Concomitant radiation doses of chemotherapy or radiation. Medical search. Frequent questions

However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. (empr.com)
The safety and efficacy of administration of Neupogen® on the same day as myelosuppressive cytotoxic chemotherapy have not been established. (ru-pills.com)
Because of the sensitivity of rapidly dividing myeloid cells to myelosuppressive cytotoxic chemotherapy, administration of Neupogen® 24 hours before or after administration of these drugs is not recommended. (ru-pills.com)
BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

While dosing regimens are designed to limit damage to healthy tissue, radiation-induced neuropathy may occur. (medscape.com)
Alternatively, seemingly active chemotherapy regimens may have been suboptimal. (jnccn.org)
The incidence and severity was highest in patients receiving trastuzumab with anthracycline-containing chemotherapy regimens. (rxlist.com)
Furthermore, several randomised trials have shown that the addition of alkylating chemotherapy, either temozolomide or nitrosourea-based regimens, to radiotherapy results in prolonged survival. (smw.ch)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. (uchicago.edu)
Treatment consisted of preoperative external beam pelvic radiation therapy (EBRT) and concomitant chemotherapy (CT) during the first and fourth weeks of radiation combining 5-fluorouracil and cisplatin. (sorbonne-universite.fr)
Note: Low-dose cisplatin given as a radiation sensitizer or hormonal therapies do not exclude patients from study participation. (who.int)
Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. (medscape.org)
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. (medscape.org)
Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. (medscape.org)

In recent years, as most evidence solidified the role of concurrent chemotherapy and radiation as either primary or postoperative therapy for locally advanced head and neck cancer, induction chemotherapy fell out of scope and practice. (jnccn.org)
Of note is that none of the previously conducted randomized trials of induction chemotherapy used concurrent chemoradiotherapy in the control arm. (jnccn.org)
Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. (uchicago.edu)
Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)
Preoperative concurrent radiation therapy and chemotherapy for bulky stage IB2, IIA, and IIB carcinoma of the uterine cervix with proximal parametrial invasion. (sorbonne-universite.fr)
Radiation pneumonitis is observed clinically in 10% to 20% of patients receiving concurrent CRT for locally advanced nonsmall cell lung cancer, with a much higher percentage of patients exhibiting asymptomatic radiographic changes. (appliedradiationoncology.com)
Patients who receive standard radiation therapy with concurrent chemotherapy may be eligible as long as other criteria are met. (childrenshospital.org)
Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. (medscape.org)
Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. (medscape.org)

The subspecialty of oncology concerned with radiotherapy is called radiation oncology. (wikipedia.org)
Radiation oncology is the medical specialty concerned with prescribing radiation, and is distinct from radiology, the use of radiation in medical imaging and diagnosis. (wikipedia.org)
Radiation oncology. (uchicago.edu)
Radiation oncology and the new biology. (uchicago.edu)
Role of gene therapy in radiation oncology. (uchicago.edu)
Dr. William Morrison is a Professor of Radiation Oncology at M.D. Anderson Cancer Center, with 31 years of clinical experience treating patients with head and neck cancer. (mdanderson.org)
He was treated with chemotherapy per protocol Children's Oncology Group Protocol ARST0332 and proton beam therapy to the involved mediastinum, pericardium, and heart. (allenpress.com)
To evaluate the quality of the brachytherapy procedure at the National Institutes of Health s Radiation Oncology Branch. (survivornet.com)
Each treatment will take place in the Radiation Oncology Clinic. (survivornet.com)
Patients will return to the Radiation Oncology Clinic for followup visits at 1, 3, 6, 9, and 12 months after the completion of radiation therapy. (survivornet.com)
The primary objective is to determine the quality of high dose rate brachytherapy implants performed in the radiation oncology branch. (survivornet.com)
This treatment will be administered in accordance with standard radiation oncology practice and per the ABS (American Brachytherapy Society) guidelines. (survivornet.com)

Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. (uchicago.edu)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)

Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
Random clinical trials conducted on a variety of cancerous tissues have highlighted the advantage of adding hyperthermia therapy to a standard radiotherapy/chemotherapy regimen. (pyrexar.com)
Patients who have contraindication to the lymphodepletion chemotherapy regimen. (moffitt.org)
The high‐dose induction chemotherapy regimen that will be used to treat this patient is profoundly myelosuppressive, and typically causes severe ulcerative oral mucositis for at least two weeks duration. (pocketdentistry.com)
With the addition of granulocytecolony-stimulating factor (G-CSF [Neupogen]) to the regimen,patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be reported with thefinal results of this phase I study. (cancernetwork.com)
This combination regimen in patients with upper gastrointestinalmalignancies and breast cancer will be investigated as partof phase II studies, once the dose-limiting toxicity is determined. (cancernetwork.com)
With the addition of granulocyte colony-stimulating factor (G-CSF [Neupogen]) to the regimen, patients received epirubicin at clinically relevant doses after dose-escalation. (cancernetwork.com)
Participants will be treated with high-dose brachytherapy appropriately sequenced with other modalities in their treatment regimen. (survivornet.com)

Continuous infusion paclitaxel, 5-fluorouracil, and hydroxyurea with concomitant radiotherapy in patients with advanced or recurrent head and neck cancer. (uchicago.edu)
and radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (empr.com)

Induction Chemotherapy for Head and Neck Cancer: Will History Repeat Itself? (jnccn.org)
Despite high objective response rates, induction chemotherapy has not resulted in tangible benefit in multiple randomized trials. (jnccn.org)
The failure of older randomized trials to show a survival benefit from induction chemotherapy can be attributed to several factors. (jnccn.org)
These trials are anticipated to redefine the role of induction chemotherapy for head and neck cancer. (jnccn.org)

Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. (uchicago.edu)
Neoadjuvant PFL augmented by methotrexate and piritrexim followed by concomitant chemoradiotherapy for advanced head and neck cancer: a feasible and active approach. (uchicago.edu)
Ninety-five percent patients completed a full-dose chemoradiotherapy as planning. (biomedcentral.com)
A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)

Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. (uchicago.edu)

In 1930, researchers reported the development of factitial proctitis in a group of patients who received pelvic radiation to treat malignant disease. (medscape.com)
The pelvic radiation dose was 40.5 Gy over 4.5 weeks. (sorbonne-universite.fr)
Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies. (medscape.org)

3. Temozolomide (TMZ) - Concomitant TMZ chemotherapy during RT and adjuvant (maintenance) TMZ for 6 cycles has been shown to significantly improve survival (HR 0.63)3. (orlandohealth.com)
15 Kurzen H, Schmitt S, Naher H, Mohler T. Inhibition of angiogenesis by non-toxic doses of temozolomide. (thieme-connect.com)

Results from the English National Cancer Survivorship initiative, which includes a study on the consequences of treatment in adult cancer, such as radiation-induced brachial plexopathy, suggest that patients benefit significantly when the prevention, detection, and treatment of some of these consequences are approached systematically. (medscape.com)
The current incidence is 1-2% in patients receiving a typical dose of less than 55 Gy. (medscape.com)
No sources in the literature have examined the racial or ethnic distribution of patients with radiation-induced brachial plexopathy. (medscape.com)
Phan C, Mindrum M, Silverman C, Paris K, Spanos W. Matched-control retrospective study of the acute and late complications in patients with collagen vascular diseases treated with radiation therapy. (medscape.com)
This prospective registry study evaluated Japanese patients to determine whether a reduced radiation dose was feasible. (nih.gov)
Intensified chemotherapy using HDC and IT-MTX might allow for a reduced prophylactic radiation dose in patients with MB with metastases. (nih.gov)
All patients received concomitant Prevnar 13 at 2, 4, 6, and 15 months of age. (renalandurologynews.com)
Renal cell cancer and melanoma are generally considered to be radioresistant but radiation therapy is still a palliative option for many patients with metastatic melanoma. (wikipedia.org)
70 years-old patients (OR = 16.02, CI95% = 11.99-21.41), with HHNR (OR = 1.84, 1.41-2.40), treated with >4 cycles (OR = 1.52, CI95% = 1.16-2.01) and high doses of cetuximab (OR = 3.80, CI95% = 2.52-5.71) are the greatest risk factors for OM. (bvsalud.org)
Conclusions: Since the clinical benefit of cetuximab in the treatment of older patients is limited and there is a high OM, especially in women with head and neck treated with radiotherapy, high doses and a high number of cetuximab cycles must be administered with caution. (bvsalud.org)
One of these is radiation therapy (RT), which is used in 20-55% of cancer patients, and its basic principle consists of inhibiting proliferation or inducing apoptosis of cancer cells. (elsevierpure.com)
Radiation to the heart is a common complication of RT, especially in patients with lymphoma, breast, lung, and esophageal cancer. (elsevierpure.com)
The understanding of these mechanisms and risk factors by physicians can lead to a tailored assessment and monitorization of these patients with the objective of early detection or prevention of radiation-induced heart disease. (elsevierpure.com)
He has personally treated 3200 head and neck patients, and gained leading technical expertise and judgement in the formulation and delivery of radiation therapy. (mdanderson.org)
Sign of multi PUB or concomitant other gastro bleeding from esophageal varices, reflux esophagitis, gastritis, Mallory Weiss rifts, ulcus simplex, Dieulafoy's lesion, colon, small bowel, or ulcer distal to the stom in Billroth-resected patients. (astrazenecaclinicaltrials.com)
Three patients received concomitant androgen deprivation therapy (ADT). (biomedcentral.com)
EBRT was followed by low-dose rate uterovaginal brachytherapy with a total dose of 20 Gy in 62 patients. (sorbonne-universite.fr)
Thirty patients who had not received preoperative uterovaginal brachytherapy underwent postoperative low-dose-rate vaginal brachytherapy at a dose of 20 Gy. (sorbonne-universite.fr)
Even at 2 years after radiation therapy, 15% of patients had grade 2 swallowing dysfunction and 8% had progressive dysphagia, so their swallowing is going to continue to get worse. (ascopost.com)
In thisopen-label phase I study, irinotecan was administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 to 7 and epirubicin starting at a dose of40 mg/m2 and escalating by 10 mg/m2 in cohorts of three patients forthose with metastatic adenocarcinomas. (cancernetwork.com)
more than one port may be required with protons if adequate skin sparing is to be achieved in patients being treated to high doses with only protons. (nature.com)
Patients with cancer who could potentially benefit from high-dose brachytherapy as part of their treatment. (survivornet.com)
In conjunction with their existing treatment, patients will be treated with high-dose brachytherapy as determined appropriate for their particular type of cancer and cancer history. (survivornet.com)
Leukocytosis: less than 5% of patients receiving Neupogen® in doses over 0.3 million units (3 µg/kg/day) had leukocyte counts increased to 100-109/l or more. (ru-pills.com)
In clinical practice accelerated postoperative radiation therapy might be a suitable option only for a subset of patients. (biomedcentral.com)
This research study involves chemotherapy as a possible treatment for pediatric patients with Diffuse intrinsic pontine glioma (DIPG) The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. (childrenshospital.org)
Given the poor prognosis of all patients with DIPG, patients may enroll at any point in their disease course provided they have received standard radiation therapy (also defined below) and meet all other eligibility requirements. (childrenshospital.org)
Patients must have received their last fraction of radiation therapy at least 2 weeks prior to treatment initiation. (childrenshospital.org)
Patients must have received their last dose of known myelosuppressive chemotherapy at least 21 days prior to enrollment (42 days if prior nitrosourea). (childrenshospital.org)
doses in patients with cervical cancer receiving pelvic and paraaortic irradiation. (medscape.org)
Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. (medscape.org)
IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. (medscape.org)
This phase I trial studies the side effects and best dose of belinostat when given together with tremelimumab and durvalumab in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and has spread to nearby tissue or lymph nodes (locally advanced). (bcan.org)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. (wikipedia.org)
Besides the tumour itself, the radiation fields may also include the draining lymph nodes if they are clinically or radiologically involved with the tumor, or if there is thought to be a risk of subclinical malignant spread. (wikipedia.org)
Radiation therapy has several applications in non-malignant conditions, such as the treatment of trigeminal neuralgia, acoustic neuromas, severe thyroid eye disease, pterygium, pigmented villonodular synovitis, and prevention of keloid scar growth, vascular restenosis, and heterotopic ossification. (wikipedia.org)
The use of radiation therapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers. (wikipedia.org)
Risk factors for a severe course of the disease in the United States among children were age under 1 year and the presence of concomitant diseases: chronic lung and heart disease, immunosuppression (malignant neoplasms, chemotherapy and radiation therapy, organ transplantation, treatment with high doses of glucocorticosteroids). (pediatrkiev.com)
Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial. (thieme-connect.com)

following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

Postoperative adhesions that fix small-bowel loops within the pelvis make these loops susceptible to radiation injury. (medscape.com)

The radiation treatment interruption due to toxicity is one of the effects that should be avoided, as it extends the total treatment time and, as a result, causes a decrease in local control(9). (rb.org.br)
The dose-limiting toxicity has not yetbeen reached. (cancernetwork.com)
The dose-limiting toxicity has not yet been reached. (cancernetwork.com)
Acute but not late radiation toxicity were more frequent with the accelerated RT technique. (biomedcentral.com)
A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer. (medscape.org)

Intensity-modulated radiotherapy (IMRT) has been demonstrating to be advantageous over traditional techniques such as conventional (2D) RT and conformational (3D) RT, as it provides a more homogeneous dose coverage of the target volume, while reducing the dose to adjacent tissues(4,5). (rb.org.br)
To date, the most advanced photon beam delivery method is intensity-modulated (IM) radiation therapy (IMRT), which can deliver higher doses of radiotherapy to tumour targets while reducing the dose delivered to selected normal tissues. (nature.com)
With IMRT, high doses to these selected normal tissues can be avoided by applying numerous radiation fields of varying intensities from different directions. (nature.com)
hence, one of the concerns of IMRT is that, over time, this exposure of more tissue to low-dose radiation will cause a second malignancy or other unwanted late normal tissue effect. (nature.com)
He received 6,300 cGy of external beam radiation therapy (EBRT) in 35 fractions to his left lung mass, left hilar adenopathy, and paratracheal lymphadenopathy using 6-field intensity-modulated radiation therapy (IMRT) (Table 1) with weekly carboplatin AUC 5 on days 1 and 22 and weekly docetaxel 20mg/m2. (appliedradiationoncology.com)

Therefore, in some views, tumor downstaging, especially pCR, was regarded as a goal in neoadjuvant treatment of locally advanced rectal cancer, which motivated the combination of systemic chemotherapy and advanced RT technique in this approaches. (biomedcentral.com)

1. Patient has received neoadjuvant/adjuvant systemic chemotherapy for primary Stage IIIc2 or IV disease and has had a recurrence or PD within 6 months of completing chemotherapy treatment prior to entering the study. (who.int)

Drugs used in chemotherapy, such as pemetrexed and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (moffitt.org)
The initial dose of Herzuma is 4 mg/kg over 90 minute IV infusion, then 2 mg/kg over 30 minute IV infusion weekly for 12 weeks (with paclitaxel or docetaxel) or 18 weeks (with docetaxel and carboplatin ). (rxlist.com)

Conventional radiation therapy, which utilises photon (X-ray) beams, is frequently used in the locoregional treatment of cancer. (nature.com)

Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. (wikipedia.org)
To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose there than in the surrounding healthy tissue. (wikipedia.org)
It is important to distinguish the radiosensitivity of a particular tumor, which to some extent is a laboratory measure, from the radiation "curability" of a cancer in actual clinical practice. (wikipedia.org)
Patient medical records were reviewed to obtain data on chemotherapy cycle and dose, sex, age, primary tumor, TNM stage, and head and neck radiotherapy (HNR) history. (bvsalud.org)
With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy. (uchicago.edu)
Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. (uchicago.edu)
Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. (uchicago.edu)
The increase in dose is related to an improvement in the tumor management and to a better survival rate. (rb.org.br)

Radiation therapy (RT) is a mainstay in the treatment of both primary and recurrent gastrointestinal (GI) and pelvic malignancies. (medscape.com)
Because RT is increasingly used to treat pelvic malignancies, the surgical prevention and treatment of the complications of radiation enteritis and proctitis continue to evolve. (medscape.com)
Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. (nature.com)
Initial clinical experience with intensity-modulated whole-pelvis radiation therapy in women with gynecologic malignancies. (medscape.org)

The HR group received intrathecal methotrexate (IT-MTX) and high-dose chemotherapy (HDC) using thiotepa and melphalan, as well as concomitant radiotherapy with a recommended CSI dose of 18 Gy and a total local dose of 50 Gy. (nih.gov)

Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. (uchicago.edu)
Radiation therapy is standardly used for unresectable or incompletely resected sarcoma. (allenpress.com)

When treating the axillary and supraclavicular lymph nodes with radiation therapy, it is impossible to avoid irradiating normal tissues, including the brachial plexus. (medscape.com)

demonstrated that altered fraction schedules are a valuable alternative to chemoradiation as they provide similar gains in reduction of overall mortality compared to standard radiation alone in the definitive therapeutic setting. (biomedcentral.com)

It will relate to the dose received and its fractionation, the concomitant treatments, and the susceptibility of the recipient. (health4fitnessblog.com)

virtually every patient has some manifestation of acute radiation-induced injury of the GI tract in the form of abdominal cramping, tenesmus, urgency, bleeding, diarrhea, and incontinence. (medscape.com)
The development of improved dosimetry techniques, as well as patient selection and positioning during delivery of RT, were crucial to decrease the harmful effects of radiation on the intestines. (medscape.com)
13. Patient must have a negative serum pregnancy test within 72 hours of the first dose of study medication, unless they are of nonchildbearing potential. (who.int)
The Bragg peak, and hence desired dose, can thus be precisely placed anywhere in the patient (see Figure 1 ). (nature.com)

The direct effects of radiation on the bowel mucosa lead to acute radiation enteritis. (medscape.com)
The rationale for proton beam therapy was that a local treatment could be provided while delivering less radiation to adjacent lungs, thereby decreasing the risk of acute and late radiotherapeutic toxicities. (allenpress.com)

Some types of cancer are notably radioresistant, that is, much higher doses are required to produce a radical cure than may be safe in clinical practice. (wikipedia.org)

Total body irradiation (TBI) is a radiation therapy technique used to prepare the body to receive a bone marrow transplant. (wikipedia.org)
For irradiation of a tumour, the proton beam energy and intensity are varied in order to achieve the desired dose over the tumour volume. (nature.com)

Although radiation therapy is used in the treatment of a myriad of neoplastic diseases, it has potentially adverse effects on several organs and systems that are exposed during treatment. (medscape.com)
Advanced age may be a risk factor for the development of brachial plexopathy after radiation treatment. (medscape.com)
Brachytherapy, in which a radioactive source is placed inside or next to the area requiring treatment, is another form of radiation therapy that minimizes exposure to healthy tissue during procedures to treat cancers of the breast, prostate, and other organs. (wikipedia.org)
It is estimated that half of the US' 1.2M invasive cancer cases diagnosed in 2022 received radiation therapy in their treatment program. (wikipedia.org)
The treatment for head and neck cancer consists of surgery, followed or not by radiotherapy (RT) or radical RT, concomitantly or not with chemotherapy. (rb.org.br)
Need for treatment during the first 7 days of the study with NSAIDs, Cyclooxygenase-2 (COX-2) inhibitors, acetyl salicylic acid (ASA) (including low dose) or clopidogrel. (astrazenecaclinicaltrials.com)
Although the benefits of treatment with radiation are well established, damage to the healthy, nonneoplastic tissue may be severe. (medscape.com)
Radiation is currently delivered with substantially more precision than in the past because of advances in imaging and treatment planning. (nature.com)
One standard way of giving radiation is to combine external beam treatment s with internal brachytherapy treatments, which involve short-range radiation therapy that gives a high dose of radiation directly to a cancer or to the area where cancer cells were removed. (survivornet.com)
Participants with cancer who could potentially benefit from the use of high dose rate brachytherapy as a component of their treatment. (survivornet.com)
Participants will undergo appropriate work-up and clinical evaluation to determine if high-dose brachytherapy would be beneficial in either primary treatment or palliation of their disease. (survivornet.com)
It is the most common side effect of chemotherapy, affecting 80% of people who undergo this treatment. (health4fitnessblog.com)
Restaging PET/CT at 5 weeks after treatment showed diffuse consolidation throughout the left-upper lobe associated with intense tracer uptake (SUVmax range, 6.8-8.5) consistent with radiation pneumonitis (Figure 2). (appliedradiationoncology.com)
Intensity-modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normal-tissue-sparing effect to margin size. (medscape.org)

The BSD-2000 is used to superheat and kill cancer cells, as well as to boost the effectiveness of radiation and chemotherapy in the effort to improve local control of cancer and increase long-term survival. (pyrexar.com)
Surgery, radiation therapy (RT), or both have been used for decades to improve loco-regional control (LRC) and overall survival (OS). (biomedcentral.com)

Chemotherapy or radiation therapies within 2 weeks prior to randomisation or planned during the course of the study. (astrazenecaclinicaltrials.com)

For example, a shorter interval between doses may facilitate avoiding vaccination during periods of more intense immunosuppression. (cdc.gov)

It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, immunotherapy or some mixture of the four. (wikipedia.org)
Temporal bone chemodectomas--comparing surgery and radiation therapy. (uchicago.edu)
Also there are many treatments for cancer, but the most common are surgery, chemotherapy, and radiation therapy. (health4fitnessblog.com)
Rapid radiographic onset of radiation pneumonitis was noted at 5 weeks after CRT (although clinical symptoms remained mild), and surgery was postponed. (appliedradiationoncology.com)

Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. (uchicago.edu)

In vivo , however, lethal tumour doses are not always achievable because of radiation-induced morbidity in normal tissues. (nature.com)
In general, a set of proton fields achieves significant dose reduction to uninvolved normal tissues compared to a matched set of photon fields. (nature.com)
Dose-volume effects for normal tissues in external radiotherapy: pelvis. (medscape.org)

Intensity-modulated radiation therapy use in the U.S., 2004. (medscape.org)
A survey of intensity-modulated radiation therapy use in the United States. (medscape.org)

Ionizing radiation works by damaging the DNA of cancerous tissue leading to cellular death. (wikipedia.org)
Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. (nature.com)

Highly emetogenic chemotherapy: 24mg once 30 mins before start of single-day chemotherapy (multi-day, single-dose not studied). (empr.com)

Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. (uchicago.edu)
Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. (uchicago.edu)
Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma. (mdanderson.org)
I. To assess the recommended phase 2 dose of belinostat in combination with tremelimumab and durvalumab in advanced solid tumors harboring ARID1A mutations with focus on urothelial carcinoma. (bcan.org)

Chronic intestinal radiation injury is a result of transmural bowel damage with associated obliterative endarteritis. (medscape.com)
all of them had concomitant diseases (hydronephrosis, leukemia, intestinal intussusception). (pediatrkiev.com)
In normal volunteers, single intravenous doses of 0.15 mg/kg of ondansetron had no effect on esophageal motility, gastric motility, lower esophageal sphincter pressure, or small intestinal transit time. (nih.gov)
Besides, If you get radiation to the abdomen, you may experience changes in intestinal transit, as well as nausea and vomiting. (health4fitnessblog.com)

Chronic radiation enteritis is an indolent but relentlessly progressive disease. (medscape.com)

Standard radiation therapy is defined, for this study, as 54-60 Gy standard focal (photon or proton) radiation therapy, administered over 6 weeks (+/- 10 days). (childrenshospital.org)

Given that breast cancer often is treated with radiation therapy, women experience a greater incidence and prevalence of radiation-induced brachial plexopathy than men. (medscape.com)
Why has so much chemotherapy done so little in head and neck cancer? (jnccn.org)
Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body, and have not spread to other parts. (wikipedia.org)
Most common cancer types can be treated with radiation therapy in some way. (wikipedia.org)
The response of a cancer to radiation is described by its radiosensitivity. (wikipedia.org)
Highly radiosensitive cancer cells are rapidly killed by modest doses of radiation. (wikipedia.org)
Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. (uchicago.edu)
The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines. (uchicago.edu)
Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. (uchicago.edu)
IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. (guidelinecentral.com)
If these children are cured of their primary cancer, they should have a relatively long lifespan, during which time they may manifest a radiation-induced malignancy. (nature.com)

In the 1950s, the incidence was as high as 66% after 60-Gy total dosing to the axillary and supraclavicular area using 5 Gy/fraction. (medscape.com)
Single high-dose fraction radiotherapy to abdomen: 8mg 1-2hrs before radiotherapy, then 8mg every 8hrs after 1st dose for 1-2 days after radiation completed. (empr.com)
In 1979, Lavery et al reported their use of gauze packs encased in a latex dam to protect the abdominal viscera during high-dose RT for osteogenic sarcoma of the iliac bone. (medscape.com)
Figure 8‐2 ) may be treated by moderate or high‐dose chemotherapy, with or without hematopoietic stem cell transplantation (HSCT). (pocketdentistry.com)
in combination with high-dose chemotherapy. (ru-pills.com)

Immune responses to FHA, PRN, and FIM in a subset of infants who received 3 doses of Daptacel in the Sweden I Efficacy Trial were compared to the Post-Dose 3 and Post-Dose 4 responses in a subset of US children from Study 494-01 who received Pentacel. (renalandurologynews.com)
Infants were randomly assigned to receive the first 3 doses of Pentacel or Daptacel + IPOL + ActHIB at 2, 4, and 6 months of age, one month after the third dose of study vaccines. (renalandurologynews.com)
Study Visits: About 7 days before participant's first dose of study drug, the following tests will be performed. (mycancergenome.org)
This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug to use for further studies. (childrenshospital.org)
OUTLINE: This is a dose-escalation study of belinostat. (bcan.org)

The history of surgical prevention of small-bowel radiation injury is based on the principle of abdominopelvic partitioning. (medscape.com)

Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. (uchicago.edu)
Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. (uchicago.edu)

Anatomy5

Organisms1

Diseases46

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment97

Phenomena and Processes33

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture6

Humanities2

Information Science11

Named Groups1

Health Care48

Geographicals3

Cytotoxic chemotherapy4

Regimens5

Cisplatin6

Concurrent9

Oncology12

Neoadjuvant chemotherapy2

Regimen8

Radiotherapy in patients2

Induction4

Chemoradiotherapy4

Combination chemotherapy1

Pelvic radiation3

Temozolomide2

Patients36

Malignant6

Adjuvant chemotherapy1

Postoperative1

Toxicity5

IMRT5

Locally advanced1

Systemic1

Carboplatin2

Locoregional1

Tumor9

Malignancies4

Methotrexate1

Unresectable2

Lymph1

Chemoradiation1

Fractionation1

Patient4

Acute2

Higher doses1

Irradiation2

Treatment14

Survival2

Therapies1

Immunosuppression1

Surgery4

Exposures1

Normal tissues3

Intensity-modulated2

Tissue2

Single dose not1

Carcinoma4

Intestinal4

Chronic1

Standard radiation1

Cancer11

High5

Study5

Small-bowel1

Tumors2