AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Protein CPorphyrinsOncogene Proteins v-sisOncogene Protein tpr-metOncogene Protein v-mafProtein C DeficiencyOncogene Protein gp140(v-fms)Oncogene Proteins v-mosProtein C InhibitorOncogene Protein p55(v-myc)Oncogene Protein p65(gag-jun)Oncogene Proteins v-rafConsensusOncogene Proteins v-fosActivated Protein C ResistanceConsensus SequenceOncogene Protein v-crkOncogene Proteins v-mybOncogene Protein v-cblOncogene Proteins v-erbBOncogenesOncogene Proteins v-ablOncogene Proteins v-relProtein SOncogene Proteins v-erbAThrombomodulinOncogene ProteinsOncogene Protein p21(ras)Proto-Oncogene Proteins c-etsBlood Coagulation FactorsMolecular Sequence DataPulmonary Surfactant-Associated Protein CBase SequenceProto-Oncogene Protein c-ets-1Factor VOncogene Protein pp60(v-src)Proto-Oncogene Protein c-ets-2Factor VaThrombinAmino Acid SequenceOncogene Proteins, FusionOncogene Proteins, ViralBlood CoagulationGenes, rasCell Transformation, NeoplasticConsensus Development Conferences as TopicOncogene Protein v-aktProthrombinBinding SitesProto-Oncogene ProteinsTranscription FactorsProtein S DeficiencyPromoter Regions, GeneticMutationReceptors, Cell SurfaceDNA-Binding ProteinsCell LineProtein BindingTranscription, GeneticReceptors, ThrombinThrombophiliaRecombinant ProteinsBlood Coagulation DisordersTransfectionPartial Thromboplastin TimeProto-OncogenesReceptor, PAR-1AnticoagulantsRNA, MessengerGene Expression RegulationDNACloning, MolecularGlycoproteinsFactor Xa1-Carboxyglutamic AcidRetroviridae Proteins, OncogenicBlood Coagulation TestsGene Expression Regulation, NeoplasticDisseminated Intravascular CoagulationCells, CulturedAntithrombin IIIThrombosisGenes, mycSignal TransductionThrombophlebitisFactor V DeficiencyTrans-ActivatorsFactor XEnzyme ActivationDelphi TechniqueNuclear ProteinsProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)KineticsCarrier ProteinsGene AmplificationSequence Homology, Amino AcidProto-Oncogene Protein c-fli-1Tumor Cells, CulturedPoint Mutation
GenesPoint mutationsBinds1997Tumor supp19981996MutationsSequencesTranscription factorBind1995ELF3TransactivatesGene promoterGeneticAmino acidsRegulateGGAAEndoglinRegulationDifferentiationActivationCharacterizationCancersCDNAKinaseCellsExonExpressionSpecificityCellIntercellularDomainPeptideDatabasesMemberComplexHumanCancerLungRecognitionFoundRegionJournalDomains
Genes13
  • The ETS family of genes are implicated in cancers such as Ewings sarcoma, acute myeloid leukemia and chronic myelomonocytic leukemia. (edu.au)
  • ETV6 is a clinically significant proto-oncogene in that it can fuse with other genes to drive the development and/or progression of certain cancers. (wikipedia.org)
  • and c) the C-terminal DNA-binding domain, ETS, which binds to the consensus DNA sequence, 5-GGAA/T-3 within a 9-to-10 bp sequence, in the target genes it regulates. (wikipedia.org)
  • Both mutant proteins failed to enter cell nuclei normally and had a reduced capacity to target genes regulated by the normal ETV6 protein. (wikipedia.org)
  • In summary, our data suggest that EWS-FLI-1 might act through the same target genes normally regulated by FLI-1, and EWS-FLI-1-induced transformation may result from dysregulation of FLI-1 target genes during cell proliferation and differentiation. (nih.gov)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • Proto-oncogenes are genes that function normally in healthy cells to promote growth and proliferation. (medscape.com)
  • While they are normally regulated by other genes, including tumor suppressor genes, proto-oncogenes can be activated to become oncogenes that are less sensitive to this regulation. (medscape.com)
  • Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
  • This database lists consensus NF-κB target genes from two curated lists at https://www.bu.edu/nf-kb/gene-resources/target-genes/ and http://bioinfo.lifl.fr/NF-KB/ . (nih.gov)
  • HN - 2006(1998) MH - Activating Transcription Factor 1 UI - D051697 MN - D12.776.260.108.61.500 MN - D12.776.930.127.61.500 MS - An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2. (nih.gov)
  • The program begins with the induction of genes involved in transcriptional regulation and signal transduction and is followed, sequentially, by the regulation of genes involved in protein biosynthesis, cell proliferation, and epithelial cell differentiation. (nih.gov)
Point mutations2
  • 28. [Detection of c-Ki-ras oncogene codon 12 point mutations in lung carcinoma, gastric carcinoma and hepatic carcinoma]. (nih.gov)
  • The main mechanisms for activation of proto-oncogenes consist of point mutations, amplifications, and chromosomal translocations. (medscape.com)
Binds4
  • ELF3 binds and transactivates ETS sequences and interestingly also shows the ability to bind a GGAT-like purine core, a preferential ETS1/ETS2 type binding site. (edu.au)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • C/EBPΑ (CCAAT/enhancer binding protein (C/EBP) alpha), a protein encoded by the C/EBPΑ gene in humans, was originally identified 30 years ago as a transcription factor that binds both promoter and enhancer regions. (scientificarchives.com)
19971
  • [email protected] SO - Anesthesiology 1997 Oct;87(4):926-934 UI - 97443327 PM - 9298188 PT - JOURNAL ARTICLE AU - Shi Y AU - Weimer PJ AU - Ralph J TI - Formation of formate and hydrogen, and flux of reducing equivalents and carbon in Ruminococcus flavefaciens FD-1. (nih.gov)
Tumor supp2
  • However, ETV6 is also an anti-oncogene or tumor suppressor gene in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers. (wikipedia.org)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
19981
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
19961
  • 1996) Nature, 380, 456-460] reveals an apparent discrepancy in which the protein domains bind with opposite polarity to their target sequences. (nih.gov)
Mutations4
  • Two unrelated kindreds were found to have autosomal dominant inherited mutations in the ETV6 gene, one family with a germline DNA substitution termed L349P that lead to replacing leucine with proline at amino acid 349 in the DNA binding domain of the ETV6, the second, termed N385fs, in germline DNA caused the lose of five base pairs ETV6 and a truncated ETV6 protein. (wikipedia.org)
  • 22. P21 protein expression and ras-oncogene mutations in gastric carcinoma: correlation with clinical data. (nih.gov)
  • 8. Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations. (nih.gov)
  • 1] Mutations found in pediatric malignancies can be categorized broadly into driver mutations and passenger mutations. (medscape.com)
Sequences4
  • We identify a novel ETS family member, ELF3, and report its human and murine cDNA sequences. (edu.au)
  • The corresponding protein, p42Ets-1, is a transcription factor as it is able to bind to specific DNA sequences and to transactivate a bona fide ETS reporter vector. (utmb.edu)
  • The alignment of cloned binding sequences showed a consensus DNA-binding site of ACCGGAAG/aT/c. (nih.gov)
  • A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. (lookformedical.com)
Transcription factor8
  • ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. (wikipedia.org)
  • We have identified the mouse exon VII splice variant of the Ets-1 transcription factor. (utmb.edu)
  • Altogether, our data suggest that p42Ets-1 acts as a distinct transcription factor from p51Ets-1. (utmb.edu)
  • 1. Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM. (nih.gov)
  • 3. The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene. (nih.gov)
  • 10. Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element. (nih.gov)
  • 13. Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (nih.gov)
  • 19. Molecular characterization of the ets-related human transcription factor ER81. (nih.gov)
Bind3
  • 18. Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene. (nih.gov)
  • AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
  • A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (nih.gov)
19951
  • 1995) Cell, 83, 761-771] and the related Pu.1 by X-ray crystallography [Kodandapani et al. (nih.gov)
ELF31
  • The expression of ELF3, unlike most other ETS family members, is absent in hematopoietic cells and hematopoietic organs in humans and mice. (edu.au)
Transactivates1
  • The specific DNA-binding properties of each isoform translates into clear differences in activity, p42Ets-1 transactivates the natural VE-cadherin gene promoter through both ETS-binding site (EBS)2 and EBS4 whereas p51Ets-1 is mainly active on EBS4. (utmb.edu)
Gene promoter1
Genetic1
  • This information is useful for the analyzing genetic relatedness of proteins and species. (lookformedical.com)
Amino acids2
  • The presence of intercalation was deduced on the basis of numerous NOEs between several amino acids in the protein and a resonance at 12.33 ppm originally assigned to a DNA imino proton. (nih.gov)
  • The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
Regulate1
  • ETV6 interacts with other proteins that regulate the differentiation and growth of cells. (wikipedia.org)
GGAA3
  • p42Ets-1 recognizes the same optimal consensus sequence as p51Ets-1, but also many variations of it, mainly at base -1, which is located just prior to the GGAA/T core sequence. (utmb.edu)
  • This family recognizes a consensus sequence rich in purine bases with a central GGAA motif. (nih.gov)
  • This consensus sequence shows greater specificity for sequence 5' of the GGAA core site than those of other Ets proteins. (nih.gov)
Endoglin1
  • The corresponding endoglin and ALK-1 proteins are specific endothelial receptors of the transforming growth factor β superfamily essential for maintaining vascular integrity. (bmj.com)
Regulation4
  • The role of Ets factors in the regulation of presenilin 1. (nih.gov)
  • 6. Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene. (nih.gov)
  • 20. Transcriptional regulation of intercellular adhesion molecule 1 by phorbol ester in human neuroblastoma cell line SK-N-SH involves jun- and fos-containing activator protein 1 site binding complex(es). (nih.gov)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
Differentiation2
Activation4
  • 35. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. (nih.gov)
  • Consistent with this we found that Fli-1 mRNA expression in lymphocytes was high in quiescent cells and disappeared upon activation while EWS mRNA expression was low in resting cells and increased in activated T cells. (nih.gov)
  • 15. Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate. (nih.gov)
  • Activation of proto-oncogenes is a common theme in childhood leukemias and solid tumors. (medscape.com)
Characterization1
  • 9. Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. (nih.gov)
Cancers1
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
CDNA1
  • Although recent data have demonstrated that the chimeric EWS-FLI-1 cDNA isolated from cases of Ewing's sarcoma can transform NIH 3T3 cells, little is known about the basis for this transformation. (nih.gov)
Kinase2
  • 12. Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism. (nih.gov)
  • Results: KLF7 overexpression promotes HCC metastasis through transactivating toll-like receptor 4 (TLR4) and protein tyrosine kinase 2 (PTK2) expression. (bvsalud.org)
Cells4
  • 2. Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells. (nih.gov)
  • Expression of Pu.1, C/Ebpa and Bach1 Transcription Factors in Immune Cells in Patients with Cancer. (scientificarchives.com)
  • Here, we evaluated expression of C/EBPa, PU.1 and BACH1 transcription factors in lymphoid and myeloid cells, including NK cells, T cells, neutrophils and monocytes, isolated from healthy donors and cancer patients. (scientificarchives.com)
  • A significant reduction in c-myc expression was observed in both NK cells and T lymphocytes in patients with cancer [ 1 , 2 ]. (scientificarchives.com)
Exon2
  • The gene has 8 exons and two start codons, one located at exon 1 at the start of the gene and an alternative located upstream of exon 3. (wikipedia.org)
  • The binding differences were quantified by surface plasmon resonance analyses and the protein region responsible for the differences in DNA sequence recognition located in the Val 280 -Glu 302 fragment, which is encoded by exon VII. (utmb.edu)
Expression8
  • 25. [Clinicopathological study on primary lung cancer--immunohistochemical expression of p53 suppressor gene and bcl-2 oncogene in relation to prognosis]. (nih.gov)
  • 26. Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer. (nih.gov)
  • 32. [Expression and clinical significance of p53 protein and p21(WAF1) in non-small-cell lung carcinoma]. (nih.gov)
  • 37. Altered retinoblastoma protein expression in nonsmall cell lung cancer: its synergistic effects with altered ras and p53 protein status on prognosis. (nih.gov)
  • Despite their DNA binding similarities, the EWS-FLI-1 translocation product is likely to have a distinct pattern of expression from that of FLI-1 since the translocation results in the replacement of the 5' regulatory region of Fli-1 with that of EWS. (nih.gov)
  • 7. An abbreviated procedure for the cloning and identification of Ets transcription factors regulating the expression of the human presenilin 1 gene. (nih.gov)
  • High mobility group box 1 (HMGB1) upregulates KLF7 expression through the TLR4/advanced glycosylation end-product specific receptor (RAGE)-PI3K-AKT-NF-κB pathway, forming an HMGB1-KLF7-TLR4 positive feedback loop. (bvsalud.org)
  • Expression of Pu.1, C/Ebp? (scientificarchives.com)
Specificity2
  • Using several truncated forms of FLI-1, we show that the Ets domain is necessary and sufficient for the DNA binding specificity of FLI-1. (nih.gov)
  • The EWS-FLI-1 protein displayed the same DNA binding specificity and affinity as FLI-1 did. (nih.gov)
Cell3
  • The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
  • 34. Ha-ras oncogene product in human oral squamous cell carcinoma. (nih.gov)
  • The variant is expressed in all cell lines which express ets-1, at lower levels, it is also expressed in the mouse embryo in vivo. (utmb.edu)
Intercellular1
Domain4
  • The ETS family of transcription factors consists of a group of proteins that share a highly conserved 85 amino acid DNA-binding domain (DBD). (nih.gov)
  • Since FLI-1 and EWS-FLI-1 contain an Ets domain, both proteins may act as sequence-specific transcription factors. (nih.gov)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Peptide1
  • A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence. (lookformedical.com)
Databases1
  • In databases they are documented as still uncharacterized and hypothetical proteins. (ijpsr.com)
Member1
  • 17. Two functionally distinct domains responsible for transactivation by the Ets family member ERM. (nih.gov)
Complex2
  • SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane protein. (nih.gov)
  • Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (lookformedical.com)
Human1
  • 5. An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene. (nih.gov)
Cancer1
  • cancer in one year and approximately 7 million patients fall victim to the cancer per anno, thereof 5.4 million alone by tobacco smoke 1 . (ijpsr.com)
Lung2
  • These results suggest that this novel ETS gene may be involved in lung tumorigenesis. (edu.au)
  • 21. Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma. (nih.gov)
Recognition1
  • It was originally reported that the ETS1-DBD bound to DNA with a bipartite motif involving major groove recognition via a helix-turn-helix element and minor groove recognition via protein side-chain intercalation. (nih.gov)
Found1
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Region1
  • A higher prevalence (1:2351) is reported in the Haut Jura region of France. (bmj.com)
Journal1
  • Journal of Chemical Information and Modeling 2018 , 58 (1) , 165-181. (acs.org)
Domains2
  • ETV6 protein contains 3 domains: a) the pointed N-terminal (i.e. (wikipedia.org)
  • The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)