Many drugs used to treat alcoholism in humans have been shown to lead to reduced ethanol consumption in mice used in this model. (wikipedia.org)
Alcohol7
However, little is presently known about the causal influence of circadian rhythm disruptions on sex differences in alcohol consumption. (mdpi.com)
Clock Δ19/Δ19 mutation) manipulations, and measured changes in alcohol consumption and preference using a two-bottle choice paradigm. (mdpi.com)
Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)
The use of animals selectively bred to prefer or to avoid alcohol has been highly instrumental in advancing the understanding of the neurobiological basis of ethanol preference. (aspetjournals.org)
Despite the above studies that focused on specific genes or categories of genes, there are few papers which provide characterization of the microglial transcriptome following alcohol treatment or consumption. (biomedcentral.com)
While pathway analysis identified many microglial associated functions, only a single study has directly examined the transcriptome of microglia acutely isolated from cortex of alcohol-fed mice [ 24 ]. (biomedcentral.com)
Seizures tend to be aggravated by sleep deprivation and alcohol consumption. (lookformedical.com)
Differences1
Research from his lab has shown that adult and adolescent mice given equal amounts of cocaine display significant differences in locomotor stimulation. (wikipedia.org)
Genes1
Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)
Susceptibility1
The lack of FcRn expression had minimal effects on the composition of the gut microbiome and did not affect susceptibility to C. difficile infection in nonimmunized mice. (bvsalud.org)
Drinking1
Rhodes was one of the developers of the Drinking in the Dark model in mice. (wikipedia.org)
Genetic3
In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)
We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. (researchsquare.com)
Genetic differentiation among autochthonous and cosmopolitan goat breeds based on information from microsatellite markers - a preliminary study. (krakow.pl)
Brain1
Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain. (researchsquare.com)
Model1
In this model, a specific mouse strain is found to voluntarily drink to the levels of intoxication. (wikipedia.org)
Human1
The database currently holds approximately 2000 complexes with the majority from Saccharomyces cerevisiae, human and mouse. (stanford.edu)
Permeable2
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. (lookformedical.com)
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. (lookformedical.com)
Alcohol consumption5
Studies that relate endophenotypes to alcohol responses such as sensitivity, tolerance and withdrawal severity will facilitate the determination of the genetic influences on the vulnerability to alcohol dependence and the gene and environment interactions contributing to the progression to compulsive alcohol consumption. (nih.gov)
Grm2 *407 was linked to increased alcohol consumption and preference in F2 rats generated by intercrossing inbred P and nonpreferring rats. (nih.gov)
Some of the key areas of alcoholism research where consilience between human and animal studies is possible are alcohol withdrawal severity, sensitivity to rewards, impulsivity, and dysregulated alcohol consumption. (nih.gov)
This article focuses on five of these areas, which encompass specific behavioral domains related to alcohol abuse: withdrawal, reward sensitivity, impulsivity, dysregulated alcohol consumption, and low level of response to alcohol. (nih.gov)
Unpacking genetic risk pathways for college student alcohol consumption: The mediating role of impulsivity. (academic-accelerator.com)
Cell Membrane1
Cell membrane glycoproteins that form channels to selectively pass chloride ions. (lookformedical.com)
Behavior2
As a career project, Rhodes tries to understand the evolution of behavior by selectively breeding for hyperactivity in mice. (wikipedia.org)
Repetitive Blast Mild Traumatic Brain Injury Increases Ethanol Sensitivity in Male Mice and Risky Drinking Behavior in Male Combat Veterans. (academic-accelerator.com)
Escalated alcohol self-a1
Pharmacologic blockade of mGluR2 escalated alcohol self-administration in Wistar rats, the parental strain of P and nonpreferring rats. (nih.gov)
Lead1
Many drugs used to treat alcoholism in humans have been shown to lead to reduced ethanol consumption in mice used in this model. (wikipedia.org)
Loss1
Selectively bred alcohol-preferring (P) rats are homozygous for a Grm2 stop codon (Grm2 *407) that leads to largely uncompensated loss of mGluR2. (nih.gov)
History1
To investigate potential translational relevance, we also examined self-report responses to the Alcohol Use Disorders Identification Test-Consumption Questions (AUDIT-C), a widely used measure to identify potential hazardous drinking and AUD, and used a novel unsupervised machine learning approach to investigate whether a history of blast-mTBI affected drinking behaviors in Iraq/Afghanistan Veterans. (academic-accelerator.com)