• The energetic origin of this isomerization process is summarized, and the folding and unfolding of disulfide-intact bovine pancreatic ribonuclease A is used as an example to illustrate the kinetics and structural features of conformational changes from the heterogeneous unfolded state (consisting of cis and trans isomers of X-Pro peptide groups) to the native structure in which only one set of proline isomers is present. (nih.gov)
  • The ability of RNAs to play multiple roles in cellular metabolism is made possible by extensive variation in length, conformational dynamics, and the over 100 post-transcriptional modifications. (nih.gov)
  • Spectroscopic techniques for investigation of polymer structure and conformational studies of macromolecules 8. (whsmith.co.uk)
  • Computational evaluation of ground-state energies of late-stage synthetic intermediates was used to guide synthetic development and aid in the investigation of the conformational rigidity of these highly constrained and compact polycyclic structures. (duke.edu)
  • Also, the concept of stereoisomerism plays an important role: Lactate dehydrogenase, for example, can only convert L-lactate to pyruvate and not its mirror image D-lactate. (lecturio.com)