• A 13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease (IPD) was introduced in China in April 2017. (cdc.gov)
  • The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in mainland China in November 2016 as a category II vaccine. (cdc.gov)
  • KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the company has submitted applications to the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) for licensure of V114, Merck's investigational 15-valent pneumococcal conjugate vaccine, for use in adults 18 years of age and older. (merck.com)
  • V114 is Merck's investigational 15-valent pneumococcal conjugate vaccine candidate for the prevention of pneumococcal disease in adults and children. (merck.com)
  • V114 consists of pneumococcal polysaccharides from 15 serotypes conjugated to a CRM197 carrier protein and includes serotypes 22F and 33F, which are commonly associated with invasive pneumococcal disease in older adults worldwide and are not contained in the pneumococcal conjugate vaccine currently licensed for use in adults. (merck.com)
  • KENILWORTH, N.J.--(BUSINESS WIRE)-- Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older. (merck.com)
  • These recommendations include information on two vaccines recently licensed for use among infants: Haemophilus b Conjugate Vaccine (PRP-T {ActHIB(TM), OmniHIB(TM)}), manufactured by Pasteur Merieux Vaccins, and TETRAMUNE{TM}, manufactured by Lederle Laboratories/Praxis Biologics. (cdc.gov)
  • On the basis of findings establishing comparable immunogenicity, a third conjugate vaccine, PRP-T (ActHIB{TM}, OmniHIB{TM}) has now been licensed for use among infants. (cdc.gov)
  • Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)
  • In the past year, four antibody-drug conjugates (ADC) were approved, nearly doubling the marketed ADCs in oncology. (aacrjournals.org)
  • That's because scientists are currently testing an experimental form of cancer treatment, called antibody-drug conjugates (ADCs). (kazanlaw.com)
  • Antibody-drug conjugates (ADCs) comprise one of the fastest growing segments of the biopharmaceutical market. (biopharminternational.com)
  • Consisting of antibodies linked to highly potent (cytotoxic) small-molecule "payloads," ADCs are designed for the targeted delivery of therapeutic actives. (biopharminternational.com)
  • [3] Antibody-drug conjugates are an example of bioconjugates and immunoconjugates . (wikipedia.org)
  • Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human CD3e PE-conjugated Monoclonal Antibody (Catalog # FAB100P ) and either (A) Mouse Anti-Human CD8a Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # FAB1509R) or (B) Mouse IgG 2B Alexa Fluor 647 Isotype Control (Catalog # IC0041R ). (rndsystems.com)
  • The conjugate will react with the antigen-antibody complex on the surface of the well resulting in a sandwich of well-antigen-antibody-antibody-enzyme. (cdc.gov)
  • If the test specimen does not contain IgG antibody to the antigen, the conjugate will not bind to the well surface and will be removed by washing. (cdc.gov)
  • The non-restricted CD45, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. (beckman.com)
  • AP is Upper AP is Lower 00 01 02 03 04 00 11 12 13 14 10 11 22 23 24 20 21 22 33 34 30 31 32 33 44 40 41 42 43 44 Let TRANSR = 'N'. RFP holds AP as follows: For UPLO = 'U' the upper trapezoid A(0:4,0:2) consists of the last three columns of AP upper. (netlib.org)
  • This covers the case N odd and TRANSR = 'N'. RFP A RFP A -- -- 02 03 04 00 33 43 -- 12 13 14 10 11 44 22 23 24 20 21 22 -- 00 33 34 30 31 32 -- -- 01 11 44 40 41 42 Now let TRANSR = 'C'. RFP A in both UPLO cases is just the conjugate- transpose of RFP A above. (netlib.org)
  • Therefore, in this system, most H+ will be hydronium ions H 3O+ instead of attached to Cl− anions and the conjugate bases will be weaker than water molecules. (wikipedia.org)
  • Organic semiconductors (OSCs) are a class of semiconductor materials consisting of conjugated molecules or polymers. (nanowerk.com)
  • Hemoglobin molecules consist of polypeptide chains whose chemical structure is genetically. (msdmanuals.com)
  • Interest in linear (1D) conjugated polymers has significantly increased in recent decades due to their semiconducting properties and promising applications in organic optoelectronics. (tu-dresden.de)
  • 2D conjugated polymers (2D CPs) consisting of multi-strands of linear conjugated polymers have been the dream of synthetic targets for several decades. (tu-dresden.de)
  • These bioinylated conjugates are prepared from our affinity-purified lectins and are optimally labeled with biotin. (vectorlabs.com)
  • Essentially free of inactive lectin conjugates and containing no free biotin, these biotinylated lectins provide ideal intermediates for examining glycoconjugates using the Biotin-Avidin/Streptavidin System. (vectorlabs.com)
  • First a biotin-labeled lectin is added, followed by the VECTASTAIN ABC Reagent, Avidin D conjugate, or streptavidin derivative. (vectorlabs.com)
  • A cation can be a conjugate acid, and an anion can be a conjugate base, depending on which substance is involved and which acid-base theory is used. (wikipedia.org)
  • 00078 * For UPLO = 'U' the upper trapezoid A(0:5,0:2) consists of the last 00079 * three columns of AP upper. (netlib.org)
  • 00131 * For UPLO = 'U' the upper trapezoid A(0:4,0:2) consists of the last 00132 * three columns of AP upper. (netlib.org)
  • Tezcat's current portfolio consists of conjugates combining its proprietary protein carrier with established drug payloads. (massbio.org)
  • Anti·His HRP Conjugate Kits consist of the QIAexpress Anti·His Antibodies chemically coupled to the reporter enzyme horseradish peroxidase (HRP). (qiagen.com)
  • Intact IL-2 or overlapping synthetic peptides of IL-2 that were chemically conjugated to tumor-targeting monoclonal antibodies (TNT-1 or Lym-1) were injected into groups of mice (n = 4) that had previously been xenotransplanted with human tumor cells (ME-180 cervical carcinoma and Raji lymphoma). (nih.gov)
  • Silymarin is orally absorbed and is excreted mainly through bile as sulphates and conjugates. (nih.gov)
  • After washing unreacted serum components from the plate, an antibody-enzyme conjugate is added to the wells and incubated. (cdc.gov)
  • The conjugate consists of antihuman IgG covalently coupled to the enzyme alkaline phosphatase. (cdc.gov)
  • Anti·His HRP Conjugate Kits, including the RGS·His HRP Conjugate Kit (His tag conjugates) and Penta·His HRP Conjugate Kit (6xHis tag conjugates), are intended for sensitive detection of recombinant proteins carrying His tags, without the need for secondary antibodies. (qiagen.com)
  • The recombinant human (rh) Granzyme B consisting of residues 19-247 was expressed and purified. (rndsystems.com)
  • Because some acids can give multiple protons, the conjugate base of an acid may itself be acidic. (wikipedia.org)
  • One use of conjugate acids and bases lies in buffering systems, which include a buffer solution. (wikipedia.org)
  • One synthetic fragment consisting of amino acids 22-58 contained 100% of the vasopermeability activity of IL-2 and was designated permeability-enhancing peptide (PEP). (nih.gov)
  • Consider the following acid-base reaction: HNO 3 + H 2O → H 3O+ + NO− 3 Nitric acid (HNO 3) is an acid because it donates a proton to the water molecule and its conjugate base is nitrate (NO− 3). (wikipedia.org)
  • The nitrate ion (NO 3 ) is a conjugated base of the nitric acid. (differencebetween.net)
  • Current recommendations for universal vaccination of infants require parenteral administration of three different vaccines (diphtheria-tetanus-pertussis {DTP}, Hib conjugate, and hepatitis B) during two or three different visits to a health-care provider. (cdc.gov)
  • They consist of anti·His antibodies conjugated to horseradish peroxidase (HRP). (qiagen.com)
  • What epitopes do the Anti-His Conjugates and Anti-His Antibodies recognize? (qiagen.com)
  • The table below lists the epitopes recognized by the Anti-His Conjugates and Anti-His Antibodies. (qiagen.com)
  • Mouse monoclonal antibodies specific to Zaire Ebola virus GP, NP and VP40 - colloid gold conjugate reacts with the Zaire Ebola virus in the specimen. (who.int)
  • The simplest anion which can be a conjugate base is the free electron in a solution whose conjugate acid is the atomic hydrogen. (wikipedia.org)
  • In an acid-base reaction, an acid and a base react to form a conjugate base and a conjugate acid respectively. (wikipedia.org)
  • High-osmolality contrast media consist of a tri-iodinated benzene ring with 2 organic side chains and a carboxyl group. (medscape.com)
  • Carbazole consists of two benzene rings fused to either side of a five-membered ring containing a nitrogen atom. (chemistryviews.org)
  • Figure 2: TdT-dNTP conjugates can extend a DNA molecule by a single nucleotide in 10-20 s, enabling stepwise DNA synthesis. (nature.com)
  • The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. (origene.com)
  • In a buffer, a weak acid and its conjugate base (in the form of a salt), or a weak base and its conjugate acid, are used in order to limit the pH change during a titration process. (wikipedia.org)
  • By definition, a buffer consists of a weak acid and its conjugate weak base. (uwo.ca)
  • NH 4 + and CH 3 -COO - are not a conjugate acid/base pair, which means that they do not constitute a buffer at pH 7. (uwo.ca)
  • Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table 1 ). (cdc.gov)
  • At its simplest, an ADC consists of three things. (kazanlaw.com)
  • Anti·His HRP Conjugate Kits can be used with chemiluminescent or chromogenic detection substrates. (qiagen.com)
  • The ICA test strip consisted of a membrane with a detection zone, a sample pad and an absorbent pad. (cdc.gov)
  • Based on the fact that the competition is between the migrating analyte in the sample and the analyte hapten immobilized on the test strip for the binding sites of the antibody-colloidal gold (Ab-CG) conjugate migrating on the test strip, this study suggests that the relative migration speed between the two migrating substances is a critically important factor for the sensitive detection by competitive ICA. (cdc.gov)
  • Hence, a conjugate base is a substance formed by the removal of a proton from an acid, as it can gain a hydrogen ion in the reverse reaction. (wikipedia.org)
  • The terms "acid", "base", "conjugate acid", and "conjugate base" are not fixed for a certain chemical substance but can be swapped if the reaction taking place is reversed. (wikipedia.org)
  • The membrane was separately coated with chlorpyrifos Hapten-OVA conjugate (test line) and anti-mouse IgG (control line). (cdc.gov)
  • A conjugate acid, within the Brønsted-Lowry acid-base theory, is a chemical compound formed when an acid gives a proton (H+) to a base-in other words, it is a base with a hydrogen ion added to it, as it loses a hydrogen ion in the reverse reaction. (wikipedia.org)
  • On the other hand, a conjugate base is what remains after an acid has donated a proton during a chemical reaction. (wikipedia.org)
  • text{conjugate base}}+{\text{conjugate acid}}} Johannes Nicolaus Brønsted and Martin Lowry introduced the Brønsted-Lowry theory, which said that any compound that can give a proton to another compound is an acid, and the compound that receives the proton is a base. (wikipedia.org)
  • In diagrams which indicate this, the new bond formed between the base and the proton is shown by an arrow that starts on an electron pair from the base and ends at the hydrogen ion (proton) that will be transferred: In this case, the water molecule is the conjugate acid of the basic hydroxide ion after the latter received the hydrogen ion from ammonium. (wikipedia.org)
  • On the other hand, ammonia is the conjugate base for the acidic ammonium after ammonium has donated a hydrogen ion to produce the water molecule. (wikipedia.org)
  • Also, OH− can be considered as the conjugate base of H 2O, since the water molecule donates a proton to give NH+ 4 in the reverse reaction. (wikipedia.org)
  • The strength of a conjugate base can be seen as its tendency to "pull" hydrogen protons towards itself. (wikipedia.org)
  • If a conjugate base is classified as strong, it will "hold on" to the hydrogen proton when dissolved and its acid will not split. (wikipedia.org)
  • If a chemical is a strong acid, its conjugate base will be weak. (wikipedia.org)
  • Since HCl is a strong acid (it splits up to a large extent), its conjugate base (Cl− ) will be weak. (wikipedia.org)
  • On the other hand, if a chemical is a weak acid its conjugate base will not necessarily be strong. (wikipedia.org)
  • Consider that ethanoate, the conjugate base of ethanoic acid, has a base splitting constant (Kb) of about 5.6×10−10, making it a weak base. (wikipedia.org)
  • In order for a species to have a strong conjugate base it has to be a very weak acid, like water. (wikipedia.org)
  • The conjugate acid in the after side of an equation gains a hydrogen ion, so in the before side of the equation the compound that has one less hydrogen ion of the conjugate acid is the base. (wikipedia.org)
  • The nitrite ion (NO 2 ) is a conjugated base of the nitrous acid. (differencebetween.net)
  • Studies have been performed with all four Hib conjugate vaccines to determine immunogenicity in infants 2-6 months of age. (cdc.gov)
  • Anti·His HRP Conjugate Kits are intended for molecular biology applications. (qiagen.com)
  • A conjugated polyelectrolyte, or CPE-K, consists of a central conjugated backbone, with alternating single and double bonds, and multiple charged side chains with ions attached. (sciencedaily.com)
  • Having conjugated bonds throughout the polymer makes it conductive, because the delocalized electrons have high mobility across the length of the polymer," explains lead author Tung Nguyen-Dang, a postdoctoral researcher in Nguyen's lab who is co-advised by Visell. (sciencedaily.com)
  • Suzhou consists of 5 municipal districts (Gusu, New and High-Tech, Wuzhong, Xiangcheng, and Industrial Park) and 5 county-level cities. (cdc.gov)
  • high levels conjugated metabolites). (cdc.gov)
  • As the pigment is one conjugated ring structure, it has a rigid, planar shape which is also not favourable for systemic uptake. (europa.eu)
  • 7 Briefly, APAC consists of mast cell-derived heparin proteoglycans in the form of a semisynthetic conjugate of unfractionated heparin and a protein core. (lww.com)
  • and c) provides updated recommendations from the Advisory Committee on Immunization Practices (ACIP) for use of conjugate Hib vaccines and TETRAMUNE{TM} for infants and children. (cdc.gov)
  • A stronger conjugate acid will split more easily into its products, "push" hydrogen protons away and have a higher equilibrium constant. (wikipedia.org)
  • This means almost every word ending is declined or conjugated. (goethe-verlag.com)
  • The verb "savoir" means "to know" and in this tense, it is conjugated as "sache" for the first and second person singular, "sache" for the third person singular, "sachions" for the first person plural, "sachiez" for the second person plural, and "sachent" for the third person plural. (proprofs.com)
  • To identify the conjugate acid, look for the pair of compounds that are related. (wikipedia.org)
  • To denote conjugate we place -- above the element. (netlib.org)
  • Tezcat Biosciences is developing a portfolio of protein-drug conjugates to provide therapeutic options for patients harboring mutant RAS cancers. (massbio.org)
  • Our lectin screening kits are designed to provide the investigator with a panel of seven lectins or lectin conjugates. (vectorlabs.com)
  • This lectin screening kit is designed to provide the investigator with a panel of seven biotinylated lectin conjugates. (vectorlabs.com)
  • They consist primarily of monosyllabic words, use similar word and sentence construction patterns, and they don't conjugate verbs and nouns. (gala-global.org)
  • The molecule consists of two fused anthraquinone systems and textbook knowledge indicates the quinone oxygen as the relevant site for xenobiotic metabolism. (europa.eu)
  • In this case, the verb "pouvoir" is conjugated differently depending on the subject pronoun. (proprofs.com)
  • In this case, the verb "aller" is conjugated as "aille" for the first and third person singular (je, il/elle/on), "ailles" for the second person singular (tu), "allions" for the first person plural (nous), "alliez" for the second person plural (vous), and "aillent" for the third person plural (ils/elles). (proprofs.com)