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  • severe
  • Some autopsy studies reported demyelination and sclerosis of the dorsal column, which was more severe in the cervical fasciculus gracilis, and atrophy of anterior horn cells. (medscape.com)
  • Extra copies of the SMN2 gene affect how severe the condition is. (nih.gov)
  • chromosome
  • The gene associated with this condition is located on the X chromosome , which is one of the two sex chromosomes . (nih.gov)
  • In males (who have only one X chromosome ), one altered copy of the gene in each cell is sufficient to cause the condition. (nih.gov)
  • mutations
  • A few females with mutations in both copies of the gene have had mild features related to the condition, including muscle cramps and occasional tremors. (nih.gov)
  • mobility
  • Most of the conditions that develop after the first two years of life include physical therapy in the treatment plan in order to improve mobility and joint movement. (cedars-sinai.edu)
  • risk
  • Your GP may refer you to a genetic counsellor to discuss the risk of the condition affecting a future pregnancy and any tests you can have. (www.nhs.uk)
  • typically
  • Children with this condition typically have issues with their legs and may have trouble standing or walking without assistance. (mercy.com)
  • Foundation
  • This study was sponsored by the Spinal Muscular Atrophy (SMA) Foundation, New York, New York, who also had a role in the design of the study, data collection and analysis, decision to publish, and preparation of the manuscript ( http://www.smafoundation.org/ ). (plos.org)