Rubella syndromeAnomaliesClonal hematopoiesisSplenomegalySplenicDisordersMyelofibrosisDifferentialIntrathoracicAbnormalitiesMalformationsPulmonary arteryTumorAnemiaMalignantAsymptomaticSyndromeManifestationsMiscarriageNeoplasticBoneWorkupMutationsUltrasoundEssentialSymptomsCharacteristicsPatientsCommonV617FPrognosisInfectionLesionsBloodIncludeCytogeneticCasesInvolvementCaseAidsMadeSurgical
Rubella syndrome6
- Congenital rubella syndrome (CRS) occurs when an unborn baby is infected with the rubella virus (German measles) via maternal-fetal transmission and develops birth defects. (wikipedia.org)
- Diagnosis of congenital rubella syndrome is made through a series of clinical and laboratory findings and management is based on the infant's clinical presentation. (wikipedia.org)
- Maintaining rubella outbreak control via vaccination is essential in preventing congenital rubella infection and congenital rubella syndrome. (wikipedia.org)
- Congenital rubella syndrome was discovered in 1941 by Australian Norman McAlister Gregg. (wikipedia.org)
- The most important complication of rubella is congenital rubella syndrome (CRS). (medscape.com)
- Immunoglobulin is not recommended unless termination of the pregnancy is not an option because cases of congenital rubella syndrome have occurred in infants born to mothers who received immunoglobulin shortly after exposure. (medscape.com)
Anomalies3
- Congenital cardiac anomalies including pulmonary artery stenosis and patent ductus arteriosus can be seen in infants with CRS. (wikipedia.org)
- Congenital and Inherited Anomalies of the Liver in Animals Portosystemic shunts are the most common congenital liver anomaly (see Portosystemic Vascular Malformations in Small Animals). (msdvetmanual.com)
- In this pictorial essay, we introduce the representative US findings of many different splenic lesions, including normal sonographic findings, normal variants and congenital anomalies, infectious conditions, benign and malignant neoplasms, and non-neoplastic lesions. (e-ultrasonography.org)
Clonal hematopoiesis2
- DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
- Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. (beds.ac.uk)
Splenomegaly2
- attacks abate with treatment response is characterized by marrow brosis, myeloid metaplasia with extramedullary hematopoiesis, and splenomegaly. (surgicalimpex.com)
- This process, called extramedullary hematopoiesis, often leads to an enlarged spleen (splenomegaly) or an enlarged liver (hepatomegaly). (nih.gov)
Splenic5
- Its noninvasiveness, extensive range of application, and low cost make US a useful and valuable tool for the detection, diagnosis, and follow-up of splenic abnormalities. (e-ultrasonography.org)
- Concomitantly with the increasing frequency of imaging, more splenic lesions are being discovered and the requirements for the differential diagnosis are rising. (e-ultrasonography.org)
- Knowledge of the US features of various splenic lesions will help narrow the differential diagnosis and guide clinical decision-making. (e-ultrasonography.org)
- Ultrasonography is a useful and valuable tool for the detection, diagnosis, and follow-up of splenic abnormalities. (e-ultrasonography.org)
- However, with the increasing frequency of imaging and advances in imaging technology, more incidental splenic lesions are being discovered and the subsequent requirements for the differential diagnosis are growing. (e-ultrasonography.org)
Disorders3
- For example, blood loss, isoimmunization, and congenital red cell disorders are common causes of anemia in newborns. (medscape.com)
- Both congenital and acquired disorders can evolve APSSs. (msdvetmanual.com)
- Denys-Drash syndrome, due to mutations of the WT1 gene, is also associated with a congenital nephropathy and disorders of sexual development. (abdominalkey.com)
Myelofibrosis3
- See "Clinical manifestations and diagnosis of primary myelofibrosis" . (medilib.ir)
- Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)
- In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
Differential1
- What are the differential diagnoses for Hemothorax? (medscape.com)
Intrathoracic1
- Tantraworasin A, Saeteng S. Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with beta thalassemia hemoglobin E disease. (medscape.com)
Abnormalities2
- In this chapter a variety of hepatobiliary cases of congenital, infective, inflammatory, neoplastic, vascular, and postsurgical abnormalities will be discussed with the goal of demonstrating the utility of combination imaging with both nuclear and non‐nuclear imaging techniques. (radiologykey.com)
- However, in the presence of certain recurrent cytogenetic abnormalities (eg, t(8;21), inv(16)), a diagnosis of AML is made regardless of the blast count. (medilib.ir)
Malformations1
- Laberge JM, Puligandla P, Flageole H. Asymptomatic congenital lung malformations. (medscape.com)
Pulmonary artery1
- May occur during the history and examination suggestive of cardiac enlargement with right ventricular contour, prominent pulmonary artery, congenital as (loudest at apex) or ps (upper left sternal border (along right sternal border. (surgicalimpex.com)
Tumor1
- Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
Anemia3
- Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. (symptoma.com)
- Diagnosis of osteopetrosis with precocious manifestations is suspected by the presence of bony overgrowths in the context of anemia, unusual bleeding, and poor growth. (msdmanuals.com)
- See " Diagnosis of anemia " for details on the general approach for a patient with anemia . (amboss.com)
Malignant2
- malignant, and congenital, manifesting during infancy. (msdmanuals.com)
- Where the diagnosis and treatment of malignant diseases requires interdisciplinary action, we collaborate with the Dresden University ComprehensiveCentre. (uniklinikum-dresden.de)
Asymptomatic1
- Rubella infection in pregnancy can result in various outcomes ranging from asymptomatic infection to congenital defects to miscarriage and fetal death. (wikipedia.org)
Syndrome1
- Watch Justin from Emory review a manifestation on congenital syndrome in an adult. (abdominalrad.com)
Manifestations3
- Mandel VD, Ferrari C, Cesinaro AM, Pellacani G, Del Forno C. Congenital "self-healing" Langerhans cell histiocytosis (Hashimoto-Pritzker disease): a report of two cases with the same cutaneous manifestations but different clinical course. (medscape.com)
- See "Clinical manifestations and diagnosis of polycythemia vera" . (medilib.ir)
- See "Clinical manifestations and diagnosis of chronic myeloid leukemia" . (medilib.ir)
Miscarriage1
- Miscarriage, abortion, and congenital toxoplasmosis are also possible. (frontiersin.org)
Neoplastic1
- Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
Bone4
- However, bone sclerosis becomes increasingly apparent as children age, and diagnosis is typically based on x-rays done for unrelated reasons. (msdmanuals.com)
- n\nBecause blood cell formation (hematopoiesis) in the bone marrow is disrupted, other organs such as the spleen or liver may begin to produce blood cells. (nih.gov)
- Effective hematopoiesis is facilitated by interactions of hematopoietic growth factors, various receptors, and the bone marrow microenvironment. (medilib.ir)
- In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
Workup1
- The results of a multiorgan workup performed at the time of diagnosis were predictive of which patients in this cohort manifested multisystem disease. (thedoctorsdoctor.com)
Mutations1
- These observations underline the heterogeneity between individuals with MPNs, and raise the possibility that monoclonal hematopoiesis may antedate rather than follow the development of mutations (described below) that are associated with MPNs or MDS. (medilib.ir)
Ultrasound1
- Although once the infarct has become established, both ultrasound and CT are sensitive to the diagnosis, in the hyperacute setting CT with contrast is the modality of choice if the diagnosis is suspected 9 . (radiopaedia.org)
Essential2
- Therefore, a noninvasive imaging diagnosis is essential. (e-ultrasonography.org)
- Studies using refined methods of X-linked DNA analysis have demonstrated polyclonal hematopoiesis in some patients with essential thrombocythemia and monoclonal hematopoiesis in healthy elderly women [ 11 ]. (medilib.ir)
Symptoms1
- Pediatric Cardiology should be consulted to assess and treat congenital heart disease , and Pediatric Neurology can help in managing immediate CNS symptoms, such as encephalitis and seizures. (symptoma.com)
Characteristics1
- CONCLUSIONS: Vesiculopustular lesions are common in congenital/neonatal LCH, but the morphologic characteristics of lesions are not helpful in predicting the extent of disease. (thedoctorsdoctor.com)
Patients2
- Viral arthritis is less common than bacterial arthritis and often the diagnosis is made in a lesser number of patients because of because of the late presentation of this condition. (symptoma.com)
- The diagnosis and treatment facilities we offer our patients are of the highest standard. (uniklinikum-dresden.de)
Common1
- Lymphoblastic lymphoma is associated with exposure to radiation or pesticides and congenital or acquired immunosuppression and is more common in children and young adults. (medscape.com)
V617F1
- Today, however, the assay for JAK2 V617F has superseded other tests for establishing the diagnosis of PV. (basicmedicalkey.com)
Prognosis1
- Congenital self-healing reticulohistiocytosis: concern for a poor prognosis. (medscape.com)
Infection1
- Infants with birth defects suspected to be caused by congenital rubella infection should be investigated thoroughly. (wikipedia.org)
Lesions1
- Today colloid imaging remains useful for confirmation of splenosis and extramedullary hematopoiesis, but has otherwise been superseded by US, CT, and MRI for detection and evaluation of liver lesions. (radiologykey.com)
Blood2
- Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the various types of mature blood cells [ 2 ]. (medilib.ir)
- Intracellular triacylglycerol droplets are present in most tissues, and diagnosis can be confirmed by a simple blood smear, in which the characteristic lipid droplets are observed in the cytoplasm of granulocytes (summary by Lefevre et al. (nih.gov)
Include1
- Other laboratory studies that may aid in diagnosis include the red cell count, mean corpuscular volume, and red cell distribution width (RDW), particularly when the hematocrit or hemoglobin levels are less than 60% or 20 g/dL, respectively. (basicmedicalkey.com)
Cytogenetic1
- Similarly, no specific cytogenetic abnormality is associated with the disease, and the absence of a cytogenetic marker does not exclude the diagnosis. (basicmedicalkey.com)
Cases2
- The mean age at diagnosis is 18 months, and about 90% of cases are diagnosed before 3 years of age. (entokey.com)
- Exceptional cases of clinically manifest congenital retinoblastoma have been reported. (entokey.com)
Involvement1
- A multiorgan evaluation at the time of diagnosis may be predictive of the probability of multisystem involvement with LCH. (thedoctorsdoctor.com)
Case1
- An unusual case of congenital, self-healing reticulohistiocytosis. (medscape.com)
Aids1
- In assessing for biliary atresia, no single modality is perfectly accurate, so a combination of tests aids in early diagnosis. (radiologykey.com)
Made1
- 20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
Surgical1
- Early diagnosis of biliary atresia and surgical intervention is imperative for optimal outcome. (radiologykey.com)