• This gene encodes a member of the lysyl oxidase gene family. (joplink.net)
  • Subsequent work from her group showed that the extracellular protein lysyl oxidase, responsible for collagen and elastin cross-linking, contains a lysine cross-linked variant of TPQ, while mechanistic probes advanced knowledge of cofactor biogenesis and catalysis in the copper amine oxidases. (nationalmedals.org)
  • We further studied lysyl oxidase (LOX) expression in CRC tissue and demonstrated that LOX expression is closely correlated with CRC progression. (ijbs.com)
  • In the process of malignant transformation, progression and metastasis of tumors, the ECM is modified by many enzymes, including matrix metalloproteinases (MMPs) and lysyl oxidase (LOX) family oxidases. (ijbs.com)
  • Description: Quantitative sandwich ELISA for measuring Rat Lysyl oxidase (LOX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (antibody-tech.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Lysyl Oxidase (LOX) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (antibody-tech.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lysyl Oxidase (LOX) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (antibody-tech.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Lysyl Oxidase (LOX) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (antibody-tech.com)
  • They catalyse the oxidation of primary amines to aldehydes, with the subsequent release of ammonia and hydrogen peroxide, which requires one copper ion per subunit and topaquinone as cofactor: RCH2NH2 + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } RCHO + NH3 + H2O2 The 3 substrates of this enzyme are primary amines (RCH2NH2), H2O, and O2, whereas its 3 products are RCHO, NH3, and H2O2. (wikipedia.org)
  • In prokaryotes, the enzyme enables various amine substrates to be used as sources of carbon and nitrogen. (wikipedia.org)
  • The systematic name of this enzyme class is amine:oxygen oxidoreductase (deaminating) (copper-containing). (wikipedia.org)
  • A team has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. (sciencedaily.com)
  • Now, in a study recently published in ACS Catalysis , a team led by researchers at Osaka Medical and Pharmaceutical University and Osaka University has used neutron crystallography to image the atom-by-atom structure of a copper amine oxidase enzyme. (sciencedaily.com)
  • We disclose binding of a second molecule of high-affinity amine substrate during the enzymatic reaction, a previously unknown event in the enzyme active site," says Toshihide Okajima, senior author. (sciencedaily.com)
  • This work has provided previously undisclosed structural details in a copper amine oxidase enzyme that has many functions in biochemical metabolism. (sciencedaily.com)
  • and ACC oxidase (ethylene-forming enzyme or EFE) (Hamilton et al. (scite.ai)
  • Human kidney diamine oxidase has been overexpressed as a secreted enzyme under the control of a metallothionein promoter in Drosophila S2 cell culture. (rhea-db.org)
  • Importantly, we also uncovered a key enzyme, a copper amine oxidase, that converts the victorin peptide into the active form. (growkudos.com)
  • A team led by researchers at SANKEN (The Institute of Scientific and Industrial Research), at Osaka University has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. (asiaresearchnews.com)
  • Also, it is hypothesized that Histamine (biogenic amine), catabolized by Diamine oxidase (DAO), induces a vascular headache. (tci-thaijo.org)
  • Human kidney diamine oxidase: heterologous expression, purification, and characterization. (rhea-db.org)
  • Active compounds delayed the disappearance of histamine from the bathing solutions and inhibited colonic diamine oxidase, an effect mimicked by standard inhibitors aminoguanidine and semicarbazide. (mcmaster.ca)
  • these enzymes catalyze the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. (wikipedia.org)
  • When your wounds heal and your liver detoxifies a poison such as histamine you ingested, you can thank the class of enzymes known as copper amine oxidases for their assistance. (sciencedaily.com)
  • Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes. (tcd.ie)
  • The copper ion is coordinated with three histidine residues and two water molecules in a distorted square pyramidal geometry, and has a dual function in catalysis and TPQ biogenesis. (wikipedia.org)
  • The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. (joplink.net)
  • In l990, she demonstrated the presence of the neurotoxin, 6-hydroxydopa quinone (referred to as TPQ), at the active site of a copper-containing amine oxidase from bovine plasma, overcoming years of incorrect speculation regarding the nature of the active site structure and opening up the field of protein-derived quino-cofactors. (nationalmedals.org)
  • An additional domain is found at the N-terminal of some copper amine oxidases, as well as in related proteins such as cell wall hydrolase and N-acetylmuramoyl-L-alanine amidase. (wikipedia.org)
  • Importantly, LOX family oxidases (LOX and its family members, LOX-like proteins 1-4) are abnormally expressed in tumors and act as modifiers of the mechanical properties in the tumor microenvironment [ 12 ]. (ijbs.com)
  • It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. (lookformedical.com)
  • ACC oxidase activity was demonstrated in young Arabidopsis seedlings. (scite.ai)
  • Some copper amine oxidase enzymes exhibit unusual biochemistry, such as quantum tunneling, which enables otherwise inexplicably fast reaction rates. (sciencedaily.com)
  • Early studies on the sources of H2O2 mainly focused on NADPH oxidases and cell-wall peroxidases. (chinaagrisci.com)
  • Here, we report the involvement of polyamine oxidases (PAOs) in ethylene-induced H2O2 production in guard cells. (chinaagrisci.com)
  • DAO contains Copper as a cofactor and is coded by the Amine oxidase copper containing 1 (AOC1) gene. (tci-thaijo.org)
  • This study aims to determine the level of serum copper (Cu), an association of the AOC1 gene and antioxidant capacity in migraine patients. (tci-thaijo.org)
  • LOX is a secreted, copper-dependent amine oxidase and collagen cross-linker [ 13 ]. (ijbs.com)
  • AMT is also a monoamine oxidase A inhibitor that conceivably could contribute to its pharmacological effect and this drug also the most potent inhibitor of semicarbazide-sensitive amine oxidase (SSAO). (ncats.io)
  • The copper amine oxidase 3-dimensional structure was determined through X-ray crystallography. (wikipedia.org)
  • The copper amine oxidases occur as mushroom-shaped homodimers of 70-95 kDa, each monomer containing a copper ion and a covalently bound redox cofactor, topaquinone (TPQ). (wikipedia.org)
  • A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. (joplink.net)
  • The catalytic domain is the largest of the 3-4 domains found in copper amine oxidases, and consists of a beta sandwich of 18 strands in two sheets. (wikipedia.org)
  • The ACC content and the in vivo activity of ACC oxidase were determined. (scite.ai)
  • Copper-containing amine oxidases are found in bacteria, fungi, plants and animals. (wikipedia.org)
  • VAP-1 mediates adhesion via heavily sialidated side chains but it also functions as a cell surface expressed ectoenzyme-a primary amine oxidase. (biomedcentral.com)
  • Similar to other low-molecular-weight amines, it has a fishy odor. (hmdb.ca)
  • In the human brain, 2-phenethylamine is believed to function as a neuromodulator or neurotransmitter (a trace amine). (hmdb.ca)