• Receptors in the posterior pharynx are then activated to initiate the involuntary phase of deglutition, which involves carefully sequenced contraction of numerous head and neck muscles. (nature.com)
  • Smooth muscle , which is found primarily in the internal body organs and undergoes involuntary, often rhythmic contractions that are not dependent on outside nerve impulses, generally shows a broad sensitivity to drugs relative to striated muscle. (britannica.com)
  • 6) Cardiac Muscle - heart wall, involuntary, striated muscle with intercalated discs connecting cells for synchronized contractions during heart beat. (exploringnature.org)
  • Cardiac muscle is under involuntary control. (bccampus.ca)
  • Cardiac muscle are short branching fibers, have a single, centrally located nucleus, show the same striations as skeletal muscle, and are under involuntary control. (histologyguide.com)
  • Smooth muscle cells are spindle-shaped (fusiform), have a single, centrally located nucleus, and are under involuntary control. (histologyguide.com)
  • The triggers for contracting and relaxing smooth muscles are controlled by the body's needs, so smooth muscles are considered involuntary muscle because they operate without a person's conscious control. (msdmanuals.com)
  • The normal storage phase is created by sympathetic autonomic domination, which results in detrusor muscle relaxation and urethral sphincter contraction created by alpha-adrenergic stimulation. (dvm360.com)
  • Titin is important in the contraction of striated muscle tissues. (wikipedia.org)
  • A number of titin isoforms are produced in different striated muscle tissues as a result of alternative splicing. (wikipedia.org)
  • IHC-P: Human cardiac muscle and spleen tissues. (abcam.com)
  • RyRs are expressed in the membrane of the sarcoplasmic (SR)/endoplasmic reticulum and are expressed in many tissues, with RyR1 and RyR2 being the predominant isoforms in skeletal and cardiac muscle respectively. (tocris.com)
  • Muscles are tissues with elastic properties, able to contract and then relax after an exciting stimulus. (wikilectures.eu)
  • Animal tissues can be classified into four main groups based on their main functions: epithelial tissue, connective tissue, nerve tissue, and muscle tissue. (britannica.com)
  • A) Signalling blots from cyclopiazonic acidity (CPA 15 arousal) dose-response test in mouse soleus and EDL muscle tissues (contraction or BTS? (bioskinrevive.com)
  • 3. Which of the following properties is not common to all three muscle tissues? (bccampus.ca)
  • Movement of the bolus through the duodenum and other parts of the small intestine is driven by peristalsis, wavelike muscular contractions. (microscopyu.com)
  • Esophageal peristalsis results from sequential contraction of circular muscle, which serves to push the ingested food bolus toward the stomach. (nature.com)
  • Esophageal longitudinal muscle may also play a role in peristalsis. (nature.com)
  • Peristaltic contractions are always preceded by inhibition that, in the case of primary peristalsis, is called deglutitive inhibition. (nature.com)
  • Peristalsis in the striated muscle part of the esophagus is dependent on central mechanisms, involving sequential activation of vagal lower motor neurons in the vagal nucleus ambiguus. (nature.com)
  • Peristalsis in the smooth muscle of the esophagus is dependent on both central and peripheral mechanisms. (nature.com)
  • The rhythmic contraction of cardiac muscle is regulated by the sinoatrial node, the heart's pacemaker. (britannica.com)
  • Voiding is consciously inhibited by voluntary contraction of striated urethral muscles and is reflexly inhibited by a spinal reflex, which tightens the external urethral sphincter when there is a sharp increase in intra-abdominal pressure (e.g., barking, coughing, sneezing, or retching). (dvm360.com)
  • Skeletal muscles are controlled by the brain and are considered voluntary muscles because they operate with a person's conscious control. (msdmanuals.com)
  • Among their most important sites of action are bronchial and uterine smooth muscle. (britannica.com)
  • Muscle contraction results from cyclic interactions between the contractile proteins myosin and actin, driven by the turnover of adenosine triphosphate (ATP). (diva-portal.org)
  • Titin is the third most abundant protein in muscle (after myosin and actin), and an adult human contains approximately 0.5 kg of titin. (wikipedia.org)
  • Skeletal muscle fibers contain a set of contractile proteins actin and myosin , which allow the muscle to contract by sliding against each other. (wikilectures.eu)
  • The muscles all begin the actual process of contracting (shortening) when a protein called actin is pulled by a protein called myosin. (bccampus.ca)
  • This occurs in striated muscle (skeletal and cardiac) after specific binding sites on the actin have been exposed in response to the interaction between calcium ions (Ca ++ ) and proteins (troponin and tropomyosin) that "shield" the actin-binding sites. (bccampus.ca)
  • All muscles require adenosine triphosphate (ATP) to continue the process of contracting, and they all relax when the Ca ++ is removed and the actin-binding sites are re-shielded. (bccampus.ca)
  • Skeletal muscles are made up of contractile proteins-actin and myosin. (bccampus.ca)
  • The actin and myosin proteins are arranged very regularly in the cytoplasm of individual muscle cells (referred to as fibers), which creates a pattern, or stripes, called striations. (bccampus.ca)
  • In all types of muscle, contraction is caused by the movement of myosin filaments along actin filaments . (histologyguide.com)
  • Skeletal muscle contracts in response to electrical impulses that are conducted along motor nerve fibres originating in the brain or the spinal cord . (britannica.com)
  • Purkinje fibers are modified cardiac muscle cells that convey electrical impulses that coordinate contraction of cardiac muscle. (histologyguide.com)
  • Despite intense studies, several molecular events in the contraction process are poorly understood, including the relationship between force-generation and phosphate-release in the ATP-turnover. (diva-portal.org)
  • Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring that is responsible for the passive elasticity of muscle. (wikipedia.org)
  • She has continued to study RyR channels, combining electrophysiology, biochemistry, protein chemistry, structural biology and molecular biology to explore normal RyR function and pathological changes that reduce skeletal muscle function and which can compromise cardiac muscle to the extent of causing heart attack. (edu.au)
  • The interests in the Muscle Research Group include the molecular structure and function of the proteins that regulate Ca 2+ signalling and contraction in skeletal muscle and the heart. (edu.au)
  • In neurons, it allows to stimulate a neuronal circuit, and in striated muscle cells, the muscular contraction. (nanowerk.com)
  • The outer muscular coat, known as the muscularis propria, is involved in bolus transport and consists of an inner layer of circularly oriented muscle fibers and an outer layer of longitudinally oriented fibers. (nature.com)
  • Muscular belly (venter musculi) - the most massive part of the muscle. (wikilectures.eu)
  • This summary discusses the basic anatomy of skeletal muscle, key features of skeletal muscle histology and physiology, and important presentations of muscular disease. (medscape.com)
  • Most of the skeletal muscular system is arranged into groups of agonists and antagonist muscles that work in concert to provide efficient and controlled motion. (medscape.com)
  • We know, for example, that contraction occurs when thick and thin filaments interact. (southalabama.edu)
  • Skeletal muscle is made up of long cylindrical multinucleated cells (syncytium) that are 60-100 µm wide. (wikilectures.eu)
  • Parallel muscles may be flat or cylindrical shaped. (medscape.com)
  • Cylindrical muscles typically have greater mass at the center of the muscle, leading to a central body or muscle belly (eg, biceps brachii). (medscape.com)
  • Muscle fibers are long and cylindrical in shape. (medscape.com)
  • There is then a transition zone where striated and smooth muscle intermix. (nature.com)
  • The lower esophageal sphincter ( LES ) and the distal one half to two thirds of the esophageal body are composed of smooth muscle. (nature.com)
  • Most of the drugs that stimulate or inhibit smooth muscle contraction do so by regulating the concentration of intracellular calcium , which is involved in initiating the process of contraction. (britannica.com)
  • Drugs such as adrenoceptor agonists, muscarinic agonists, nitrates, and calcium channel blockers all affect smooth muscle. (britannica.com)
  • Hormones can also influence smooth muscle function. (britannica.com)
  • During the phase of storage or continence the urinary bladder remains relaxed and slowly adapts to the filling due to the activation of the β-adrenergic receptors generated by autonomous sympathetic route by the hypogastric nerve towards the β-activated receptors in the bladder and simultaneously generating the excitation of the β-adrenergic receptors in the smooth muscle of the urethra. (vin.com)
  • The bladder detrusor smooth muscle cells (SMCs) and fibroblasts were observed under transmission electron microscopy (TEM). (hindawi.com)
  • The level of myosin light chain (MLC) phosphorylation is an important determinant of smooth muscle contraction. (hindawi.com)
  • The phosphorylation of MLC primarily regulates the force production and maintenance in the smooth muscle [ 6 ]. (hindawi.com)
  • The function of striated or smooth muscle is regulated by the balance of myosin light chain kinase (MLCK) and MLCP activity. (hindawi.com)
  • It is suggested that the phosphorylation of MLC catalyzed by Ca 2+ -calmodulin- (CAM-) dependent MLCK and dephosphorylation catalyzed by MLCP help regulate the contraction and relaxation of smooth muscle [ 8 , 9 ]. (hindawi.com)
  • The phosphorylation of smooth muscle regulatory light chain by MLCK is the basic requirement for smooth muscle contraction and hollow organ physiological activities [ 10 ]. (hindawi.com)
  • Muscles belong to the locomotor system and are divided into several classes - striated muscle, smooth muscle, cardiac myocardium. (wikilectures.eu)
  • Alpha-adrenergic fibers innervate the smooth muscle fibers in the trigone and urethra, resulting in contraction of these muscle fibers to form a functional internal urethral sphincter. (dvm360.com)
  • The subsequent spread of excitation to adjoining muscle fibers through tight junctions of smooth muscle cells leads to contraction of the detrusor muscle. (dvm360.com)
  • 5) Which of the following is true about the smooth muscle cells? (mrcoggoal.com)
  • Muscle is one of the four primary tissue types of the body, and the body contains three types of muscle tissue: skeletal muscle, cardiac muscle, and smooth muscle ( Figure 1 ). (bccampus.ca)
  • On the other hand, both cardiac muscle and smooth muscle can respond to other stimuli, such as hormones and local stimuli. (bccampus.ca)
  • The body contains three types of muscle tissue: (a) skeletal muscle, (b) smooth muscle, and (c) cardiac muscle. (bccampus.ca)
  • Ca ++ also is required for the contraction of smooth muscle, although its role is different: here Ca ++ activates enzymes, which in turn activate myosin heads. (bccampus.ca)
  • The uniform, nonstriated appearance gives rise to the name smooth muscle. (histologyguide.com)
  • Smooth muscle surrounds many arteries and contracts to adjust blood flow. (msdmanuals.com)
  • Smooth muscle also is controlled by the brain but not voluntarily. (msdmanuals.com)
  • Muscle fibers can broadly be divided into 3 muscles types: skeletal, cardiac, and smooth muscle. (medscape.com)
  • Movement, the intricate cooperation of muscle and nerve fibres, is the means by which an organism interacts with its environment . (britannica.com)
  • The innervation of muscle cells, or fibres, permits an animal to carry out the normal activities of life. (britannica.com)
  • The motor nerve fibres reach the muscle fibres at sites called motor end plates, which are located roughly in the middle of each muscle fibre and store vesicles of the neurotransmitter acetylcholine (this meeting of nerve and muscle fibres is known as the neuromuscular junction ). (britannica.com)
  • The contractile mechanism of skeletal muscles entails the binding of acetylcholine to nicotinic receptors on the membranes of muscle fibres. (britannica.com)
  • Dulhunty's research has focussed on the translation of electrical signals in the surface membrane of muscle fibres into the release of the calcium ions from their internal in the sarcoplasmic reticulum (SR), to enable muscle contraction in the process of excitation contraction coupling (ECC). (edu.au)
  • An incision is made through the skin and onto muscle with fibres passing inferiorly in an oblique direction. (mrcoggoal.com)
  • The discovery of asymmetric charge movement arising from dihydropyridine receptors in T-tubules allowed her to examine this voltage sensor for ECC in fast and slow-twitch mammalian muscle and to apply this to her subsequent studies of the voltage dependence for ECC. (edu.au)
  • This occurs through sequential or "peristaltic" contraction of circular muscle in the esophageal body, in concert with appropriately timed relaxation of the upper and lower esophageal sphincters. (nature.com)
  • It is generally believed that sustained contraction mainly occurs through Ca 2+ sensitization. (hindawi.com)
  • [ 5 ] In double elevator palsy, a deficiency in elevation of the globe occurs in all positions of gaze, secondary to an apparent weakness of the superior rectus and inferior oblique muscles. (medscape.com)
  • Gabbi's project will explore how the structural properties of muscle contribute to its contractile and force producing properties. (southalabama.edu)
  • I'm examining the impact of thick filament protein components on muscle assembly and how these protein components effect muscle contractile dynamics. (southalabama.edu)
  • muscle , contractile tissue found in animals , the function of which is to produce motion . (britannica.com)
  • Muscle is contractile tissue grouped into coordinated systems for greater efficiency . (britannica.com)
  • To clarify the relative sufficiency and necessity of SR Ca2+ vs. feedback signals to contraction-stimulated glucose transport we currently mixed contractile BRL-15572 myosin blockers AMPK transgenic mice Ca2+ ATPase inhibitors and electric activated contraction in incubated mouse muscle groups a traditional model system enabling cell culture-like manipulations and complete environmental control of completely differentiated contraction-competent striated muscle tissue. (bioskinrevive.com)
  • Skeletal muscles are bundles of contractile fibers that are organized in a regular pattern, so that under a microscope they appear as stripes (hence, they are also called striped or striated muscles). (msdmanuals.com)
  • It is at the level of the myofiber where the basic contractile element of muscle, the sarcomere, is found. (medscape.com)
  • Excitation-contraction coupling. (ucsd.edu)
  • Modeling cardiac excitation-contraction coupling. (ucsd.edu)
  • She was awarded a DSc degree by the University of NSW in 1988 for her extensive research into muscle excitation-contraction coupling (ECC). (edu.au)
  • Excitation-contraction (EC) coupling is broadly defined as the signal transduction process that links a surface membrane action potential to contraction. (edu.au)
  • The RyRs have a well-established role in the mechanism of excitation-contraction (EC) coupling in striated muscle contraction, and also have a role in secretion and synaptic transmission . (tocris.com)
  • Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca2+ channels and Ca2+ release channels on sarcoplasmic reticulum within junctional membrane complexes. (duke.edu)
  • AIMS:Transverse tubules (TTs) provide the basic subcellular structures that facilitate excitation-contraction (EC) coupling, the essential process that underlies normal cardiac contractility. (duke.edu)
  • We here review these issues in relation to controversies regarding basic physiological properties of striated muscle. (diva-portal.org)
  • For example RyR1 is activated following membrane depolarization of skeletal muscle, whereas depolarization of cardiac muscle results in Ca 2+ influx through L-type Ca 2+ channels, which activates RyR2 by CICR. (tocris.com)
  • The nuclei in the muscle fiber are concentrated under the cytoplasmatic membrane, which is why skeletal muscle can be easily distinguished from other types under the microscope. (wikilectures.eu)
  • In addition, EA repaired the damaged bladder detrusor muscle of diabetic rats by reducing mitochondrial damage of the SMCs and fibroblasts. (hindawi.com)
  • stimulation results in detrusor muscle relaxation and facilitates bladder filling. (dvm360.com)
  • stimulation of the pelvic nerve results in depolarization of pacemaker fibers throughout the detrusor muscle. (dvm360.com)
  • Parasympathetic activity via the motor portion of the pelvic nerve causes the detrusor muscle to contract and there is simultaneous inhibition of the sympathetic stimulation that closes the internal urethral sphincter. (dvm360.com)
  • the outflow tract closes and the detrusor muscle relaxes for filling. (dvm360.com)
  • When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
  • This work will contribute to our understanding of the assembly properties of striated muscle. (southalabama.edu)
  • Three RyR isoforms have been identified to date, RyR1, RyR2 and RyR3, roles of which include contraction, secretion and synaptic transmission . (tocris.com)
  • In 1954, Reiji Natori proposed the existence of an elastic structure in muscle fiber to account for the return to the resting state when muscles are stretched and then released. (wikipedia.org)
  • In 1977, Koscak Maruyama and coworkers isolated an elastic protein from muscle fiber that they called connectin. (wikipedia.org)
  • The structures are connected by ligaments , which are referred to as the epimysium (the layer surrounding the entire muscle), the perimysium (the layer surrounding the fiber bundles) and the endomysium (enclosing the individual muscle fibers). (wikilectures.eu)
  • The terms muscle cell and muscle fiber are synonymous. (histologyguide.com)
  • This article mainly focuses on the end organ of this complex interaction, the muscle fiber (myofiber). (medscape.com)
  • Body?1 Optimization from the cyclopiazonic acidity (CPA)-induced tonic contraction-model. (bioskinrevive.com)
  • Acetylcholine binding causes ion channels to open and allows a local influx of positively charged ions into the muscle fibre, ultimately causing the muscle to contract. (britannica.com)
  • Because this mechanism is relatively insensitive to drug action, the most important group of drugs that affect the neuromuscular junction act on (1) acetylcholine release, (2) acetylcholine receptors, or (3) the enzyme acetylcholinesterase (which normally inactivates acetylcholine to terminate muscle fibre contraction). (britannica.com)
  • Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the uniform thin-filament lengths crucial for normal sarcomere structure and function. (nih.gov)
  • What remains constant, however, is that the muscle fibers are aligned in the same direction so that individual muscle fibers can work in concert. (medscape.com)
  • The PMC coordinates the urethral sphincter relaxation and detrusor contraction to facilitate urination. (medscape.com)
  • This involves two major phenomena, namely the sequential contraction of circular muscle of the esophageal body, which results in a peristaltic wave that pushes the food toward the stomach, and relaxation and opening of the LES . (nature.com)
  • Finally, some muscles are circular in shape and contract around an opening. (medscape.com)
  • Examples of skeletal circular muscles include the orbicularis oris and orbicularis oculi. (medscape.com)
  • It limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. (wikipedia.org)
  • In cross-sections of single fibers from the frog semitendinosus muscle the number of thick myofilaments per unit area (packing density) is a direct function of the sarcomere length. (rupress.org)
  • The "expanding-sarcomere, sliding-filament" model of sarcomere shortening is discussed in terms of the current concepts of muscle architecture and contraction. (rupress.org)
  • The upper esophageal sphincter ( UES ) and proximal one third of esophageal body is composed of striated muscle. (nature.com)
  • Carme Nogués, from the UAB, explains that "these kinds of channels are present in several excitable cells like neurons, muscle or bone cells, to which this same method could be applied. (nanowerk.com)
  • Example: tendons that attach muscle to bone. (freezingblue.com)
  • Tendon (tendo) - an organized collagenous ligament that fastens a muscle most often to a bone, sometimes to the skin or a joint. (wikilectures.eu)
  • A muscle insertion transmits the force of contraction from a muscle to a tendon or bone. (histologyguide.com)
  • What is the structure of Titin like, springy and stretchy, or is it straight and firm when the muscle contracts and relaxes? (southalabama.edu)
  • However, cardiac muscle contracts and relaxes rhythmically without a person's awareness. (msdmanuals.com)
  • We distinguish slow muscles (performing static work, less powerful, less tiring - e.g. postural muscles) and fast muscles (allowing fast, intense but short-term performance - e.g. arm muscles ). (wikilectures.eu)
  • However, existing vertex models do not distinguish contraction forces on the cell boundary from adhesion between cells, employing a single parameter to express both. (hokudai.ac.jp)
  • In the future, this kind of electrical stimulation could be applied to other cells, such as neurons or muscle cells, opening the way for bioelectronic therapies and a change of paradigm, different from the current one based on pharmacological treatments", Gonzalo Murillo says. (nanowerk.com)
  • Stimulation of the pudendal nerve causes contraction of the striated skeletal muscle of the external urethral sphincter. (dvm360.com)
  • Motor points have been identified for all major muscle groups for the purpose of functional electrical stimulation by physical therapists, in order to increase muscle power. (medscape.com)
  • The wink reflex consists of a momentary upper eyelid retraction or elevation to an equal or higher level than the normal fellow eyelid upon stimulation of the ipsilateral pterygoid muscle. (medscape.com)
  • I use functional assays to measure movement and contraction. (southalabama.edu)
  • Deduce the structural and functional l roles of My-BP-C in muscle contraction, collaboration with University of Massachusetts Medical School. (iit.edu)
  • Deduce the structural and functional and structural roles of nebulin in muscle contraction and their role in nemaline myopathy, collaboration with University of Arizona/NIH. (iit.edu)
  • Small units contribute to the finely graded contractions used for delicate manipulations. (medscape.com)
  • We also briefly consider actomyosin mutation effects in cardiac and skeletal muscle function and the possibility to treat these defects by drugs. (diva-portal.org)
  • Electromyographic studies demonstrate this synkinetic innervation by showing simultaneous contraction of the external pterygoid and levator muscle. (medscape.com)
  • Skeletal muscle cells are grouped into primary bundles (fasciculi), secondary bundles and finally bundles of higher orders. (wikilectures.eu)
  • Different aspects of the force-generating transition are reflected in the changes in tension development by muscle cells, myofibrils and single molecules upon changes in temperature, altered phosphate concentration, or length perturbations. (diva-portal.org)
  • Muscle cells fuel their actions by converting chemical energy in the form of adenosine triphosphate (ATP), which is derived from the metabolism of food, into mechanical energy . (britannica.com)
  • In humans the muscle systems are classified by gross appearance and location of cells. (britannica.com)
  • Muscle tissue is composed of cells specialized for contraction. (histologyguide.com)
  • Individual skeletal muscle cells can be seen by teasing apart a muscle. (histologyguide.com)
  • In this paper, we introduce the rest length of the cell boundary and its dynamics into the existing vertex model, giving a novel formulation of the model that treats separately the contraction force and the strength of adhesion between cells. (hokudai.ac.jp)
  • We apply this vertex model to the phenomenon of compartment boundary in the fruit fly pupa, recapturing the observation that increasing the strength of adhesion between cells straightens the compartment boundary, even though contraction forces at cell boundaries remain unchanged. (hokudai.ac.jp)
  • The reinforced adhesion of homotypic cell contacts, together with pulsed cell contraction, achieves a biased vertex sliding action by resisting the separation of homotypic cell contacts in boundary cells. (hokudai.ac.jp)
  • This work reveals a self-organizing system that integrates a differential adhesion system with pulsed contraction of cells to maintain lineage restriction boundaries. (hokudai.ac.jp)
  • The three types of muscles are striated (or skeletal), cardiac, and smooth (or nonstriated). (britannica.com)
  • Cardiac muscle structure and function. (ucsd.edu)
  • The function of this muscle layer is unclear, but it likely is involved in mucosal movement. (nature.com)
  • In between these two muscle layers lies the myenteric plexus, which controls the motor function of these muscles. (nature.com)
  • Likewise, the number of muscle fibers within each of these, as well as the shape of muscles (depending on their function), can also vary greatly. (medscape.com)
  • The diaphragm divides the chest cavity from the abdominal cavity in mammals through a partition of skeletal muscle and connective tissue. (microscopyu.com)
  • The inner mucosal layer consists of squamous epithelium and underlying connective tissue, within which lies a longitudinally oriented muscle layer called the muscularis mucosa. (nature.com)
  • Gross inspection of a skeletal muscle reveals collections of muscle fascicles surrounded by a layer connective tissue termed the epimysium. (medscape.com)
  • Each muscle fascicle represents a group of muscle fibers bound together by a layer of connective tissue termed the perimysium. (medscape.com)
  • If the Titin protein in humans and animals is longer in size than in invertebrates, how long does this Titin protein extend during muscle contractions as well as when the muscle relaxes? (southalabama.edu)
  • More narrowly the term encapsulates the processes that intervene between the action potential depolarization and Ca 2+ release from the SR. EC coupling in the heart depends on RyR activation by Ca 2+ ions that enter the muscle cell through the DHPR ion channel. (edu.au)
  • Cardiac muscle forms the heart and is not part of the musculoskeletal system. (msdmanuals.com)