• The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. (wikipedia.org)
  • Nephroblastoma Overexpressed Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Nephroblastoma Overexpressed Protein" by people in this website by year, and whether "Nephroblastoma Overexpressed Protein" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Nephroblastoma Overexpressed Protein" by people in Profiles. (childrensmercy.org)
  • The CCN acronym is derived from the first three members of the family being identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates and have been renamed CCN1-6 in the order of their discovery by international consensus. (wikipedia.org)
  • A CCN protein family member found at high levels in NEPHROBLASTOMA cells. (childrensmercy.org)
  • Connective tissue cells near the traumatized region respond by initiating the process of replication. (nih.gov)
  • A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
  • Both of these peptide families have important local actions in maintaining tissue homeostasis and repair after injury, and when mechanisms governing their regulation are disrupted they may contribute to disease progression. (embl.de)
  • They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
  • The CCN acronym is derived from the first three members of the family being identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, together with WISP1 (CCN4), WISP2 (CCN5), and WISP3 (CCN6) comprise the six-member CCN family in vertebrates and have been renamed CCN1-6 in the order of their discovery by international consensus. (wikipedia.org)
  • The WNT1 inducible signaling pathway protein 1 (WISP1), a member of the connective tissue growth factor family, plays a crucial role in several important cellular functions in a highly tissue-specific manner. (nih.gov)
  • Wnt family members are critical to many developmental processes, and components of the Wnt signaling pathway have been linked to tumorigenesis in familial and sporadic colon carcinomas. (nih.gov)
  • The results confirmed that WISP1 is a stroma-specific secreting protein, enhancing the cell migration and contraction of prostate fibroblasts, as well as the proliferation, invasion, and tumor growth of prostate carcinoma cells. (nih.gov)
  • HN - 2009 BX - alpha-Globin MH - AMP-Activated Protein Kinases UI - D055372 MN - D8.811.913.696.620.682.700.85 MN - D12.644.360.62 MN - D12.776.476.62 MS - Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (nih.gov)