• Human Leukocyte Antigen (HLA)-G and E are nonclassical human MHC class I molecules. (pasteur.fr)
  • Aim of the second part of this doctoral thesis was to investigate Dsg3-specific cellular and humoral immune responses in a novel human leukocyte antigen (HLA)-DRB1*04:02-transgenic (tg) mouse model of PV under the genetic restriction by HLA-DRB1*04:02. (uni-marburg.de)
  • It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)
  • Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. (wjgnet.com)
  • These cells have emerged as an important contributor to tumor progression. (aacrjournals.org)
  • Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
  • While genetic and environmental factors contribute to the pathogenic process of AIH [ 2 ], dysfunctional immune responses are also crucial for the development and progression of AIH [ 3 ]. (hindawi.com)
  • Escape from immune surveillance is thought to contribute to the development and progression of GB. (frontiersin.org)
  • The acidic pH and lactate induce a regulatory phenotype in inflammatory associated cells and are associated with tumor progression. (fapesp.br)
  • It is involved in several processes such as hypoxia, tumor progression, and chemoresistance. (bvsalud.org)
  • Finally, GSEA analysis highlighted the association of A2AR with biological mechanisms involved in tumor escape and progression. (bvsalud.org)
  • Mumm and other folks 2011).Cytokines as Prognostic Things in Breast CancerIn addition to their effects on tumor progression, the levels of a number of cytokines happen to be correlated with tumor stage, survival, and malignancy, rendering them prospective prognostic factors. (trpv1inhibitor.com)
  • Inhibitors of tumor necrosis factor alpha (anti-TNFα) have been used to treat irEC. (bmj.com)
  • Moreover, the Wnt pathway is activated by hepatitis C virus proteins including NS3 and NS5, which leads to alterations in micro RNA-155 expressions and increasing tumor necrosis factor-alpha (TNF-) levels. (forgetmenotinitiative.org)
  • This therapy also led to significant reductions in serum levels of tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), two inflammatory cytokines associated with SLE. (nature.com)
  • Intratumoral delivery of hIL-7/mIL-12-VV induced CRs in mice bearing B16F10 or small CT26.WT tumors, and suppressed tumor growth in mice bearing poorly immunogenic TRAMP-C2 prostate adenocarcinoma or large CT26.WT tumors. (acir.org)
  • Due to random genetic recombinations, immune cells genetically express receptors for the specific self and foreign antigens in the central lymphoid organs. (tutorialspoint.com)
  • We will determine the role of self and foreign antigens in the formation of these subsets and match corresponding subsets between mice and humans. (cas.cz)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • Doxorubicin enhances the expression of "eat-me" signals by dying tumor cells, facilitating their phagocytosis by dendritic cells (DC). (aacrjournals.org)
  • Tumor-associated plasmocytoid dendritic cells (TApDCs) have an effect on immune tolerance by means of tumor-associated regulatory T-cell expansion and differentiation of IL-10-secreting T cells. (trpv1inhibitor.com)
  • Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)
  • Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
  • This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
  • Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
  • Due to the modulatory effects of hypoxia and lactate in cells of the immune system, it is possible that these induce suppressor phenotype in inflammatory cells associated with HPV -positive tumors. (fapesp.br)
  • This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. (hopkinsmedicine.org)
  • Monoclonal antibodies targeting the immune regulatory "checkpoint" receptors programmed death receptor 1 (PD-1), its ligand, PD-L1, and cytotoxic T cell associated antigen 4 (CTLA-4) have demonstrated remarkable efficacy against advanced cancers [ 1 ]. (bmj.com)
  • Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
  • Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
  • Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
  • Central tolerance processes of negative selection and receptor editing work to eliminate many auto-reactive T cells in the thymus and auto-reactive B cells in bone marrow respectively. (tutorialspoint.com)
  • V region which is specific to antigens in developing B cells usually undergoes receptor editing. (tutorialspoint.com)
  • Intestinal antigens (IAg) (originating either from pathogenic microorganisms or from food) that enter the portal circulation, are captured by intrahepatic antigen-presenting cells (APCs), leading to T cell receptor (TCR) recognition and hence the activation of the adaptive immune system. (frontiersin.org)
  • Its broad portfolio of oncology product candidates includes individualized and off-the-shelf mRNA-based therapies, innovative chimeric antigen receptor T cells, bi-specific checkpoint immuno-modulators, targeted cancer antibodies and small molecules. (pharmaceuticaldaily.com)
  • Notably, CAR T cells targeting IL 13 receptor alpha 2 and GD2 showcased early success in glioblastoma and midline glioma, respectively, indicating a shift in the narrative for solid tumor treatments. (oncologytube.com)
  • Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. (novoprolabs.com)
  • In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
  • A proprietary composition of Andrographis paniculata (ParActin®, standardized to a particular compound, 14-Neo Andro) has been shown to promote favorable immune tolerance through its ability to activate/stimulate the PPAR gamma receptor (aka PPAR gamma agonist), which effectively turns off the master switch-NF Kappa B-responsible for exerting the overreactive inflammatory response. (naturalproductsinsider.com)
  • Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
  • In the thymus, the thymocytes which have a high affinity for self-antigens undergo apoptosis leading to their death, whereas the thymocytes with a low and moderate affinity towards the self-antigens cross the barrier and enter the periphery during negative selection hence we need peripheral tolerance as well. (tutorialspoint.com)
  • Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. (novoprolabs.com)
  • The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)
  • As modified self antigens, they are potentially immunogenic when compared to unmodified self proteins as the immune cells (T-cells) which recognise them are possibly not subject to central tolerance mechanisms. (wikipedia.org)
  • The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
  • The mechanisms by which these forms of tolerance are established are distinct but the resultant effect is similar. (tutorialspoint.com)
  • Some of the mechanisms for peripheral tolerance involve the T regulatory cells (subsets of CD4 and CD8). (tutorialspoint.com)
  • Furthermore, given the continuous exposure to antigens through the portal vein blood supply, liver-intrinsic mechanisms create an immunosuppressed environment in the liver [35]. (forgetmenotinitiative.org)
  • Immune Tolerance and Chronic Necroinflammation in HCC Tumorigenesis Hepatic cells is constantly exposed to several toxins and antigens and it has intrinsic tolerance and immune escape mechanisms to prevent auto-immune destruction of the cells. (forgetmenotinitiative.org)
  • Current studies are aimed at the further characterization of the mechanisms through which these genes act, the identification of other genes that play a role in this tumor type, and the application of this knowledge to patient management. (hopkinsmedicine.org)
  • The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. (hopkinsmedicine.org)
  • However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)
  • Current Research and Scholarly Interests My research is on the translational application of next-generation sequencing technologies to breast cancer care: (1) the value of hereditary cancer genetic panel testing in clinical practice, (2) the mechanisms by which inherited genetic variants lead to breast cancer development, and (3) the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics. (stanford.edu)
  • Her goal is to understand the mechanisms governing immunological tolerance, and to leverage this knowledge to cure currently incurable diseases. (stanford.edu)
  • There, she is working to uncover the underlying molecular mechanisms that govern the differentiation and function of antigen-inducible regulatory T cells called type 1 regulatory T (Tr1) cells, and use this knowledge to design Tr1 cell-based therapies to improve the outcomes of patients with cancer, autoimmunity, or receiving allogeneic cell or organ transplants. (stanford.edu)
  • It is critical for our survival and is the body's natural mechanisms to defend against a diverse variety of pathogens including bacteria, viruses, fungi, tumors and a number of various other harmful agents (chemicals, radiation, burns, and various wounds). (naturalproductsinsider.com)
  • In addition, given the higher degree of antigen exposure from your gastrointestinal tract through the portal vein, an immune-suppressive environment is created by immune-suppressive cytokines such as interleukin-4, 5, 8 and 10. (forgetmenotinitiative.org)
  • This immunosuppression is definitely partly achieved by inhibitory cytokines interleukin-4, 5, 8, 10 and tumor growth element- released by Kupffer cells and endothelial cells of the liver [33]. (forgetmenotinitiative.org)
  • For example, numerous studies have revealed a transient and moderate increase in the production of Th1 cytokines, including interleukin-2 (IL-2), interferon- γ (IFN- γ ), and tumor necrosis factor α (TNF- α ) in AIH patients [ 6 , 7 ]. (hindawi.com)
  • Aim of the first part of this doctoral thesis was to investigate antigen-presenting cells (APC) and APC-derived cytokines, as well as their relation to T helper (Th) cell subsets and the auto-ab response in the pathogenesis of pemphigus. (uni-marburg.de)
  • As discussed, cytokines are vital mediators of tumor development and metastasis, some of which also enable the tumor evade immune responses and benefit from them. (trpv1inhibitor.com)
  • Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
  • 1 ]. Interleukinc8 (ILc8) and tumour necroc ing PCs prepared from apheresis of single sis factor alfa (TNF-) are some of the donors or from pooled samples, is not still cytokines responsible for NHFR [ 2 ]. (who.int)
  • Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
  • Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
  • In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
  • Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel option for immunotherapy. (biomedcentral.com)
  • On-going translational and clinical research will hopefully provide us with a better understanding of tumor markers, genetic aberrations and other factors that determine the immunotherapy response in HCC. (forgetmenotinitiative.org)
  • To determine if the improved response to treatment in the absence of iNKT cells was independent from the immunotherapy employed, 4T1-tumor bearing WT and iNKT −/− mice were treated with local radiotherapy in combination with antibody-mediated CD137 co-stimulation. (biomedcentral.com)
  • 2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. (novoprolabs.com)
  • We observed robust tumor growth in mice transplanted with LMS cell lines expressing TJP1 while no tumor mass was found in mice transplanted with SK-LMS-1 Sh-TJP1 cells with silenced TJP1 expression. (molcells.org)
  • However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
  • The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)
  • Engineered TCR-modified T cells (TCR-T cells) are reprogrammed to express a TCR that can recognize specific antigens only present on tumor cells, thereby enabling a precise and potent immune response to attack a patient's tumor. (pressetext.com)
  • The sale and licensing deal with BioNTech is an important validation from a global leading biotech company of our proprietary technologies to discover and characterize highly specific TCRs and empower resulting TCR-T cells to fight solid tumors. (pressetext.com)
  • NK cells coordinate tumor immunosurveillance and the immune response against pathogens. (scielo.br)
  • In tumors treated with both viruses, the researchers identified secretion of hIL-7 and mIL-12, increased IFNγ, and increased infiltration by immune cells compared to Cont-VV or either monotherapy. (acir.org)
  • In a phase I/II trial in patients with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was well tolerated and influenced the frequency of vaccine-antigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). (biomedcentral.com)
  • This mechanism produces the less reactive auto receptors with a moderate affinity for self-antigens that would lead to disease allowing the cells to survive. (tutorialspoint.com)
  • Here the mechanism involves selecting self-recognizing cells that can protect which relies on a subset of T cells, Treg cells that inhibit immune responses against self-antigens and foreign antigens. (tutorialspoint.com)
  • T cells with moderate affinity for self-antigen generate T regulatory cells or Treg cells during negative selection with an upregulation of transcription factor FOXP3 and enter the periphery where they inhibit or down-regulate the proliferation of self-reactive T cells. (tutorialspoint.com)
  • TREG cells recognize specific self-antigens and foreign antigens through the TCR interactions. (tutorialspoint.com)
  • Our findings demonstrated that an imbalance between Tregs and Th1-Th17-Th22 cells might contribute to the pathogenic process of AIH. (hindawi.com)
  • In addition, recent studies also suggested that Th17 cells and further released cytokine IL-17 may induce accumulation of proinflammatory cells [ 8 , 9 ], which contributed to the occurrence of AIH. (hindawi.com)
  • We believe that Th22 cells may partially contribute to the pathogenesis of AIH, and their expressions are likely time-dependent. (hindawi.com)
  • Regulatory T cells (Tregs) are important regulators of immune tolerance to self-antigens [ 14 , 15 ], and their impairment has been associated with the development of autoimmune diseases [ 16 , 17 ]. (hindawi.com)
  • Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
  • Therefore the aim of this work is to investigate the role of hypoxia and lactate in modulating the phenotype of macrophages in contact with tumor cells positive for HPV. (fapesp.br)
  • On tumor infiltrating immune cells, A2AR was found to correlate positively with PD-1 and negatively with CTLA-4. (bvsalud.org)
  • On the other hand, our findings disclosed more profuse infiltration of protumoral cells such as M0 and M2 macrophages, Tregs, endothelial and exhausted CD8+ T cells within A2ARhigh tumors. (bvsalud.org)
  • Invariant natural killer T (iNKT) cells are CD1d-restricted T cells, which respond rapidly to antigen recognition and promote development of anti-tumor immunity in many tumor models. (biomedcentral.com)
  • The effects of antibody-mediated blockade of CD1d on DC number and phenotype, priming of anti-tumor T cells, and tumor response to treatment with local radiotherapy and anti-CTLA-4 antibody were evaluated. (biomedcentral.com)
  • 0.05), suggesting the selective elimination of DCs cross-presenting tumor-associated antigens by iNKT cells. (biomedcentral.com)
  • Consistently, priming of T cells to a tumor-specific CD8 T cell epitope in mice treated with radiotherapy and anti-CTLA-4 or anti-CD137 was markedly enhanced in iNKT −/− compared to WT mice. (biomedcentral.com)
  • Here we describe a novel mechanism of tumor immune escape mediated by iNKT cells that limit priming of anti-tumor T cells by controlling DC in tumors and draining lymph nodes. (biomedcentral.com)
  • We hypothesize that pathways triggered by these receptors substantially contribute to the functional diversity of T cells. (cas.cz)
  • During the presentation, Dr. Keenan explores targeting the TME through immunotherapies, focusing on tumor metabolism and immunosuppressive myeloid cells. (oncologytube.com)
  • In vitro , doxorubicin microparticles were less cytotoxic to DCs than to B lymphoma cells, did not require internalization by tumor cells, and significantly enhanced phagocytosis of tumor cells by DCs as compared with soluble doxorubicin. (aacrjournals.org)
  • Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
  • [email protected] ‡ Authors contributed equally Aim: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. (studylib.net)
  • Consequently, it was shown by others that tumor cells also expressed MHC-I and presented short tumor-associated peptides to immune cells [6]. (studylib.net)
  • IL-10 is actually a potent anti-inflammatory cytokine that CXCR6 medchemexpress inhibits gene expression, cytokine synthesis by T cells and macrophages, and their antigen presentation. (trpv1inhibitor.com)
  • As an important stress-response mechanism, autophagy plays crucial role in the tumor formation and drug resistance of cancer cells including osteosarcoma (OS). (biomedcentral.com)
  • OS cancer stem cells (CSCs) also are considered a key factor of tumorigenesis, drug resistance and tumor recurrence. (biomedcentral.com)
  • Moreover, autophagy-deficient CD271+ OS cells lost the advantage of tolerance to LH condition compared to CD271- OS cells. (biomedcentral.com)
  • Cancer stem cells (CSCs) are seen as a subpopulation of self-renewing tumor cells, which can differentiate into the daughter tumor cells, have the lower sensitivity to chemotherapy and radiotherapy, and exhibit tumor re-initiating property. (biomedcentral.com)
  • Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
  • Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)
  • Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)
  • We look forward to working closely with Medigene to develop new treatments which address solid tumors with high unmet medical need. (pressetext.com)
  • In a recent discussion on adoptive T cell therapies for solid tumors, Anusha Kalbasi, MD, provided a comprehensive analysis of various modalities, shedding light on their challenges and potential breakthroughs. (oncologytube.com)
  • Moving to CAR T cell therapy for central nervous system (CNS) tumors, Kalbasi, MD, acknowledged the historic success in hematologic cancers and emerging victories in solid tumors. (oncologytube.com)
  • This may contribute to the potential capability of phosophopeptides to serve as tumor antigens in the treatment of colorectal cancer. (wikipedia.org)
  • The major focus of the Department of Immunology is on Translational Immunology and its spectrum of basic research covers T cell biology, antibodies, antigen presentation and innate immunity. (immunology-tuebingen.de)
  • The results will provide understanding of the adaptive immunity in particular disease context and resolve longstanding questions concerning the roles of T-cell diversity in protective immunity and tolerance to healthy tissues and tumors. (cas.cz)
  • On the basis of recent advances in the understanding of antitumor immunity, we designed a three-step approach to in situ immunization to lymphoma: (i) inducing immunogenic tumor cell death with the chemotherapeutic drug doxorubicin. (aacrjournals.org)
  • This selection removes the T or B cell clones before they attain maturation if they possess receptors that recognize self-antigens and bind to them with strong affinity. (tutorialspoint.com)
  • Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
  • Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. (hopkinsmedicine.org)
  • Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. (hopkinsmedicine.org)
  • The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. (hopkinsmedicine.org)
  • Osteosarcoma (OS) is one of the most common primary malignant bone tumors and mainly affects children, adolescents, and young adults (between the ages of 10 to 25) [ 1 ]. (biomedcentral.com)
  • Tolerance can be classified into 2 types depending on where this state is originally induced in the thymus or bone marrow or in other tissues and lymph nodes. (tutorialspoint.com)
  • In immunocompetent mice bearing B16F10 melanoma, CT26.WT colon carcinoma, or LLC lung carcinoma, intratumoral administration of Cont-VV induced some antitumor efficacy in all tested tumor models, along with infiltration by various immune cell subsets. (acir.org)
  • When mice bearing LLC tumors were treated with hIL-7-VV, none showed complete responses (CRs), however, 1 out of 7 mice treated with mIL-12-VV alone showed a CR, and 4 out of 7 mice treated with both hIL-7-VV and mIL-12-VV showed CRs. (acir.org)
  • injected the virus into one side of mice bearing contralateral CT26.WT tumors. (acir.org)
  • Ultimately, injected tumors disappeared completely in 6 out of 6 treated mice, and contralateral tumors completely regressed in 3 out of 6 mice. (acir.org)
  • To this end, the researchers tested the antitumor efficacy of anti-PD-1 and anti-CTLA-4 in mice bearing contralateral CT26.WT tumors pretreated with either hIL-7/mIL-12-VV or a control. (acir.org)
  • Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
  • In mice, this three-step therapy induced CD4- and CD8-dependent systemic immune responses that enhanced T-cell infiltration into distant tumors, leading to their eradication and significantly improving survival. (aacrjournals.org)
  • Tumorigenicity ability was evaluated by colony and sphere formation assay, the protein expression of stemness markers and tumor formation in nude mice. (biomedcentral.com)
  • Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)
  • MHC-II was also found to be upregulated on M1 macrophages in the contralateral tumor, and CD11b + DCs from the spleen were found to be activated, indicating a systemic antitumor immune response. (acir.org)
  • Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
  • Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
  • RNA analysis revealed that the viral component of the treatment upregulated the innate immune pathway and the type I IFN pathway, while hIL-7 and mIL-12 production upregulated genes related to T cell function and antigen processing. (acir.org)
  • Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
  • The cell-based therapeutic vaccine Sipuleucel T targeting the antigen PAP has been approved by the US Food and Drug Administration in 2010 and recently by the European Medicines Agency for the treatment of asymptomatic - minimally symptomatic metastatic CRPC based on a median prolongation in overall survival by 4.1 months compared to placebo controls [ 4 ]. (biomedcentral.com)
  • In biopsies and cell lines derived from tumors of the cervix HIF - 1± ( hypoxia -induced factor - 1 alpha ) and monocarboxilados transporters ( MCT ) expression was observed. (fapesp.br)
  • The logical gating of antigen recognition further addresses the perennial challenge of identifying suitable tumor antigens in CAR T cell therapy, showcasing the evolving landscape of adoptive T cell therapies. (oncologytube.com)
  • In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)
  • 2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. (novoprolabs.com)
  • Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)
  • Pro-inflammatory 5-LOX metabolites were selectively increased in post COVID-19 MDM, suggesting that SARS-CoV-2 infection drives a pro-inflammatory eicosanoid reprogramming that contributes to long-term alterations in innate immune cell function. (nature.com)
  • Phosphopeptides are modified self antigens which may induce an immune response. (wikipedia.org)
  • Immune tolerance or immunological tolerance is the state of unresponsiveness of the immune system to the substances or tissues that are capable to induce an immune response. (tutorialspoint.com)
  • 2009. Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance. (unimedizin-mainz.de)
  • They may promote tolerance leading to virus and tumor immune escape. (pasteur.fr)
  • Altogether these data suggest that HLA-G and not HLA-E could contribute to the immune escape of RABV. (pasteur.fr)
  • An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
  • In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
  • Results: Gene and protein analysis showed that A2AR was overexpressed in breast tumors and was significantly associated with high grade, elevated Ki-67, aggressive molecular and histological subtypes, as well as poor survival. (bvsalud.org)
  • Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. (hopkinsmedicine.org)
  • The laboratory focuses on developing new therapies for brain and skull base tumors , and has established the first primary skull base chordoma xenograft mouse model. (hopkinsmedicine.org)
  • It develops during the selection of immature lymphocytes where they encounter self-antigens within the primary lymphatic organs (thymus and bone marrow). (tutorialspoint.com)
  • Pretreatment with hIL-7/mIL-12-VV alone or in combination with either anti-PD-1 or anti-CTLA-4 induced CRs in almost all injected tumors, and the addition of either anti-PD-1 or anti-CTLA-4 significantly increased the portion of CRs in uninjected tumors, suggesting that pretreatment with hIL-7/mIL-12-VV can sensitize uninjected tumors to checkpoint blockade. (acir.org)
  • Frank O. Nestle and Sophia N. Karagiannis contributed equally to this work. (jci.org)
  • These authors contributed equally to this work. (cdc.gov)
  • Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. (aacrjournals.org)
  • Medigene's automated, high throughput TCR discovery platform is designed to bypass central tolerance to yield high affinity TCRs. (pressetext.com)
  • Exploring the MHC-peptide matrix of central tolerance in the human thymus. (unimedizin-mainz.de)
  • The hypoxia in tumors contributes to this phenomenon by increasing the efficiency of glycolysis. (fapesp.br)
  • Dr. Pascual had previously discovered that IL-1beta is a key pathogenic player in systemic juvenile idiopathic arthritis (sJIA), but the immune alterations contributing to IL-1beta-mediated inflammation remained unknown. (stanford.edu)
  • Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors . (hopkinsmedicine.org)
  • Peripheral tolerance is the key to preventing the over-reactivity of the immune system to various environmental entities. (tutorialspoint.com)
  • However, functional analysis on the cellular level could not confirm an enhanced immunogenicity status of APC in active pemphigus patients, yet we found in these patients increased plasma levels of the proinflammatory tumor necrosis factor (TNF)-α. (uni-marburg.de)
  • CV9103 is a prostate-cancer vaccine containing self-adjuvanted mRNA (RNActive®) encoding the antigens PSA, PSCA, PSMA, and STEAP1. (biomedcentral.com)
  • However, tumors may relapse after a period of time ranging from a few months to several years at which time they progress into castration-resistant prostate cancer (CRPC). (biomedcentral.com)
  • Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase. (unimedizin-mainz.de)
  • 2014. HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification. (unimedizin-mainz.de)
  • The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. (biomedcentral.com)