Conductance kv1 2 potassium channel. Medical search. Frequent questions

Potassium voltage-gated channel subfamily E member 4, originally named MinK-related peptide 3 or MiRP3 when it was discovered, is a protein that in humans is encoded by the KCNE4 gene. (wikipedia.org)
Kv1.1 belongs to the Kv1 subfamily, consisting of eight members (Kv1.1 to Kv1.8). (biomedcentral.com)

KCNE4 is best known for modulating the KCNQ1 Kv α subunit, but it also regulates KCNQ4, Kv1.x, Kv2.1, Kv4.x and BK α subunits in heterologous co-expression experiments and/or in vivo. (wikipedia.org)
KCNE4 often, but not always, acts as an inhibitory subunit to suppress potassium channel function, but this varies depending on the channel subtype. (wikipedia.org)
10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)

The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al. (antibodiesinc.com)

Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. (epfl.ch)

Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. (antibodiesinc.com)
Andreasen M, Hablitz JJ (1993) Local anesthetics block transient outward potassium currents in rat neocortical neurons. (yale.edu)
Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. (yale.edu)
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. (modeldb.science)
Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. (modeldb.science)
Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neurons. (epfl.ch)

In this work, we developed an efficient system for the production of three potent Kv1.3 channel blockers from different scorpion venoms: Vm24, AnTx, and Ts6. (mdpi.com)
Treatment with potassium channel blockers have been shown to block apoptosis in various cell types [ 11 ]. (biomedcentral.com)
To determine the vasoactive effect mechanisms of elabela, the specified experimental protocol was repeated after the incubation of signaling pathway inhibitors and potassium channel blockers. (bvsalud.org)

2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)

TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
A direct link between potassium channel dysfunction and apoptosis is that reduced intracellular potassium levels appear to promote critical events early in the suicide program. (biomedcentral.com)
A sustained increase in the intracellular Ca²⁺ concentration induces proteolytic cleavage of EAG2 channel. (epfl.ch)
Roles of surface residues of intracellular domains of heag potassium channels. (epfl.ch)

The KCNE4 gene encodes KCNE4 (originally named MinK-related peptide 3 or MiRP3), a member of the KCNE family of voltage-gated potassium (Kv) channel ancillary or β subunits. (wikipedia.org)
The majority of studies of KCNE4 function, structure-function relationships and effects of pathological gene sequence variants within KCNE4 have utilized the widely reported 170 residue version of the protein encoded by exon 2 of the human KCNE4 gene. (wikipedia.org)
Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. (uc.edu)
1. McKinnon D (1989) Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. (aspetjournals.org)
9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)
The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. (biomedcentral.com)

1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra. (antibodiesinc.com)
8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)

KCNE4 strongly inhibits the KCNQ1 potassium channel, which is known to play important roles in human cardiac myocyte repolarization, and in multiple epithelial cell types. (wikipedia.org)
KCNE4 strongly inhibits Kv1.1 and Kv1.3 channels when co-expressed in HEK cells and in Xenopus laevis oocytes, while leaving Kv1.2 and Kv1.4 currents unaffected. (wikipedia.org)
Our data indicate that cynarin, through the suppression of P/Q-type Ca2+ channels, inhibits PKA activation and attenuates synapsin I and SNAP-25 phosphorylation at PKA-specific residues, thus decreasing synaptic vesicle availability and contributing to glutamate release inhibition in cerebral cortex terminals. (bvsalud.org)

Christie JM, Westbrook GL (2003) Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. (yale.edu)

Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (epfl.ch)

Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. (uc.edu)
Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. (uc.edu)
The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. (uc.edu)
The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. (mdpi.com)

Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. (bvsalud.org)
Molecular basis of potassium channels in pancreatic duct epithelial cells. (epfl.ch)
Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling]. (epfl.ch)
Molecular regions responsible for differences in activation between heag channels. (epfl.ch)

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). (antibodiesinc.com)

We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (ß-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA. (bvsalud.org)

These oscillations are driven primarily by voltage-gated sodium channels and are distinct from resonant properties derived from other active membrane properties. (jneurosci.org)
In addition, we model sodium channel remodeling as a homeostatic control of nodal excitability. (springeropen.com)

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)

This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)

KCNE4 has no known effect on KCNQ2, KCNQ3 or KCNQ5 channels, but augments activity of KCNQ4 in HEK cells, mesenteric artery and Xenopus laevis oocytes. (wikipedia.org)
Interactions between MCEPH and other Kv1 subunits were studied in cell culture, Xenopus oocytes and the brain. (biomedcentral.com)

To better understand how mild demyelination gives rise to the early symptoms of demyelinating diseases, one approach is to build mathematical models of the axon and study the link between demyelination patterns and axonal conduction properties [ 2 , 3 , 4 , 5 ]. (springeropen.com)

KCNE4 slows activation and inactivation of Kv4.2 channels, and induces overshoot upon recovery from inactivation. (wikipedia.org)
My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
Divalent cations slow activation of EAG family K+ channels through direct binding to S4. (epfl.ch)

The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region. (epfl.ch)
Differential localization of rat Eag1 and Eag2 potassium channels in the retina. (epfl.ch)

They regulate the excitability of cells and contribute to their resting membrane potential [ 1 , 2 ]. (ersjournals.com)
12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)

Potassium (K + ) channels constitute the largest group of ion channels in the human genome. (ersjournals.com)
Differential expression of potassium ion channels in human renal cell carcinoma. (epfl.ch)
Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types. (epfl.ch)

Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice. (biomedcentral.com)
Kv1.1, Kv1.2 and Kv1.4 are the most abundant Kv1 subunits expressed in the brain [ 6 ]. (biomedcentral.com)

In the rat heart, KCNE4 protein co-localizes with Kv4.2, a channel that KCNE4 also functionally regulates. (wikipedia.org)

Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)

PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)

Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. (antibodiesinc.com)
We demonstrate that subthreshold oscillations mediated by voltage-gated Na + channels play a key role in conferring graded differences in firing properties. (jneurosci.org)

Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. (epfl.ch)

KCNE4 has also been found to regulate the large-conductance Ca2+-activated potassium channel, BK. (wikipedia.org)
In rat mesenteric artery, KCNE4 augments KCNQ4 channel activity to regulate arterial tone. (wikipedia.org)

1. Role of ion channels in T cell response and adaptation to hypoxia. (uc.edu)

The conformation of this bond, connecting Loop 2 and Loop 6, appears to be elongase-specific. (bvsalud.org)

7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. (epfl.ch)

Whether through touch, smell or vision, all the information we have about the external world is channeled through bundles of axons. (springeropen.com)
External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. (epfl.ch)

An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells. (epfl.ch)

Potassium channels of T lymphocytes take center stage in the fight against cancer. (uc.edu)

A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. (uc.edu)

For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap. (antibodiesinc.com)

Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
The channels are hetero- or homotetramers, formed by a great variety of subunits, classified in 12 subfamilies [ 5 ]. (biomedcentral.com)

Anatomy27

Organisms16

Diseases7

Chemicals and Drugs148

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology1

Phenomena and Processes41

Disciplines and Occupations4

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Subfamily2

Subunit5

Kv2.11

Voltage-gated po3

Neurons6

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Intracellular4

Gene6

Rectifier2

Inhibits3

Currents1

Transient1

Kv1.34

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Axonal1

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Human3

Kv1.12

Protein1

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Differences2

Residue1

Regulate2

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Loop1

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