Control of gene genes euchromatic. Medical search. Frequent questions

Eight cellular heterochromatic DNA sat ellites of different chromosomes served as controls for hy poacetylation. (sodiumchannel-signal.com)
TAS appear cytologically condensed (that is, heterochromatic) [ 5 ] and confer silencing on nearby genes, apparently because of spreading of silent heterochromatin. (biomedcentral.com)
Heterochromatic position effect variegation (PEV) is the epigenetic disruption of genes expression near the new-formed eu-heterochromatic border. (refine.bio)
Euchromatic breakpoint of In(2)A4 inversion was localized at 105 bp region (chr2L:21182214-21182318) of the second exon of the Mcm10 gene, the heterochromatic breakpoint is located at the block of dodecasatellite in 2L pericentromeric heterochromatin. (refine.bio)
2009 Alosetron Hydrochloride During differentiation ESC chromatin shifts from a transcriptionally permission euchromatic to a more heterochromatic state (Azuara et?al. (cancerrealitycheck.com)
It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. (inrae.fr)
Two NPCs neighboring (1) heterochromatic and Polycomb -repressed domains or (2) actively transcribed genes are highlighted within the yellow box. (biomedcentral.com)
These analyses are fundamental in the design of control specimens present C-heterochromatic blocks in most of campaigns because their results will help determine the their 22 chromosomes, whereas non-Andean specimens have only 4-7 autosomes with C-banding. (cdc.gov)

Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. (biomedcentral.com)
In order to check the effects of heterochromatin on neighbor euchromatic genes and estimate the distance of inactivation spreading, we performed RNA-seq analysis of genes expression in larvae and adults females of genotypes A12/A12 (control) and In(2)A4/In(2)A4. (refine.bio)
Cis-influence of heterochromatin in the inversion causes not only repression, but also activation of genes, and the effects of heterochromatin are different at different developmental stages. (refine.bio)
Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. (yeastgenome.org)
the pericentric heterochromatin area or a euchromatic area of chromosome. (bioxorio.com)
In htz1Delta cells, Sir2 and Sir3 spread into flanking euchromatic regions, producing changes in histone H4 acetylation and H3 4-methylation indicative of ectopic heterochromatin formation. (sdbonline.org)
Htz1 is enriched in these euchromatic regions and acts synergistically with a boundary element to prevent the spread of heterochromatin. (sdbonline.org)
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
Here we show, using a LacI-tethering system, that JIL-1 mediated ectopic histone H3S10 phosphorylation is sufficient to induce a change in higher-order chromatin structure from a condensed heterochromatin-like state to a more open euchromatic state. (silverchair.com)
In mammalian cells, histone H3 Lys 9 (H3K9) methylation and histone hypoacetylation are usually associated with methylated DNA, heterochromatin, and gene silencing. (aacrjournals.org)

The EHMT1 gene provides instructions for making an enzyme called euchromatic histone methyltransferase 1. (medlineplus.gov)
Some of these mutations change single protein building blocks (amino acids) in euchromatic histone methyltransferase 1. (medlineplus.gov)
Either a deletion or a mutation affecting the EHMT1 gene results in a lack of functional euchromatic histone methyltransferase 1 enzyme. (medlineplus.gov)

Kleefstra syndrome is caused by the loss of the EHMT1 gene or by mutations that disable its function. (medlineplus.gov)
instead, these individuals have mutations in the EHMT1 gene. (medlineplus.gov)
Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence. (inrae.fr)
Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence. (inrae.fr)
we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation. (collaslab.org)
We hypothesize that there might be at least three types of autism susceptibility genes/mutations that can be (i) specific to an individual patient or family, (ii) in a genetically isolated sub-population and (iii) a common factor shared amongst different populations. (neurotransmitter.net)
The genes/mutations could act alone or interact with other genetic and/or epigenetic or environmental factors, causing autism or related disorders. (neurotransmitter.net)

This was reversed during the lytic phase, Suggesting that this change of chromatin structure is used to control the[clarification needed] and maintain the lytic and latent phases. (wikipedia.org)
This means that these genes are controlled through a mechanism affecting the chromatin structure that allows them to be expressed in the latent phase. (wikipedia.org)
Confocal microscopy reveals that Set1A and Set1B each localize to a largely non-overlapping set of euchromatic nuclear speckles, suggesting that Set1A and Set1B each bind to a unique set of target genes and thus make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. (elsevierpure.com)
2006 Meshorer and Misteli 2006 Niwa 2007 These changes in chromatin packaging are accompanied by alterations in histone post-translational modifications (PTMs) crucial for modulation of chromatin structure and gene expression (Bernstein et?al. (cancerrealitycheck.com)
Higher order chromatin structure is important for epigenetic regulation and control of gene activation and silencing. (silverchair.com)
Histones are subject to numerous post-translational modifications that correlate with the state of higher-order chromatin structure and gene expression. (silverchair.com)

compared transcriptional profiles using DNA microarrays to survey differentially expressed genes between parthenotes (2 maternal genomes) and control fetuses (1 maternal, 1 paternal genome). (wikipedia.org)
The outcomes for the genome wide histone acetylation prole have been in accordance together with the inactive state of most viral genes in latency, because the viral genome was inside a primarily underacetylated state. (sodiumchannel-signal.com)
Thus, about 100 human "twin genes", were found in the Arabidopsis genome, including, those responsible for such severe diseases as cystic, ﬁbrosis and breast cancer [50]. (centrocardiobogota.com)
The term functional genomics can be referred to as the "development and application of global (genome-wide or system-wide) experimental approaches to assess gene function by making use of the information and reagents provided by structural genomics" (Hieter and Boguski, 1997). (centrocardiobogota.com)
For comparison, in the Droso-, phila genome the number of such "gaps" reaches, The Arabidopsis genes are compact, contain se, eral exons (with an average size of 250 bp) separated, by short introns. (centrocardiobogota.com)
We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. (inrae.fr)
The genome of P. falciparum contains hundreds of genes that show CVGE, such that individual parasites within an isogenic population express these genes at very different levels, often fully active or completely silenced [15] . (plos.org)
We discuss associated epigenetic and genome conformation changes elicited by the lamin A R482W mutation at the gene level. (frontiersin.org)

The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
Sex steroid hormones exert a wide variety of biological actions through the transcriptional control of a particular set of target genes. (bioxorio.com)

By adding a molecule called a methyl group to histones, histone methyltransferases can turn off (suppress) the activity of certain genes, which is essential for normal development and function. (medlineplus.gov)
A lack of this enzyme impairs proper control of the activity of certain genes in many of the body's organs and tissues, resulting in the abnormalities of development and function characteristic of Kleefstra syndrome. (medlineplus.gov)
Appropriate imprinting of certain genes is important for normal development. (wikipedia.org)
Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)

METHOD: Mutation screening of positional candidate genes was performed in two stages. (neurotransmitter.net)
The first stage involved identifying, in unrelated subjects showing linkage to 2q24-q33, genetic variants in exons and flanking sequence within candidate genes and comparing the frequency of the variants between autistic and unrelated nonautistic subjects. (neurotransmitter.net)
Sixty-eight candidate genes involved in drought tolerance were identified in the set of ILs. (frontiersin.org)

The deletion occurs near the end of the long (q) arm of the chromosome at a location designated q34.3, a region containing the EHMT1 gene. (medlineplus.gov)
The loss of the EHMT1 gene from one copy of chromosome 9 in each cell is believed to be responsible for the characteristic features of Kleefstra syndrome in people with the 9q34.3 deletion. (medlineplus.gov)
The inheritance of Kleefstra syndrome is considered to be autosomal dominant because a deletion in one copy of chromosome 9 in each cell or a mutation in one copy of the EHMT1 gene is sufficient to cause the condition. (medlineplus.gov)
With the human DNA probe, signals were detected in the major sites of the ribosomal genes on chromosomes 5I (7H) and 6I (6H) only when the chromosome preparations were obtained using an optimized technique with obligatory pepsin treatment followed by hybridization. (centrocardiobogota.com)
gene is mapped on the wheat chromosome 5B, but, neither obtaining a physical marker nor microdissec-, tion of this chromosomal region gave practical results, [56]. (centrocardiobogota.com)
Finally, higher-order 3D chromosome folding is also thought to modulate gene expression and might contribute to inheritance 15 . (nature.com)
Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. (sdbonline.org)
Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes, and many coding sequences overlap. (inrae.fr)
We have determined 99.3% of the euchromatic sequence of the X chromosome. (inrae.fr)
Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. (inrae.fr)
We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. (inrae.fr)

In females, all chromosomes remain euchromatic and functional. (wikipedia.org)
However, in 2004, experimental manipulation by Japanese researchers of a paternal methylation imprint controlling the Igf2 gene led to the birth of a mouse (named Kaguya) with two maternal sets of chromosomes, though it is not a true parthenogenone since cells from two different female mice were used. (wikipedia.org)

Microarray analysis revealed that HTZ1-activated genes cluster near telomeres. (sdbonline.org)

The mechanism that controls this is very complex because expression of viral proteins during latency is decreased a great deal, meaning that the virus must have transcription of its genes repressed. (wikipedia.org)
Transcription reprogramming during cell differentiation involves targeting enhancers to genes responsible for establishment of cell fates. (bvsalud.org)
In both cases, formation of new CTCF loops leads to strengthening of enhancer promoter interactions and increased transcription of genes adjacent to loop anchors. (bvsalud.org)
This spot also contains a gene with powerful homology for the family of dihydrofolate re ductases, even so, its transcription seems unaffected by histone acetylation, considering that expression of this gene can't be detected. (sodiumchannel-signal.com)
The pluripotency of the initial cell and the establishment of cell types depend to a large extent on the coordinated deployment of hundreds of transcription factors that bind to specific DNA sequences to activate or repress the transcription of cell lineage genes 1 . (nature.com)
2000 2003 BRD4 has a direct role in transcription as it associates with positive transcription elongation factor b (P-TEFb) to enhance RNA polymerase II Alosetron Hydrochloride (RNAP II) and control productive mRNA synthesis (Yang et?al. (cancerrealitycheck.com)
2008 At many developmental genes RNAP II stalls or pauses after transcribing a nascent transcript about 20-65 nucleotides in length (Adelman and Lis 2012 Nearly 30% of the genes in human ESCs commence transcription initiation but do not undergo transcriptional elongation (Guenther et?al. (cancerrealitycheck.com)
This transcriptional control is usually mediated by nuclear steroid hormone receptors that act as hormone-dependent transcription factors. (bioxorio.com)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
Group A act on histone in chromatin and involved with control of transcription. (microbiologynotes.org)
methylation of lysine at 9th position of H3 is associated with gene silincing/ chromatin condensation whereas methylation of lysine at 4th position of H3 is associated with transcription activation. (microbiologynotes.org)

During the latent phase, researchers have found more methylated chromatin in the lytic genes and less acetylated chromatin, whereas in the LAT region there is less methylation and more acetylation found during latency. (wikipedia.org)
H4 includes acetylation and methylation , which can alter expression of genes located on DNA related to its parent histone octamers. (microbiologynotes.org)

In the lytic phase, the viral genes are being actively transcribed and many times ultimately lead to cell death. (wikipedia.org)

Within this PEV program, the placed reporter transgene encodes the green fluorescence proteins (GFP) controlled with a basal promoter associated with eight upstream copies of consensus sequences of androgen receptor (AR) response components (ARE) as well as the white proteins powered by its endogenous promoter. (bioxorio.com)
We found 1,098 genes in the sequence, of which 99 encode proteins expressed in testis and in various tumour types. (inrae.fr)
This positive link echoes the observation that endogenous CAB ( CHLOROPHYLL A/B-BINDING PROTEINS ) genes are repositioned from the interior to the periphery of Arabidopsis cotyledon nuclei when induced by light signaling [ 8 ]. (biomedcentral.com)

Although imprinting accounts for a small proportion of mammalian genes they play an important role in embryogenesis particularly in the formation of visceral structures and the nervous system. (wikipedia.org)
Such a CBP corepressor function for AR was observed in the transcriptionally silent promoter of an AR target gene in cultured mammalian cells. (bioxorio.com)
G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regions and is essential for mouse embryogenesis. (novusbio.com)

We postulate that histone readers together with OCT4 play a role in the transcriptional control of the XCI lncRNAs as well as pluripotent genes. (cancerrealitycheck.com)

The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. (sdbonline.org)

We found that knockdown of Bonus in early oogenesis results in severe defects in ovarian development and in ectopic expression of genes that are normally repressed in the germline, demonstrating its essential function in the ovary. (elifesciences.org)
Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)
Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)
Parthenogenetic/gynogenetic embryos have twice the normal expression level of maternally derived genes, and lack expression of paternally expressed genes, while the reverse is true for androgenetic embryos. (wikipedia.org)
These results suggest an important role for CTCF and cohesin in controlling gene expression during cell differentiation. (bvsalud.org)
Cellular identity is now accepted to be the result of the expression of specific combinations of genes (Fig. 1 ). (nature.com)
Our studies show that Brd4 interacts with the pluripotent factor OCT4 and is important for maintaining stem cell fate and the expression of the lncRNAs controlling XCI. (cancerrealitycheck.com)
Gene expression microarray profile for human embryonic kidney cells (HEK293T, CRL-11268) under untreated conditions. (refine.bio)
Gene expression analysis of HP1B mutants in D. melanogaster. (refine.bio)
We profile gene expression changes in two mutant strains lacking the D. melanogaster HP1 homolog HP1B at the third instar larval stage. (refine.bio)
Gene expression profiling is a promising diagnostic and prognostic tool. (refine.bio)
Real-time quantitative PCR (RT-qPCR) is a crucial and widely used method for gene expression analysis. (biomedcentral.com)
The expression stability of the ten genes was analyzed using four methods (geNorm, NormFinder, BestKeeper, and ∆Ct). (biomedcentral.com)
Our study is the first to select reference genes for RT-qPCR from transcriptome data in Echiura and provides important information for future gene expression studies in U. unicinctus . (biomedcentral.com)
Reference genes are used for the normalization of gene expression because of the stability of expression levels among different tissues, different developmental stages, or under various treatments [ 5 ]. (biomedcentral.com)
Overall, the influence of peripheral proximity on gene expression remains poorly explored in plants [ 4 ], and is also the subject of intense investigations in metazoan cells, in which opposite trends have seemingly been observed in studies using differing approaches. (biomedcentral.com)
In the early 21st century, DNA microarrays for characterizing gene expression patterns have been used to more distinctly classify diseases, including cancer subtypes [ 6 , 7 ]. (genominfo.org)
The 3-dimensional layout of the genom e, including interactions of chromatin with the nuclear lamina at the nuclear periphery, plays an important role in the establishment of gene expression programs that govern lineage-specific differentiation and cell identity. (collaslab.org)
Clonally variant gene expression (CVGE) lies at the base of a bet-hedging adaptive strategy consisting of the stochastic generation of phenotypic diversity followed by natural selection upon environmental changes (for a recent discussion on bet-hedging, see [14] ). (plos.org)
H2A package DNA molecules into chromatin, the packaging process will effect gene expression. (microbiologynotes.org)
H2A has been found to regulate gene expression. (microbiologynotes.org)
This nucleoplasmic lamin A environment tends to be euchromatic, suggesting distinct roles of lamin A in the regulation of gene expression in peripheral and more central regions of the nucleus. (frontiersin.org)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)
Central to the epigenetic control of gene expression is the histone code through which input signals can be translated into a heritable pattern of gene expression defining cellular output states ( Fig. 1 ). (aacrjournals.org)
Histone hyperacetylation and H3K4 methylation are associated with unmethylated DNA, euchromatin, and gene expression ( Fig. 2 ). (aacrjournals.org)

Euchro matic, and thereby known, hyperacetylated controls were rep resented by the promoter and five coding areas of 27 cellular housekeeping genes. (sodiumchannel-signal.com)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the candidate reference genes were significantly enriched in cellular metabolic process, protein metabolic process and ribosome in early development and normal adult tissues as well as in cellular localization and endocytosis in the hindgut under sulfide stress. (biomedcentral.com)
Hence, the debate about the use of the term epigenetics is a terminology issue that affects our understanding of how cellular processes are ultimately controlled. (plos.org)
Together with mapping of disease-related genes, this transcriptomic mapping of the developing human spinal cord opens new avenues for interrogating the cellular basis of motor control in humans and guides human stem cell-based models of disease. (uni-saarland.de)

Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness, and also in regions where no function is evident. (inrae.fr)
Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of duck adipogenesis. (biomedcentral.com)

The ﬁrst section introduces sequence-basedanalyses,includinggeneﬁnd-ing, gene family and phylogenetic analy-ses, and comparative genomics approaches. (centrocardiobogota.com)

Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the mother or the father. (wikipedia.org)

2007 This suggests that transcriptional pausing is an additional checkpoint control during development (Levine 2011 The release from transcriptional pausing is associated with P-TEFb recruitment the eviction of pause factors the phosphorylation at serine 2 of the carboxyl-terminal domain Alosetron Hydrochloride (CTD) in RNAP II and the production of elongated mRNAs. (cancerrealitycheck.com)
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. (yeastgenome.org)
In Drosophila phosphorylation of histone H3S10 in euchromatic chromatin regions by the JIL-1 tandem kinase has been implicated in counteracting heterochromatization and gene silencing. (silverchair.com)

This phenomenon, called 'telomeric silencing', or 'telomere position effect' (TPE), was initially discovered and studied using transgenes but it also appears to regulate endogenous subtelomeric genes [ 6 - 8 ]. (biomedcentral.com)

Functional control of Eco1 through the MCM complex in sister chromatid cohesion. (yeastgenome.org)

The candidate reference genes STX12 , EHMT1 , and LYAG were the most stable genes in early development, normal adult tissues, and hindgut under sulfide stress, respectively. (biomedcentral.com)

Based on these findings, we propose a model where JIL-1 kinase activity functions to maintain euchromatic regions by antagonizing Su(var)3-9-mediated heterochromatization. (silverchair.com)

This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)

As of 2019, 260 imprinted genes have been reported in mice and 228 in humans. (wikipedia.org)

This long non-coding RNA accumulates in the latent phase and has been found to suppress the lytic genes. (wikipedia.org)

Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint. (yeastgenome.org)

2002 suggesting a role for this gene in the cell differentiation-linked processes of XCI and pluripotency. (cancerrealitycheck.com)

H3 is an important protein in the emerging feild of epigenetics, where its sequence varients and variables modification states are thought to play a role in the dynamic and long term regulation of gene. (microbiologynotes.org)

No naturally occurring cases of parthenogenesis exist in mammals because of imprinted genes. (wikipedia.org)

Compared to the yw control strain, several hundred genes are deregulated, with metabolic genes being over-represented among the deregulated gene set. (refine.bio)

These findings expand on the current understanding of the pathogenesis of NDV and provide new insights to control and prevent NDV contamination. (immune-source.com)
Negative association findings and research involving the serotonin transporter gene, FMR1, RELN, WNT2, HOXA1, and HOXB1 genes may be found elsewhere on this site . (neurotransmitter.net)

HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism. (refine.bio)

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7. (yeastgenome.org)

These hormone receptors are members of the nuclear receptor (NR) gene superfamily (36, Masitinib cell signaling 48). (bioxorio.com)
Each of the nuclear occasions concerning NR-mediated gene legislation is apparently facilitated by many classes of coregulator complexes (19, 36, 48). (bioxorio.com)

Fine-scale recombination occurs in hotspots of varying intensity along the sequence, and is enriched near genes. (inrae.fr)

An intriguing study surveying the transcriptome of murine brain tissues revealed over 1300 imprinted gene loci (approximately 10-fold more than previously reported) by RNA-sequencing from F1 hybrids resulting from reciprocal crosses. (wikipedia.org)

There are many factors and mechanisms that control this process and epigenetics is one way this is accomplished. (wikipedia.org)

We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. (inrae.fr)
Importantly, the changes observed post-recovery are consistent with those modeled in vivo, and associate with alterations in transcripts encoding multiple homeobox genes directing neurogenesis. (biomedcentral.com)

In genetic screening for AR AF-1 coregulators, CREB binding protein (dCBP) was found to corepress AR transactivation at the pericentric region whereas it led to coactivation in the Masitinib cell signaling euchromatic area. (bioxorio.com)
Our study, together with and sylvatic populations), as well as their domestication previous historical and genetic data, suggests that T. infes- and spreading capabilities, are essential tools for effective tans was originally a sylvatic species, with large quantities vector control (2). (cdc.gov)
free janes of genetic ν and quantile factors Reaching binding genes reveals stochastic for N-butanol lines. (scoutconnection.com)

Heterochromatic8

Heterochromatin10

Histone methyltransferase3

Mutations7

Chromatin structure6

Genome8

Target genes2

Certain genes4

Candidate genes3

Chromosome12

Chromosomes2

Near telomeres1

Transcription11

Acetylation2

Actively transcribed1

Proteins3

Mammalian3

Transcriptional control1

Sir21

Expression26

Cellular4

Specific genes2

Genomics1

Genomic1

Phosphorylation3

Telomeric1

Functional1

EHMT11

Kinase1

Promoter1

20191

Suppress1

Yeast1

Cell differentiation1

Regulation1

Mammals1

Metabolic1

Findings2

Drosophila1

Replication1

Nuclear2

Occurs1

Tissues1

Mechanisms1

Transcripts2

Genetic3