At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. (lu.se)
The role of hypoxia-inducible factors-1 and -2 in the regulation of CXCL12 expression was examined using over-expression and short hairpin RNA knockdown constructs, electrophoretic mobility shift assays and chromatin immunoprecipitation. (haematologica.org)
Hypoxia -inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress and play essential roles in maintaining lunghomeostasis . (bvsalud.org)
INOS6
Observations were made with and without inhibition of constitutive (endothelial constitutive NOS (ecNOS) and COX‐1) and inducible isoforms (iNOS and COX‐2) of NOS and COX. (ersjournals.com)
However, these previous studies did not determine the relative contributions of COX (COX‐1 and COX‐2) and nitric oxide synthase (NOS) isoforms (endothelial constitutive (ecNOS) and inducible NOS (iNOS)) to the abnormal acinar microvessel response to HA 4 , 7 . (ersjournals.com)
The increase in arginine levels results in a significant upregulation of inducible nitric oxide synthase (iNOS) and arginase 1 (ARG1), giving rise to an M1/M2 hybrid macrophage. (aacrjournals.org)
The immune and inflammatory response involves the inducible form of nitric-oxide synthase (iNOS), and subsequent nitric oxide (NO) production. (okstate.edu)
The loss of dopaminergic neurotics in the substantia nigra with Parkinson's disease may result from inflammation-induced proliferation of microglia and reactive macrophages expressing inducible nitric oxide synthase (iNOS). (herts.ac.uk)
Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) exerts inhibitory and cytotoxic effects on various cells including neuronal cells. (elsevierpure.com)
Constitutive and inducible1
The aim of the present study was to compare microvessel responses to hypercapnic and isocapnic acidosis in hyperoxia-injured lungs and to assess the role of constitutive and inducible forms of nitric oxide synthase (NOS) and cyclo-oxygenase (COX). (ersjournals.com)
Kinase2
Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. (elifesciences.org)
We report here that the abundance of serum- and glucocorticoid-inducible kinase (SGK) is increased in spinal cord tissue from animals reared in microgravity in comparison with 1G-reared controls. (northwestern.edu)
Promoter2
Promoter analyses revealed increased hypoxia-inducible factor-2 binding to the CXCL12 promoter under hypoxic conditions. (haematologica.org)
In summary, these results indicate that HBV polymerase is a general inhibitor of IFN signalling and can inhibit IFN-inducible MyD88 expression by inhibiting the activity of the MyD88 promoter through blocking the nuclear translocation of Stat1. (edu.au)
Gene3
This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between baseline BLyS mRNA/protein levels and/or type 1 IFN-inducible gene signature (IFN-1) and responses to the BLyS-targeting monoclonal antibody belimumab in SLE. (biomedcentral.com)
Thus to avoid clinical therapeutic failure in the resistance case mediated by erm gene, it is very important to detect inducible clindamycin resistance phenotypes in vitro which can be made by erythromycin-clindamycin disc approximation test (D-test) as its sensitivity was found 100% in different studies when compared with erm and msr gene detection by polymerase chain reaction [ 6 , 7 , 8 ]. (biomedcentral.com)
Previous studies have suggested that hepatitis B virus (HBV) blocks expression of the alpha interferon (IFN-alpha)-inducible myeloid differential primary response protein (MyD88) gene. (edu.au)
Clindamycin resistance2
Methicillin resistance was detected by cefoxitin disc diffusion method and inducible clindamycin resistance by erythromycin and clindamycin disc approximation test (D-test). (biomedcentral.com)
It is very difficult to detect the inducible clindamycin resistance in the routine laboratory as they appear erythromycin-resistant and clindamycin sensitive in vitro when not placed adjacent to each other. (biomedcentral.com)
Nitric Oxide1
Constitutive, but not inducible, isoforms of cyclo-oxygenase and nitric oxide synthase play an important role in abnormal microvessel responses to carbon dioxide and hydrogen ions in hyperoxia-injured lungs. (ersjournals.com)
Protein3
Design and Methods The expression of hypoxia-inducible factor protein was examined in patients' bone marrow biopsy specimens using immunohistochemistry. (haematologica.org)
Results Strong hypoxia-inducible factor-2 protein expression was detected in CD138 + multiple myeloma plasma cells in patients' biopsy specimens. (haematologica.org)
Background: Human papillomavirus can stabilize and induce hypoxia-inducible factor 1α (HIF-1α) protein, which is associated with diminished response to treatment and poor prognosis for cervical cancer. (ewha.ac.kr)
Vivo3
The contribution of CXCL12 to hypoxia-induced angiogenesis was examined in vivo using a subcutaneous murine model of neovascularization. (haematologica.org)
Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
Here we report an in vivo analysis of inducible conditional Kiss1 knockdown male mice. (elsevierpure.com)
Hepatic1
[ 1 ] Type I is found in the liver and contributes the vast majority of hepatic arginase activity, whereas type II is inducible and found in extrahepatic tissues. (medscape.com)
Isolates1
Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. (mdpi.com)
Angiogenesis2
Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
Stromal1
The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. (otago.ac.nz)
To minimize side effects, we designed a hypoxia-inducible CAR (HiCAR), which is driven by a hypoxia response element (HRE), and consists of a conventional CAR and an oxygen-dependent degradation domain (ODD) that is actively degraded under normoxia but stabilized under hypoxia. (biomedcentral.com)
A previous study showed that oxygen-sensitive multichain CAR-T cells are responsive to hypoxia [ 7 ], while a simple single-chain hypoxia-inducible CAR-T cells (HiCAR-T cells) could respond to hypoxia within solid tumors is elusive. (biomedcentral.com)
Isoforms1
An orthotopic tracheal transplantation model further evaluated the contribution of individual HIF isoforms in airway endothelial cells . (bvsalud.org)
Endothelial1
Endothelial Hypoxia-Inducible Factor-2α Is Required for the Maintenance of Airway Microvasculature. (bvsalud.org)
Factor6
Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). (biomedcentral.com)
In this study, we demonstrated that hypoxia-inducible factor-1α (HIF-1α) is suppressed in scalp tiss. (researchgate.net)
In this study, we demonstrated that hypoxia-inducible factor-1a (HIF-1a) is suppressed in scalp tissues of androgenetic alopecia patients and potentially associated with hair fol. (researchgate.net)
Hypoxia-inducible factor 1 (HIF-1) is one of the master regulators that orchestrate the cellular responses to hypoxia. (northwestern.edu)
Hypoxia-Inducible Factor-2-Altered Urothelial Carcinoma: Clinical and Genomic Features. (cdc.gov)
Expression3
He developed a novel doxycycline-inducible "reprogrammable mouse" transgenic models with drug controlled over expression of the Yamanaka reprogramming factors. (wikipedia.org)
While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors. (haematologica.org)
12 It is well established that hypoxia is an important selective force in the evolution of tumor cells, 13 and elevated expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 has been documented in several human cancers. (haematologica.org)
Rabbits1
this P-450 isozyme is recognized by antibody (anti-3a IgG) raised against the ethanol-inducible P-450 in rabbits. (elsevierpure.com)
Mechanism2
Inducible defenses, representing a form of phenotypic plasticity, are an appropriate mechanism to cope with the variable impact of a frequently changing predator spectrum. (nature.com)
These results with an inducible conditional Kiss1 knockdown in the ARC of male mice suggest that ARC kisspeptin neurons are responsible for pulsatile LH secretion in male mice, and indicate the possibility of a compensatory mechanism that restores GnRH/LH pulse generation. (elsevierpure.com)
Tissues1
Low-level synthesis of certain cycle intermediates in extrahepatic tissues also makes a small contribution to waste nitrogen disposal. (medscape.com)
Systemic1
However, the contribution of asthmatic bronchial fibroblasts in systemic dissemination of lung cancer cells remains unaddressed. (spandidos-publications.com)
Progression1
However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors. (otago.ac.nz)
Form1
Furthermore, we reveal the exoskeleton's chemical changes associated with inducible defense mechanisms in the form of more substantial mineralization, which is probably correlated with enhanced carapace stability. (nature.com)
Patients2
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
Scientific2
Hanna made scientific contributions to understanding the iPSC phenomenon in its early days. (wikipedia.org)
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. (researchgate.net)
Early1
Here, we hypothesized that various components of colonic physiology, including permeability, ion exchange and protective inducible heat shock proteins (HSP) are influenced in the short- and long-terms by early disturbances in microbial colonization. (figshare.com)
Highlight1
We, therefore, highlight the importance of calcium-biominerals for inducible morphological defenses in Daphnia . (nature.com)