Conjugates polysaccharide carrier proteins. Medical search. Frequent questions

Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)
This article reviews recent studies on mucosal immune responses induced by polysaccharide based vaccines and some protein vaccine antigens against several pathogenic nasopharyngeal bacteria, and discusses the mechanisms and functions of these immune responses that may help our understanding of mucosal immune responses to both immunisation and infection. (bmj.com)
Menactra®, Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, is a sterile, intramuscularly administered vaccine that contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. (mesvaccins.net)
Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens. (biomedcentral.com)
Two different periplasmic carrier proteins, AcrA from C. jejuni and a toxoid form of Pseudomonas aeruginosa exotoxin were glycosylated with Shigella O antigens in E. coli . (biomedcentral.com)
Here, we examine and discuss the impact of glycan chain length on the efficacy of glycoconjugate vaccines and report the methods employed to size polysaccharide antigens, while highlighting the underlying reaction mechanisms. (jenner.ac.uk)
13vPCV and 23vPPV vary in the number of pneumococcal serotypes they protect against, that is, valency (v). 23vPPV contains 23 variant types of antigens in the form of polysaccharides (sugars). (ncirs.org.au)
13vPCV contains 13 variant types of polysaccharide antigens. (ncirs.org.au)
Polysaccharides are T-independent antigens, and can not be processed or presented on MHC molecules to interact with T-cells. (allindianpatents.com)
A conjugate vaccine binds to polysaccharide-specific B-cells that communicate carrier protein antigens to T-cells, inducing a T-cell-dependent immune response. (pfizerpro.in)
In addition, non-replicating mRNAs can be used to produce RNA-related vaccines that involve mRNA sequences encoding pathogen-specific proteins (antigens) in host cells. (medicaltrend.org)
Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. (biomedcentral.com)
These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants. (biomedcentral.com)
However, inclusion of protein antigens fromStreptococcus pneumoniaecombined with potent adjuvants and a suitable delivery system are expected to both extend protection to serotype strains not represented in the formulation and stimulate a broader immune response, thus more effective in young children, elderly, and immunocompromised populations. (univ-nantes.fr)

Conjugate vaccine technology, where a polysaccharide antigen is coupled chemically to a protein carrier, either by direct linkage or by indirect coupling via diamino spacer molecules, can render the PS specific immune response T cell dependent. (bmj.com)
Potency of Menactra vaccine is determined by quantifying the amount of each polysaccharide antigen that is conjugated to diphtheria toxoid protein and the amount of unconjugated polysaccharide present. (mesvaccins.net)
However, the polysaccharide antigen in the vaccine product is in the conjugate form (CRM197 linked) and hence using NP as a reference standard may not be suitable. (bvsalud.org)
In the case of COVID-19, the antigen is typically the characteristic spike protein (S protein) found on the surface of the virus, which it normally uses to help it invade human cells (see Figure 2). (edu.gh)
in both cases it provides the instructions for making a specific protein from the pathogen, which the immune system will recognise as foreign (an antigen). (edu.gh)
Strategies, which have been designed to overcome this lack of immunogenicity in infants, include the linking of the polysaccharide to large immunogenic proteins, which provide bystander T-cell help and which induce immunological memory against the polysaccharide antigen to which it is conjugated. (allindianpatents.com)
Upon first exposure to a T-cell-dependent antigen (i.e. protein), the immune system mounts a slow primary response and induces the formation of long-lived memory cells. (pfizerpro.in)
Clutterbuck EA, Lazarus R, Yu L-M, Haber M, May L, Klugman K. Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells. (pfizerpro.in)
In RNA vaccines, mRNA is used as a template for the endogenous synthesis of the target pathogenic protein (antigen). (medicaltrend.org)
Like other polysaccharides, the polyribosyl ribitol phosphate (PRP) of the Hib capsule is a T-independent antigen and not immunogenic when administered as a vaccine in infancy. (ox.ac.uk)
Bioconjugation relies on single cells that simultaneously produce a polysaccharide antigen along with an engineered carrier protein and a conjugating enzyme to precisely link them together. (omniose.com)
Our platform enables the precise enzymatic attachment of virtually any bacterial polysaccharide (sugar) antigen to engineered carrier proteins within a single E. coli cell. (omniose.com)

Prevnar (PCV7) was produced from the seven most prevalent strains of Streptococcus pneumoniae bacteria in the U.S. The bacterial capsule sugars, a characteristic of these pathogens, are linked (conjugated) to CRM197, a nontoxic recombinant variant of diphtheria toxin (from cultures of Corynebacterium diphtheriae). (wikipedia.org)
Through reductive amination, the sugars are directly conjugated to the protein carrier CRM197 to form the glycoconjugate. (wikipedia.org)
V114 consists of pneumococcal polysaccharides from 15 serotypes conjugated to a CRM197 carrier protein and includes serotypes 22F and 33F, which are commonly associated with invasive pneumococcal disease in older adults worldwide and are not contained in the pneumococcal conjugate vaccine currently licensed for use in adults. (merck.com)
Several protein carriers have been used including tetanus toxoid (TT), diphtheria toxoid, mutant diphtheria toxin (CRM197), and the outer membrane protein of N meningitidis . (bmj.com)
Both Prevenar 13 and Prevenar use CRM197 -- an immunological carrier protein with a 20-year history of use in pediatric vaccines. (science20.com)
The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated then conjugated to the protein carrier CRM197 to form the glycoconjugate. (creativebiomart.net)
There are several warnings associated with the use of Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) that users should be aware of: 1. (qwarkhealth.com)

The Committee also adopted updated requirements for Haemophilus influenzae type b conjugate vaccine. (who.int)
Diphtheria, Tetanus, Pertussis, Hepatitis B and Haemophilus influenzae type b Conjugate Vaccine Adsorbed as supplied by Serum the parent's history with respect to possible sensitivity and any previous adverse reactions to the vaccine or similar vaccines. (who.int)
B y la Haemophilus influenzae tipo b, en la forma suministrada por el Serum Institute of India Pvt. (who.int)
The introduction of Haemophilus influenzae type b conjugate vaccines during the 1990s was followed by dramatic decreases both in the incidence of Haemophilus influenzae type b related invasive disease and in nasopharyngeal carriage of the organism. (bmj.com)
The extent of this effect has been influenced by the fact that Haemophilus influenzae type b conjugate vaccines reduce nasopharyngeal carriage and induce herd immunity. (bmj.com)
Based on the success of Haemophilus influenzae type b conjugate vaccines, chemical conjugation has been applied to the development of pneumococcal and meningococcal polysaccharide conjugate vaccines. (bmj.com)
Most notably routine immunization of infants with conjugate vaccines against Haemophilus influenzae type B led to a fast and dramatic drop in respective disease incidents after implementation. (biomedcentral.com)
A similar strategy could be applied to test and release monovalent or multivalent polysaccharide-protein conjugate vaccines (Meningococcal, Haemophilus influenza Type B, Typhoidal, and non-typhoidal salmonella). (bvsalud.org)

Testing the final formulated product for individual serotype polysaccharide content is critical in vaccine quality control which requires an assay specific to each serotype polysaccharide present in the formulated product. (bvsalud.org)
Antibodies specific to the serotypes specific polysaccharide were used in rate nephelometry assay for quantifying individual serotype polysaccharides in the formulated vaccine. (bvsalud.org)
Pneumococcus is encapsulated with a chemically linked polysaccharide which confers serotype specificity. (allindianpatents.com)
pneumoniae serotype 14 capsular polysaccharide (CP14) linked to the Pneumococcal surface protein A (PsaA) using chitosan NPs (CNPs). (univ-nantes.fr)

It contains purified capsular polysaccharide of pneumococcal serotypes conjugated to a carrier protein to improve antibody response compared to the pneumococcal polysaccharide vaccine. (wikipedia.org)
Prevnar (PCV7) is a heptavalent vaccine, meaning that it contains the cell capsule sugars of seven serotypes of the bacteria S. pneumoniae (4, 6B, 9V, 14, 18C, 19F, and 23F) conjugated with diphtheria proteins. (wikipedia.org)
Pneumococci are classified into serotypes depending on their capsular polysaccharide, which is a main virulence factor for pneumococcus ( 4 ). (cdc.gov)
During 2018-2019, approximately 60%-75% of all IPD in adults was caused by the 24 pneumococcal serotypes that were included in the formulations of commercially available polysaccharide conjugate vaccine (PCV) or pneumococcal polysaccharide vaccine (PPSV) vaccines (i.e. (cdc.gov)
New data from Phase 3 European clinical trials reinforce that Wyeth's (NYSE: WYE) investigational pneumococcal vaccine, Prevenar 13* (Pneumococcal Polysaccharide Conjugate Vaccine, 13-valent [Adsorbed]), has the potential to provide coverage against the 13 most prevalent serotypes associated with pneumococcal disease (PD), the leading cause of vaccine-preventable death in children younger than five worldwide. (science20.com)
Vaxcyte Inc. VAX-24 Pneumococcal Conjugate Vaccine candidate addresses infection from 24 serotypes of pneumococcal disease. (precisionvaccinations.com)
The multivalent pneumococcal conjugate vaccine (PCV) contains purified polysaccharides of different serotypes conjugated to a carrier protein. (bvsalud.org)

In this study, we investigated the human antibody repertoire, avidity maturation, epitope specificity, and function after immunization with a single dose of Vi-tetanus toxoid conjugate vaccine (Vi-TT) and after a booster with plain Vi PS (Vi-PS). (ox.ac.uk)

In vivo enzymatic coupling using the general glycosylation pathway of Campylobacter jejuni in recombinant Escherichia coli has been suggested as a simpler method for producing conjugate vaccines. (biomedcentral.com)
Glycoconjugate synthesis, in particular expression of oligosaccharyltransferase PglB, strongly inhibited growth of E. coli cells after induction, making it necessary to separate biomass growth and recombinant protein expression phases. (biomedcentral.com)
The presented data demonstrate that glycosylated proteins can be produced in recombinant E. coli at a larger scale. (biomedcentral.com)
We prepared GBS capsular polysaccharide (CPS) - recombinant cholera toxin B subunit (rCTB) conjugate vaccines by different methods and evaluated their systemic and mucosal immunogenicity in mice. (gu.se)
An immunogenic composition comprising 2 S. pneumoniae recombinant proteins wherein one of the proteins is selected from the Poly Histidine Triad family (PhtX) at a dose of between 1-100 µg and optionally comprising an adjuvant. (allindianpatents.com)
Generally, pathogen products used in subunit vaccines include purified or recombinant protein-inactivated bacterial toxins, or polysaccharides present on surface capsules. (medicaltrend.org)

New generation vaccines, in which the polysaccharide is conjugated to protein carriers, induce a better immune response in the population under 2 years of age. (scielo.sa.cr)
Evidence has begun to accumulate that these new polysaccharide based conjugate vaccines can also reduce nasopharyngeal carriage and can induce immune responses at the local mucosal level, which may be responsible for these effects. (bmj.com)
Recent studies show that parenterally administered capsular polysaccharide (PS) based vaccines can induce mucosal immune responses. (bmj.com)
In contrast to isolated bacterial polysaccharides, conjugate vaccines induce a long-lasting T-lymphocyte dependent immunological memory [ 4 , 5 ]. (biomedcentral.com)
Such vaccines do not include other protein sequences that induce self-amplification of the inserted mRNA sequence. (medicaltrend.org)

To ascertain if the specificity of the natural and mutated PglBs have been altered we will test separate capsular polysaccharides from the important pathogens Streptococcus pneumoniae and Burkholderia pseudomallei to determine if the respective capsules can now be coupled/conjugated to an appropriate carrier protein. (ukri.org)

Ltd., es un líquido homogéneo que contiene los toxoides purificados de difteria polysaccharide chemically conjugated to a protein (Tetanus Toxoid). (who.int)
A CPS-tetanus toxoid conjugate administrated i.n. induced a strong serum IgG but only a weak mucosal IgA response, while CPS-rCTB conjugates elicited high IgG as well as IgA antibodies in both serum and the lungs after i.n. immunization. (gu.se)
Neisseria meningitidis serogroup Y polysaccharide, 5 µg, conjugated to tetanus toxoid carrier protein of 44 µg. (rxhealthmed.ca)
Vaccine production uses a modified reductive amination conjugation method between periodate-oxidized meningococcal C polysaccharide (MPCO) and hydrazide-activated monomeric tetanus toxoid (MATT). (fiocruz.br)

Hib capsule is composed of polyribosyl-ribitol-phosphate (PRP), a polysaccharide used in Hib vaccines. (cdc.gov)
Non-conjugated vaccines that utilize as its basis only the polysaccharide capsule are helpful in epidemic scenarios, but fail to produce adequate long-term immunogenicity in the population at greater risk, those under 2 years of age. (scielo.sa.cr)
In order to evoke an appropriate immune response, vaccines against these bacteria consist of capsule linked to a protein carrier forming a glycoprotein or glycoconjugate. (ukri.org)
However, despite the success of these glycoconjugate vaccines they have major drawbacks in terms of the technical difficulties in purifying the capsule material from bacterial cells and then conjugating the capsule to carrier proteins. (ukri.org)
There are two types of vaccine against pneumococcus, both based on the induction of an immune response against the polysaccharides that make up the capsule: the 23-valent polysaccharide vaccine and the 20-valent, 10-valent and 13-valent conjugate vaccines. (corvelva.it)
Conjugate vaccines are made by combining polysaccharide residues in the bacterial surface capsule with carrier proteins (such as diphtheria toxoid protein). (medicaltrend.org)
During childhood, acquisition of antibody directed against the polysaccharide capsule of the organism, presumably as a result of asymptomatic carriage, confers protection and disease is much less common after the age of 4 years. (ox.ac.uk)
Because the highest rates of disease occur in the first 2 years of life, efficacious Hib vaccines have been designed by covalently linking the PRP capsule to a carrier protein that recruits T-cell help for the polysaccharide immune response and induces anti-PRP antibody production even in the first 6 months of life. (ox.ac.uk)

This report contains updated information regarding a) antimicrobial resistance among pneumococci, b) vaccine effectiveness and cost-effectiveness, c) indications for vaccination, d) guidelines for revaccination, e) strategies for improving delivery of vaccine, and f) development of pneumococcal conjugate vaccine. (cdc.gov)
Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm. (ipe.ac.cn)

Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine. (ipe.ac.cn)

The transmission of these bacteria primarily between asymptomatic carriers is through droplet spread or contact with respiratory secretions. (bmj.com)
The processes are time-consuming and costly, and often large-scale cultivation of pathogenic bacteria is required for polysaccharide biosynthesis, making conjugate vaccines prohibitively expensive for vaccination campaigns in developing countries. (biomedcentral.com)
These polysaccharides occur on the surface of the pneumococcal bacteria. (ncirs.org.au)
Pneumococcal polysaccharide conjugate vaccine (20-valent, adsorbed) given to persons 18 years of age and older for the prevention of disease caused by 20 types of Streptococcus pneumoniae bacteria. (corvelva.it)
Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines. (pfizerpro.in)

Subunit vaccines only include a portion of the pathogen, such as a protein or a sugar molecule, which can stimulate the immune system without actually infecting the patient. (reportsanddata.com)
Specific IgM, IgG and IgA antibodies to the CPS were tested in serum and IgG and IgA antibodies in lungs, intestinal, rectal and vaginal extracts by ELISA.We found, as tested with GBS type III CPS, that generally CPS III conjugates were superior to unconjugated CPS in eliciting CPS-specific immune responses in serum and mucosal tissue extracts. (gu.se)
However, the smaller conjugates in most cases elicited a lower anti-CPS IgA immune response as compared with the larger conjugates, and the strongest anti-CPS responses in both tissues and serum were obtained with the large fraction of a CPS III-rCTB conjugate prepared by reductive amination.The CPS specific immune responses in various organs were dependent on the route of immunization. (gu.se)
conjugate subunit vaccines bind a polysaccharide chain to a carrier protein to try and boost the immune response. (edu.gh)
However, the combination of the bacterial part and the carrier protein induces a powerful and comprehensive immune response. (medicaltrend.org)
Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins, Process Biochemistry, 2017, 52:183-91. (jenkem.com)

To prepare the polysaccharides for conjugation, they are depolymerized, derivatized, and purified by diafiltration. (mesvaccins.net)
Conjugation of-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine. (ipe.ac.cn)
Preparation, structural analysis and bioactivity of ribonuclease A-albumin conjugate: tetra-conjugation or PEG as the linker. (ipe.ac.cn)
The technology that is used in the production of the NmCV-5 vaccine is based on cost-effective methods for carrier protein production, polysaccharide fermentation and purification, and chemical conjugation," they noted. (medpagetoday.com)
Conjugation of staphylokinase with the arabinogalactan-PEG conjugate: Study on the immunogenicity, in vitro bioactivity and pharmacokinetics, International Journal of Biological Macromolecules, 2019, V. 131, P. 896-904. (jenkem.com)
Conjugation of PEG-hexadecane markedly increases the immunogenicity of pneumococcal polysaccharide conjugate vaccine, Vaccine, 2017, 35(13):1698-704. (jenkem.com)

3) GBS CPS III-rCTB and Ia-rCTB conjugates prepared by reductive amination may serve as a basis for development of effective bivalent or multivalent mucosal vaccines to prevent mucosal colonization and invasive infection caused by GBS. (gu.se)

The vaccine's polysaccharide sugars are grown separately in soy peptone broths. (wikipedia.org)
The key enzyme in the C. jejuni pathway that couples proteins to sugars is the oligosaccharyltransferase protein termed CjPglB. (ukri.org)

The diphtheria toxoid protein is purified by ammonium sulfate fractionation and diafiltration. (mesvaccins.net)
Each 0.5 mL dose of vaccine is formulated in sodium phosphate buffered isotonic sodium chloride solution to contain 4 mcg each of meningococcal A, C, Y and W-135 polysaccharides conjugated to approximately 48 mcg of diphtheria toxoid protein carrier. (mesvaccins.net)

Pneumococcal conjugate vaccine is a pneumococcal vaccine and a conjugate vaccine used to protect infants, young children, and adults against disease caused by the bacterium Streptococcus pneumoniae (pneumococcus). (wikipedia.org)
KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older. (merck.com)

After induction glycoconjugates generally appeared later than unglycosylated carrier protein, suggesting that glycosylation was the rate-limiting step for synthesis of conjugate vaccines in E. coli . (biomedcentral.com)

The conjugates when administrated subcutaneously induced only IgG responses in serum, lung and vagina, while intranasal (i.n.) vaccination also elicited specific anti-CPS IgA responses in the lungs and vagina. (gu.se)
Generally, as tested with four routes of mucosal vaccination, including i.n. oral, vaginal and rectal immunizations, the highest levels of IgA and IgG anti-CPS antibody responses were generated in the regions or sites of conjugate exposure. (gu.se)
All four routes of vaccination with the conjugate elicited similar, high levels of anti-CPS IgG in serum. (gu.se)
Impact of pneumococcal conjugate vaccination of infants on pneumonia and influenza hospitalization and mortality in all age groups in the United States. (pfizerpro.in)

The present invention relates to a combination of 2 or more S. pneumoniae proteins, their manufacture and use in medicine as a vaccine. (allindianpatents.com)
In yet another related aspect is a method for making the vaccine of the invention by selecting and isolating 2 different S. pneumoniae proteins and mixing both proteins with a pharmaceutically acceptable carrier. (allindianpatents.com)

The outermost structure of encapsulated H. influenzae is composed of a polysaccharide, a key virulence factor. (cdc.gov)
WHO Requirements for H. influenzae type b conjugate vaccine were first published in 1991. (who.int)

The derivatized polysaccharides are covalently linked to diphtheria toxoid and purified by serial diafiltration. (mesvaccins.net)

Antibodies to Hib capsular polysaccharide are protective. (cdc.gov)

In June 2021, the U.S. Food and Drug Administration (FDA) approved the pneumococcal 20-valent conjugate vaccine, sold under the brand name Prevnar 20 (PCV20), for adults 18 years of age and older. (wikipedia.org)
In 2021, two new pneumococcal conjugate vaccines (PCVs), a 15-valent and a 20-valent PCV (PCV15 and PCV20), were licensed for use in U.S. adults aged ≥18 years by the Food and Drug Administration. (cdc.gov)

Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. (pfizerpro.in)

The focus of this report is the prevention of invasive pneumococcal disease (i.e., bacteremia, meningitis, or infection of other normally sterile sites) through the use of pneumococcal polysaccharide vaccine. (cdc.gov)
Introduction of Hib protein-polysaccharide conjugate vaccines into many industrialized countries over the past 15 years has resulted in the virtual elimination of invasive Hib disease. (ox.ac.uk)

Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine. (ipe.ac.cn)
PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine. (ipe.ac.cn)

The market for human vaccinations is divided into many types based on kind, including live attenuated, inactivated, subunit, conjugate, and DNA vaccines. (reportsanddata.com)

Vaccine development to prevent Salmonella Typhi infections has accelerated over the past decade, resulting in licensure of new vaccines, which use the Vi polysaccharide (Vi PS) of the bacterium conjugated to an unrelated carrier protein as the active component. (ox.ac.uk)

We will seek to identify or engineer alternative PglB proteins that will have a modified specificity for different glycostructures. (ukri.org)
Recently, along with our collaborators we have demonstrated that CjPglB has a relaxed specificity enabling transfer of diverse polysaccharides, including lipopolysaccharide and capsules, to proteins with appropriate D/E-X-N-Z-S/T consensus sequons. (ukri.org)

Before 2021, ACIP recommended 23-valent pneumococcal polysaccharide vaccine (PPSV23) alone (up to 2 doses), or both a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) in combination with 1-3 doses of PPSV23 in series (PCV13 followed by PPSV23), for use in U.S. adults depending on age and underlying risk for pneumococcal disease. (cdc.gov)

Prevnar 13 (PCV13) is produced by the Wyeth subsidiary of Pfizer and it replaces Prevnar (PCV7), the pneumococcal 7-valent conjugate vaccine (PCV7). (wikipedia.org)

13]Mu Qimeng, Hu Tao*, Yu Jingkai*.Molecular insight into the steric shielding effect of PEG on the conjugated staphylokinase: biochemical characterization and molecular dynamics simulation. (ipe.ac.cn)

In this study we describe the in vivo biosynthesis of two novel conjugate vaccine candidates against Shigella dysenteriae type 1, an important bacterial pathogen causing severe gastro-intestinal disease states mainly in developing countries. (biomedcentral.com)

Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature, Biomaterials, 2017, V. 116, P. 57-68. (jenkem.com)

This report updates the last recommendations by the Advisory Committee on Immunization Practices (ACIP) concerning pneumococcal polysaccharide vaccine (MMWR 1989;38:64-8,73-6). (cdc.gov)
I.n. immunization was usually the most efficient way to obtain strong anti-CPS responses in both serum and mucosal tissues including both the lungs and the vagina.Priming with pure GBS CPS III alone or with GBS CPS III-rCTB conjugate induced comparable levels of specific IgG and IgA in serum, lungs and vagina. (gu.se)
Union Health Minister expands Pneumococcal Conjugate Vaccine Under Universal Immunization Program. (chemrobotics.in)
Union Minister for Health and Family Welfare, Dr Mansukh Mandaviya launched the nationwide expansion of Pneumococcal Conjugate Vaccine (PCV) under the Universal Immunization Programme (UIP) as a part of Azadi ka Amrit Mahotsav. (chemrobotics.in)

Anatomy8

Organisms23

Diseases3

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes51

Disciplines and Occupations2

Technology, Industry, Agriculture2

Information Science5

Health Care4

Antigens14

Antigen12

CRM1977

Haemophilus8

Serotype4

Serotypes7

Toxoid Conjugate Vaccine1

Recombinant6

Induce5

Capsular polysaccharides1

Tetanus4

Capsule8

Development of pneumococcal2

Meningococcal polysaccharide1

Bacteria5

Immune6

Conjugation6

Reductive amination1

Sugars2

Diphtheria toxoid protein2

Streptococcus2

Glycoconjugates1

Vaccination4

Pneumoniae2

Influenzae2

Covalently1

Antibodies1

PCV202

Immunisation1

Invasive2

Immunogenicity2

Live attenuated1

Bacterium1

Specificity2

Single dose1

PCV131

Staphylokinase1

Vaccine candidates1

Synthesis1

Immunization4