• To comparatively analyze conjunctiva proteome changes in ocular surface diseases (OSD) such as dry eye (DE) and meibomian gland dysfunction (MGD) by 2D-Differential in gel electrophoresis (2D-DIGE). (arvojournals.org)
  • Our lab has previously established the mouse model of allergic eye disease (AED), which involves robust eosinophil and T cell recruitment to the conjunctiva, and mimics the severe/chronic form of ocular allergy in humans. (arvojournals.org)
  • However, whether innate lymphoid populations change in the conjunctiva during the progression of this disease has not been addressed and therefore was the purpose the current study. (arvojournals.org)
  • Conjunctival diagram for tumour mapping displaying the conjunctiva as a flat surface. (nature.com)
  • Conjunctival Nevus, also known as nevus of conjunctiva , is related to malignant conjunctival melanoma and melanoma . (malacards.org)
  • We have extended the concept of autologous conjunctival transplantation for corneal resurfacing as recommended by Thoft to reconstruction in 14 patients with unilateral abnormalities of the bulbar and palpebral conjunctiva caused by alkali burns (2), irradiation (2), neoplasms (3), degenerative diseases (5), trauma (1), and developmental anomalies (1). (nih.gov)
  • viral load undetectable) and hepatitis C. On examination, a fleshy yellow conjunctival lesion with subconjunctival hemorrhage was noted ( Figure 1 A), with a follicular reaction on the tarsal conjunctiva. (jamanetwork.com)
  • Further, increased frequency of P-selectin ligand expressing IL-4-producing T cells was observed in conjunctiva compared to that in PBMC of the patients with allergic conjunctival diseases. (nii.ac.jp)
  • These results suggest that IL-4-producing T cells that have infiltrated into the conjunctiva play an important role in the immunopathogenesis of allergic conjunctival diseases, and P-selectin ligand is involved in the entry of T cells into allergic inflammatory site and correlation between tear cytokines show various patterns suggesting the complexity and redundancy of cytokines. (nii.ac.jp)
  • However, the circulations of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and palpebral conjunctival vessels are supplied by both the ophthalmic artery and the external carotid artery, to varying extents. (wikipedia.org)
  • With age, the conjunctiva can stretch and loosen from the underlying sclera, leading to the formation of conjunctival folds, a condition known as conjunctivochalasis . (wikipedia.org)
  • A progression of the disease to involve the conjunctiva was then suspected and a conjunctival biopsy was performed. (hindawi.com)
  • 1995. Immunopathologic Study of the Conjunctiva in Patients with BehÂet's Disease. (uveitis.org)
  • Slit-lamp examination demonstrated salmon colored lesion in the upper conjunctiva, with little conjunctival injection, but no significant neovascularization. (bireme.br)
  • We report 2 cases of patients referred to our ocular oncology services with herpetic conjunctivitis that masqueraded as conjunctival tumors. (jamanetwork.com)
  • Some examples include conjunctivitis, conjunctival nevus and tumors. (rightdiagnosis.com)
  • Tear -conjunctival samples from 5 patients (16%) without conjunctivitis yielded positive PCR results, 3 of whom had positive and 2 negative nasopharyngeal PCR results. (bvsalud.org)
  • Five of 32 patients (16 %) without conjunctivitis or any eye symptoms had viral RNA in their tear -conjunctival samples. (bvsalud.org)
  • The possibility of transmission via tears and conjunctival secretions should be recognized even in the absence of conjunctivitis or other ocular manifestations. (bvsalud.org)
  • The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. (elsevier.com)
  • Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. (elsevier.com)
  • A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. (elsevier.com)
  • Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. (nih.gov)
  • Bacterial conjunctivitis causes the rapid onset of conjunctival redness, swelling of the eyelid, and a sticky discharge. (wikipedia.org)
  • The frequency of IL-4-producing conjunctival T cells in patients with vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (VKC) were significantly higher than that in patients with allergic conjunctivitis (AC). (nii.ac.jp)
  • Allergic conjunctivitis and conjunctival retraction are the most frequent illnesses in the patients wearing ocular prosthesis for more than one year, due to Staphylococcus aureus presence resulting from frequent hygienic handling of the prosthesis. (bireme.br)
  • Neonates presenting with signs of conjunctivitis should have a conjunctival swab sent for Gram stain and culture. (cfp.ca)
  • Conjunctivitis is an inflammatory disease characterized by conjunctival erythema, swelling, and discharge. (cfp.ca)
  • Conjunctival melanoma (CoM) constitutes about 2% of all ocular malignancies and 5% of all ocular melanoma. (nature.com)
  • Clinical appearance of conjunctival melanosis: (a) freckle, (b) racial, (c) melanocytic intra-epithelial neoplasia (C-MIN) (d) invasive melanoma, and (e) pigmented squamous cell carcinoma. (nature.com)
  • Histology micrographs of conjunctival melanosis (haematoxylin and eosin): (a) freckle/racial, (b) C-MIN=1, (c) C-MIN ⩾ 5, (d) naevus, and (e) melanoma. (nature.com)
  • ClinicalTrials.gov lists trials that are related to Conjunctival melanoma. (cdc.gov)
  • There currently is no effective treatment for metastatic uveal melanoma, whereas conjunctival melanomas, like cutaneous melanomas, can be treated with targeted therapy and/or immunotherapy. (springer.com)
  • All-Ericsson C, Girnita L, Seregard S, Bartolazzi A, Jager MJ, Larsson O (2002) Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. (springer.com)
  • Aziz HA, Gastman BR, Singh AD (2015) Management of conjunctival melanoma: critical assessment of sentinel lymph node biopsy. (springer.com)
  • Blum ES, Yang J, Komatsubara KM, Carvajal RD (2016) Clinical management of uveal and conjunctival melanoma. (springer.com)
  • Collaborative Ocular Melanoma Study, G (2001) Assessment of metastatic disease status at death in 435 patients with large choroidal melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS report no. 15. (springer.com)
  • Damato B, Coupland SE (2008b) Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging. (springer.com)
  • The purpose of the present study is to describe the clinical characteristics and outcomes of patients diagnosed and treated for conjunctival melanoma in the Ocular Oncology Unit of the University Hospital Clinic of Valladolid. (elsevier.es)
  • A retrospective observational case series study was conducted on patients diagnosed with conjunctival melanoma in the Ocular Oncology Unit of University Hospital Clinic of Valladolid, from January 1992 to December 2017. (elsevier.es)
  • Among a total of 462 consecutive patients, the tumour was classified as melanocytic in 252 cases (54.5%), with 27 patients having the pathological diagnosis of conjunctival melanoma. (elsevier.es)
  • Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells. (nih.gov)
  • Rebamipide suppresses PolyI:C-stimulated cytokine production in human conjunctival epithelial cells. (nih.gov)
  • The microscopic features of the conjunctival epithelial cells were described by both direct analysis of the membrane-attached cells and analysis of cytospinned captured cells using several staining procedures. (frontiersin.org)
  • Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. (springer.com)
  • This article reviews the major feline-specific infectious and non-infectious causes of conjunctival disorders. (vetcpd.co.uk)
  • A conjunctival epithelium proteome map formed by 348 resolved spots. (arvojournals.org)
  • Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium. (nih.gov)
  • Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders. (nih.gov)
  • [5] Additional cells present in the conjunctival epithelium include melanocytes , T and B cell lymphocytes . (wikipedia.org)
  • First, AM acts as a physical barrier to protect conjunctival and corneal epithelium as it heals, and it reduces pain caused by friction of the eyelids over the surface. (aao.org)
  • Recently, the use of conjunctival swab (CS) has been evaluated as a non-invasive sampling technique for quantitative real-time PCR (qPCR). (biomedcentral.com)
  • The tear and conjunctival samples were collected by a conjunctival swab. (bvsalud.org)
  • He did not undergo formal ophthalmologic examination or tion pending results of conjunctival swab specimen testing. (cdc.gov)
  • Several types of collagen make up the basement membrane, including type VII collagen, which is also present in the conjunctival and corneal basement membranes. (aao.org)
  • The data suggest that PMNs might contribute to the etiology of MG obstruction in inflammatory eyelid disease. (sciencemag.org)
  • Although chronic eyelid inflammation, such as allergic eye disease, is an associated risk factor for obstructive MG dysfunction, it is not clear whether inflammatory processes contribute to the pathophysiology of MG obstruction. (sciencemag.org)
  • Methods: Nine dogs (12 eyes) diagnosed with progressive corneal edema underwent superficial keratectomy followed by placement of conjunctival advancement hood flaps. (elsevier.com)
  • Deep ulcers and descemetoceles may require conjunctival grafts or conjunctival flaps, soft contact lenses, or corneal transplant. (thefreedictionary.com)
  • Conjunctival tissue holds particular promise as it can be used both for treating corneal and conjunctival stem cell disorders. (uio.no)
  • Knowledge and recognition of the aetiological possibilities of conjunctival disorders in cats versus other species is central to successful case management. (vetcpd.co.uk)
  • Wrongly Diagnosed with Conjunctival disorders? (rightdiagnosis.com)
  • Read more about Deaths and Conjunctival disorders . (rightdiagnosis.com)
  • Visit our research pages for current research about Conjunctival disorders treatments . (rightdiagnosis.com)
  • What is Conjunctival disorders? (rightdiagnosis.com)
  • By combining these approaches, Dr. Machado seeks to gain novel insights into the pathogenesis and treatment of these complex lung disorders, which would hopefully lead to an improvement in the morbidity and mortality associated with sickle cell disease and pulmonary hypertension. (iu.edu)
  • Large, free conjunctival grafts from bulbar and forniceal donor sites were used. (nih.gov)
  • Hypertension is associated with an increase in the tortuosity of bulbar conjunctival blood vessels and capillary and arteriole loss. (wikipedia.org)
  • The bulbar conjunctival microvasculature contains arterioles , meta-arterioles , venules , capillaries , and communicating vessels. (wikipedia.org)
  • In horses, combined keratectomy, strontium-90 radiation and permanent bulbar conjunctival grafts was reported to be effective in at least 83% of the cases of corneolimbal squamous cell carcinoma (MOSUNIC et al. (thefreedictionary.com)
  • Various ocular surface changes have been reported in oGVHD, including meibomian gland atrophy (MGA) and clinical conjunctival scarring or subepithelial fibrosis (CSEF). (elsevier.com)
  • Clinical infectious diseases , 42 (4). (lshtm.ac.uk)
  • BACKGROUND: Nucleic acid amplification testing frequently detects conjunctival Chlamydia trachomatis infection in subjects without clinical signs of trachoma. (lshtm.ac.uk)
  • The data support conclusions from primate challenge studies that live Chlamydiae species or antigens derived from them are needed to provoke the clinical signs of disease. (lshtm.ac.uk)
  • Mapping and clinical staging of conjunctival disease has improved. (nature.com)
  • Multicentre studies are under way to enhance survival prediction by integrating clinical stage of disease with histological grade of malignancy and genetic abnormalities. (nature.com)
  • 1 , 4 Furthermore, our understanding of the biology of these neoplasms is hampered by a lack of adequate correlation between clinical, histological, and genetic features of the disease. (nature.com)
  • We have developed methods for clinical mapping of conjunctival tumours 6 ( Figure 1 ). (nature.com)
  • On the basis of clinical features, conjunctival melanocytic abnormalities can be divided into 'congenital' and 'acquired' 8 ( Table 1 and Figure 2 ). (nature.com)
  • The term 'PAM' correctly describes the clinical appearance of brown conjunctival pigmentation, developing after birth, and unrelated to any underlying ocular or systemic disease. (nature.com)
  • On the basis of clinical inves- mucosal disease, stomatitis, and fever, including bovine vi- tigation, 41 cattle were suspected to have EHD. (cdc.gov)
  • some of the clinical signs ruled out these diseases. (cdc.gov)
  • Howev- er, the clinical signs of the disease were consistent with ei- ther EHD or BTV infection ( 6 , 8 - 10 ). (cdc.gov)
  • The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. (ingentaconnect.com)
  • Dr. Machado's clinical interests include pulmonary hypertension and pulmonary complications of sickle cell disease. (iu.edu)
  • In addition to the above clinical findings, Kawasaki disease causes aneurysm formation in medium-sized arteries, particularly the coronary arteries. (nih.gov)
  • 2016). "Intracardiac thrombus in patients with Behcet's disease: clinical correlates, imaging features, and outcome: a retrospective, single-center experience" . (wikidoc.org)
  • 2011). "Clinical characteristics of pediatric-onset neuro-Behçet disease" . (wikidoc.org)
  • The NDA for lifitegrast now includes data from five randomized controlled clinical trials, with more than 2,500 patients, making it the largest data set for an investigational stage compound in dry eye disease to date,' said Philip J. Vickers , Ph.D., Head of Research & Development, Shire. (prnewswire.co.uk)
  • Damato B, Coupland SE (2008a) Clinical mapping of conjunctival melanomas. (springer.com)
  • The results from OPUS-3, where lifitegrast demonstrated symptom improvement as early as two weeks, provide compelling efficacy data that contribute to the totality of evidence from the lifitegrast clinical development program, now the largest for an investigational stage compound in dry eye disease with more than 2,500 patients," said Philip J. Vickers, Ph.D., Head of Research & Development, Shire. (takeda.com)
  • Because the observed lesions did not have the typical appearance of a conjunctival lymphoma and the diagnostic uncertainty, incisional biopsy was taken. (springer.com)
  • Conjunctival biopsy was performed and revealed a dense, highly polymorphic lymphocytic population. (hindawi.com)
  • Mycoplasmal and viral diseases, or conjunctival biopsy for h. (pacoimabeautiful.org)
  • We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. (bireme.br)
  • Lid swelling, tearing, conjunctival chemosis, and conjunctival redness were each scored on a scale of 1 to 3 and then summed. (arvojournals.org)
  • Leptospirosis , an infection with Leptospira, can cause conjunctival suffusion , which is characterized by chemosis, and redness without exudates. (wikipedia.org)
  • Purpose: Dry eye symptoms greatly impact patients' quality of life in ocular graft-versus-host disease (oGVHD). (elsevier.com)
  • The Ocular Surface Disease Index (OSDI) is a 12-question validated questionnaire used to measure ocular symptoms, visual function, and environmental factors that may affect a patient's vision. (clinicaltrials.gov)
  • Monarch's tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. (cdc.gov)
  • For children infected with Zika virus, most have symptoms of fever, rash, and conjunctival hyperemia, with viral loads decreasing as the number of days since symptom onset increases, according to results published in JAMA Pediatrics . (infectiousdiseaseadvisor.com)
  • Although several signs and symptoms occurred, 4 signs experienced by most children included fever, facial or neck erythema, conjunctival hyperemia, and a maculopapular rash that was often pruritic," the authors noted. (infectiousdiseaseadvisor.com)
  • Dry eye is a complex disease that may result in symptoms like discomfort, visual disturbance, and dryness. (clinicaltrials.gov)
  • Lifitegrast is an investigational treatment for dry eye disease in adults and, if approved, has the potential to be the first treatment indicated to address both signs and symptoms of the disease. (drugs.com)
  • As defined by the 2007 Dry Eye WorkShop ("DEWS"), sponsored by the Tear Film & Ocular Surface Society (TFOS), dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. (drugs.com)
  • If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids. (medicines.org.uk)
  • Shire plc (LSE: SHP, NASDAQ: SHPG) today announced it has resubmitted the New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for its investigational candidate, lifitegrast, for the treatment of signs and symptoms of dry eye disease in adults. (prnewswire.co.uk)
  • Because we believe that, if approved, lifitegrast has the potential to help the millions of U.S. adults living with symptoms of dry eye disease, we worked diligently to submit our response to the CRL as quickly as possible. (prnewswire.co.uk)
  • It is diagnosed based on patient reported symptoms, such as eye dryness, overall eye discomfort, stinging, burning, a gritty feeling or fluctuating blurry vision, as well as signs, which can be measured by an eye care professional to determine the presence of dry eye disease (e.g. (prnewswire.co.uk)
  • Lexington, Mass. - March 2, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) announced today that the company has submitted a New Drug Application (NDA) with the U. S. Food and Drug Administration for its investigational compound lifitegrast for the treatment of signs and symptoms of dry eye disease in adults. (fiercebiotech.com)
  • Lifitegrast has potential to be the first treatment indicated to address both the signs and symptoms of dry eye disease, a chronic inflammatory condition which affects millions of people,' said Philip J. Vickers, Ph.D., Head of Research and Development, Shire. (fiercebiotech.com)
  • Ocular inserts reduce symptoms resulting from moderate to severe dry eye disease. (medscape.com)
  • It is indicated for treatment of the signs and symptoms of dry eye disease in adults. (medscape.com)
  • These data showed OPUS-3 met the primary endpoint of significantly improving patient-reported symptoms of dry eye disease from baseline to day 84 (p=0.0007). (takeda.com)
  • Shire plans to use these data as part of the resubmission of the New Drug Application (NDA) for lifitegrast for the treatment of signs and symptoms for dry eye disease in the first quarter of 2016. (takeda.com)
  • Flemming Ornskov, M.D., CEO, Shire said, "We're delighted with the positive topline findings from OPUS-3 and look forward to resubmitting to FDA the New Drug Application for lifitegrast for the treatment of signs and symptoms for dry eye disease in the first quarter of 2016. (takeda.com)
  • More than 29 million adults in the U.S. live with symptoms of dry eye disease, which typically include eye dryness, overall eye discomfort, stinging, burning, a gritty feeling, and may include episodes of blurred vision. (takeda.com)
  • Human amniotic membrane (AM) has been shown to provide a substantial benefit in treating certain types of conjunctival and corneal disease. (aao.org)
  • The patient was otherwise healthy with no travelling history and reported no coincidence between the appearance of conjunctival lesions and tonsillitis. (springer.com)
  • A diagnosis of conjunctival involvement by MF was made. (hindawi.com)
  • At evaluation, 96.9% (n=340) were discharged following examination, 99.4% (n=349) had fever, 79.8% (n=280) had a rash, 69.2% (n=243) had facial/neck erythema, 66.7% (n=234) had fatigue, 63.5% (n=223) had headache, 60.4% (n=212) had chills, 58.7% (n=206) had pruritus, and 58.1% (n=204) had conjunctival hyperemia. (infectiousdiseaseadvisor.com)
  • Ophthalmic inspection revealed left-sided conjunctival hyperemia and mild chemosis with obvious discomfort. (archcid.com)
  • After use for hematologic analysis, samples and edema of the conjunctival mucosae (Figure 2), sore were stored at -30°C until virologic and serologic tests muzzle, hyperemia of the teats and udder, hemorrhage, de- could be performed. (cdc.gov)
  • Conjunctival eosinophils in allergic ocular disease. (harvard.edu)
  • Dry eye, an often chronic and progressive ocular disease, is one of the most common complaints to eye care professionals, and represents a significant unmet need. (drugs.com)
  • Dry eye is an often chronic ocular disease associated with inflammation that may eventually lead to damage to the surface of the eye. (prnewswire.co.uk)
  • Evaluation of Chemokine mRNA Expression to Assess Allergic Inflammation of the Ocular Surface in Chronic Allergic Conjunctival Diseases. (nih.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • SUGGESTED CITATION: Centers for Disease Control and Prevention. (cdc.gov)
  • The first choice of treatment for primary uveal melanomas is radiotherapy in most centers, whereas conjunctival melanomas are treated by excision with adjunctive radiotherapy and/or topical chemotherapy. (springer.com)
  • Softacor® is an ocular corticosteroid registered for the treatment of mild non-infectious allergic or inflammatory conjunctival diseases. (zorginstituutnederland.nl)
  • Treatment of mild non-infectious allergic or inflammatory conjunctival diseases. (medicines.org.uk)
  • have discovered that polymorphonuclear neutrophils (PMNs) promoted MG obstruction in a mouse model of inflammatory eye disease. (sciencemag.org)
  • We show that polymorphonuclear neutrophils (PMNs) promoted MG obstruction in a chronic inflammatory model of allergic eye disease in mice. (sciencemag.org)
  • In vitro studies have demonstrated that lifitegrast inhibits T-cell adhesion to ICAM-1 expressing cells and inhibits secretion of key inflammatory cytokines (IFNγ, TNFα, IL-2) as well as inhibiting other proinflammatory cytokines: IL-1α, IL-1β, IL-2, IL-4, IL-5, and IL-13, all of which are known to be associated with dry eye disease. (prnewswire.co.uk)
  • 1994. Treatment Strategies for Scleritis and Uveitis Associated with Inflammatory Bowel Disease . (uveitis.org)
  • Pathological examination revealed a chronic inflammatory process with conjunctival folicular hyperplasia. (bireme.br)
  • The aim of the study is to present a rare case of postreptococcal conjunctival lesions mimicking a lymphoma. (springer.com)
  • A 19-year-old Caucasian female was referred to the Ocular Oncology Service, Department of Ophthalmology, Poznań, Poland in April 2009 with a suspicion of conjunctival lymphoma. (springer.com)
  • T-cell lymphoma should be considered in patients with a history of MF presenting with conjunctival and skin lesions. (hindawi.com)
  • We hereby report a rare case of conjunctival involvement of T-cell lymphoma in a patient with MF. (hindawi.com)
  • Though MIS shares features of Kawasaki disease , the classic bilateral conjunctival injection, rash, and strawberry tongue aren't always present. (medscape.com)
  • Postreptococcal uveitis is a well recognized entity with quite a few descriptions in the literature, but so far no conjunctival involvement has been reported. (springer.com)
  • To conclude, this is, to the best of our knowledge, the first report of conjunctival involvement in the course of PSS related to group A streptococci. (springer.com)
  • but, to date, conjunctival involvement has not been reported. (springer.com)
  • however, conjunctival involvement is rarely reported. (hindawi.com)
  • Herein, we report a rare case of conjunctival involvement of MF. (hindawi.com)
  • The use of free conjunctival grafts provides significant advantage over the use of buccal mucous membrane grafts. (nih.gov)
  • The techniques and results of our experience with free conjunctival grafts in 14 patients are discussed. (nih.gov)
  • Tissue adhesives of different types had been used in previous studies to attach conjunctival grafts and compared with the use of sutures were associated with a shorter operative time and reduced postoperative complaints. (thefreedictionary.com)
  • 15,16,17) The conjunctival grafts were positioned leaving no open scleral tissue starting from the nasal and temporal limbus, with the epithelial side up and the limbal area aligned with the limbus. (thefreedictionary.com)
  • For example, the terminology of conjunctival melanocytic lesions is confusing. (nature.com)
  • Complementary flow-cytometry did not show monoclonal proliferation of lymphocytes B. During follow-up we observed the complete regression of conjunctival lesions after the benzyl penicillin treatment prescribed by ENT specialist due to elevated plasma ASO levels. (springer.com)
  • A + B) - Anterior segment of right eye (RE) - April 2009, and disappearance of conjunctival lesions after benzyl penicilin treatment in June 2009 (C + D). (springer.com)
  • RATIONALE: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. (bireme.br)
  • Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. (clinicaltrials.gov)
  • The percentage of cornea covered by the conjunctival flap was correlated (P = 0.0159) with a reduction in CCT by USP at 12.3 months postoperatively. (elsevier.com)
  • Thinning of the cornea and sclera (caused by diseases) may increase the risk of perforations with the use of topical steroids. (medicines.org.uk)
  • Physical examination revealed wound and conjunctival myiasis. (archcid.com)
  • Slit lamp examination of both eyes showed erythematous conjunctival growth that extended circumferentially. (hindawi.com)
  • Amyloidosis can affect any organ and may be a localized or systemic disease. (healio.com)
  • Cutaneous amyloidosis can be localized or secondary to systemic disease. (healio.com)
  • LCD type II (Meretoja syndrome) is a systemic disease presenting in young adulthood with cutaneous, nervous and corneal manifestations. (healio.com)
  • Vora GK, Marr B, Cummings TJ, Mruthyunjaya P. Conjunctival Pseudotumor Caused by Herpes Simplex Virus Infection. (jamanetwork.com)
  • We describe a conjunctival exposure to WNV that occurred in the field and probably resulted in infection in the exposed person. (cdc.gov)
  • Reverse ral diarrhea, foot and mouth disease, and infectious bovine transcription-PCR and sequence analyses indicated that the virus belonged to EHD virus serotype 6, thus confi rming rhinotracheitis, were considered, but the rate of spread and EHD virus infection of cattle in Turkey. (cdc.gov)
  • Five-year, disease-specific survival was 81.4 % for those patients receiving pre-operative radiotherapy plus IORT (n = 69) compared to 58.1 % for those patients in the mesorectal excision group (n = 44). (aetna.com)
  • A conjunctival mass in a patient with human immunodeficiency virus (HIV) can have a long differential diagnosis, ranging from opportunistic infections to malignant neoplasms. (jamanetwork.com)
  • Regression of conjunctival tumor in celiac disease patient attributed to glutenfree diet. (greenmedinfo.com)
  • With uveal melanomas, the prognosis for survival is mostly based on genetic studies, whereas with conjunctival melanomas tumor size and location are more predictive. (springer.com)
  • By the time of the first collection of conjunctival- tear samples, the mean time of the onset of complaints was 6.84 ± 6.81 (1-35) days. (bvsalud.org)
  • Alpha-1 antitrypsin and serum albumin levels in tear fluid of healthy subjects and in persons with conjunctival diseases. (bvsalud.org)
  • Schirmer test, corneal fluorescein staining, conjunctival lissamine green staining, and tear break-up time). (prnewswire.co.uk)
  • DES is also called keratoconjunctivitis sicca (KCS), keratitis sicca, sicca syndrome, xerophthalmia, dry eye disease (DED), ocular surface disease (OSD), or dysfunctional tear syndrome (DTS), or simply dry eyes [ 1 ]. (hindawi.com)
  • Dry eye disease is characterized by instability of the tear film that can be due to insufficient amount of tear production or due to poor quality of tear film, which results in increased evaporation of the tears. (hindawi.com)
  • Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. (clspectrum.com)
  • Conjunctival tissue was collected from AED mice after the final day of challenge, and from naïve mice as our negative control. (arvojournals.org)
  • A front of the eye or anterior ocular condition is a disease, ailment or condition which affects or which involves an ocular region or site, such as a periocular muscle, an eye lid or an eye ball tissue or fluid which is located anterior to the posterior wall of the lens capsule or ciliary muscles. (google.com)
  • Detection of SARS-CoV-2 in the tears and conjunctival secretions of Coronavirus disease 2019 patients. (bvsalud.org)
  • Current studies suggest that tears and conjunctival secretions may be an important transmission route in coronavirus disease 2019 (COVID-19). (bvsalud.org)
  • An important gene associated with Conjunctival Nevus is MLANA (Melan-A), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Development Endothelin-1/EDNRA signaling . (malacards.org)
  • Conjunctival melanomas are biologically similar to cutaneous melanomas, with common mutations of BRAF or NRAS as initiating mutations. (springer.com)
  • For treatment of dry eye disease (DED), or keratoconjunctivitis sicca (KCS), artificial tears are administered with and without preservatives, depending on severity. (medscape.com)
  • Progressive motor impairment from a critically located lesion in highly restricted CNS-demyelinating disease. (mayo.edu)
  • Primary acquired melanosis is now differentiated histologically into hypermelanosis and conjunctival melanocytic intra-epithelial neoplasia, for which an objective reproducible scoring system has been developed. (nature.com)
  • 5 We have also devised a system for histological scoring for conjunctival melanocytic intra-epithelial neoplasia (C-MIN), which in our institution has replaced the term primary acquired melanosis (PAM) with varying (subjectively evaluated) degrees of atypia. (nature.com)
  • Histologically, conjunctival melanosis is divided into two groups according to the pathological processes involved: 'hypermelanosis' and 'melanocytic neoplasia' ( Table 2 and Figure 3 ). (nature.com)
  • Type II diabetes is associated with conjunctival hypoxia , [9] increased average blood vessel diameter, and capillary loss. (wikipedia.org)
  • Lima CS, Rocha EM, Silva NM, Sonatti MF, Costa FF, Saad ST. Risk factors for conjunctival and retinal vessel alterations in sickle cell disease. (medscape.com)
  • The study aims to evaluate the presence of severe acute respiratory syndrome Coronavirus -2 ( SARS-CoV-2 ) virus in tears and conjunctival secretion of patients with COVID-19. (bvsalud.org)
  • Sjögren's syndrome (SjS) is a human autoimmune disease characterized by exocrine dysfunction resulting from chronic autoimmune attack primarily against the lacrimal and/or salivary glands. (duke.edu)
  • Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and multiple evanescent white dot syndrome (MEWDS) are self-limited, spontaneously-remitting diseases for which treatment typically is not needed. (ophthalmologytimes.com)
  • Sokol JA, Baron E, Lantos G, Kazim M. Orbital compression syndrome in sickle cell disease. (medscape.com)
  • These stem cells can become deficient as a result of various diseases affecting the ocular surface. (uio.no)
  • Methods: This student thesis is based on a number of review articles and original articles on PubMed using the search words limbal, limbal stem cell deficiency, conjunctival and/or ocular surface reconstruction. (uio.no)
  • Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. (sciencemag.org)
  • Dry eye is a multifactorial disease of the tears and ocular surface diagnosed by an eye care professional. (prnewswire.co.uk)
  • A corresponding, slightly larger, area is similarly removed from the under or conjunctival surface of the upper lid (Fig. 139). (dictionary.com)
  • This multifactorial disease of the tears and ocular surface is associated with inflammation that may eventually lead to damage to the surface of the eye. (takeda.com)
  • For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. (stanford.edu)
  • Research helps us better understand diseases and can lead to advances in diagnosis and treatment. (cdc.gov)
  • Purpose: To evaluate the efficacy of superficial keratectomy and conjunctival advancement hood flap (SKCAHF) for the treatment of bullous keratopathy in canine patients. (elsevier.com)
  • The FDA grants Priority Review designation to drugs that have the potential to provide significant improvements in the safety or effectiveness for the treatment, diagnosis or prevention of a serious disease. (drugs.com)
  • As Europe's leading Ophthalmic Drugs conference, we will explore new discoveries in the treatment of ocular rare disease, innovations in gene therapy, the challenges in drug delivery through a complex barrier, patient comfort, and regulatory compliance which make up such core components within the Ophthalmic Drug sphere. (smi-online.co.uk)
  • These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. (cdc.gov)
  • This again is another disease in which treatment should be initiated with both immunosuppression and oral steroids, Dr. Jabs suggested. (ophthalmologytimes.com)
  • An Increasing Prominent Disease of Klebsiella pneumoniae Liver Abscess: Etiology, Diagnosis, and Treatment. (biomedsearch.com)
  • Topical cyclosporine 0.05% ophthalmic emulsion has proven to be an effective FDA-approved treatment for dry eye disease. (medscape.com)
  • The aim of this review is to provide awareness among the patients, health care professionals, and researchers about diagnosis and treatment of KCS and recent developments and future challenges in management of dry eye disease. (hindawi.com)
  • A remarkable case of a scleral melting reaction in association with conjunctival rhinosporidiosis is presented and its surgical treatment with a scleral. (molecularstation.com)
  • Evidence is scarce regarding appropriate treatment of conjunctival RLH. (bireme.br)
  • IKA was also formed to promote the awareness and understanding of the most appropriate and effective treatment strategies for managing these diseases. (clspectrum.com)