Acetylcholine precursors, such as choline and lecithin, have not proven beneficial, but inhibition of acetylcholine metabolism using inhibitors of acetylcholinesterase has been found to be partially successful in improving symptoms of Alzheimer disease. (nih.gov)
Computational Psychiatry is at least partially motivated by the shortcomings of the current psychiatric classification systems (the Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, 1 and the International Classification of Diseases, or ICD-10 2 ), in which the symptoms entail the diagnosis and which lack mechanistic explanations for mental symptoms. (bmj.com)
Conditions2
These cohorts will be defined by the applicant and can include subjects with specific symptoms or conditions, with comorbid conditions, with a specific genetic profile, or other applicant defined criteria. (nih.gov)