Contains an extracellular protein tyrosine phosphatase. Medical search. Frequent questions

Wild type as well as substrate-trapping DA forms of PTPϵM suppressed phosphorylation of IR downstream enzymes such as Akt, extracellular regulated kinase (ERK) and glycogen synthase kinase 3 (GSK3). (bioone.org)
As a mechanism to control EGFR phosphorylation at the plasma membrane, receptor endocytosis and vesicular trafficking relocalizes activated, phosphorylated EGFR to perinuclear compartments rich in Protein Tyrosine Phosphatases (PTPs), such as PTPN1, which dephosphorylate and inactivate the receptor. (tu-dortmund.de)
Using single cell measurements of phosphorylation of the EGFR downstream signaling tyrosine residue Y1068, we generated a spatial-temporal reactivity map to identify local phosphatase activity. (tu-dortmund.de)
DUSP3 regulated OCLN ubiquitination and degradation through decreasing OCLN tyrosine phosphorylation directly or through suppressing focal adhesion kinase, the OCLN kinase. (biomedcentral.com)
Phosphorylation is the most common post-translational modification on proteins, with approximately 80% occurring on serine, 20% on threonine, and 0.1 to 1% on tyrosine residues. (thermofisher.com)
The usual consequence of this unregulated state is reduced recovery of total protein and biologically meaningless representation of protein activities (i.e., phosphorylation status). (thermofisher.com)
Proteases inhibitors are nearly always needed, while phosphatase inhibitors are required only when phosphorylation states (activation states) are being investigated. (thermofisher.com)
Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (uni-freiburg.de)
The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. (uni-freiburg.de)
Control of tyrosine phosphorylation is an essential element of many cellular processes, including proliferation, differentiation neurite outgrowth, and synaptogenesis. (sciety.org)
ed protein tyrosine phosphatase non-receptor type 12 (PTPN12) at Ser434 and inhibited PTPN12 activity, thus enhancing phosphorylation of Janus kinase 2 (JAK2), which phosphorylated growth factor receptor bound protein 2 (GRB2) at Tyr160 to promote GRB2 dimers dissociation and recruitment of GRB2 to SVCT2, leading to further ERK activation. (archive.org)

ARP-1536 binds the extracellular domain of vascular endothelial protein tyrosine phosphatase (VE-PTP) inhibiting its ability to interact with Tie-2. (financialmodelingprep.com)

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. (wikipedia.org)
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. (wikipedia.org)
Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
Dual specificity phosphatase 3 (DUSP3), a suppressor of multiple protein tyrosine (Tyr) kinases, is decreased in lung cancer tissues. (biomedcentral.com)
DUSP3/VHR, related to the vaccinia virus phosphatase VH1, is initially found to be a phosphatase that dephosphorylates multiple protein tyrosine kinases (PTKs) in vitro [ 21 ]. (biomedcentral.com)
Upon binding, the tyrosine residues in the signaling motifs are phosphorylated by membrane-associated tyrosine kinases. (encyclopedia.pub)
Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
It has additionally been reported that VCAM-1 ligation activates the serine/threonine kinases extracellular controlled kinases 1 and 2 (ERK1/2) [12] however the mechanism because of this activation isn't known. (pkc-inhibitor.com)

The signaling cascade is down-regulated by dephosphorylation by protein tyrosine phosphatases. (encyclopedia.pub)
Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)
MKP-1 protein was also markedly up-regulated following 1-8 h of Dex treatment, and this correlated precisely with dephosphorylation of ERK. (ox.ac.uk)

They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. (embl.de)
The deduced amino acid sequence of PPS1p shows similarity with protein-tyrosine phosphatases (PTPases) and is most closely related to a subfamily of PTPases that are capable of dephosphorylating phosphoseryl and phosphothreonyl residues as well as phosphotyrosyl residues. (embl.de)
The PPS1 protein was expressed in Escherichia coli, and the protein was shown to catalyze the hydrolysis of p-nitrophenyl phosphate, dephosphorylate phosphotyrosyl, and phosphothreonyl residues in synthetic diphosphorylated peptides and to inactivate the human ERK1 protein. (embl.de)
For that tyrosine residues in the cytoplasmic tail of the receptors have to be phosphorylated, hence the receptors are referred to as tyrosine-phosphorylated receptors. (encyclopedia.pub)
They are called non-catalytic receptors, as the receptors have no intrinsic tyrosine kinase activity and cannot phosphorylate their own tyrosine residues. (encyclopedia.pub)
Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)

Here, I investigate the role of one intrinsic factor (receptor-type protein tyrosine phosphatase alpha) and one extrinsic factor (ionizing radiation) in facilitating cancer cell invasion. (ubc.ca)
Receptor-type protein tyrosine phosphatase alpha (PTPα is a widely expressed transmembrane-bound protein that has been implicated in integrin signaling, focal adhesion formation, and normal cell migration. (ubc.ca)
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (exbio.cz)

Known phosphatases are specific for cleavage of either serine-threonine or tyrosine phosphate groups. (thermofisher.com)

Proteases and phosphatases are important enzymes in a variety of biochemical pathways in living cells. (thermofisher.com)
In whole cells, protease and phosphatase activities are tightly regulated by compartmentalization or inhibitors to prevent indiscriminate damage to cellular proteins and to maintain proper function of signaling pathways. (thermofisher.com)
In this model, we demonstrate that inhibitors of PTP1B, a protein tyrosine phosphatase that regulates signaling pathways of fundamental importance to homeostasis and inflammation, prevented lung injury and increased survival. (jci.org)
pathways involving PTPRC protein from the Biocarta Pathways dataset. (maayanlab.cloud)
Although important, the capability to multiplex and assay a wide range of protein focuses on (including intracellular signalling pathways) has been limited20. (irjs.info)

The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. (embl.de)
It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. (ayassbioscience.com)

A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesion recognition motif and a single cytosolic protein tyrosine phosphate domain. (online-medical-dictionary.org)

Among these negative regulators, protein tyrosine phosphatases (PTPs) are likely to play a pivotal role in IR signaling. (bioone.org)

Mammalian bone morphogenetic protein-binding (BMP-binding) endothelial regulator protein. (embl.de)
H2O2 diffuses through membranes to oxidize and transiently activate endothelial cell-associated proteins kinase C (PKC) [7], [8]. (pkc-inhibitor.com)
PKC after that phosphorylates and activates endothelial cell proteins tyrosine phosphatase 1B (PTP1B) [7], [8]. (pkc-inhibitor.com)

Mutation of the catalytic cysteinyl residue in the active phosphatase domain reduced the in vitro activity of the mutant protein to less than 0.5% of wild type activity, while mutation of the corresponding cysteinyl residue of the inactive phosphatase-like domain had no effect on in vitro activity. (embl.de)
The most prominent feature is the presence of conserved signalling motifs containing tyrosine residue, such as Immunoreceptor tyrosine-based activation motifs (ITAMs), in the cytoplasmic tail of the receptors. (encyclopedia.pub)

its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively) as well as differing levels of glycosylation. (bdbiosciences.com)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
What is the precise role of intracellular and extracellular galectins in the control of cell death programs? (nature.com)
Fatty acid binding proteins (FABP) are a family of proteins facilitating intracellular fatty acid transport. (biomedcentral.com)
These results suggest that, as channel modulators, β subunits play important roles in control of electrical signaling and, as CAMs, β subunits act as critical communication links between extracellular and intracellular signaling molecules. (jneurosci.org)
First, single-stage immunoassays have difficulty with multiplexed measurements of surface and intracellular proteins for each solitary cell21. (irjs.info)
Circulation cytometry also suffers from multiplexing shortcomings, especially with intracellular protein focuses on. (irjs.info)

Although the molecular mechanisms responsible for the selective vulnerability of these cells are not well understood, activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway has been implicated in neuroprotective responses to excitotoxicity in other neuronal populations. (jneurosci.org)
Here, we report that high levels of the striatal-enriched protein tyrosine phosphatase (STEP), a key regulator of ERK/MAPK signaling, are found in vulnerable somatostatin-immunoreactive hilar interneurons. (jneurosci.org)
Along these lines, accumulating evidence shows that the p42/44 mitogen-activated protein kinase (MAPK) pathway plays an important role in neuronal cell survival. (jneurosci.org)
Coupled with the rapidity of Dex action, this indicates immediate-early gene phosphatase involvement, and we therefore used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases, MKP-1 and MKP-3. (ox.ac.uk)

PZR promotes cell migration on the extracellular matrix (ECM) molecule, fibronectin, by interacting with SHP-2 (Src homology-2 domain-containing protein tyrosine phosphatase-2), a molecule essential for skeletal development and often mutated in Noonan and Leopard syndrome patients sharing overlapping musculoskeletal abnormalities and cardiac defects. (ox.ac.uk)

Alternatively spliced transcript variants encoding different protein isoforms have been described. (wikipedia.org)
Several different splice isoforms of the extracellular domain of CD45 are expressed on T cells, and the isoform expressed depends on the particular subpopulation of cell, the state of cell maturation, and whether the cells have been exposed to antigen. (lsbio.com)
The mouse monoclonal antibody HI30 recognizes an extracellular epitope on all isoforms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. (exbio.cz)
these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. (exbio.cz)
Although mass spectrometry can measure most protein isoforms, the analytical level of sensitivity is insufficient for detection of important signalling proteins with single-cell resolution26. (irjs.info)

Several inhibitors of the IR tyrosine kinase activity have recently been described and associated with human insulin resistance. (bioone.org)
The receptors themselves have no intrinsic tyrosine kinase activity. (encyclopedia.pub)

Our data reveal that the vulnerable cells express high levels of striatal-enriched protein tyrosine phosphatase (STEP), which is a key regulator of the extracellular signal-regulated kinase (ERK) pathway. (jneurosci.org)
Gas6 is the product of growth arrest-specific gene 6 which was in the beginning cloned from serum-starved fibroblasts and shares about CUDC-305 (DEBIO-0932 ) 44% sequence identity and related website organization with protein S a negative regulator of blood coagulation (48). (exposed-skin-care.net)

Treatment with PTP1B inhibitors attenuated the aberrant neutrophil function that drives ALI and was associated with release of myeloperoxidase, suppression of neutrophil extracellular trap (NET) formation, and inhibition of neutrophil migration. (jci.org)

Biotin has an extremely high affinity for the Avidin family of proteins (Kd = 10-15 M), making it the perfect tool to link two molecules. (bdbiosciences.com)
In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)

P0-related protein (PZR), a Noonan and Leopard syndrome target, is a member of the transmembrane Immunoglobulin superfamily. (ox.ac.uk)
Rho proteins belong to the Ras superfamily. (biomedcentral.com)

Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. (ayassbioscience.com)

A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)

Immunoprecipitation of CD45 protein from BaF3 cell extracts. (cellsignal.com)
CD45RB is a splice isoform of CD45 (also called protein tyrosine phosphatase, receptor type, C), a glycoprotein receptor that is required for T-cell activation. (lsbio.com)
The antibody MEM-143 reacts with a protein determinant of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). (lsbio.com)

Rather, a mixture or inhibitor cocktail of several different inhibitor compounds are used to ensure that protein extracts do not degrade before analysis for targets of interest. (thermofisher.com)
Research experiments may necessitate the use of single inhibitors or customized mixtures, but most protein work is best served by using a suitable protease inhibitor cocktail . (thermofisher.com)
This inhibition is reversed by cotreatment with the protein synthesis inhibitor, cycloheximide, and by the GC receptor antagonist, RU486, suggesting a classical transcriptional mechanism. (ox.ac.uk)
Phosphatase activity was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate. (ox.ac.uk)
There she led a team of 6 chemists performing lead optimization on a macrocycle inhibitor of the hedgehog protein which resulted in analogs with superior potency, improved metabolic stability, excellent in vivo pharmacokinetics and no in vitro safety liabilities. (harvard.edu)

Its cytoplasmic tail contains two immune-receptor tyrosine-based inhibitory motifs (ITIMs), implicated in adhesion-dependent signaling and regulating cell adhesion and motility. (ox.ac.uk)
All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)

Pharmacological inhibition of ERK1/2 restores GSK3β activity and protein synthesis levels in a model of tuberous sclerosis. (wikipedia.org)

Autocatalytic activation of Epidermal Growth Factor Receptor (EGFR) at the plasma membrane increases the sensitivity of the cell to extracellular growth factors but can also generate spontaneous receptor activation in the absence of stimulation. (tu-dortmund.de)
These inhibitors block or inactivate endogenous proteolytic and phospholytic enzymes that are released from subcellular compartments during cell lysis and would otherwise degrade proteins of interest and their activation states. (thermofisher.com)
Extracellular Vc binding to SVCT2 initiated ERK activation, then transmembrane transport of Vc induced dimerization of SVCT2. (archive.org)

Proximity ligation assay, immunoblotting, and phosphatase assay were performed to study the effect of DUSP3 on the TJ protein occludin (OCLN). (biomedcentral.com)
use an assay in which alkaline phosphatase-tagged cell surface proteins are used to stain live embryos overexpressing other cell surface proteins to identify Sticks and stones (Sns) as a possible ligand for the Lar receptor protein tyrosine phosphatase. (sciety.org)
For decades, researchers have resolved single-stage immunoassay specificity limitations by prepending an upstream polyacrylamide gel electrophoresis (PAGE) protein separation to a downstream immunoassay, therefore developing a two-stage assay known as western blotting. (irjs.info)

This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. (origene.com)
This domain can be found in dual specificity phosphatases. (embl.de)
Taxonomic distribution of proteins containing DSPc domain. (embl.de)
The complete taxonomic breakdown of all proteins with DSPc domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing DSPc domain in the selected taxonomic class. (embl.de)
Analysis of the predicted amino acid sequence suggests that the protein consists of an active phosphatase domain, an inactive phosphatase-like domain, and an NH2-terminal extension. (embl.de)
Taxonomic distribution of proteins containing VWD domain. (embl.de)
20 nm) extracellular domain and the binding to ligands that are anchored to solid surfaces or membranes of other cells. (encyclopedia.pub)
A mutation (C121W) in the extracellular Ig domain of β1 causes generalized epilepsy with febrile seizures plus type 1 (Wallace et al. (jneurosci.org)
A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)

There are 17170 DSPc domains in 17099 proteins in SMART's nrdb database. (embl.de)
There are 25698 VWD domains in 12416 proteins in SMART's nrdb database. (embl.de)
Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
The receptor signaling pathway is initiated by ligand binding to the extracellular domains of the receptor. (encyclopedia.pub)
Receptor-like protein-tyrosine phosphatases (RPTPs) have cytoplasmic phosphatase domains and cell adhesion molecule (CAM)-like extracellular domains that interact with cell-surface ligands and/or co-receptors. (sciety.org)
Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)

We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
Phosphatases play a key role in regulating signal transduction events in eukaryotic cells. (thermofisher.com)

Tyrosine specific protein phosphatases (PTPases) contain two conserved cysteines, the second one has been shown to be absolutely required for activity. (embl.de)
The resulting unregulated proteolytic activity can reduce protein yield and function. (thermofisher.com)
Protease and phosphatase inhibitors can be added to the lysis reagents in order to prevent degradation of extracted proteins, and to obtain the best possible protein yield and activity following cell lysis. (thermofisher.com)

Direct binding between the two proteins was confirmed in vitro, although it requires extensive multimerization of Lar, and is conserved between PTPRF/D and Nephrin homologues. (sciety.org)

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth. (phoenixpeptide.com)

During normal cell migration, cells use focal adhesions to facilitate cycles of cell adhesion to, and release from, the extracellular matrix (ECM). (ubc.ca)

Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)

Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
TJs, tightly fused regions between the outer membrane of adjacent cells, are formed by integral transmembrane proteins such as OCLN and claudins, anchoring proteins such as zonula occludens (ZO)1-3, and other TJ-associated/regulatory proteins [ 4 , 5 ]. (biomedcentral.com)

At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Proteases are required for many cellular functions, including cellular repair and the digestion of extracellular material. (thermofisher.com)
Cell lysis disturbs the carefully controlled cellular environment, allowing proteases and phosphatases to become unregulated. (thermofisher.com)
Many of the cellular proteins are kept separate from proteolytic enzymes. (thermofisher.com)
Disruption of cellular and tissue architecture during protein extraction distorts the in vivo state by making all proteins potentially accessible for degradation or modification by endogenous proteases and phosphatases. (thermofisher.com)
Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. (biomedcentral.com)
Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission. (phoenixpeptide.com)

pps1Delta mutant strains did not differ from PPS1 strains under any of the conditions tested, but overexpression of the PPS1 protein in S. cerevisiae led to synchronous growth arrest and to aberrant DNA synthesis. (embl.de)

These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
Non-Catalytic Tyrosine-Phosphorylated Receptors" Encyclopedia , https://encyclopedia.pub/entry/36839 (accessed November 29, 2023). (encyclopedia.pub)
Non-catalytic tyrosine-phosphorylated receptors (NTRs), also called immunoreceptors or Src-family kinase-dependent receptors, are a group of cell surface receptors expressed by leukocytes that are important for cell migration and the recognition of abnormal cells or structures and the initiation of an immune response. (encyclopedia.pub)

I demonstrated that tumor cells secreted proteins that drove the recruitment and/or expansion of pulmonary TAMs, Tregs, and granulocytic-MDSCs (G-MDSCs), resulting in increased primary lung tumor growth and pulmonary metastasis of mammary carcinoma cells, respectively. (ubc.ca)
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

Rho GTPases are key integrating molecules from different extracellular signals, as they can be activated by different GEFs. (biomedcentral.com)

Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. (biomedcentral.com)

Although the amyloid precursor protein (APP) and its proteolysis are regarded as key elements of the pathology of Alzheimer's disease, the physiological function of APP is not well understood and mice lacking App and the related gene Aplp2 die early postnatally without any obvious histopathological abnormalities. (phoenixpeptide.com)

Several studies shown that Axl could mediate cell adhesion and aggregation through homotypic ectodomain associations (9 23 Both CUDC-305 (DEBIO-0932 ) murine and human being Axl proteins undergo proteolytic processing to yield a soluble form of this molecule. (exposed-skin-care.net)
What are proteases (proteolytic enzymes) and phosphatases? (thermofisher.com)

In this study, we showed that receptor-type PTPϵ (PTPϵM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163 were primary targets of PTPϵM. (bioone.org)
Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation. (colorado.edu)

Strikingly, most single-cell protein assays (for unmodified endogenous focuses on) are single-stage immunoassays, including enzyme-linked immunosorbent assays (with direct or sandwich readout) and immunocytochemistry, as well as newer immunoassay types designed to improve multiplexing using spatial barcoding15,16 or mass cytometry17. (irjs.info)

A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
This paper claims to identify a long-sought ligand for the receptor protein tyrosine phosphatase Lar that mediates its functions in neuromuscular junction development, mushroom body development, and photoreceptor axon targeting. (sciety.org)

Space-filling model of the PTEN protein (blue) complexed with tartaric acid (brown). (ayassbioscience.com)

[ 10 ] In one case, monoclonal IgM was found to target 50-, 31-, and 17-kd proteins within epidermal extracts. (medscape.com)

Anatomy18

Organisms14

Diseases2

Chemicals and Drugs146

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Phosphorylation11

Vascular Endothelial Protein Tyrosine Ph1

Kinases8

Dephosphorylation3

Residues6

Receptor-type protein3

Serine1

Pathways5

Dual specificity protein2

Phosphate1

PTPs1

Endothelial3

Residue2

Intracellular7

MAPK4

Fibronectin1

Isoforms5

Kinase activity2

Regulator2

PTP1B1

Family of proteins2

SuperFamily2

Dephosphorylates1

Binds1

CD453

Inhibitor5

Motifs2

Inhibition1

Activation3

Assay3

Domain10

Domains6

Signal transduction2

Activity3

Vitro1

Homologue1

Focal1

Intrinsic1

Membrane2

Cellular7

Overexpression1

Receptors3

Growth2

Signals1

Biological1

Proteolysis1

Proteolytic2

Type2

Endogenous1

Ligand2

PTEN1

Monoclonal1