ResiduesCarbohydrate moietiesAminoProteinSequenceInteractionsInhibitorDiscoveryOccursEvolutionaryStructural conservationSpeciesPolarRecognitionAnalysisSiteScience and TechnoStructurePresenceValuesHighAromaticReceptorAssumptionProteinsAdenosineInducesEvolutionary ConservationCovalentDerivativesEnvironmental conservationHydrogenFunctionalHERITAGEEnzymesMassMechanismImplicationsImportantSideUniqueEffectsAffectEnergyCultural
Residues3
- Phylogenetic analysis of FlvF and related fungal homologues reveals conservation of residues that interact with the tetracyclic sesquiterpene in this model, but less conservation of residues interacting with the pendant amino moiety. (anl.gov)
- Sequence comparison associated with three-dimensional modeling of the LBP revealed that the residues contacting the amino acid moiety of glutamate (the alpha-COO(-) and NH(3)(+) groups) were conserved in mXRs, whereas the residues interacting with the gamma-carboxylic group were not. (pasteur.fr)
- This has revealed remarkably poor overall conservation at the site thought to be involved in actin binding, but several highly conserved residues have been identified that may be functionally important. (embl.de)
Carbohydrate moieties3
- We extend our structural characterization of NiV-G with mass spectrometric analysis of the carbohydrate moieties. (ox.ac.uk)
- Lectin blotting of frog, chicken and bovine desmosomal glycoproteins demonstrated that the carbohydrate moieties were different in these species. (soton.ac.uk)
- It is possible that desmosomal carbohydrate moieties have a role in controlling desmosome formation. (soton.ac.uk)
Amino2
- Ubiquitin is a small eukaryotic protein of 76 amino acids whose name (i.e., it occurs ubiquitously) results from its remarkable evolutionary conservation [1]. (123dok.net)
- Together, these results indicate that the structure of the rhodopsin N terminus must be maintained by an appropriate amino acid sequence surrounding N2 and may require a carbohydrate moiety at N15. (jneurosci.org)
Protein2
- For example, although a protein in a phosphorylation cycle is conserved during the interconversion, over a longer time scale, there will be low levels of protein synthesis and degradation, which change the level of protein moiety. (wikipedia.org)
- Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing comparative protein structure prediction methods, we are now able to quantify the relationship between sequence and structure conservation in RNA. (biomedcentral.com)
Sequence1
- However, to date no general large-scale study has systematically addressed the quantitative analysis of the relationship between sequence and structure conservation in RNA molecules. (biomedcentral.com)
Interactions2
- This difference stems from the fact that the aminoquinoline moiety of huprine X makes interactions similar to those made by tacrine, but additional bonds to the enzyme are made by the huperzine-like substructure and the chlorine atom. (proteopedia.org)
- The interactions between the thumb domain and the RNA primer are concentrated in a contiguous region of five nucleotides, from position two to six of the RNA primer and involve solely the ribose and phosphate moieties of the RNA backbone. (cathdb.info)
Inhibitor2
- It is a synthetic hybrid that contains the 4-aminoquinoline substructure of one anti-Alzheimer drug, tacrine, and a carbobicyclic moiety resembling that of another AChE inhibitor, (-)-huperzine A. Cocrystallization of huprine X with Torpedo californica AChE yielded crystals whose 3D structure was determined to 2.1 A resolution. (proteopedia.org)
- Some of the tested stones were then treated with a non-toxic phospho-organic compound containing carboxylic moieties as a salt inhibitor and the corresponding non-phosphorylated compound, as aqueous solutions at different concentrations. (csic.es)
Discovery1
- The high degree of structural conservation in and around the IspF active site suggests that any structural model might be suitable to support a program of structure-based drug discovery. (biomedcentral.com)
Occurs1
- Comparisons with orthologues, indicate a high degree of order and conservation in parts of the active site where Zn 2+ is bound and where recognition of the cytidine moiety of substrate occurs. (biomedcentral.com)
Evolutionary1
- Color by evolutionary conservation (ConSurf) to identify functional sites. (powerandbulk.com)
Structural conservation2
- The structural conservation of the active sites comprising the catalytic triad or dyad and of substrate binding pouches has been shown by high-resolution three-dimensional (3D) constructions of the 3Cpro and 3CLpro of these viruses (2, 19, 29, 30, 45, 46). (monossabios.com)
- Finally, by mapping structural conservation and glycosylation site positions from other members of the paramyxovirus family, we suggest the molecular surface involved in oligomerization. (ox.ac.uk)
Species1
- Moiety conservation is the conservation of a subgroup in a chemical species, which is cyclically transferred from one molecule to another. (wikipedia.org)
Polar1
- Findings suggest that, although a cross-linked network may form upon curing, some triglycerides fail to cross-link to the wider network and oxidize to form acidic and hydroxylated polar moieties. (acs.org)
Recognition1
- Such a conservation in ligand recognition indicates a strong selective pressure during evolution to maintain the ligand recognition selectivity of mGluRs and suggests that structural constraints within the ligand binding pocket (LBP) would hinder divergent evolution. (pasteur.fr)
Analysis2
- Moiety-conserved cycles in nature exhibit unique network control features which can be elucidated using techniques such as metabolic control analysis. (wikipedia.org)
- perform conservation analysis. (github.io)
Site1
- The active site of ZK177.8 recognizes both 2' OH and triphosphate moieties of dNTPs but not base moiety. (bvsalud.org)
Science and Techno1
- World Health Organization, Consumers international, Physicians and Scientists for Responsible Application of Science and Technology, international Union for Conservation of Nature and Natural Resources, the Council of the University of Costa Rica, and the independent Science Panel showing the current uncertainty and limitations of science in this area, as well as those of proposed and applied biosafety approaches. (verticogestao.com.br)
Structure3
- Finally, with the aim of characterizing RNA structure diversity, Abraham and co-workers recently studied the RNA conservation at three levels: primary, secondary, and tertiary structure. (biomedcentral.com)
- This striking conservation in structure, function, and allosteric regulatory mechanism for the hydrolysis of the DNA building blocks supports their host developmental roles. (bvsalud.org)
- Conservation within the myosin motor domain: implications for structure and function. (embl.de)
Presence2
- The presence of conserved moieties can affect how computer simulation models are constructed. (wikipedia.org)
- C.) have also been determined to evaluate the presence of organic and metallic moieties in sewage and sludge environment. (envirobiotechjournals.com)
Values1
- The primary function of Dhimurru is to facilitate the protection, conservation and sustainable management of natural and cultural resource values, concentrating on those areas which are subject to recreational use. (dhimurru.com.au)
High1
- The HBS were derived from source data characterizing locations with concentrated at-risk biodiversity or existing source data of a prioritization exercise that identified areas of high conservation significance. (sciencebase.gov)
Aromatic3
- Liu Yu, Chen Yong and colleagues, Nankai University, Tianjin, China, have synthesized a highly ordered organic two-dimensional microplate assembly made of the macrocyclic host cucurbit[8]uril and an aromatic guest, i.e., a central phenanthroline moiety with two terminal 4,4′-bipyridin-1-ium units. (chemistryviews.org)
- In particular, we have validated the hypothesis that retinol isomerization by RPE65 proceeds via a carbocation (or possibly a radical cation) mechanism, rather than a SN2' mechanism of nucleophilic addition to the carbon-11 of the retinyl moiety, and we have identified several aromatic and non-aromatic binding cleft residues of RPE65 critical for retinyl moiety isomerization. (nih.gov)
- 15: 667-683 (1994)) that is applied to all atoms in the topology file with non-zero charge, which currently comprise only the atoms of the aromatic moieties of the Phe, Trp, and Tyr sidechains and the Tyr -OH group. (nih.gov)
Receptor2
- The similarity of these findings to previous results in preparations of rodent brain highlight the conservation of the modulation of GABAA receptor function during the evolution of vertebrates. (nih.gov)
- The cytokine activity of AMF is inhibited by carbohydrate phosphate compounds as they compete for AMF binding with the carbohydrate moiety of the AMF receptor (AMFR), which is a glycosylated seven transmembrane helix protein. (proteopedia.org)
Assumption1
- When invoking the conserved-moiety assumption on a particular moiety, we are, in effect, assuming the system is closed to that moiety. (wikipedia.org)
Proteins3
- Finally, as a serendipitous finding, of the t(4;14) (p16.3;q32.3) translocations recently described in multiple myelomas, at least three breakpoints merge the IgH and WHSC1 genes, potentially causing fusion proteins replacing WHSC1 exons 1-4 by the IgH 5'-VDJ moiety. (embl.de)
- Proteins can contain paramagnetic moieties in form of stable cofactors, transiently formed intermediates, or spin labels artificially introduced to cysteine sites. (frontiersin.org)
- The data based on the sequence and three-dimensional surface information are used to categorize proteins in various functional conservation sub-types [5]. (crimsonpublishers.com)
Adenosine2
- A typical example of a conserved moiety in biochemistry is the Adenosine diphosphate (ADP) subgroup that remains unchanged when it is phosphorylated to create adenosine triphosphate (ATP) and then dephosphorylated back to ADP forming a conserved cycle. (wikipedia.org)
- Shows conservation of mass for Adenosine, creatine, and phosphate. (nih.gov)
Induces1
- The crystal structures of the syn1- and anti1-mouse AChE complexes at 2.45- to 2.65-A resolution reveal not only substantial binding contributions from the triazole moieties, but also that binding of the syn1 isomer induces large and unprecedented enzyme conformational changes not observed in the anti1 complex nor predicted from structures of the apoenzyme and complexes with the precursor reactants. (proteopedia.org)
Evolutionary Conservation1
- An in vitro acetylation assay clearly demonstrated that the acetylated substrates of the NatC catalytic subunit from T. cruzi were similar to those of yeast and human NatC, suggesting evolutionary conservation of function. (hindawi.com)
Covalent1
- Fluorinated ketones can function as covalent warheads applied in the design of reversible covalent inhibitors, however, the reactivity of certain fluorinated moieties remains underexplored. (nature.com)
Derivatives1
- 13. Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety. (nih.gov)
Environmental conservation2
- Roads that probe, but not too far, into each of Kakadu's seven regions, treading the delicate balance between "access for all" and environmental conservation. (insidethetravellab.com)
- Letter from Plumley Engineering, on behalf of of Sungeel MCC Americas LLC, on the surrender of the Air Permit, to the NY State Department of Environmental Conservation. (fluoridealert.org)
Hydrogen2
- The hydrogen masses are set to 12.01 amu, a holdover from early in the development of the force field when a single-sided harmonic potential was used to model volume exclusion ( as opposed to the current implementation, which employs the repulsive part of the Weeks-Chandler-Andersen decomposition of the CHARMM22 Lennard-Jones term) and required the increased hydrogen mass to allow for energy conservation with a 2-fs timestep. (nih.gov)
- Common structural requirements include hydrogen bond donor/acceptor area, hydrophobic domain, carbon spacer, and distal hydrophobic domain flanked by hydrogen bond donor/acceptor moieties. (dovepress.com)
Functional1
HERITAGE1
- The observed physical and mechanical proprieties of these fiber composites candidates them to have future interesting applications in the field of conservation of cultural heritage. (unical.it)
Enzymes2
- B) A multiple sequence alignment in the vicinity of TgENR Asn130 (shown by an asterisk) of a number of parasitic and plant ENR enzymes showing full sequence conservation across HS3ST1 parasite and plant families. (lacbiosafety.org)
- For example, out of 28 binding site categories, many have a variety of substrates, while in the category enzymes for binding to phosphoenolpyruvate, the conservation is very high. (crimsonpublishers.com)
Mass2
- Bergen P. F. van, Poole I. , Ogilvie T. M. A., Caple C. , Evershed R. P. Evidence for demethylation of syringyl moieties in archaeological wood using pyrolysis-gas chromatography/mass spectrometry // Rapid Commun. (sibjforsci.com)
- Advanced tools such as mass conservation, multi- wavelength, and global analysis are introduced and discussed in the context of the experimental design. (nih.gov)
Mechanism3
- This striking conservation in structure, function, and allosteric regulatory mechanism for the hydrolysis of the DNA building blocks supports their host developmental roles. (bvsalud.org)
- All reactions can be clustered into two mechanisms by which the C8-H is induced to be labile via the coordination of a backbone carbonyl to C6-NH 2 of the adenyl moiety, namely a "push" mechanism, and a "pull" mechanism, based on the protonation of N7. (biomedcentral.com)
- The "push" mechanism and a "pull" mechanism are responsible for inducing the C8-H of adenyl moiety to become more labile. (biomedcentral.com)
Implications2
- Conservation within the myosin motor domain: implications for structure and function. (embl.de)
- Understanding what limits, or promotes, species' geographical spread can have considerable conservation, economic, and health implications through effects on at-risk species, the spread of invasives, and even zoonotic disease risk. (lakeheadu.ca)
Important1
- Our data suggests that both signal and mature moiety sequences play important roles and should be considered in the development of predictive tools. (biomedcentral.com)
Side1
- Gorgosterol and its derivative demethylgorgosterol are two long known marine steroids with unusual properties and a unique structure, containing a cyclopropane moiety in the side chain. (logos-verlag.de)
Unique1
- Moiety-conserved cycles in nature exhibit unique network control features which can be elucidated using techniques such as metabolic control analysis. (wikipedia.org)
Effects1
- In biochemistry, moiety conservation can have profound effects on the system's dynamics. (wikipedia.org)
Affect1
- The presence of conserved moieties can affect how computer simulation models are constructed. (wikipedia.org)
Energy2
Cultural1
- Budrugeac P., Emandi A. The use of thermal analysis methods for conservation state determination of historical and/or cultural objects manufactured from lime tree wood // J. Therm. (sibjforsci.com)