• The Cells for Sight Team is aiming to understand the biology and therapeutic potential of stem cells (and the cells with which they interact) to develop and deliver novel cell-based therapies and anti-scarring strategies for patients with blinding corneal and conjunctival disease. (ucl.ac.uk)
  • Corneal verticillata is characteristic of Fabry disease however it may also bee seen with long term use of systemic medications such as amiodarone, chloroquine, chlorpromazine, and indomethacin. (harvard.edu)
  • In addition to corneal verticillata and anterior subcapsular cataract, patients with Fabry disease also may have spoke like posterior subcapsular cataract. (harvard.edu)
  • Background: Inflammatory cells infiltrating to the tarsal conjunctiva are thought to be involved in the pathogenesis of corneal lesions in severe allergic conjunctival diseases. (elsevier.com)
  • Although corneal tissue damage in allergic ocular diseases is thought to be induced by inflammatory cells that infiltrate from conjunctival tissue, the mechanisms of recruiting these cells remain unclear. (elsevier.com)
  • My research is focused in the areas of corneal infections and inflammatory diseases of the ocular surface. (ucl.ac.uk)
  • There was 1+ conjunctival injection and a new peripheral corneal infiltrate was noted noted in the left eye. (harvard.edu)
  • A conjunctival epithelium proteome map formed by 348 resolved spots. (arvojournals.org)
  • We investigated the expression of the chemokine RANTES in conjunctival epithelium from two patients with atopic keratoconjunctivitis (AKC) and one patient with vernal keratoconjunctivitis (VKC) by using immunohistochemistry. (elsevier.com)
  • Conjunctival epithelium from a patient with AKC stained positively for RANTES. (elsevier.com)
  • The etiology of the disease is complex and related to the development of autoimmune responses at the ocular surface epithelium. (arvojournals.org)
  • To comparatively analyze conjunctiva proteome changes in ocular surface diseases (OSD) such as dry eye (DE) and meibomian gland dysfunction (MGD) by 2D-Differential in gel electrophoresis (2D-DIGE). (arvojournals.org)
  • We characterized antigen-presenting cell (APC)-relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 cell immunity and dry eye disease severity. (arvojournals.org)
  • Conjunctival impression cytology (CIC) specimens for proteomic analyses and PAS-hematoxylin staining were collected. (arvojournals.org)
  • Evaluation of the relative percentages of inflammatory cells in brush cytology samples is a useful method of assessing disease activity in allergic conjunctival disease. (elsevier.com)
  • Taken together, human conjunctival epithelial cells were capable of producing RANTES in response to inflammatory stimuli such as TNF-α and may play a role in recruiting inflammatory cells such as eosinophils and T lymphocytes toward the ocular surface. (elsevier.com)
  • As a Consultant at Moorfields he developed an additional interest in severe inflammatory eye diseases. (ucl.ac.uk)
  • Systemic Lupus Erythematosus (SLE) is a chronic multisystem disease with a wide range of inflammatory involvement in almost every organ of the body. (harvard.edu)
  • This has identified some of the mechanisms underlying both the associated conjunctival inflammation and scarring as well as evaluating medical and surgical treatment strategies for the condition. (ucl.ac.uk)
  • Conjunctival tissue was collected from AED mice after the final day of challenge, and from naïve mice as our negative control. (arvojournals.org)
  • To test this hypothesis, we investigated RANTES expression in the conjunctival tissue and also RANTES production by cytokine stimulation in a human conjunctival epithelial cell line. (elsevier.com)
  • Our lab has previously established the mouse model of allergic eye disease (AED), which involves robust eosinophil and T cell recruitment to the conjunctiva, and mimics the severe/chronic form of ocular allergy in humans. (arvojournals.org)
  • 1 Within that age range, we may see it more often in patients who have concurrent dry eye or meibomian gland disease, though those often go hand in hand with the aging population and can all cause similar symptoms. (modernmedicine.com)
  • Allergic eye disease (AED) progression in the mouse model is associated with quantitative changes in conjunctival innate lymphoid populations. (arvojournals.org)
  • T-cell characterization in chronic allergic eye disease. (ucl.ac.uk)
  • We also investigated the production and suppression of RANTES from a human conjunctival epithelial cell line, Wong-Kilbourne-derived human conjunctiva (WK-hC) by using enzyme-linked immunosorbent assay (ELISA). (elsevier.com)
  • The immunomodulatory role of human conjunctival epithelial cells. (ucl.ac.uk)
  • To determine the functional role of CCR7 in DED, mice were treated topically with either anti-CCR7, a control isotype antibody, or left untreated, and clinical disease severity, Th17 responses, and molecular markers of DED were quantified. (arvojournals.org)
  • Mice treated topically with anti-CCR7 antibody displayed a significant reduction in clinical disease severity and Th17 response compared to the isotype and untreated groups. (arvojournals.org)
  • Systemic Lupus Erythematosus (SLE) was first described by Rose and Pillsbury in 1939.1 It is a chronic, often progressive and pleomorphic multisystem disease of unknown etiology. (harvard.edu)
  • Peripheral and autonomic neuropathy are common in Fabry disease. (harvard.edu)
  • A conjunctival biopsy was performed and this disclosed lymphocytic perivasculitis around the conjunctival and episcleral vasculature next to the area of peripheral keratitis, a finding typical of marginal keratitis associated with systemic lupus erythematosus. (harvard.edu)
  • Fabry disease is an X-linked recessive error of glycosphingolipid metabolism that results in accumulation of neutral glycosphingolipid in cellular lysosomes. (harvard.edu)
  • Conjunctival cells that stained for CD45+ CD3- B220- CD11b- GR-1- were considered as the general innate lymphoid population profile. (arvojournals.org)
  • The objective of this study was to demonstrate whether conjunctival epithelial cells have the ability to produce 'regulated on activation, normal T-cell expressed and secreted' (RANTES). (elsevier.com)
  • Fabry disease patients also develop characteristic ectasia of skin vessels called angiokeratoma. (harvard.edu)
  • Dry eye disease (DED) is recognized as a common cause of ocular surface inflammation, and remains one of the most frequent reasons leading patients to seek ophthalmic care in the United States. (arvojournals.org)
  • Together these findings support the diagnosis of Fabry disease. (harvard.edu)
  • We also investigated the role of bacterial biofilms in ocular infections and contact lens related disease. (ucl.ac.uk)
  • However, whether innate lymphoid populations change in the conjunctiva during the progression of this disease has not been addressed and therefore was the purpose the current study. (arvojournals.org)
  • Careful patient evaluation, as well as a logical stepwise approach to management of the ocular and systemic manifestations prove to be an effective way to prevent the blinding ocular consequences of this disease. (harvard.edu)
  • Conjunctival chalasis, or conjunctivochalasis (Cch), is a commonly observed condition in our everyday patient care experiences. (modernmedicine.com)
  • Aneurysmal dilatations of conjunctival veins, and retinal vascular tortuousity is also common in Fabry disease. (harvard.edu)
  • Progressive renal failure is a classic finding in Fabry disease. (harvard.edu)
  • A major area of this research has been into scarring conjunctivitis using mucous membrane pemphigoid (MMP) as a model disease. (ucl.ac.uk)
  • Vascular endothelium is particularly sensitive to glycosphingolipid deposition, and endothelial damage contributes to much of the pathology in Fabry disease. (harvard.edu)