• Scientists from Nigde Omer Halisdemir University in Turkey successfully stacked insecticidal genes in potatoes to confer effective resistance against the Colorado potato beetle. (isaaa.org)
  • Overexpression of Rice Auxilin-Like Protein, XB21, Induces Necrotic Lesions, up-Regulates Endocytosis-Related Genes, and Confers Enhanced Resistance to Xanthomonas oryzae pv. (escholarship.org)
  • Together, we have found that a single resistance locus leads to a higher immune response in resistant mosquitoes, and we identify genes in this region that may be responsible for this trait. (cam.ac.uk)
  • The possible pleiotropic effects of PH3 resistance on development and reproduction were investigated in the red flour beetle, Tribolium castaneum (Herbst), by introgressing two genes known to be major contributors to strong resistance (tc_rph1 and tc_rph2) into a susceptible background. (qld.gov.au)
  • Molecular screening confirmed that the introgressed strain was homozygous for the resistance genes, but was otherwise indistinguishable from the susceptible strain based on screening with 12 neutral DNA markers. (qld.gov.au)
  • In light of data pointing to the importance of Ch5 in C. albicans drug resistance, there is a growing need to better understand the control of Ch5 ploidy and regulation of genes on this chromosome. (biomedcentral.com)
  • We have previously reported multiple genes encoding negative regulators of laboratory resistance to echinocandins or sorbose that are scattered across Ch5 [ 9 ]. (biomedcentral.com)
  • There is zero tolerance for the virus in seed production in the western U.S. The best control is via deployment of resistance genes in the common bean host. (usda.gov)
  • These adjustments to the model direct breeders worldwide to deploy bc-u in combination with other genes to broaden and enhance the stability of resistance to BCMNV. (usda.gov)
  • SNP markers for bc-1 and bc-u, and new markers for I and bc-3 genes were used to genotype the resistance genes underpinning BCMNV phenotypes in the DDP, host group differentials, and segregating F3 families. (usda.gov)
  • These candidate genes, markers, and adjustments to the host-pathogen interaction will facilitate breeding for resistance to BCMNV and related Bean common mosaic virus (BCMV) in common bean. (usda.gov)
  • Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. (lu.se)
  • The finding of multiple-drug resistance in MCRPEC isolates suggests these organisms were able to recruit other resistance genes, "which could raise difficulties in the treatment of patients with clinical infection due to MCRPEC," the authors write. (medscape.com)
  • In the CNU study, the researchers aimed to confer sulfamethoxazole (Smex) herbicide resistance through insertion and deletion mutations using CRISPR-Cas9 editing of the OXP1 gene in Arabidopsis. (isaaa.org)
  • Based on the findings, the authors concluded that generating insertion-deletion mutations can be a potential technique to confer herbicide resistance in plants. (isaaa.org)
  • Mutations in α-tubulin confer dinitroaniline resistance at a cost to m" by Christopher Ma, Catherine Li et al. (wustl.edu)
  • Mutations in the and loci in the green alga confer resistance to phosphorothioamidate and dinitroaniline herbicides. (researchhunt.com)
  • Target-site resistance is an important genetic resistance mechanism caused by mutations in the voltage-gated sodium channel (Vgsc) gene that encodes the pyrethroid target-site. (lstmed.ac.uk)
  • We develop a Bayesian statistical spatiotemporal model to interpret species-specific trends in the frequency of the most common resistance mutations, Vgsc-995S and Vgsc- 995F, in three major malaria vector species Anopheles gambiae, An. (lstmed.ac.uk)
  • We demonstrate that TaHRC encodes a nuclear protein conferring FHB susceptibility and that a deletion spanning the start codon of this gene results in FHB resistance. (nature.com)
  • States revealed the emerging mosaic penA 60 allele, first identi- for testing and treatment and received ceftriaxone (250 mg) fied in Japan in 2016 ( 1 ), which confers reduced susceptibility intramuscularly and azithromycin (1 g) orally. (cdc.gov)
  • These data suggest that HLA-DR4 and DRw11(5) with their associated DQw7(w3) and DQw8(w3) specificities may confer susceptibility to alopecia areata, while DRw52a may confer resistance. (jamanetwork.com)
  • Here we show that TaHRC , a gene that encodes a putative histidine-rich calcium-binding protein, is the key determinant of Fhb1 -mediated resistance to FHB. (nature.com)
  • A research team at Chonnam National University (CNU) used CRISPR-Cas9 to confer herbicide resistance in Arabidopsis by targeting the 5-oxoprolinase 1 ( OXP1 ) gene. (isaaa.org)
  • Results showed that the transgenic plants with cry3A + SN-19 and OCII + SN-19 gene combinations had high resistance to Colorado potato beetle, showing 100% mortality of all insects in larval and adult stages. (isaaa.org)
  • Here, we identify a critical role of PerR-regulated gene expression in GAS phagocytosis resistance and in virulence during pharyngeal infection. (harvard.edu)
  • Disease Resistance Conferred by the Expression of a Gene Encoding a Sy" by Kanniah Rajasekaran, Jeffrey W. Cary et al. (kennesaw.edu)
  • A mutant of Ustilago maydis (VR43) with single-gene resistance to the dicarboximide fungicide vinclozolin was previously isolated and characterized. (psu.edu)
  • A GWAS approach using a panel of 182 lines from race Durango (DDP) challenged by BCMNV isolates NL-8 (Pathogroup-III) and NL-3 (Pathogroup-VI), and genotyped with 1.26 million SNPs, revealed significant peak regions on chromosomes Pv03 and Pv05, which correspond to bc-1 and bc-u resistance gene loci, respectively. (usda.gov)
  • The gene that confers colistin resistance is called mcr-1 . (medscape.com)
  • Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)
  • We found that our mapped Vgsc allele frequencies are a significant partial predictor of phenotypic resistance to the pyrethroid deltamethrin in An. (lstmed.ac.uk)
  • instead, ibrutinib resistance can arise from a primary mutation in the target kinase or its immediate downstream target, neither of which are recurrently mutated in CLL. (aacrjournals.org)
  • In patients with a known PDGFRA D842V mutation conferring imatinib resistance, sunitinib is a reasonable option. (medscape.com)
  • Fhb1 , a quantitative trait locus discovered in Chinese germplasm, provides the most stable and the largest effect on FHB resistance in wheat. (nature.com)
  • Exome and transcriptome sequencing of Aedes aegypti identifies a locus that confers resistance to Brugia malayi and alters the immune response. (cam.ac.uk)
  • We designed exome captures to target protein-coding regions of the genome, and used association mapping in a wild Kenyan population to identify a single, dominant, sex-linked locus underlying resistance. (cam.ac.uk)
  • This falls in a region of the genome where a resistance locus was previously mapped in a line established in 1936, suggesting that this polymorphism has been maintained in the wild for the at least 80 years. (cam.ac.uk)
  • We identified Rph24 as a locus in barley (Hordeum vulgare L.) controlling adult plant resistance (APR) to leaf rust, caused by Puccinia hordei. (qld.gov.au)
  • Evaluation of F2:3 families confirmed that a single locus from ND24260-1 conferred partial resistance. (qld.gov.au)
  • Resistance to chemotherapy represents a major limitation in the treatment of colorectal cancer. (figshare.com)
  • We provide the first evidence that Rac1b expression confers resistance to chemotherapy in colorectal cancer. (figshare.com)
  • Additionally, we show that the use of a Rac inhibitor prevents chemoresistance by blocking activation of chemotherapy induced NF-κB signaling, providing a novel strategy to overcome resistance to chemotherapy in colorectal cancer. (figshare.com)
  • Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis. (bvsalud.org)
  • Deletion of the short arm of chromosome 1 is the most common chromosomal abnormality present in neuroblastoma and confers a poor prognosis. (medscape.com)
  • Deletion of perR in M-type 3 strain 003Sm was associated with reduced resistance to phagocytic killing in human blood and by murine macrophages in vitro. (harvard.edu)
  • These data show that high levels of deltamethrin resistance in the main malaria vector species, conferred by enzymatic detoxification, are present in the DRC. (biomedcentral.com)
  • Resistance in malaria vectors to pyrethroids, the most widely used class of insecticides for malaria vector control, threatens the continued efficacy of vector control tools. (lstmed.ac.uk)
  • The importation of ART-R malaria into Singapore is possible given the close proximity and significant travel volume between Singapore and the GMS countries reporting artemisinin resistance. (who.int)
  • 5 Since then, artemisinin against malaria since 2010, growing resistance to resistance has been observed in other countries in antimalarial drugs remains the biggest challenge the GMS and in neighbouring India. (who.int)
  • In view of the emergence of was performed by the Malaria Reference Centre from resistance across the GMS and the spread beyond its the National Public Health Laboratory (MRC-NPHL) borders, we carried out an analysis to assess the risk by polymerase chain reaction (PCR) amplification and of importation and secondary spread of ART-R malaria sequencing according to the protocol of Ariey et al. (who.int)
  • We conclude that PerR controls expression of a diverse regulon that enhances GAS resistance to phagocytic killing and allows adaptation for survival in the pharynx. (harvard.edu)
  • Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c. (oncotarget.com)
  • Surprisingly, Rac1b expression and NF-κB activity were upregulated in cells treated with chemotherapeutics, suggesting that Rac1b facilitates chemo-resistance through activation of NF-κB signaling. (figshare.com)
  • Taken together, our results demonstrated that TAMs promote CRC chemotherapy resistance via elevating the expression of GRP78 to promote the membrane translocation of MRP1 and drug efflux, providing direct proof for TAM-induced drug resistance . (bvsalud.org)
  • Unexpectedly, 8-oxoguanine DNA glycosylase1 (Ogg1) knockout mice show enhanced stimuli-driven IFN expression that confers increased resistance to viral and bacterial infections and allergen challenges. (lu.se)
  • The rice immune receptor XA21 confers resistance to the bacterial pathogen, Xanthomonas oryzae pv. (escholarship.org)
  • Understanding ibrutinib resistance mechanisms can guide efforts to treat or prevent resistant disease. (aacrjournals.org)
  • Although few ibrutinib-treated patients have relapsed to date, as the number of patients receiving ibrutinib increases it is crucial to characterize ibrutinib resistance mechanisms in order to devise treatment strategies for those who have relapsed and guide development of combination approaches to prevent resistance from developing. (aacrjournals.org)
  • Although additional ibrutinib resistance mechanisms likely remain to be discovered, this characterization of patients who have relapsed on ibrutinib may help initiate strategies to prevent or overcome ibrutinib resistance. (aacrjournals.org)
  • Resistance mechanisms for the Bruton's tyrosine kinase inhbitor ibrutinib. (aacrjournals.org)
  • Due to political instability and socio-economic challenges in the region, knowledge of insecticide resistance status and resistance mechanisms in these vectors is limited. (biomedcentral.com)
  • A number of mechanisms confer resistance to a small pool of insecticides and for this reason, insecticide resistance management is both challenging and essential. (biomedcentral.com)
  • These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel. (oncotarget.com)
  • Our predictive maps show how spatiotemporal trends in insecticide target-site resistance mechanisms in African An. (lstmed.ac.uk)
  • Molecular surveillance of resistance mechanisms will help to predict resistance phenotypes and track their spread. (lstmed.ac.uk)
  • Novel strategies to circumvent resistance are critical to prolonging patient survival. (figshare.com)
  • Although CDK1 was highly expressed in tumor tissues, its loss from the cytoplasm unexpectedly predicted poor survival and conferred resistance to chemotherapy in multiple cell lines, especially microtubule-directed agents. (johnshopkins.edu)
  • Despite the apparent survival advantage of early diagnosis conferred by PSA screening, a 2008 US Preventive Services Task Force statement recommended against screening for prostate cancer in men aged 75 years or older. (medscape.com)
  • Thioredoxin (Trx) overexpression is known to be a cause of chemotherapy resistance in various tumor entities. (uni-koeln.de)
  • Aberrant drug efflux mediated by transporters acts as a key approach for tumor cells to acquire chemotherapy resistance. (bvsalud.org)
  • Overexpression of XB21 in rice variety Kitaake and a Kitaake transgenic line expressing XA21 confers a necrotic lesion phenotype and enhances resistance to Xoo. (escholarship.org)
  • In a mouse model of bronchiolitis induced by RSV infection, functional ablation of OGG1 by a small molecule inhibitor (TH5487) enhances IFN-λ production, decreases immunopathology, neutrophilia, and confers antiviral protection. (lu.se)
  • Increasing evidence implies that tumor-associated macrophages (TAMs) play a pivotal role in both tumorigenesis and drug resistance . (bvsalud.org)
  • Yet, the contribution of cancer cell-derived ECM and tumor mechanics to drug adaptation and therapy resistance remains poorly understood. (crcm-marseille.fr)
  • Tumor cells can evade chemotherapy by acquiring resistance to apoptosis. (ucsf.edu)
  • These results indicate that integrin-induced polarity may drive tumor cell resistance to apoptosis-inducing agents via effects on NFkappaB. (ucsf.edu)
  • ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
  • Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. (uni-koeln.de)
  • BRAF-mutant melanomas treated with BRAF and MEK inhibitors almost invariably develop resistance that is frequently associated with transcriptional reprogramming and a de-differentiated cell state. (crcm-marseille.fr)
  • Synergist assays indicated a strong role for P450s in deltamethrin resistance in both species. (biomedcentral.com)
  • 9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
  • Bean common mosaic necrosis virus (BCMNV) is a major disease in common bean (Phaseolus vulgaris L.). Host plant resistance is the primary disease control. (usda.gov)
  • CONCLUSIONS: PNPLA3-I148M confers an antiatherogenic plasma lipid profile particularly in insulin-resistant individuals. (lu.se)
  • Here, we discovered that TAMs endow CRC cells with resistance to 5-fluorouracil ( 5-FU ) treatment via a cell - cell interaction -mediated MRP1-dependent drug efflux process. (bvsalud.org)
  • We conclude that MAPK pathway targeting therapies mechanically reprogram melanoma cells to confer a drug-protective matrix environment. (crcm-marseille.fr)
  • We show that regardless of growth status, formation of polarized, three-dimensional structures driven by basement membrane confers protection to apoptosis in both nonmalignant and malignant mammary epithelial cells. (ucsf.edu)
  • Given that DDT and pyrethroid resistance is widespread, interest in the carbamates and organophosphates for IRS is growing (see Refs. (biomedcentral.com)
  • A genomic library was constructed, and an 8.7-kb resistance- conferring fragment was isolated by sib selection. (psu.edu)
  • This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)
  • These classes of anti-fungals suffer from restrictions in route of administration, spectrum of activity, poor bioavailability in target tissues, undesirable drug interactions, limited therapeutic index and the emergence of drug resistance 2 . (nature.com)
  • The dismal lethality of lung cancer is due to late stage at diagnosis and inherent therapeutic resistance. (johnshopkins.edu)
  • The proteins binding site usually in the C terminus can be highly adjustable among different Hsp40s and confers customer proteins binding specificity. (researchhunt.com)
  • This discovery opens a new avenue to improve FHB resistance in wheat, and possibly in other cereal crops, by manipulating TaHRC sequence through bioengineering approaches. (nature.com)
  • Buerstmayr, H., Ban, T. & Anderson, J. A. QTL mapping and marker‐assisted selection for Fusarium head blight resistance in wheat: a review. (nature.com)
  • Bai, G. & Shaner, G. Management and resistance in wheat and barley to Fusarium head blight. (nature.com)
  • A feed-forward mechanosignaling loop confers resistance to therapies targeting the MAPK pathway in BRAF-mutant melanoma. (crcm-marseille.fr)
  • The progress is sometimes fragile, threatened by factors ranging from drug resistance to uncertain funding for the future. (who.int)
  • China, has long been the epicentre of antimalarial drug Organization (WHO) since 1982, Singapore is at risk of resistance. (who.int)
  • Failure of the chaperone system to recognize or fold the client protein(s) results in increased microtubule stability and resistance to the microtubule-destabilizing effect of the herbicides. (researchhunt.com)
  • CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi. (ouhsc.edu)
  • Furthermore, cated that eradication of H. pylori from there are few reports of H. pylori resistance the human stomach is hard to achieve and to furazolidone [ 18,19 ]. (who.int)
  • Mosquitoes were collected from a mining site in the north-eastern part of the country and, following identification, were subjected to extensive testing for the target-site and biochemical basis of resistance. (biomedcentral.com)
  • This switch adds to concerns about resistance, Dr Yang and colleagues write, because risk factors for mcr-1 dissemination in humans "are likely to be exacerbated when colistin is used clinically. (medscape.com)
  • Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. (jyu.fi)
  • Understanding the geographic distribution of target-site resistance, and temporal trends across different vector species, can inform strategic deployment of vector control tools. (lstmed.ac.uk)
  • OBJECTIVE: To study whether PNPLA3-I148M confers an antihyperlipidemic effect in insulin-resistant patients. (lu.se)
  • In patients with an SDH-deficient or NF-related GIST, imatinib is not recommended because of resistance. (medscape.com)
  • The patients were diag- resistance is believed to result from clonal nosed with ulcer (9), oesophagitis (18), Bar- selection of resistant variants rather than rett's oesophagus (15) and gastritis (28). (who.int)
  • Insulin resistance (IR) amplifies the effect of PNPLA3-I148M on liver fat. (lu.se)
  • Immunization is one of the most effective public health vaccination coverage in Nigeria has shown an upward interventions available, which involves conferring shift over the past 10 years. (who.int)