AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, AutologousHematopoietic Stem Cell TransplantationStem Cell TransplantationTransplantation, HomologousBone Marrow TransplantationMultiple MyelomaPeripheral Blood Stem Cell TransplantationTransplantation ConditioningMelphalanAntineoplastic Combined Chemotherapy ProtocolsBone MarrowCombined Modality TherapyTreatment OutcomeBone Marrow CellsRemission InductionSalvage TherapyStem CellsCyclophosphamideDisease-Free SurvivalLymphoma, Non-HodgkinHematopoietic Stem Cell MobilizationEtoposideBone Marrow PurgingRecurrenceHodgkin DiseaseGraft vs Host DiseaseCarmustineHematopoietic Stem CellsCytarabineMyeloablative AgonistsLiver TransplantationSurvival RateWhole-Body IrradiationGraft SurvivalSurvival AnalysisHematologic NeoplasmsVincristineAntigens, CD34Retrospective StudiesBusulfanThiotepaGranulocyte Colony-Stimulating FactorPrognosisFollow-Up StudiesTime FactorsDoxorubicinKidney TransplantationDexamethasoneLeukapheresisLymphoma, Mantle-CellAmyloidosisCell TransplantationBone and BonesAntineoplastic Agents, AlkylatingAntibodies, Monoclonal, Murine-DerivedThalidomideBoronic AcidsTransplantation ChimeraAntineoplastic AgentsPyrazinesBlood Cell CountLymphomaTissue DonorsMesenchymal Stem Cell TransplantationLeukemia, Myeloid, AcuteLymphoma, FollicularPrednisoneLymphoma, T-Cell, PeripheralNeoplasm, ResidualHematopoiesisAutograftsMyelodysplastic SyndromesIfosfamideImmunosuppressive AgentsCord Blood Stem Cell TransplantationHeart TransplantationCell DifferentiationInduction ChemotherapyPodophyllotoxinProspective StudiesLeukemiaLung TransplantationIdarubicinLymphoma, Large B-Cell, DiffuseAntibodies, MonoclonalBlood Component RemovalLeukocyte CountCells, CulturedHistocompatibility TestingMaintenance ChemotherapyBone Marrow DiseasesFeasibility StudiesFlow CytometryTransplantation ImmunologyGraft RejectionLeukemia, MyeloidLymphoma, B-CellT-LymphocytesPlatelet CountOrgan Transplantation
AllogeneicTransplantTransplantsCommon side effects of cHematopoietic Cell TransplantationLymphomasCancersGerm cell tMalignancyLymphocytesDonorPatient'sLong-term survivorsRegimenMammalianCytotoxicGeneticallyRadiotherapyTumorTissueMobilisationPediatricOrganNeutrophilPlateletUmbilical-cordDiseasesAbnormalDisordersImmatureInfectionMimicTherapyHemoglobinTumorsClinicalLeukemiasInhibitBiologicalPatientsProliferationRenalRegistrySymptomsEpithelial cellsInvolvesApoptosisApheresisTransfusionsEfficiencyMethodsIntracellularTreatments2016NormalMalignantApparentlyColonyHarvestImmunogenicity
Allogeneic4
Transplant17
  • What is an autologous stem cell transplant? (leukaemia.org.au)
  • Most people have a single autologous transplant. (leukaemia.org.au)
  • It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
  • In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
  • In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • Note: For transplant-eligible patients enrolled to Part 1 or Part 2, induction plus conditioning chemotherapy/ASCT +/- maintenance therapy constitute one regimen. (who.int)
  • Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma. (astct.org)
  • Introduction: The novel low-dose anti-thymocyte (ATG, 5 mg/kg) plus low-dose post-transplant cyclophosphamide (PTCy, 50 mg/kg) (low-dose ATG/PTCy)-based regimen had promising activity for prevention of graft-versus-host disease (GVHD) in haploidentical-peripheral blood stem cell transplantation (haplo-PBSCT), but its impacts on long-term outcomes remain to be defined. (bvsalud.org)
  • Every day, we help save lives by adding more potential donors to the bone marrow registry and connecting patients in need of a transplant with matching donors who can make it happen. (dkms.org)
  • Dr. Dora Ho specializes in infection complications in immunocompromised patients, such as those with bone marrow transplant, solid organ transplant, cancers and other forms of immunodeficiency. (stanford.edu)
  • Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)
  • Clinical trials for stem cell and bone marrow transplant patients are an important tool for identifying new and more effective treatments for many diseases. (bmtinfonet.org)
  • She serves as a scientific director for the Center for International Blood & Marrow Transplant Research or CIBMTR, under their infection and immune reconstitution committee. (bmtinfonet.org)
  • And she's also an associated editor for the medical journal Bone Marrow Transplantation as well as a protocol officer and medical monitor for the National Heart Lung and Blood Institute, National Cancer Institute, Blood & Marrow Transplant Clinical Trials Network. (bmtinfonet.org)
Transplants5
  • In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
  • Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
  • Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
  • Bone marrow transplantation and organ transplants in general have been found to introduce foreign DNA into patients. (wikipedia.org)
  • Below, you will find answers to frequently asked questions about DKMS, bone marrow and blood stem cell donation, transplants, and fundraising efforts. (dkms.org)
Common side effects of c2
  • During this time you are likely to be experiencing some of the common side effects of chemotherapy and radiotherapy which may include nausea, vomiting, mucositis (sore mouth) and bowel problems (diarrhoea). (leukaemia.org.au)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
Hematopoietic Cell Transplantation2
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • The nature of the underlying disease process - For example, a patient who is given an immunosuppressive drug shortly after undergoing hematopoietic cell transplantation for malignancy may be at greater risk than a patient receiving the same drug for chronic, stable rheumatologic disease. (medilib.ir)
Lymphomas3
  • Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
  • Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
  • Leukemias begin in the bone marrow, whereas lymphomas start in the lymphatic system. (dkms.org)
Cancers3
  • 12 Sarah Cannon Research Institute and Tennessee Oncology Center for Blood Cancers, Nashville, Tennessee. (aacrjournals.org)
  • All blood cancers involve the degeneration of certain blood cells, which multiply uncontrollably and suppress the healthy blood-forming system. (dkms.org)
  • In the future, this approach may offer personalized diagnostics to classify cancers and better target their treatment and identify new pharmacological targets for transplantation. (regenerativemedicine.net)
Germ cell t3
  • OBJECTIVE: To assess fertility outcomes in long-term survivors of malignant ovarian germ cell tumors treated with fertility-sparing surgery with or without additional chemotherapy. (bvsalud.org)
  • METHODS: Women diagnosed and treated for malignant ovarian germ cell tumors at Charing Cross Hospital or Mount Vernon Cancer Centre between 1977 and 2015 were included. (bvsalud.org)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Malignancy1
Lymphocytes5
  • Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)
  • In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • A slow clearance of leukemic cells by the initial course of chemotherapy, as measured by the morphologic analysis of peripheral blood or bone marrow smears 1 to 3 weeks from diagnosis, predicts a higher risk of relapse, but can be inaccurate because ALL blast cells are remarkably similar in appearance to bone marrow lymphoid precursors (alias hematogones) and, in some instances, to mature lymphocytes. (ashpublications.org)
  • The first demonstration that bone marrow samples apparently devoid of ALL cells may, in fact, contain measurable levels of leukemia (ie, "minimal residual disease" or MRD) was provided soon after the advent of polyclonal antisera against leukocyte antigens: combinations of cell markers were used to distinguish T-lineage ALL cells from normal immature and mature lymphocytes by immunofluorescence microscopy. (ashpublications.org)
Donor6
  • She did this by incubating the patient's cells in tissue culture with DNA extracted from a donor with normal hemoglobin. (wikipedia.org)
  • DKMS stands for 'Deutsche Knochenmarkspenderdatei', or German Bone Marrow Donor Center. (dkms.org)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
  • Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
Patient's3
  • They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
  • Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
  • To help venous blood return in a patient who is in shock, the nurse should elevate the patient's legs no more than 45 degrees. (rnpedia.com)
Long-term survivors1
Regimen2
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
  • At 6 months, event-free survival in these patients, whose prognosis was unfavorable, was 65% with temsirolimus versus 50% with bevacizumab, when these agents were added to a chemotherapy regimen of vinorelbine and cyclophosphamide. (medscape.com)
Mammalian6
  • Gene therapy was first conceptualized in the 1960s, when the feasibility of adding new genetic functions to mammalian cells began to be researched. (wikipedia.org)
  • Several methods to do so were tested, including injecting genes with a micropipette directly into a living mammalian cell, and exposing cells to a precipitate of DNA that contained the desired genes. (wikipedia.org)
  • One of the first scientists to report the successful direct incorporation of functional DNA into a mammalian cell was biochemist Dr. Lorraine Marquardt Kraus (6 September 1922 - 1 July 2016) at the University of Tennessee in Tennessee, United States. (wikipedia.org)
  • WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
  • US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)
  • Some examples include the specialized hair cells of the mammalian cochlea, that display a spectacularly polarized organization of kinocilia and stereocilia on their apical surfaces, the dynamic ciliated cells of the tracheal and reproductive tract epithelia, and cells in the gastrulating vertebrate embryo that display polarized migration and intercalation behaviors. (stanford.edu)
Cytotoxic6
  • The safety and efficacy of Neupogen are similar in adults and children receiving cytotoxic chemotherapy. (medicines.org.uk)
  • The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)
  • Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
  • In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of Neupogen therapy. (medicines.org.uk)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Genetically2
  • In 1961, she managed to genetically alter the hemoglobin of cells from bone marrow taken from a patient with sickle cell anaemia. (wikipedia.org)
  • Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
Radiotherapy1
  • Standard treatments involve chemotherapy and radiotherapy. (rxharun.com)
Tumor6
  • The goal was to cure malignant brain tumors by using recombinant DNA to transfer a gene making the tumor cells sensitive to a drug that in turn would cause the tumor cells to die. (wikipedia.org)
  • Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • CONCLUSIONS: Our results suggest that fertility may not be hampered in patients with malignant ovarian germ cell tumor treated with fertility-sparing surgery or receiving additional chemotherapy. (bvsalud.org)
  • The results, published in the journal Scientific Reports , will allow better analysis of cell front behavior, in terms of both wound healing and tumor development. (regenerativemedicine.net)
  • Patrycja Paruch, professor in the Department of Quantum Matter Physics at the UNIGE Faculty of Science, explains: "For cancer tumor invasion, or in the event of a wound, cell front proliferation is crucial, but the speed and morphology of the front is highly variable. (regenerativemedicine.net)
Tissue4
  • It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
  • Applied to biological elements, such as the cell fronts bordering a wound, this approach makes it possible to identify the various interactions which play a defining role during tissue growth, differentiation, and healing, but above all to highlight their hierarchy at the different scales observed. (regenerativemedicine.net)
  • The cell fronts then proliferate to fill the opening and heal the tissue. (regenerativemedicine.net)
  • The idea is to see what happens in normal healthy tissue, or when processes such as cell division and communication between neighboring cells are inhibited, when cell mobility is reduced or when cells are permanently pharmacologically stimulated. (regenerativemedicine.net)
Mobilisation3
  • This process is called stem cell mobilisation and usually involves the use of chemotherapy in combination with colony stimulating growth factor injections - usually G-CSF. (leukaemia.org.au)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
Pediatric1
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
Organ3
  • The first attempt, an unsuccessful one, at gene therapy (as well as the first case of medical transfer of foreign genes into humans not counting organ transplantation) was performed by geneticist Martin Cline of the University of California, Los Angeles in California, United States on 10 July 1980. (wikipedia.org)
  • treatment that involves the removal or destruction of the function of an organ, as in the surgical removal of the ovaries or the administration of some types of chemotherapy that causes the ovaries to stop functioning. (thewomenofhope.org)
  • When mean arterial pressure falls below 60 mm Hg and systolic blood pressure falls below 80 mm Hg, vital organ perfusion is seriously compromised. (rnpedia.com)
Neutrophil5
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range. (medicines.org.uk)
  • However, for a sustained therapeutic response, Neupogen therapy should not be discontinued before the expected nadir has passed and the neutrophil count has recovered to the normal range. (medicines.org.uk)
  • 6. Absolute neutrophil count (ANC) =1000/mm3 at Screening. (who.int)
  • Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Platelet1
Umbilical-cord2
Diseases7
  • White blood cells (also called WBCs or leukocytes) - help the body fight infections and other diseases. (rxharun.com)
  • Blood cancer' is the umbrella term used for a variety of malignant diseases of the blood-forming (hematopoietic) system. (dkms.org)
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • OVERVIEW - Biologic therapies that can increase the risk of infectious diseases include antithymocyte globulin, monoclonal antibodies to T and B cells, anticytokine therapies, agents that disrupt T cell costimulation signals, and agents that interfere with T cell inhibitory (checkpoint) signals. (medilib.ir)
  • These agents selectively target cells and pathways of the immune system to achieve specific therapeutic effects and are used primarily in the treatment of rheumatic, inflammatory, and malignant diseases. (medilib.ir)
  • In each case, PCP is critical to the function of these cells and tissues, and errors in the signaling system controlling PCP lead to human diseases and developmental defects, including congenital deafness, neural tube closure defects and cardiac outflow tract anomalies. (stanford.edu)
Abnormal2
  • Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
  • Typically taking months or years to progress, the cells are produced at a much higher rate than normal, resulting in many abnormal white blood cells. (rxharun.com)
Disorders1
  • It has been a pleasure to treat patients with cancer and blood disorders for the past 34 years. (floridacancer.com)
Immature2
Infection4
  • During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
  • p>Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). (nemours.org)
  • a protein that is present in the blood, made by cells of the immune system to fight infection. (thewomenofhope.org)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Mimic2
  • Disseminated rhabdomyoblasts in the bone marrow may mimic the symptoms and light microscopic findings of leukemia. (medscape.com)
  • Using rat epithelial cells, they established flat colonies (2D) in which the cells grow around a silicone insert, subsequently removed to mimic an open lesion. (regenerativemedicine.net)
Therapy8
  • Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
  • Gene therapy is a medical technology which aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells. (wikipedia.org)
  • 0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
  • a partial or complete loss of hair that may result from radiation therapy to the head, chemotherapy, skin disease, drug therapy, and natural causes. (thewomenofhope.org)
  • In patients with localized disease, overall 5-year survival rates have improved to more than 80% with the combined use of surgery, radiation therapy, and chemotherapy. (medscape.com)
  • Treatment for patients with rhabdomyosarcoma involves a combination of surgery, chemotherapy, and radiation therapy. (medscape.com)
  • Most patients with rhabdomyosarcoma require radiation therapy to achieve adequate local control, though this treatment is not usually performed until after initial surgical resection and the start of chemotherapy. (medscape.com)
Hemoglobin2
Tumors1
  • p>Our combined expertise allows us to diagnose and treat common, rare and complex bone tumors in children. (nemours.org)
Clinical1
Leukemias2
  • Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell. (rxharun.com)
  • In myeloid or myelogenous leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (rxharun.com)
Inhibit1
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
Biological2
  • The primary goal of my work on PCP has been to elucidate, at molecular and cell biological levels, the nature of the signals that induce subcellular asymmetry, and how cells then respond to this molecular asymmetry to orient their cytoskeletons. (stanford.edu)
  • Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)
Patients7
  • Since the first large cohort of patients was cured in the 1970s, much has been learned about the long-term effects of exposure to chemotherapy, radiation, and surgery in childhood. (medscape.com)
  • [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • In 1968, researchers Theodore Friedmann, Jay Seegmiller, and John Subak-Sharpe at the National Institutes of Health (NIH), Bethesda, in the United States successfully corrected genetic defects associated with Lesch-Nyhan syndrome, a debilitating neurological disease, by adding foreign DNA to cultured cells collected from patients suffering from the disease. (wikipedia.org)
  • After any treatment, 39/46 patients (85%) became pregnant: the conception rate was not different between those receiving surgery only and those receiving also chemotherapy (85.7% vs 84.4%, p=1.0). (bvsalud.org)
  • The probability of live birth at 5 years was 48% and 40% for patients in the surgery only and chemotherapy group, respectively (p=0.55). (bvsalud.org)
  • In multivariate analysis, the disease status at transplantation was associated with inferior survivor outcomes for all patients and myeloid and lymphoid malignancies, while cGVHD had superior outcomes for all patients and myeloid malignancies, but not for lymphoid malignancies. (bvsalud.org)
Proliferation5
  • FAs are structures composed of clustered transmembrane proteins called integrins that bind to the extracellular matrix and link to the actin cytoskeleton and control cell migration, proliferation, survival and differentiation (Gardel et al. (bio2009.org)
  • Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
  • Physicists at the University of Geneva (UNIGE), in collaboration with the University of Zurich (UZH), used the framework of disordered elastic systems to study the process of wound healing -- the proliferation of cell fronts which eventually join to close a lesion. (regenerativemedicine.net)
  • Moreover, they observed that proliferation speed varied greatly between the different pharmacochemical conditions, slowing when cell division and motility were inhibited, and accelerating when cells were stimulated. (regenerativemedicine.net)
  • More surprisingly, the fastest proliferation speed was achieved when gap-junction communication between cells was blocked," says Guillaume Rapin. (regenerativemedicine.net)
Renal1
  • Liver and renal function, as well as blood electrolytes and chemistry, must be assessed before chemotherapy. (medscape.com)
Registry1
  • Everyone who registered with Delete Blood Cancer remains on file with DKMS and on the national registry. (dkms.org)
Symptoms2
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (worldsbest.rehab)
Epithelial cells1
  • Our major project is to investige a pathway that controls the polarity of epithelial cells within the plane of the epithelium. (stanford.edu)
Involves1
  • The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
Apoptosis1
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
Apheresis2
  • Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
  • The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
Transfusions1
  • Red blood cell transfusions are given when your haemoglobin levels are too low. (leukaemia.org.au)
Efficiency1
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
Methods1
  • WO 2013/002880 describes compositions and methods comprising bio-energetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures. (justia.com)
Intracellular1
  • In general, infections with common bacterial pathogens may become more frequent with agents targeting the B cell system, whereas intracellular pathogens, including opportunistic microbes, are often seen in treatment that is more focused on T cell immunity. (medilib.ir)
Treatments1
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
20162
  • If you registered before 2016, you may have registered with Delete Blood Cancer. (dkms.org)
  • In 2016, Delete Blood Cancer DKMS changed its name to DKMS as part of a global rebranding of DKMS offices around the world. (dkms.org)
Normal4
  • G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • Because ALL cells arise from the oncogenic transformation of a single lymphoid precursor, they have clonal antigen-receptor (immunoglobulin and/or T-cell receptor) gene rearrangements in most cases, which can be used to distinguish ALL cells from normal lymphoid cells (expressing gene rearrangements with different sequences) and nonlymphoid cells (lacking the rearrangements). (ashpublications.org)
  • After a 12-hour fast, the normal fasting blood glucose level is 80 to 120 mg/dl. (rnpedia.com)
Malignant1
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
Apparently1
  • Although most were apparently well, survivors at 10 years and 15 years after HSCT continued to have an increased risk of death compared with a group of individuals from the healthy population who were age-matched and sex-matched. (medscape.com)
Colony1
  • However, we believe that only a few dominant interactions during this process will define the dynamics and the shape -- smooth or rough, for example -- of the cell colony edge. (regenerativemedicine.net)
Harvest1
Immunogenicity1
  • AAVs are characterized by stabilizing the viral capsid, lower immunogenicity, ability to transduce both dividing and nondividing cells, the potential to integrate site specifically and to achieve long-term expression in the in-vivo treatment. (wikipedia.org)