• Metabolic syndrome is an important cause of cardiovascular disease. (who.int)
  • Nearly 35 percent of U.S. adults are estimated to have metabolic syndrome, which significantly increases the risk of cardiovascular disease and type 2 diabetes. (medindia.net)
  • Metabolic syndrome (MetS) is a cluster of interrelated metabolic conditions which increase the risk of developing cardiovascular disease (Kaur, 2014). (ugr.es)
  • The study found the Mediterranean diet supplemented with virgin olive oil or nuts can deliver a host of health benefits related to cardiovascular disease, diabetes, metabolic syndrome and brain health. (australian-macadamias.org)
  • Can metabolic syndrome usefully predict cardiovascular disease and diabetes? (medscape.com)
  • The U.K. researchers found Montmorency tart cherry juice led to a significant, clinically-relevant reduction in systolic blood pressure when compared to the placebo 2 hours after consumption, and Montmorency tart cherry juice and Montmorency tart cherry capsules both lowered insulin levels significantly more than the placebo at 1 hour and 3 hours, respectively. (medindia.net)
  • In the present study, a high-fructose diet fed rat model of hypertriglyceridemia, dyslipidemia, insulin resistance and hepatic steatosis was employed to investigate the global transcriptional changes in the lipid metabolizing pathways in three insulin sensitive tissues: liver, skeletal muscle and adipose tissue in response to chronic dietary administration of NDGA. (biomedcentral.com)
  • Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)
  • Blood levels of the hormone adiponectin-which promotes insulin sensitivity along with healthy blood sugar and lipid levels, were also higher in those who took astaxanthin. (optixanthin.com)
  • A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)
  • Emulsifiers are also supposedly linked to metabolic syndrome - a group of very common obesity-related disorders that can cause type-2 diabetes, cardiovascular and liver conditions. (tips-healthy.com)
  • All of the above-mentioned disorders contribute to metabolic syndrome and are related to the development of type 2 diabetes and ischaemic heart disease. (hindawi.com)
  • Metabolic syndrome is a group of very common obesity-related disorders that can lead to type-2 diabetes, cardiovascular and/or liver diseases. (eurekalert.org)
  • So, in 40 out of 70 percent of people with normal weight, doctors diagnose metabolic disorders. (healsens.com)
  • Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. (researchsquare.com)
  • The global prevalence of two medical conditions constituting a major burden on public health systems is on unrelenting rise over the last decades: obesity-related cardiometabolic diseases and mood disorders. (researchsquare.com)
  • The Joslin Diabetes Center has created a BMI calculator for Asian people, and this resource lowers the beginning point for overweight BMI to 23 and the beginning point for obesity to 27. (everydayhealth.com)
  • Furthermore, the WHO outlined overweight as a "body mass index (BMI) more than or equivalent to 25, and obesity as a BMI above or equally 30" [13] . (diabeets.com)
  • It should be understood that metabolic syndrome is a problem for not only overweight people. (healsens.com)
  • In the Western countries, cutoff points of 25 and 30 kg/m2 are used for describing overweight and obesity. (eurekaselect.com)
  • The international obesity task force (IOTF) suggested the cutoff points to be 23 kg/m2 for overweight and 25 kg/m2 for obesity in Asian countries. (eurekaselect.com)
  • Malaysia has the highest rate of obesity among Asian countries, with 64% of male and 65% of female population being either obese or overweight 2 . (optixanthin.com)
  • Globally, 44% of the burden of disease due to diabetes, 23% of that due to ischaemic heart disease, and 7% to 41% for certain cancers, particularly breast cancer, are attributable to overweight and obesity. (who.int)
  • Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)
  • Overweight and obesity are significantly associated with metabol- tients and the general population. (cdc.gov)
  • However, no systematic effort has lipoprotein cholesterol [HDL-C], elevated triglycerides, and apoli- explored the effect of overweight and obesity on the prevalence of poprotein B-containing lipoproteins), elevated blood pressure, el- metabolic syndrome in India. (cdc.gov)
  • If similar results are obtained, it would indicate a role for this class of food additive in driving the epidemic of obesity, its inter-related consequences and a range of diseases associated with chronic gut inflammation. (eurekalert.org)
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
  • Brand new research published in the last few weeks reveals important information for people with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Fibromyalgia (FM). (wellnessresources.com)
  • It improves insulin sensitivity, reduces cholesterol and triglyceride production, and suppresses chronic inflammation. (wellnessresources.com)
  • Non-alcoholic fatty liver sickness (NAFLD) is a variety of liver pathological conditions that intensely related to other chronic diseases including obesity and diabetes. (egyptianjournal.xyz)
  • It is also defined as the hepatic factor interventions involving eating regimen, weight for metabolic syndrome and the most long- reduction and exercise which could decrease the established etiology for international chronic activity and biomarkers of NAFLD in adults. (egyptianjournal.xyz)
  • As a consequence, there has also been a marked increase in the prevalence of type 2 diabetes all over the world and this chronic metabolic disease is now considered as a coronary heart disease risk equivalent. (researchgate.net)
  • Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomized controlled trials. (cranberryinstitute.org)
  • One of the characteristics of obesity and insulin resistance is low-grade chronic inflammation. (ambersnaturalnutrition.com)
  • Waterpipe smoking, sex, low-density lipoprotein and wrist circumference were also associated with metabolic syndrome. (who.int)
  • Identifying risk factors for erectile dysfunction, including as smoking, obesity, sedentary lifestyle, and persistent alcohol intake, is crucial for preventing erectile dysfunction ( 6 - 8 ). (frontiersin.org)
  • Because type 2 diabetes in children and adolescents is strongly associated with obesity and sedentary lifestyle, any intervention designed to increase physical activity and improve dietary habits should be encouraged. (medscape.com)
  • According to a 2017 review published in the journal Nutrients , "diets rich in carbohydrates, and notably rich in refined sugars and fructose, are associated with the metabolic syndrome … carbohydrate restriction has been proposed to be the single most effective intervention for reducing all features of the metabolic syndrome. (draxe.com)
  • However, the potential roles of BACE1 in insulin resistance and the risk of cognitive impairment in T2DM remain unclear. (bvsalud.org)
  • DISCUSSION: The elevated BACE1 levels in T2DM may contribute to increasing the cognitive impairment risk through both amyloidogenesis and insulin resistance. (bvsalud.org)
  • Importantly, both lifestyle (diet and exercise) and pharmacological interventions that are known to alleviate peripheral IR effectively restore hippocampal neuroplasticity in rodent models of T2DM and AD, and this effect may be due to restoration of insulin signalling in the hippocampus. (nature.com)
  • This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD. (nature.com)
  • HFD ± NDEA caused T2DM, neurodegeneration with impairments in brain insulin, insulin receptor, IGF-2 receptor, or insulin receptor substrate gene expression, and reduced expression of tau and choline acetyltransferase (ChAT), which are regulated by insulin and IGF-1. (biomedcentral.com)
  • There are limited data on the prevalence rate of Metabolic Syndrome (MetS) among college students attending any Historically Black College and University (HBCU), which are mostly attended by young African Americans (AA). (biomedcentral.com)
  • However, the wide variation in geographic distribution of MetS emphasizes that the consumption of excess calories and lack of physical activity are the major contributors to the development of the disease. (healsens.com)
  • If similar results are acquired, it would indicate a duty for this course of food additive in driving the epidemic of obesity, its inter-related consequences and a variety of diseases related to persistent gut swelling. (tips-healthy.com)
  • meaning that at the same BMI, they may have a lower risk of developing obesity-related diseases. (everydayhealth.com)
  • Metabolic syndrome is an unhealthy metabolism that leads to fatal diseases such as heart attacks, diabetes , and cancer. (healsens.com)
  • Thus, care with the obesity control in children and adolescents with DS should be redoubled, because excess body fat is one of the characteristics of the syndrome, which can seriously contribute to the increased incidence of several diseases. (bvsalud.org)
  • These conditions are normally caused by central obesity and physical inactivity, which further increases the risk of cardiovascular diseases (CVD), particularly heart failure. (optixanthin.com)
  • As with other diseases, careful history taking is important in metabolic syndrome. (medscape.com)
  • [ 11 , 12 ] C3 hypocomplementemia likely contributes to the association of this syndrome with autoimmune diseases and with a propensity for patients to acquire bacterial infections. (medscape.com)
  • A waistline of 102 cm or more for men and 88 cm or more for women (measured across the belly) is the form of central obesity most strongly associated with metabolic syndrome which is a collection of risk factors such as high cholesterol, insulin resistance and high blood pressure. (nestle-family.com)
  • Since HDL particles carry the "good cholesterol" and are highly anti-atherogenic particles, the lowering of plasma HDL levels in obesity, is of particular concern. (eurekaselect.com)
  • However, even in the absence of the hyperglycaemic state which characterizes type 2 diabetic patients, non diabetic individuals with a specific form of obesity, named abdominal obesity, often show clustering metabolic abnormalities which include high triglyceride levels, increased apolipoprotein B, small dense low density lipoproteins and decreased high density lipoproteins-cholesterol levels, a hyperinsulinemic-insulin resistant state, alterations in coagulation factors as well as an inflammatory profile. (researchgate.net)
  • In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
  • It's also used for high levels of cholesterol or other fats (lipids) in the blood, diabetes, obesity, and many other conditions. (medlineplus.gov)
  • Good Metabolic Health is the absence of abnormalities in blood sugar levels, triglycerides, blood pressure levels and central obesity. (healthifyme.com)
  • No significant differences were found in hepatic insulin signaling, as assessed by phosphorylation of INSR or AKT levels or in activation of the insulin-responsive transcription factor SREBP-1c. (bvsalud.org)
  • METHODS: We measured plasma BACE1 levels, BACE1 cleavage activities for Swedish mutant amyloid precursor protein (APPsw) and insulin receptor ß subunit (INSR-ß), and soluble INSR (sINSR) levels in a clinical cohort study. (bvsalud.org)
  • Moreover, the glycemic status correlated with elevated BACE1 levels and BACE1-mediated INSR cleavage, which was associated with insulin resistance. (bvsalud.org)
  • Montmorency tart cherries reduced systolic blood pressure, insulin levels, and insulin concentrations in adults with metabolic syndrome participating in a small pilot study. (medindia.net)
  • Consuming Montmorency tart cherry juice and capsules can reduce blood pressure (BP), insulin levels and triglycerides. (medindia.net)
  • Increased activity alone can improve your insulin levels. (nestle-family.com)
  • In addition, a prospective Quebec study has found that even with no increase in blood sugar, elevated insulin levels (i.e., insulin resistance) are associated with a risk of coronary heart disease. (healsens.com)
  • Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (eurekaselect.com)
  • In children and adolescents with Down syndrome (DS), high obesity levels were also recorded from the 80's to the present days 5,6 . (bvsalud.org)
  • Therefore, the study of the body fat behavior through the assessment of the body composition, occupies an important space in the identification of the levels of obesity in various populations, especially in children and adolescents with Down syndrome. (bvsalud.org)
  • Research (New England Journal of Medicine) shows that this is because low-carb diets help rid the body of excess water, lowering insulin levels and leading to rapid weight loss within the first month, or sooner. (superfat.com)
  • Studies prove that cutting carbs lowers both blood sugar and insulin levels drastically. (superfat.com)
  • At the end of the study, the mean insulin and HOMA-IR levels were significantly lower in the cranberry group compared with the placebo group. (cranberryinstitute.org)
  • Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2014). (benthamscience.com)
  • While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
  • The use of anti-obesity drug has become increasingly common in the last 30 years. (eurekaselect.com)
  • 2003). Changes in lifestyle, i.e. caloric restriction, low fat and low glycemic index diets, consumption of foods rich in beneficial bioactive ingredients, and regular physical activity, are the primary interventions chosen to improve the alterations associated with the specific pathology. (ugr.es)
  • Metabolic syndrome is an asymptomatic pathophysiological condition characterized by high blood pressure, central obesity, insulin resistance, dyslipidaemia and hyperglycaemia (1). (who.int)
  • Most studies on the incidence and risk factors of metabolic syndrome have been conducted in developed countries or regions where the populations have a relatively high socioeconomic status. (who.int)
  • Metabolic problems like Hyperuricemia/Gout where high level of uric acid in blood damages lumbar spine also this uric acid may get crystalised to form monosodium urate monohydrate and settle in the intervertebral joints and damage them. (atomictherapy.org)
  • Metabolic syndrome is an asymptomatic pathophysio- a relatively high socioeconomic status. (who.int)
  • Few studies have logical condition characterized by high blood pressure, been done in more deprived regions and regions with low central obesity, insulin resistance, dyslipidaemia and income (9) . (who.int)
  • Obesity linked with high consumption of ready-to-eat meals equally exists in low- and middle-income countries (LMICs) and high-income countries (HICs) [7-12] . (diabeets.com)
  • Researchers observed that communities who show high fish consumption patterns have lower risks of heart attacks and strokes. (naturalfoodseries.com)
  • In diabetic men, components of the insulin resistance syndrome (IRS) loaded on Factor 1 (the insulin resistance factor), which reflected high fasting insulin, obesity (high BMI), central obesity (high waist-to-hip ratio), high total triglycerides, and a short duration of diabetes. (diabetesjournals.org)
  • 11 , 12 Visceral obesity is associated with hyperleptinemia, leptin-resistance and hypoadiponectinemia configuring a high cardiovascular risk phenotype. (dovepress.com)
  • Obesity is associated with an increased risk of diabetes and metabolic syndrome, characterized by high triglycerides and high blood sugar. (ambersnaturalnutrition.com)
  • Interventions promoting physical activ- ity should be developed and implemented in phases in high-prevalence ic syndrome. (cdc.gov)
  • Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)
  • Electrophoresis of the rats' plasma proteins was performed, followed by Western Blot (WB) for insulin and for the outer portion of the insulin receptor. (bvsalud.org)
  • The bands corresponding to insulin and to the receptor external part were at the same molecular weight level, 25-fold higher than that of free insulin. (bvsalud.org)
  • Soluble insulin receptor increase in blood might be an early sign of metabolic syndrome. (bvsalud.org)
  • Figure 3: Insulin receptor signalling in the hippocampus. (nature.com)
  • Insulin signaling through the insulin receptor increases linear growth through effects on bone and the GH-IGF-1 axis. (medscape.com)
  • Intermittent fasting is one of the ways to boost your metabolism and keep your metabolic health. (healthifyme.com)
  • Any abnormalities in metabolism can lead to metabolic syndrome. (healthifyme.com)
  • While detailed mechanisms underlying the effect of emulsifiers on metabolism remain under study, the team points out that avoiding excess food consumption is of paramount importance. (eurekalert.org)
  • A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
  • The prevalence of metabolic and cardiovascular comorbidities increased with increasing OSA severity. (cdc.gov)
  • screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
  • Polycystic ovary syndrome (PCOS), a common cause of infertility, often coexists with obesity, too. (everydayhealth.com)
  • Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis. (medscape.com)
  • Central obesity refers to excessive abdominal fat around the stomach area, which increases your chances significantly towards developing this disease. (getoberit.com)
  • As a result of rapid economic changes, the increased popularity of the western lifestyle and lack of physical activity, the world faces the threat of obesity and type 2 diabetes epidemics. (who.int)
  • If the current trend in obesity and type 2 diabetes continues unchanged, the incidence of metabolic syndrome will be expected to increase, especially in developing countries (2,6). (who.int)
  • Study design and sample the threat of obesity and type 2 diabetes epidemics. (who.int)
  • metabolic syndrome, type 2 diabetes, cardiovascular lesions and malignancies. (benthamscience.com)
  • Obesity is considered a major risk factor for insulin resistance and type 2 diabetes. (draxe.com)
  • In type 2 diabetes, the body gradually has reduced effectiveness when utilizing its insulin. (liquid-nutrition-vitamins.com)
  • Type 2 diabetes interferes with the body's natural system of responding to insulin as the body becomes less sensitive to its own insulin. (liquid-nutrition-vitamins.com)
  • Helping the body to utilize its own insulin is of the utmost importance in treating type 2 diabetes, as this disorder is caused by insulin resistance. (liquid-nutrition-vitamins.com)
  • Type 2 diabetes is a condition in which the pancreas gradually loses the capacity to produce enough insulin, or when the body becomes resistant to the normal effects of insulin. (optixanthin.com)
  • Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
  • A study by Loimaala et al study showed that long-term endurance and strength training resulted in improved metabolic control of type 2 diabetes compared with standard treatment. (medscape.com)
  • The role of fructose in NAFLD (steatosis) pathogenesis has received a great deal of attention in part because from 1999 to 2004 the consumption of fructose increased by ~32 % [ 36 ]. (biomedcentral.com)
  • Montmorency tart cherries can offer amazing health-promoting benefits for adults with metabolic syndrome, reports a new study. (medindia.net)
  • Global rates of metabolic syndrome are on the rise, and the results of the present study suggest Montmorency tart cherries, in juice or capsule form, could exert beneficial effects for adults with this condition when incorporated into an overall healthy diet," said Desai. (medindia.net)
  • Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
  • A study by Fasset on adults with metabolic syndrome showed that astaxanthin supported healthy blood circulation and promoted arterial health 8 . (optixanthin.com)
  • Dairy consumption and related nutrient intake in African-American adults and children in the United States: continuing survey of food intakes by individuals 1994-1996, 1998, and the National Health And Nutrition Examination Survey 1999-2000. (thefunctionalmedicinecenter.com)
  • Risk Factors and Metabolic Syndrome Among Adults in India: A We searched databases PubMed Central, EMBASE, MEDLINE, Systematic Review and Meta-Analysis of Observational Studies. (cdc.gov)
  • They observed that emulsifier consumption changed the species composition of the gut microbiota and did so in a manner that made it more pro-inflammatory. (eurekalert.org)
  • The effects of emulsifier consumption were eliminated in germ-free mice, which lack a microbiota. (eurekalert.org)
  • Insulin signaling is preserved in skeletal muscle during early diabetic ketoacidosis. (medscape.com)
  • But for the purposes of this guide, we'll focus on the World Health Organization's (WHO) definition of obesity: abnormal or excessive fat accumulation in the body that may pose a risk to your health. (everydayhealth.com)
  • Obesity in Adolescents Obesity is now twice as common among adolescents than it was 30 years ago and is one of the most common reasons for visits to adolescent clinics. (msdmanuals.com)
  • to evaluate the prevalence of obesity and the body fat topography in children and adolescents from both sexes aged 6 to 19 years old with Down syndrome, residents in the city of Campinas, São Paulo. (bvsalud.org)
  • the assessment of the prevalence of obesity and subcutaneous fat topography are important resources to support researchers, and practitioners who work directly on improving the quality of life of children and adolescents with Down syndrome. (bvsalud.org)
  • Is metabolic and bariatric surgery a safe and effective therapeutic option for adolescents with severe obesity? (medscape.com)
  • Pediatric obesity remains an ongoing serious international health concern affecting ~17% of US children and adolescents, threatening their adult health and longevity. (medscape.com)
  • Adolescents undergoing lifestyle therapy, medication regimens, or bariatric surgery for obesity will need cohesive planning to help them effectively transition to adult care, with continued necessary monitoring, support, and intervention. (medscape.com)
  • Obesity can not only lower quality of life during childhood but may increase the chance that the excess weight will persist into adulthood, says Sheila Perez-Colon, MD , who is a double-board-certified pediatric oncologist and practices at Elite Endocrine MD in San Juan and Dorado, Puerto Rico. (everydayhealth.com)
  • The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
  • Endocrine etiologies for obesity are rare and usually are accompanied by attenuated growth patterns. (medscape.com)
  • The application of WHtR provides an alternative anthropometric index of central obesity that avoids the limitations of WC because the inclusion of height into the index enhances the avoidance of any potential confounding of cardiometabolic risk by height [ 19 ]. (hindawi.com)
  • Likewise, more than standard salt intake adversely affects the cardiovascular system, renal system, and central nervous system (CNS), especially the brain. (diabeets.com)
  • It encourages frequent intake of fish and shellfish, moderate consumption of wine with meals, and low intake of red and processed meat, milk and milk products and simple sugars. (australian-macadamias.org)
  • Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)
  • Studies suggest that the keto diet helps improve metabolic health markers in several ways: the diet tends to reduce overall caloric intake, increases satiety (fullness after eating), may increase the thermal effect of eating (calories we burn digesting food) due to higher protein intake, and increases gluconeogenesis, which is increased with carbohydrate restriction and is energy demanding. (draxe.com)
  • the obvious preventive strategy against the calcium-alkali syndrome is to limit the intake of calcium to no more than 1.2 to 1.5 grams per day. (qualitycounts.com)
  • With increasing age, consumption of fried foods declined, whereas fish intake increased. (cdc.gov)
  • however, this may vary significantly by age, dietary habits, gender, and even among participants with morbid obesity [ 9 ]. (hindawi.com)
  • Obesity increases the chances that you'll experience severe illness, become hospitalized, or die if you contract COVID-19. (everydayhealth.com)
  • The number of patients with metabolic syndrome increases with age. (hindawi.com)