• It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • Only 60% of yeast and 73% of the human RBPs have functions assigned to RNA biology or structural motifs known to convey RNA binding, and many intensively studied proteins surprisingly emerge as RBPs (termed 'enigmRBPs'), including almost all glycolytic enzymes, pointing to emerging connections between gene regulation and metabolism. (nature.com)
  • We show that this conserved RNA interactome harbours many proteins without previously assigned roles in RNA biology (enigmRBPs), including surprisingly many metabolic enzymes. (nature.com)
  • RVxP motif is a protein motif involved in localizing proteins into cilia. (wikipedia.org)
  • Examples of proteins with RVxP motifs associated with cilia: Mouse Ahi1, the homologue of human AHI1, fails to localize to cilia if its RVxP sequence is mutated. (wikipedia.org)
  • Other proteins associated with cilia for which the occurrence of a RVxP motif has been discussed are PKD1 and PSEN2. (wikipedia.org)
  • YXXL motifs in cellular and viral proteins have a variety of functions. (iucc.ac.il)
  • OXR1 contains the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) domain, a motif present in a family of proteins including TBC1 domain family member 24 (TBC1D24), a protein mutated in a range of disorders characterized by seizures, hearing loss, and neurodegeneration. (ox.ac.uk)
  • Further, we describe the separation of the ALP and Enigma subfamilies in lower vertebrates and identify a novel consensus motif, which we call 'ALP-like motif' (AM). This motif is highly-conserved between ALP subfamily proteins of diverse organisms. (princeton.edu)
  • The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
  • All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
  • These proteins had a signal sequence in the amino-terminal end and a cell wall-sorting region in the carboxy-terminal end, which contained an LPATG-motif, a hydrophobic domain and a positively charged tail. (lu.se)
  • All isolates had either one or two of these asp-genes located in a conserved locus, designated Locus encoding Aerococcal Surface Proteins (LASP). (lu.se)
  • For other Gram-positive bacteria, cell wall-anchored surface proteins with an LPXTG-motif play a key role for virulence. (lu.se)
  • A superfamily of proteins that share a highly conserved MADS domain sequence motif. (bvsalud.org)
  • A search for short sequence patterns revealed a number of motifs which are over-represented in EC-CNSs relative to CNSs from the control gene sets. (duke.edu)
  • This sequence is conserved among species. (wikipedia.org)
  • Using a multiple alignment of 175 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified with the program PCPMer. (utmb.edu)
  • This highly conserved sequence consists of aspartic acid followed by phenyalalanine and isoleucine ( Losh,2015 , Falk,2014 ). (eu.org)
  • Additionally, the aspartic acid of the highly conserved sequence interacts via electrostatic and polar interactions with an arginine and an asparagine side chain of Mtr4 ( Falk,2014 , 4U4C ). (eu.org)
  • The next position downstream of the highly conserved sequence accepts serine, alanine, proline, lysine and glutamine. (eu.org)
  • The sequence contains a conserved tyrosine (Y390) whose phosphorylation is induced by agrin and whose mutation abolished clustering of β loop chimeras and their ability to inhibit agrin-induced clustering of the endogenous AChR. (jneurosci.org)
  • This amino acid sequence is conserved in organisms as diverse as yeast and humans. (the-scientist.com)
  • The most highly conserved motif within the RBD is the ribonucleoprotein consensus sequence (RNP-CS). (the-scientist.com)
  • G4 motifs peaked around the 5' untranslated region (5' UTR), the first coding domain sequence, and the first intron start sites on antisense strands. (usda.gov)
  • A helix initiation motif and a helix termination motif segment can be found at either end of the alpha-helical rod and are highly conserved in sequence between keratins. (medscape.com)
  • Scholars@Duke publication: Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. (duke.edu)
  • This review aims to link recent molecular data, often translated into amino acid sequences and predicted three dimensional structural motifs, to known mechanical properties. (bioone.org)
  • DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)
  • The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. (ox.ac.uk)
  • The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
  • Members of the evolutionarily conserved Nanos gene family are preferentially expressed in the ovaries and are known to play an important role in germ cell development, maintenance, and survival [ 24 - 30 ]. (hindawi.com)
  • The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. (nih.gov)
  • It was found that the G/SxS selectivity filter (glycine/serine, non-conserved residue, serine) and other well conserved residues play a crucial role in ion selectivity. (surrey.ac.uk)
  • Following the evaluation of the model and the identification of motifs characteristic of the Flaviviridae family, data from previous publications on the treatment of HCV were incorporated, with the aim of detecting the ideal residues in the Spondweni model, which are similar to those of the HCV structure and are inhibitor targets. (spandidos-publications.com)
  • Fast, sensitive discovery of conserved genome-wide motifs" by NNamdi E. Ihuegbu, Gary D. Stormo et al. (wustl.edu)
  • In this study, genome-wide identification of G4 motifs in barley was performed, followed by a comparison of genomic distribution and molecular functions to other monocot species, such as wheat, maize, and rice. (usda.gov)
  • Scanning mutagenesis of this motif showed that the glycine residue at position 470 was crucial for TelE membrane destabilization activity. (pasteur.fr)
  • The motif in the ENaC/DEG Family is (G/S)XS, where X is a non-conserved residue within this ion channel family. (surrey.ac.uk)
  • RED motif mutations dramatically reduce helicase activity, and the DRD and ThM, which flank the RED motif, appear structurally as well as functionally analogous to the MutS mismatch recognition and DNA polymerase thumb domains. (neb.com)
  • As with most other keratin disorders, most mutations in pachyonychia congenita occur in these highly conserved helix boundary domains at the end of the rod domain. (medscape.com)
  • The TLDc domain is highly conserved across species, although the structure-function relationship is unknown. (ox.ac.uk)
  • The cryo-EM structure of SW186 bound to the receptor-binding domain (RBD) of the viral spike protein showed that SW186 interacted with an epitope of the RBD that is not at the interface of its binding to the ACE2 receptor but highly conserved among SARS coronaviruses. (flutrackers.com)
  • While DNMT3, the maintenance DNA methyltransferase DNMT1, HELLS, and CDCA7 are all highly conserved in vertebrates and green plants, they are frequently co-lost in other evolutionary clades. (elifesciences.org)
  • Here we report the 2.8 ¿ resolution crystal structure of the highly conserved S15-rRNA complex. (unboundmedicine.com)
  • One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. (cdc.gov)
  • Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. (lu.se)
  • As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • G4 containing genes in monocots showed conserved molecular functions like transcription initiation and hydrolase activity. (usda.gov)
  • Autophagy is a bulky catabolic process that responds to nutrient homeostasis and extracellular stress signals and is a conserved mechanism in all eukaryotes. (rcsb.org)
  • 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. (elifesciences.org)
  • It is conceivable that a conserved OR is tuned to signals that are relevant for both species, although their ecological roles are yet unknown. (frontiersin.org)
  • Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
  • Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity. (pasteur.fr)
  • Seven homologs of TelE harboring a conserved glycine zipper motif at the C terminus were identified in different SGG isolates. (pasteur.fr)
  • Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes within a conserved functional core. (neb.com)
  • Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure? (hindawi.com)
  • The RxxxH motif gives R3H domain its name. (nih.gov)
  • Caenorhabditis elegans Arl13b requires a RVxP motif to localize to cilia, a property shared by human ARL13B but in the latter case a coiled-coil domain is also needed. (wikipedia.org)
  • The YAGL motif did not act as a late (L) domain, however, since hMPV budding was independent of the cellular endosomal sorting complex required for transport (ESCRT) machinery and because replacement of the YAGL motif with classical L domains generated defective viruses. (iucc.ac.il)
  • Another motif, DPHK, is in the DNA-binding domain. (cdc.gov)
  • The consensus motif has been used by many investigators to assign an RNA-binding function to newly discovered. (the-scientist.com)
  • The poly(A) polymerase Trf4 ( P53632 or Trf5 P48561 ) binds to the DExH core ( PF00270 ) of Mtr4 ( P47047 ) via a short motif. (eu.org)
  • This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
  • This short motif is about 40 amino acids in length. (nih.gov)
  • CNSs which contain this motif are no closer to the promoter than an average CNS. (duke.edu)
  • Additionally, single-nucleotide polymorphisms (SNPs) was shown to be depleted in G4 motifs in comparison to the promoter region. (usda.gov)
  • The non-covalent binding of Trf4 and Mtr4 is mediated via a short motif, which interacts with the DExH core of Mtr4. (eu.org)
  • Protein S15 interacts in the minor groove with a G-U/G-C motif and a three-way junction. (unboundmedicine.com)
  • Human PKD2 trafficking into cilia has been found in vitro to rely on a N-terminal RVxP motif as PKD2 mutants with alterations in this motif do not appear in cilia. (wikipedia.org)
  • Algal MIPs, high diversity and conserved motifs. (lu.se)
  • Combined analyses of these and recently published data sets define the core RBP repertoire conserved from yeast to man. (nature.com)
  • Here we identify a large set of RBPs that are conserved between yeast and human cells. (nature.com)
  • Our results demonstrate a conserved function of an odorant receptor in two moths that are phylogenetically and ecologically distant. (frontiersin.org)
  • Together, these findings suggest that agrin-induced phosphorylation of the β subunit motif increases the stoichiometry of rapsyn binding to the AChR, thereby helping to stably cluster the receptor and anchor it at high density in the postsynaptic membrane. (jneurosci.org)
  • gallolyticus (SGG) were sequenced and a genetic locus encoding the type VIIb secretion system (T7SSb) was found conserved and absent from 16 genomes of the closely related S. gallolyticus subsp. (pasteur.fr)
  • This motif is also found in animal CNGB1 homologues. (wikipedia.org)
  • This motif is also found in animal PKD2 homologues but not in Hydra. (wikipedia.org)
  • Seventeen other conserved motifs were found in PgNACs . (biomedcentral.com)
  • These results demonstrated that SW186 neutralizes diverse SARS coronaviruses by binding to a conserved RBD epitope, which could serve as a target for further antibody development. (flutrackers.com)
  • Both binding partners exhibit a similar α-helical structure containing a conserved binding motif termed AFIM. (rcsb.org)
  • The non-covalent binding of Trf4 ( P53632 ) and the DExH-helicase core of Mtr4 ( P47047 , PF00270 ) is mediated by the described motif, which is conserved in both Trf4 ( P53632 ) and Trf5 ( P48561 ) in Fungi . (eu.org)
  • Reference: Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair. (neb.com)
  • This is followed by the core motif. (eu.org)
  • The latter is constrained by a conserved base triple and stacking interactions, and locked into place by magnesium ions and protein side chains, mainly through interactions with the unique three-dimensional geometry of the backbone. (unboundmedicine.com)
  • Human ATP1A4 has a motif similar to RVxP that may play a role in localizing the protein to sperm flagella. (wikipedia.org)
  • Finally, we demonstrate that the role of PilU as a PilT-dependent retraction ATPase is conserved in Acinetobacter baylyi , suggesting that the role of PilU described here may be broadly applicable to other type IVa pilus systems. (biorxiv.org)
  • Conserved RBPs harbour defined repetitive motifs within disordered regions, which display striking evolutionary expansion. (nature.com)
  • More importantly, chromatin immunoprecipitation (ChIP) coupled with high-throughput sequencing captured C/EBPα motif signatures at the enhancer regions of the ULBP 2/5/6 genes. (bvsalud.org)