Conformational crystal structures glutamate binds. Medical search. Frequent questions

Here we show the first molecular view of reception of a taste substance by a taste receptor, where the binding of the taste substance elicits a different conformational state of T1r2/T1r3 LBD heterodimer. (nature.com)
Förster resonance energy transfer and X-ray solution scattering have revealed the transition of the dimerization manner of the ligand binding domains, from a widely spread to compactly organized state upon taste substance binding, which may correspond to distinct receptor functional states. (nature.com)
The receptor activation mechanism of the class A GPCR members, consisting solely of the transmembrane region, has been considered to occur via agonist binding, which changes the conformational dynamics of the protein by lowering the transition energy between the different states, and results in the transition towards the active-state conformation 9 . (nature.com)
In this context, docking allows predicting the preferred pose of a ligand inside a receptor binding site. (mdpi.com)
For this, two experiments were performed: (A) to reconstruct the ligand-receptor complex by performing docking of the ligand in its own crystal structure receptor (defined as self-docking), and (B) to reconstruct the ligand-receptor complex by performing docking of the ligand in a crystal structure receptor that contains other ligand (defined as cross-docking). (mdpi.com)
His main research interests are the structure-based design, synthesis and evaluation of small-molecule enzyme inhibitors and receptor ligands. (degruyter.com)
In this work, simulations have been performed on the receptor binding domain of SARS-CoV-2 spike glycoprotein to study what residues are more susceptible to be attacked by ·OH, which is one of the most reactive radicals associated to oxidative stress. (ibecbarcelona.eu)
Crystal structure of a human GABAA receptor (Miller & Aricescu, 2014). (ox.ac.uk)
Conformational plasticity of type IIa receptor protein tyrosine phosphatases facilitates proteoglycan binding (Coles at al, 2011). (ox.ac.uk)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
In contrast to X-ray crystallography, EM doesn't NPY Y5 receptor Antagonist review demand protein-crystal formation and has much more potential to cope with conformationally heterogeneous proteins and protein complexes. (namptinhibitor.com)
It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetylcholine channel open which releases ions used in creating an action potential. (proteopedia.org)
There must be 5 molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. (proteopedia.org)
The 2nd image depicts an individual toxin binding with one chain on the receptor, both in the same color. (proteopedia.org)
3D structures in Adrenergic receptor . (proteopedia.org)
The human β2 adrenergic receptor bound to a G-protein ( 3sn6 ) is featured in a scene above, and additional structures are on the Adrenergic receptor page . (proteopedia.org)
We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. (edu.au)
Taken together, our data demonstrate that fALS-associated mutations enhance the propensity of SFPQ to bind zinc and form aggregates, leading to the dysregulation of AMPA receptor subunit composition, which may contribute to neuronal dysfunction in ALS. (edu.au)
The cryo-EM structure of the endocytic receptor DEC-205. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
Using this approach, we obtained structures of neurotensin 1 receptor bound to antagonist SR48692, mu-opioid receptor bound to alvimopan, apo somatostatin receptor 2 and histamine receptor 2 bound to famotidine. (stanford.edu)

Detergent Applications in Research of Integral Membrane Proteins Applying Biophysical and Structural Biology Approaches Detergent-solubilized IMPs have already been extensively studied by nearly all readily available biophysical and structural biology procedures to ascertain physiologically relevant or disease-linked protein conformations and conformational transitions with and without ligands, e.g., substrates or inhibitors, bound to the protein molecules. (namptinhibitor.com)
In the last decade, EM and single-particle cryoEM in certain have made historic progress in studying detergent-solubilized IMPs by expanding this technique's applications to diverse households of IMPs and by determining these proteins' 3D structure at high resolution down to ca. three [21,95]. (namptinhibitor.com)
From there, he worked with Markus Grütter at the University of Zurich, elucidating the structures of numerous proteins. (psi.ch)
We are interested in protein structure both from a structure determination and from a structural bioinformatics perspective, which means obtaining high resolution "bioimages" of proteins and extracting as much information as possible from them. (psi.ch)
RNA-binding proteins of the DBHS (Drosophila Behavior Human Splicing) family, NONO, SFPQ, and PSPC1 have numerous roles in genome stability and transcriptional and posttranscriptional regulation. (edu.au)
Critical to DBHS activity is their recruitment to distinct subnuclear locations, for example, paraspeckle condensates, where DBHS proteins bind to the long noncoding RNA NEAT1 in the first essential step in paraspeckle formation. (edu.au)
Proteins called guanine nucleotide exchange factors, or GEFs for short, activate the Rab protein by promoting the release of GDP and the binding of GTP. (elifesciences.org)
The Rab subfamily of proteins is part of the large Ras superfamily, and all members of this superfamily are activated and inactivated in a similar way, with the binding and unbinding of GDP and GTP taking place at a structure called the G-domain. (elifesciences.org)
The reason why Peter Lansbury and others used the term 'natively unfolded' for a-synuclein and other proteins, especially peptides, is that they do not exist, to a significant degree, in the same kind of stable structure that larger native proteins like myoglobin do. (alzforum.org)
Despite the overall architectural similarity with our earlier structures of Ric-8A complexed to Galphaq and Galphai1, Ric-8B distinctly accommodates an extended loop found only in Galphas/olf proteins. (stanford.edu)
TA binding stabilizes breaks in the middle of transmembrane helices 6 and 7 that facilitate aGPCR coupling and activation of heterotrimeric G proteins. (stanford.edu)
progenitors signal the non-motile mechanisms and proteins considered by the photosynthetic canonical conference-goers remain I and II plus conformational human cations of TGF-beta-mediated granulocyte( Bruckner 2010). (familie-vos.de)

T1rs are class C G-protein coupled receptors (GPCRs), and the extracellular ligand binding domains (LBDs) of T1r1/T1r3 and T1r2/T1r3 heterodimers are responsible for binding of chemical substances eliciting umami or sweet taste. (nature.com)
The extracellular domain consists of the ligand binding domain (LBD), responsible for primary agonist binding, followed by the cysteine rich domain (CRD), which mainly serves as a linker between the LBD and the transmembrane region ( Fig. 1a ). (nature.com)
Quintyn Royston S., Zhou Mowei, Dagan Shai, Finke John, Wysocki Vicki H.: Ligand binding and unfolding of tryptophan synthase revealed by ion mobility-tandem mass spectrometry employing collision and surface induced dissociation. (iupac.org)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
Transporter in FC-16 detergent has larger ATPase activity and ligand binding in comparison to LmrA solubilized in DDM [78]. (namptinhibitor.com)
Guanidine-II aptamer conformations and ligand binding modes through the lens of molecular simulation. (mpg.de)
Crystal Structure of a ligand-bound LacY-Nanobody Complex. (ucsf.edu)
In the current study, docking calculations were performed using AutoDock4.2.21 Initially, to test the reproducibility of the binding poses by the docking algorithm, compound 2 was redocked by manual removal of compound 2 from the crystal structure and docked using cocrystallized ligand as the grid center. (lavoixdesrroms.org)
Six (Mcl1 protein in ligand free (apo) form and Mcl1 protein complexed with five different 2-indole amide inhibitors (holo)) independent systems were used as the starting structures for MD simulations. (lavoixdesrroms.org)

Although they do not affect the density of dendritic spines, the presence of SFPQ cytoplasmic aggregates causes a marked reduction in the levels of the GluA1, but not the GluA2 subunit of AMPA-type glutamate receptors on the neuronal surface. (edu.au)
Low-resolution maps of the receptors in their N-terminal fragment-bound state indicate that the GAIN domain projects flexibly towards the extracellular space, keeping the encrypted TA peptide away from the seven-transmembrane domain. (stanford.edu)
forces are distinct, encoding development to incoming parts with responses under IL7 groups of receptors or binds. (familie-vos.de)

2011). Quaternary structure of the oxaloacetate decarboxylase membrane complex and mechanistic relationships to pyruvate carboxylases. (tcdb.org)
Chen Chang-Hwei, Wu Susan J., Martin David L.: Structural Characteristics of Brain Glutamate Decarboxylase in Relation to Its Interaction and Activation. (iupac.org)
Notable structures include thioredoxin structures, glutamate decarboxylase, and bacterial type 1 pili. (psi.ch)

The neurotransmitters glutamate and gamma-amino-butyric acid (GABA) mediate most synaptic signalling in the vertebrate central nervous system. (ox.ac.uk)
Ion transport and regulation in a synaptic vesicle glutamate transporter. (ucsf.edu)
Sodium and aspartate symporter Glt Ph is an archaeal homolog of human glutamate transporters, which clear the neurotransmitter glutamate from the synaptic cleft following rounds of neurotransmission ( Danbolt, 2001 ). (elifesciences.org)

Escherichia coli MurD has been the first Mur ligase for which the tridimensional (3D) structure was solved. (degruyter.com)
Nishio Kazuya, Ogasahara Kyoko, Morimoto Yukio, Tsukihara Tomitake, Lee Soo Jae, Yutani Katsuhide: Large conformational changes in the Escherichia coli tryptophan synthase β2 subunit upon pyridoxal 5′-phosphate binding : Apo- and holo-tryptophan synthase β2 subunits. (iupac.org)
and (iv) the conformation of loop 2 in the Escherichia coli DHPS structure. (dadospdf.com)

The conformational dynamics observed by the biochemical experiments were further validated using DEER measuring the distance between the spin-labelled pairs. (bvsalud.org)
These structures also show that ATP synthases exist in different conformational states, illustrating the flexibility and dynamics of these complexex ( Guo and Rubinstein 2018 ). (tcdb.org)
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. (ucsf.edu)
Open in a separate window Figure 1 2D-chemical structures of high affinity 2-indole amide inhibitor PIM447 (LGH447) series.19 Molecular Dynamics Simulations on Mcl1CInhibitor Complexes The MD parameters used for the current investigation was adapted from our previous studies2,18,22,23 and are summarized here. (lavoixdesrroms.org)

Thereafter, several co-crystal structures with different ligands or inhibitors were released. (degruyter.com)

Conserved residues therein, D203 (IIIa), Y229 (IV) and N373, G377, S382 and R389 (VIII), provide Na + binding sites and the translocation pathway. (tcdb.org)
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. (umassmed.edu)
Dual translocation pathways in smectic liquid crystals facilitated by molecular flexibility. (mpg.de)
Electron cryoEM structures of mitochondrial, chloroplast, and bacterial ATP synthases have revealed the architecture of the FO region, helping to explain the mechanisms of proton translocation, dimerization of the enzyme in mitochondria, and cristae formation. (tcdb.org)
The structures show that both substrate translocation and release involve movements of the bulky transport domain through the lipid bilayer. (elifesciences.org)

While the two crystal structures suggested an elevator-like movement to afford alternating access to the substrate binding site, the mechanistic role of Na+ and substrate in the conformational isomerization remains unclear. (bvsalud.org)

One huMAb, K8b, binds quaternary epitopes with heavy and light chains separately interacting with overlapping envelope protein dimer units spanning domains I, II, and III through cryo-electron microscopy and structure-based mutagenesis. (bvsalud.org)
Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. (ibecbarcelona.eu)

The crystal structures of two bacterial homologues ASBTNM and ASBTYf have previously been determined, with the former showing an inward-facing conformation, and the latter adopting an outward-facing conformation accomplished by the substitution of the critical Na+-binding residue glutamate-254 with an alanine residue. (bvsalud.org)
For more than 30 years, his main research interests have been the functional and structural study of the enzymes of peptidoglycan biosynthesis, the determination of the structure of peptidoglycan from certain bacterial species, and the search for peptidoglycan biosynthesis inhibitors that could act as antibacterial agents. (degruyter.com)

In this study, we utilized site-directed alkylation monitored by in-gel fluorescence (SDAF) to probe the solvent accessibility of the residues lining the substrate permeation pathway of ASBTNM under different Na+ and substrate conditions, and interpreted the conformational states inferred from the crystal structures. (bvsalud.org)
The main residues responsible for specific binding of the inhibitor are Arg180, which forms a strong salt bridge with the alpha-carboxylate and Tyr55, which is involved in a short hydrogen bond with the alpha-amino group. (unipr.it)
On the other hand, the MRD data are consistent with a local conformational change in response to ionization of the internal residues. (lu.se)
The accuracy of this powerful computational method is usually high, providing useful insights around the binding mode of Mcl1 inhibitors and helping to identify hot spot residues responsible for binding. (lavoixdesrroms.org)

HP2 lies on the surface of a large extracellular bowl formed by the transporter and occludes L-asp and three Na + -binding sites (NA1, 2, and 3). (elifesciences.org)

Of these two mutations, a crystal structure of the E285A mutant has been taken, showing that the loss of the hydrogen bonding from glutamate leads to a conformational change that distorts the active site and alters the substrate binding, leading to the much lower catalytic activity. (wikipedia.org)
2005). Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria. (tcdb.org)

Inhibition of this enzyme's activity by sulfonamide and sulfone drugs depletes the folate pool, resulting in growth inhibition Ê resolution crystal structure of and cell death. (dadospdf.com)

Hioki Yusaku, Ogasahara Kyoko, Lee Soo Jae, Ma Jichun, Ishida Masami, Yamagata Yuriko, Matsuura Yoshiki, Ota Motonori, Ikeguchi Mitsunori, Kuramitsu Seiki: The crystal structure of the tryptophan synthase β2 subunit from the hyperthermophile Pyrococcus furiosus : Investigation of stabilization factors. (iupac.org)
The crystal structure of the S. cerevisiae c-subunit ring with bound oligomycin revealed the inhibitor docked on the outer face of the proton-binding sites, deep in the transmembrane region ( Zhou and Faraldo-Gómez 2018 ). (tcdb.org)

The crystal structure of the enzyme-inhibitor complex was solved at a resolution of 1.95 A. No significant conformational changes compared with the native enzyme structure were observed. (unipr.it)
The structure reveals the atomic details of the cofactor-inhibitor adduct and its interactions with the active site of the enzyme. (unipr.it)
They further reveal a novel mode of inhibitor binding and show how solutes release is coupled to protein conformational changes. (elifesciences.org)

Our results revealed that Na+ ions shift the conformational equilibrium of ASBTNM toward the inward-facing state thereby facilitating cytoplasmic uptake of substrate. (bvsalud.org)
D203 and S382 may provide two binding sites for the two Na + ions. (tcdb.org)
We report Cryo-EM structures of Glt Ph reconstituted into nanodiscs, including those structurally constrained in the cytoplasm-facing state and either apo, bound to sodium ions only, substrate, or blockers. (elifesciences.org)
Briefly, the transporters are homotrimers with each protomer consisting of a centrally located scaffold or trimerization domain and a peripheral transport domain that harbors the L-aspartate (L-asp) and three sodium (Na + ) ions binding sites. (elifesciences.org)
The reaction starts with the fully reduced form of the enzyme, presumably with a water molecule weakly coordinated to the type-2 copper (Cu-T2) ion and no bridging moiety between the two type-3 copper (Cu-T3) ions.17,22 The incoming di- oxygen is immediately reduced, yielding a peroxide-level intermediate (PI),12 with a peroxide ion bound in the centre of the TNC. (lu.se)

Multiscale Simulation of Small Peptides: Consistent Conformational Sampling in Atomistic and Coarse-Grained Models. (mpg.de)
High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)

As the transport domain translocates into the IFS, HP2 replaces HP1 on the domains interface, while HP1 now lines an intracellular vestibule leading to the substrate-binding site ( Figure 1-figure supplement 1 ). (elifesciences.org)

A transferable coarse-grained model for diphenylalanine: How to represent an environment driven conformational transition. (mpg.de)

We are studying protein structures and crystal lattices by employing a variety of approaches, in particular concepts from the field of molecular evolution. (psi.ch)
Molecular simulation of oligo-glutamates in a calcium-rich aqueous solution: insights into peptide-induced polymorph selection. (mpg.de)

Therefore, in addition to maintaining protein stability, detergents with shorter chain supply a good environment for IMP crystallization since they form smaller sized micelles, which facilitate tighter packing in the crystal lattice and higher-quality crystal diffraction [82,880]. (namptinhibitor.com)
Nevertheless, prosperous IMP structure determination via EM requires higher stability and suitable folding from the detergent-solubilizedMembranes 20. (namptinhibitor.com)
Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure. (umassmed.edu)
The structures, along with results from Ric-8 protein thermal stability assays and cell-based Galphaolf folding assays, support a requirement for the Galpha C-terminal region for binding specificity, and highlight that multiple structural elements impart specificity for Ric-8/G protein binding. (stanford.edu)

Cryogenic electron microscopy (cryo-EM) has widened the field of structure-based drug discovery by allowing for routine determination of membrane protein structures previously intractable. (stanford.edu)

A Rab protein is always bound to another molecule, which determines whether it is inactive or active. (elifesciences.org)
Binding to a molecule called GDP makes the Rab protein inactive, while binding to GTP makes it active. (elifesciences.org)

The binding of an agonist to them causes a sympathetic response. (proteopedia.org)

Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. (edu.au)
Tau is a protein that is important in neuronal function, but can misfold and aggregate into pathological structures that accumulate in neurodegenerative disorders such as Alzheimer's disease. (utsa.edu)

However, one hypothesis is that it is potentially used as a chemical reservoir that can be tapped into for acetate for acetyl-CoA synthesis or aspartate for glutamate synthesis. (wikipedia.org)
His main research topics have been the design, synthesis, and study of the binding modes of peptidoglycan biosynthetic pathway inhibitors. (degruyter.com)

The degree of conformational order in the prefibrillar aggregates is not yet known, I don't think. (alzforum.org)

I do not think there is a contradiction to the conventional thinking of protein structure-function relation. (alzforum.org)

Glutamate transporters are essential players in glutamatergic neurotransmission in the brain, where they maintain extracellular glutamate below cytotoxic levels and allow for rounds of transmission. (elifesciences.org)

Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. (umassmed.edu)
Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
Both mutants display increased zinc-binding affinities, which can be explained by the presence of a second zinc-binding site revealed by the 1.83 Å crystal structure of the human SFPQ L534I mutant. (edu.au)
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. (ucsf.edu)

Finally, we describe how domain movements are associated with the displacement of bound lipids and significant membrane deformations, highlighting the potential regulatory role of the bilayer. (elifesciences.org)

Comparison to other DHPS structures reveals that the M. tuberculosis DHPS structure is in a unique conformation in which loop 1 closes over the active site. (dadospdf.com)
Finally, the Mtb DHPS structure reveals a highly conserved pterin binding pocket that may be exploited for the design of novel antimycobacterial agents. (dadospdf.com)
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. (umassmed.edu)

Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. (ucsf.edu)

Crystal and solution structures of an HslUV protease-chaperone complex. (colorado.edu)
Structures of Ric-8B in complex with Galpha protein folding clients reveal isoform specificity mechanisms. (stanford.edu)
Here, we determined cryoelectron microscopy (cryo-EM) structures of Ric-8B in complex with Galphas and Galphaolf, revealing isoform differences in the relative positioning and contacts between the C-terminal alpha5 helix of Galpha within the concave pocket formed by Ric-8 alpha-helical repeat elements. (stanford.edu)

The class C GPCR structure is characterized by the presence of a large extracellular domain upstream of the hepta-helical transmembrane region, which is commonly found among GPCRs. (nature.com)

EC 2.6.1.13), a pyridoxal-5'-phosphate-dependent mitochondrial enzyme controls the l-ornithine level in tissues by catalyzing the transfer of the delta-amino group of l-ornithine to 2- oxoglutarate, producing l-glutamate- gamma-semialdehyde and l- glutamate. (unipr.it)

He was a prolific crystallographer, with 70 protein structures in the Protein Data Bank (PDB) over the past two decades. (psi.ch)
He continued to solve protein structures at the Swiss Light Source, and also put forward a program of large-scale bioinformatic analysis of structures. (psi.ch)
Laskowski RA, Rullmannn JA, MacArthur MW, Kaptein R & Thornton JM 1996 AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. (jmolbiochem.com)

Accordingly, in the case of T1r, the major taste substances, including sugars and l -glutamate, are considered to target the LBD of T1r heterodimer 14 , and thus consequently induce the conformational change of the LBD. (nature.com)
Conformational Change? (lu.se)
This would fundamentally change our conventional thinking about protein structure-function relationship, no? (alzforum.org)

Electron microscopy has showed a characteristic dimeric structure. (nature.com)

This information can be useful not only to understand protein structure (structure analysis) but also for structure determination and validation. (psi.ch)
It represents a very interesting system to study hybrid approaches to structure determination and structure-function relationships. (psi.ch)
Structure determination of inactive-state GPCRs with a universal nanobody. (stanford.edu)

The N-terminal domain binds the glutaconyl-CoA, and the C-terminal domain binds the biotinyl lysine moiety. (tcdb.org)
The fact that the detailed structure of this domain (at the level of individual amino acids) has been conserved over evolution is often taken as an indication that its mechanism has also been conserved. (elifesciences.org)

Here we demonstrate that the same single-chain camelid antibody (nanobody) recognizing a grafted intracellular loop can be used to obtain cryo-EM structures of inactive-state GPCRs at resolutions comparable or better than those obtained by X-ray crystallography. (stanford.edu)

It is proposed that the neutralization of the active site Arg413 by a salt bridge with Glu235 also plays an important role in productive binding of both 5-fluoromethylornithine and l-ornithine. (unipr.it)

This contrasts with a previous cryogenic crystal structure of the V66E mutant, but is consis- tent with the room-temperature crystal structure reported here. (lu.se)

The IMP structures from diverse households have already been solved, and some of these structures capture precisely the same protein in distinct conformations. (namptinhibitor.com)
It was found that the final model of biglycan resembles in structure its template protein bearing a set of distinct parallel β-sheet structure patterns. (jmolbiochem.com)

D203 is absolutely essential for function and may provide the primary intramembranous Na + -binding site. (tcdb.org)
The Mtb DHPS structure hints at a mechanism in which both loops 1 and 2 play important roles in catalysis by shielding the active site from bulk solvent and allowing pyrophosphoryl transfer to occur. (dadospdf.com)
A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. (umassmed.edu)
Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. (ucsf.edu)
These GAGs can be head-to-tail of L-Glutamate( L-Glu), L-Aspartate( L-Asp) and D-Aspartate( D-Asp) with component of 3 Na+ sources and H+ and antiport of a K+ site. (familie-vos.de)

Understanding the Control of Mineralization by Polyelectrolyte Additives: Simulation of Preferential Binding to Calcite Surfaces. (mpg.de)

Does it mean that a-synuclein (and also Ab) is sort of flopping about unstructured in its physiological state and then prodded into folding by a binding partner? (alzforum.org)

In the present review, we will deal with work performed on substrate specificity, reaction mechanism and 3D structure of E. coli MurD. (degruyter.com)
The lord of the rings: Structure and mechanism of the sliding clamp loader. (umassmed.edu)
Structure and mechanism of the ATPase that powers viral genome packaging. (umassmed.edu)
The QM/MM calculations were further supported by multireference calculations of the MCO spectroscopic properties20 and combined extended X-ray absorption fine- structure EXAFS/QM/MM calculations.21 This has led to the consensus reaction mechanism depicted in Fig. 1. (lu.se)

Anatomy8

Organisms14

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes79

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science7

Health Care2

Receptor21

Proteins12

Ligand9

Receptors3

Decarboxylase3

Synaptic3

Escherichia3

Dynamics4

Ligands1

Translocation5

Mechanistic1

Quaternary2

Bacterial2

Residues4

Transporter1

Hydrogen2

Inhibition1

Subunit2

Inhibitor3

Ions5

Peptides2

Substrate bind1

Transition1

Molecular2

Stability4

Membrane-protein1

Molecule2

Agonist1

Neuronal2

Synthesis2

Aggregates1

Relation1

Transporters1

Human4

Lipids1

Reveals3

Intermediate1

Complex3

Transmembrane1

Enzyme1

Protein structures3

Change3

Electron Microscopy1

Determination3

Domain2

Crystallography1

Ornithine1

Mutant1

Distinct2

Site5

Simulation1

Physiological state1

Mechanism4