types of membrane receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2), simultaneous activation of the JAK/signal transducer and activator of transcription (STAT) pathway within their cytoplasmic domains. (wikipedia.org)
These cases highlight the importance of the interleukin (IL)-12/interferon (IFN)-γ and signal transducer and activator of transcription 3 (STAT3) pathways in host defense. (cdc.gov)
Signal transducer and activator of transcription 3 (STAT3) is activated in majority of ovarian tumors and confers resistance to cisplatin treatment in patients with ovarian cancer. (biomedcentral.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)
Signal transducer and activator of transcription (STATs) are transcription factors which play a critical role in mediating signaling downstream of cytokine receptors and are important for shaping the host immune response during Leishmania infection. (hindawi.com)
The type I IFNs (IFN-α and IFN-β), which are crucial in antiviral defense and immune regulation, signal via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway with activation of STAT1 and STAT2. (jci.org)

IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. (wikipedia.org)
In spontaneously hypertensive rats, metformin reduced proteinuria and increased the production of vascular endothelial growth factor (VEGF)-A in rat kidneys, probably by hypoxia-inducible factor (HIF)-2 activation [41]. (exposed-skin-care.net)
Hydrocortisone- or rapamycin-treated PHKs demonstrate increased number and length of desmosomes by electron microscopy and are resistant to PV IgG-induced loss of cell adhesion, whereas constitutive activation of Stat3 in PHKs abrogates DSG3 upregulation and inhibits hydrocortisone and rapamycin's therapeutic effects. (jci.org)
In this study, we have identified STAT-3 as an important transcription factor controlling the induction of expression of immune and inflammatory mediators by poultry dust extracts in airway epithelial cells and in mouse lungs and delineated the cellular pathway for STAT-3 activation. (cdc.gov)
Our studies show that poultry dust extract controls the induction of immune and inflammatory mediator expression via a cellular pathway involving oxidative stress-mediated STAT-3 activation by TYK2 and EGFR tyrosine kinases. (cdc.gov)
This pattern of gene activation was consistent with a specific regulated transcriptional cascade or genetic program induced by the growth factor. (nih.gov)
Also, the absence of NK cells promoted the activation of the Th17 lineage-specific transcription factors Rorc and STAT3 in a manner that was dependent on microglia. (grantome.com)
Western blotting analysis of tumor lysates indicated increased apoptosis and reduced STAT3 activation. (biomedcentral.com)
TEL-AML1 induces STAT3 activation via RAC1 and leading to induction of MYC expression. (ashpublications.org)
Mechanistically, autophagy reduction correlated with the downregulation of RAB7 and ATG5 expression and STAT3 activation, leading to the accumulation of SQSTM1/p62. (uniroma5.it)
Cytokines, interleukins, and growth factors, lead to the activation of the JAK/STAT signaling pathway. (biomedcentral.com)
Interestingly, IL-20 subfamily can also activate Stat3, but the outcome is different from the activation of IL-10 [ 11 ]. (ijbs.com)

It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
9. Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3. (nih.gov)
12. The role of Stat3 in apoptosis and mammary gland involution. (nih.gov)
13. Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution. (nih.gov)
Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. (drugbank.com)
Imipramine induced apoptosis via caspase-dependent/-independent pathways, inhibited EMT, and down-regulated phosphorylated AKT, ERK, and STAT3. (bvsalud.org)
Overexpression of STAT3 by gene transfection blocked DIM-induced apoptosis. (biomedcentral.com)

Background Transmission transducers and activators of transcription (STAT) proteins are critical transcription element that are aberrantly activated in various types of malignancies including renal cell carcinoma (RCC). (biospraysehatalami.com)

Its impact on transcription factors and modulation of the AKT/ERK/STAT3 pathway suggest a multifaceted approach. (bvsalud.org)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

Importantly, breast cancer cells that ectopically express AUF1 were more efficient in forming orthotopic tumor xenografts in nude mice than their corresponding controls with limiting cell inocula. (nature.com)
Preclinical studies show that LPS-activated microglia enable the conversion of trophic to A1 astrocytes by releasing several cytokines, including tumor necrosis factor alpha (TNF-alpha), interlukin-1 alpha (IL-1 alpha), and complement component C1q. (frontiersin.org)
The expression of pro-inflammatory cytokines and chemokines, notably tumor necrosis factor α (TNF-α), Interleukin 1ß (IL-1ß), IL-6, CC-motif chemokine ligand 2 (CCL2), CCL20, CCL28, and CXC motif chemokine 9 (CXCL9), etc., was significantly reduced by quercetin supplementation. (bvsalud.org)
Among all STAT family members, STAT3 is often associated with tumor genesis and is considered as an oncogene. (sciarena.com)
It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. (biomedcentral.com)
Moreover, aberrant expression of miRNAs has been associated with therapeutic resistance in cancer that suggests these factors as probable efficient therapeutic targets in tumor cells [ 8 ]. (biomedcentral.com)
Accordingly, understanding the regulatory role of these factors during tumor progression can be used for diagnostic and therapeutic purposes [ 12 ]. (biomedcentral.com)
Therefore, in the present review we discussed the molecular mechanisms of miR-216a during tumor progression to introduce that as a reliable diagnostic and prognostic factor in cancer patients (Table 1 ). (biomedcentral.com)

Treatment of primary human keratinocytes (PHKs) with hydrocortisone or rapamycin, but not the p38 MAPK inhibitor SB202190, significantly increases DSG3 mRNA and protein expression and correspondingly reduces phospho-S727 Stat3. (jci.org)
Topical hydrocortisone, rapamycin, or Stat3 inhibitor XVIII prevents autoantibody-induced blistering in the PV passive transfer mouse model, correlating with increased epidermal DSG3 expression and decreased phospho-S727 Stat3. (jci.org)
Rapamycin, an mTOR inhibitor, was reported to induce rapid remission of PV ( 5 ), leading us to speculate that rapamycin also upregulates DSG3 transcription. (jci.org)
We demonstrate that human leukemic cell lines carrying this translocation are highly sensitive to treatment with S3I-201, a specific STAT3 inhibitor, and, more interestingly, that primary human leukemic samples are also responsive to the drug in the same concentration range. (ashpublications.org)
The identification of nidogen-1 as an endothelial-derived inhibitor of migration of distinct cancer cell types reveals a novel mechanism of endothelial control over cancer progression. (biomedcentral.com)

Interleukin-21 (IL-21) is a pleiotropic cytokine that induces expression of transcription factor BLIMP1 (encoded by Prdm1), which regulates plasma cell differentiation and T cell homeostasis. (gsea-msigdb.org)

Fate-mapping experiments to address T cell plasticity and stability are being performed using reporter mice in which inducible-Cre expression is under the control of cytokine or transcription factor locus. (nih.gov)

DIM treatment also inhibited cell invasion and angiogenesis by suppressing hypoxia-inducible factor 1α (HIF-1α) and vascular epithelial growth factor (VEGF). (biomedcentral.com)

Here we show that the microbiota regulates body composition through the circadian transcription factor NFIL3. (researcher-app.com)
NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. (researcher-app.com)

Methods: We generated an AHR-positive cardiomyocyte lineage differentiated from mouse ES cells that expresses puromycin resistance and enhanced green fluorescent protein (eGFP) under the control of the Cyp1a1 (cytochrome P450 1a1) promoter. (nih.gov)
In the immune system, the STAT3 protein transmits signals for the maturation of immune system cells, especially T cells and B cells. (medlineplus.gov)
These cells help control the body's response to foreign invaders such as bacteria and fungi. (medlineplus.gov)
In the skeletal system, the STAT3 protein is involved in the formation of specialized cells that build and break down bone tissue. (medlineplus.gov)
A shortage of functioning STAT3 protein prevents cells from reacting to signals that trigger allergic reactions, which explains why people with AD-HIES do not have an increased risk of allergies, despite having high levels of IgE. (medlineplus.gov)
Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. (nature.com)
Here we combine transcriptional profiling at high temporal resolution, novel computational algorithms, and innovative nanowire-based perturbation tools to systematically derive and experimentally validate a model of the dynamic regulatory network that controls the differentiation of mouse T H 17 cells, a proinflammatory T-cell subset that has been implicated in the pathogenesis of multiple autoimmune diseases. (nature.com)
In vivo , GBM cells co-injected with human CSF generated larger and more proliferative tumors compared to controls. (frontiersin.org)
Differentiation of Th cells is tightly regulated by the networks of specific transcription factors. (nih.gov)
In addition, the expression of these factors may not be mutually exclusive, in some cases resulting in massive heterogeneity of CD4 T cells. (nih.gov)
Interestingly, ILCs also express many key transcription factors that are found in Th cells, suggesting that a given transcription factor may regulate one particular type of immune response in different immune cells. (nih.gov)
A complete understanding of how transcription factor complexes are regulated and how they precisely control heterogeneity, plasticity, and stability of Th cells and ILCs has great implication in designing strategies to treat a broad range of immune-related diseases, including chronic bacterial and viral infections such as HIV, autoimmune diseases, allergic diseases, and cancers. (nih.gov)
Background: This project began in 1982 with the objective of understanding how growth factors cause quiescent mammalian cells to enter the cell division cycle. (nih.gov)
When cultured fibroblastic cell lines are grown to confluence and maintained in a quiescent or non-proliferating state (Go) following the last cell division, the addition of serum or suitable growth factors cause the cells synchronously to enter G1 followed by S phase, G2, mitosis, and cell division. (nih.gov)
Our central hypothesis is that NK cells control microglia in the inflamed CNS, and that NK cell/microglia interactions can inhibit myelin-reactive Th-17 cells and protect against CNS autoimmunity. (grantome.com)
Importantly, diindolylmethane treatment potentiated the effects of cisplatin in SKOV-3 cells by targeting STAT3. (biomedcentral.com)
The STATs are a novel class of transcription factors that are positively associated with the growth and survival of cells [ 6 ]. (biomedcentral.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
In both human and experimental models of CL, control of infection is mediated by T lymphocytes and is critically dependent upon the early induction of an IL-12-driven Th1-type immune response and the production of IFN- by CD4+ T cells [ 5 , 9 ]. (hindawi.com)
Correspondingly, ChIP-Seq analysis of Irf4_/_ T cells showed greatly diminished STAT3 binding after IL-21 treatment, and Irf4_/_ mice showed impaired IL- 21-induced Tfh cell differentiation in vivo. (gsea-msigdb.org)
Terminal differentiation from monocytes (MOs) to dendritic cells (DCs), macrophages (MACs) and other related cell types, like osteoclasts (OCs), represent ideal biological processes to investigate the mechanisms by which extracellular stimulation is translated in nuclear epigenetic control. (biomedcentral.com)
MO conversion into inflammatory DCs or MACs can be recapitulated in vitro, by exposing cells to granulocyte macrophage colony-stimulating factor (GM-CSF)/interleukin 4 (IL-4) or GM-CSF only, respectively [ 12 ]. (biomedcentral.com)
In mammalian biology, ER is a phenotypically and functionally diverse platform for nutrient sensing, which is critical for cell type-specific metabolic control by hepatocytes, adipocytes, muscle cells, and neurons. (molecularmetabolism.com)

Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. (medlineplus.gov)
The STAT3 protein is active in tissues throughout the body. (medlineplus.gov)
Most of the mutations involved in this condition change single amino acids in the STAT3 protein. (medlineplus.gov)
Most of these mutations have a dominant-negative effect, which means that the altered protein produced from one copy of the STAT3 gene interferes with the function of the normal protein produced from the other copy of the gene. (medlineplus.gov)
The role of STAT3 protein in the formation and maintenance of bone tissue may help explain why STAT3 gene mutations lead to the skeletal and dental abnormalities characteristic of this condition, but it is unclear what causes blood vessel abnormalities in AD-HIES. (medlineplus.gov)
5. Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue. (nih.gov)
Additionally put-miR-34, and put-miR-35 showed a high fold enrichment in argonaute-immunoprecipitation compared to the controls, indicating their ability to form a complex with argonaute protein and RNA induced silencing complex (RISC), a typical mode of action found with miRNAs. (cdc.gov)
Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. (drugbank.com)
Our validation studies demonstrated that quercetin markedly curbed the mRNA expression of the toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein (MyD88) and the nuclear factor-κB (NF-κB) in LPS-treated BREC. (bvsalud.org)
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
We discuss the implications of ER stress in metabolic disorders by reviewing evidence implicating ER phenotypes and organelle communication, protein quality control, calcium homeostasis, lipid and carbohydrate metabolism, and inflammation as key mechanisms in the development of ER stress and metabolic dysfunction. (molecularmetabolism.com)

Anti-phospho-STAT3(Tyr705) anti-phospho-STAT3(Ser727) anti-phospho-JAK1(Tyr1022/1023) anti-JAK1 anti-phospho-JAK2(Tyr1007/1008) anti-JAK2 and anti-phospho-Src(Tyr416) antibodies were purchased from Cell Signaling Technology (Beverly MA). (biospraysehatalami.com)

These findings have biologic significance not only for the mechanism of rapid disease control in PV, but also for the physiologic regulation of DSG3 expression in the epidermis and its dysregulation in various disease states. (jci.org)
MicroRNAs are essential regulators of gene expression in humans and can control pathogenesis and host-virus interactions. (cdc.gov)
The Smad complexes interact with transcription factors, co-activators, and co-repressors where they participate in the regulation of target gene expression [reviewed in 5 ]. (springer.com)
RNA sequencing was also conducted to quantify unbiased gene expression in 95 human kidney samples, including controls and diabetic kidney disease. (asn-online.org)
To identify and study Th and ILC subsets at a finer level, multi-color "reporter" mice reflecting the expression of key transcription factors, such as T-bet, GATA3, RORγt and Foxp3, have been generated. (nih.gov)
After treating BREC with different doses of LPS (1, 5, and 10 µg/mL) for 6 h or 24 h, the mRNA expression of inflammatory factors was detected. (bvsalud.org)
From the beginning our focus was on the presumed changes in gene expression underlying the growth factor response. (nih.gov)
Moreover, STAT3 is active as an oncogene and its high expression is reported around 70 percent of solid and bloody tumors. (sciarena.com)
It is likely to increase expression in breast cancers, and this increase in the expression of STAT3 gene may be helpful in early diagnosis of breast cancer. (sciarena.com)
First, HRRT1 gene was selected as a control gene, and then the condition of STAT3 gene expression was studied in 30 samples of malignant tissue and 10 samples of normal tissues using the Real Time PCR technique. (sciarena.com)
Increased expression of STAT3 gene was seen in 26 out of 30 samples using the Real Time PCR technique. (sciarena.com)
In this study, STAT3 gene expression has a considerable expression in the malignant tissue of women with breast cancer compared with the expression of the same gene in normal breast tissue, and it can be considered as a prognosis and biomarker. (sciarena.com)
We identified an IL-21 response element downstream of Prdm1 that binds the transcription factors STAT3 and IRF4, which are required for optimal Prdm1 expression. (gsea-msigdb.org)
To identify and study Th and ILC subsets at a finer level, multi-color "reporter" mice reflecting the expression of key transcription factors, such as T-bet, GATA3, RORγ t and Foxp3, are being prepared through cross-breeding after generation of single reporter mouse strains using BAC transgenic or knock-in strategies. (nih.gov)

We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways. (cdc.gov)
STAT3 is a receptor tyrosine kinase that is activated either by upstream receptor kinases such as Janus activated kinases (JAKs) or cytokines such as interleukin (IL)-6 [ 7 ]. (biomedcentral.com)
In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive dendritic cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. (biomedcentral.com)

Our earlier studies have shown that replication and survival of influenza virus is modulated by certain transcription factors, such as, NF-ĸB. (cdc.gov)
The Activating transcription factor 3 increases the cell survival, growth and immunity tolerance in body. (sciarena.com)

STAT proteins are called transcription factors on the basis of this action. (medlineplus.gov)
These activated STAT molecules form heterodimers that translocate to the nucleus and associate with an additional factor, IFN regulatory factor-9 (IRF-9), forming the complex termed IFN-stimulated gene factor-3 (ISGF3). (jci.org)

When IL-6 binds to its receptors, it activates STAT3 by phosphorylating it at Tyr-705. (biomedcentral.com)

The functional characteristics, biological pathways and transcription factor sites were analyzed. (nih.gov)

1. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. (nih.gov)
16. Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli. (nih.gov)

4. Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3. (nih.gov)
Therefore in our study we examined whether RES can exert its anticancer effects by negative rules of STAT3/5 signaling cascade. (biospraysehatalami.com)

In addition, diindolylmethane treatment inhibited nuclear translocation, DNA binding, and transcriptional activity of STAT3. (biomedcentral.com)
Also RES abrogated DNA binding capacity and nuclear translocation of these two transcription factors. (biospraysehatalami.com)
Although this rearrangement involves 2 well-characterized transcription factors, TEL and AML1, the molecular pathways affected by the result of the translocation remain largely unknown. (ashpublications.org)

Our data suggests that put-miR-34 could be a good target for the antiviral therapy as the hyperactivation or inactivation of STAT3 results in viral disease, as tightly regulated STAT3 function is central to health. (cdc.gov)

Similar to its control over the physiological processes in normal tissue, the microenvironment exerts regulatory control during tumour development and progression [ 3 , 4 ]. (biomedcentral.com)

TGF-β is part of a large family of polypeptide growth factors that includes activins, inhibins, and bone morphogenetic proteins (BMPs). (springer.com)
Immediate early proteins included various transcription factors, secreted proteins, membrane proteins, cytoskeletal-matrix proteins, and diverse enzymes (7). (nih.gov)

However, information on transcription factors and cellular and molecular mechanisms controlling the production of immune and inflammatory mediators induced by organic dust is limited. (cdc.gov)
At the Molecular and Cellular Immunoregulation Section (MCIS), the functions of known key transcription factors, including GATA3 and T-bet, and novel, potentially critical transcription factors during Th and ILC differentiation/development are being investigated with various genetically modified mice including conditional knockout strains. (nih.gov)
Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress. (affbiotech.cn)
Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. (biomedcentral.com)

In general, STAT3 turned to the active form in a wide range of tumors in the cell, and especially, the structural activity of STAT3 which is reported in different types of tumors including multiple myeloma, lymphoma and leukemia, prostate cancer, ovary cancer, melanoma, kidney cancer, and colorectal cancer. (sciarena.com)

Required with NCOA2 to control energy balance between white and brown adipose tissues. (nih.gov)

However, emerging data suggest that there are many more critical transcription factors in the regulatory network that are critical for T cell fate determination and functions. (nih.gov)

STAT3 is a transcription factor crucially involved both in epithelial proliferation during regeneration of many different tissues and in maintenance of pregnancy especially during embryo implantation (4-6). (biobender.com)

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. (nature.com)
Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs. (uniroma5.it)
However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. (biomedcentral.com)

Amongst the transcription factors, we identified ELF3 as a key transcriptional factor strongly associated with renal fibrosis in all mouse models and patient samples. (asn-online.org)

More than 100 germline mutations in the STAT3 gene have been identified in people with autosomal dominant hyper-IgE syndrome (AD-HIES), a disorder of the immune system that leads to recurrent skin and lung infections as well as abnormalities of the bones, teeth, and blood vessels. (medlineplus.gov)
The ability of the host to control infection and resolve disease requires the generation of cell-mediated immune responses capable of activating host macrophages to eliminate intracellular parasites. (hindawi.com)
The clear Th1/Th2 dichotomy observed in murine cutaneous leishmaniasis has not been demonstrated in humans, as the factors governing the nature of the host immune response and disease outcome during leishmaniasis are far more complex in men than in mice [ 14 ]. (hindawi.com)

Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo, and furthermore, revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. (gsea-msigdb.org)

The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the underlying mechanisms remain unclear. (researcher-app.com)
The molecular mechanisms underlying the diverse effect of Stat3 signaling remain poorly understood. (ijbs.com)

However, the mechanism by which glucocorticoids upregulate DSG3 transcription remains poorly defined. (jci.org)

epidermal growth factor receptor. (gsea-msigdb.org)
Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma. (cancerindex.org)
In addition, it has been found that the epidermal growth factor receptor gene (EGFR) is frequently over-expressed and amplified in primary GBs. (cancerindex.org)

To identify the target(s) of these putative miRNAs, we screened 84 transcription factors that have a role in viral pathogenesis. (cdc.gov)
NGS and PCR array data submitted to the Gene Ontology also predicted the role of transcription factors modulated by put-miR-34. (cdc.gov)
Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. (nih.gov)
In the current study we elucidated the role of STAT3 in uterine epithelial regeneration in the DMT mouse model utilizing conditional knockout mice. (biobender.com)

Glucocorticoids improve disease within days by increasing DSG3 gene transcription, although the mechanism for this observation remains unknown. (jci.org)
Glucocorticoids are first-line therapy in PV because, in addition to their immunosuppressive function, they upregulate DSG3 gene transcription ( 4 ), which rapidly counteracts the PV IgG-induced loss of DSG3 from desmosomes. (jci.org)

17. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. (nih.gov)
STAT3 activity is necessary for TEL-AML1 leukemia maintenance. (ashpublications.org)
Our results suggest that extended AP-1 binding sites, together with adjacent binding sites for additional TFs, encode part of the information that governs transcription factor binding sites activity in the genome. (cusabio.com)

The theory of the developmental origins of adult disease proposes that the environment encountered during fetal life and infancy permanently changes the body's structure, function, and metabolism and shapes the long-term control of tissue physiology and homeostasis ( Barker 2007 ). (nih.gov)

7. Stat3 and the inflammation/acute phase response in involution and breast cancer. (nih.gov)

Anatomy16

Organisms8

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Phosphorylation15

Genes19

STAT55

Inhibition8

Group 3 Innate Lymphoid Cells1

Activator of transcription7

Activation12

Apoptosis7

Transducers and Activators of Transcription1

Pathway2

Tumor8

Inhibitor5

Induces1

Cytokine1

Angiogenesis1

Regulates2

Cells23

Protein11

Tyr7051

Expression14

Interleukin3

Survival2

STAT2

Binds1

Pathways and transcription1

Epithelium2

Cascade2

Translocation3

Tightly1

Progression1

Proteins2

Cellular4

Tumors1

Adipose1

Critical transcription1

Proliferation1

Differentiation3

Transcriptional factor1

Immune3

Regions1

Mechanisms2

Poorly1

Epidermal growth3

Role4

Gene transcription2

Activity3

Tissue1

Inflammation1