Drug InteractionsArea Under CurveCross-Over StudiesAdministration, OralKetoconazoleDrug Therapy, CombinationMeasles-Mumps-Rubella VaccineDrug CombinationsCimetidineDrug Administration ScheduleHalf-LifeDrug SynergismDose-Response Relationship, DrugTime FactorsRats, Sprague-DawleyMetabolic Clearance RateBiological AvailabilityDouble-Blind MethodRats, WistarInfusions, IntravenousAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyEnzyme InhibitorsCytochrome P-450 Enzyme SystemBlood PressureTreatment OutcomeDisease Models, AnimalKidneyLiverInjections, IntravenousUnited States Food and Drug AdministrationDrug Administration RoutesAdministration, IntranasalInjections, IntraperitonealMice, Inbred C57BLInjections, SubcutaneousAdministration, RectalInjections, IntramuscularAdministration, TopicalMice, Inbred BALB CRats, Inbred StrainsInjections, IntraventricularDogsAdministration, IntravenousRNA, MessengerTissue DistributionBrainAdministration, CutaneousRecombinant ProteinsBody WeightCells, CulturedRandom AllocationInfusions, ParenteralAnalysis of VarianceAdministration, InhalationRabbitsBehavior, AnimalAdministration, SublingualChromatography, High Pressure LiquidMice, KnockoutKineticsDrug ToleranceAntineoplastic AgentsOrgan SizeMorphinePlant ExtractsLungInjectionsPregnancyMice, Inbred ICRHeart RateInjections, SpinalImmunohistochemistryEthanolRats, Inbred F344Mice, Inbred StrainsAntibodies, MonoclonalHemodynamicsSignal TransductionEstradiolAnalgesics, OpioidApoptosisAnti-Inflammatory Agents, Non-SteroidalMotor ActivitySpleenProspective StudiesBlood GlucoseInsulinNitric OxideCytokinesDrug Evaluation, PreclinicalRetrospective StudiesPiperidinesAnalgesicsMice, TransgenicSelf AdministrationBlotting, WesternTumor Necrosis Factor-alphaProdrugsGene Expression Regulation