Concerning the genetic control organizers during embryonic development organizers embryonic. Medical search. Frequent questions

Such DNA constructs, when electroporated in fertilised eggs, produce transiently transgenic embryos and allow rapid gene functional and gene regulatory analyses , in precisely identifyable tissue precursors, from earliest embryonic stages in vivo . (uibk.ac.at)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)

The Spemann-Mangold organizer is located in the dorsal blastopore lip, where gastrulation movements originate. (wikipedia.org)
Gastrulation movements are orchestrated by a small, heterogeneous group of cells with inductive and morphogenetic properties located in the dorsal lip of the blastopore (DBL) of the amphibian gastrula known as the Spemann-Mangold organizer or dorsal organizer. (nature.com)
Role of Otx2 in dopaminergic neurogenesis: dose-dependent, anterior -posterior and dorsal-ventral integrated control by Otx2 regulates proliferation, number and neurotransmitter phenotype of dopaminergic progenitors. (cnr.it)
Larval equivalent stages of ascidians and vertebrates have resembling structures such as a central notochord (embryonic structure forming the vertebral colomn in vertebrates), a dorsal neural tube and flanking muscles. (uibk.ac.at)

Spemann also showed that by transplanting a piece from the upper blastopore lip into an area of presumptive epidermis, a secondary embryonic primordium formed, including a secondary neural tube, notochord and somites. (wikipedia.org)
This secondary embryo had the normal features of the primary embryo, including structures such as the neural plate and notochord, although they lagged slightly in development. (wikipedia.org)

Edward B. Lewis studied embryonic development in Drosophila, including the discovery of the cis-trans test for recessive genes, and the identification of the bithorax complex and its role in development in Drosophila. (asu.edu)
Christiane Nusslein-Volhard studied how genes control embryonic development in flies and in fish in Europe during the twentieth and twenty-first centuries. (asu.edu)
Mutations within coding genes have traditionally been considered the major genetic cause of human disease. (enhpathy.eu)
Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
Differentiation is controlled by specific regulatory genes and signaling pathways. (microbiologynote.com)
It involves studying how genes and their interactions regulate the various processes of development, including the formation of body axes, the specification of cell fates, and the patterning of tissues and organs. (microbiologynote.com)
To fully understand this process it will be necessary to identify additional genes involved in wiring, define their expression patterns over the course of development and elucidate their cellular functions and molecular interactions. (kcl.ac.uk)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)

The Spemann-Mangold organizer is a group of cells that are responsible for the induction of the neural tissues during development in amphibian embryos. (wikipedia.org)
The Spemann-Mangold organizer was first described in 1924 by Hans Spemann and Hilde Mangold. (wikipedia.org)
The discovery of the Spemann-Mangold Organizer is considered one of the most influential findings in the field of developmental biology and resulted in Hans Spemann being awarded the Nobel Prize in 1935 for his work (Mangold tragically died before the Nobel prize was awarded, thus was not eligible). (wikipedia.org)
The Spemann-Mangold organizer refers to the population of cells in the Xenopus laevis embryo that establishes the dorso-ventral and antero-posterior axes. (wikipedia.org)
While an organizer exists in other species, the term Spemann-Mangold organizer is specifically reserved for the amphibian embryo. (wikipedia.org)
The Spemann-Mangold organizer is particularly important in mesoderm induction. (wikipedia.org)

German biologist, Christiane Nusslein-Volhard is renowned for elucidation of the genetic control of embryonic development of fruit flies. (wepapers.com)

Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. (nature.com)
Role of Otx2 in the control of identity and fate of neuronal precursors in the ventral midbrain. (cnr.it)

Expression complexity of the Otx2 locus: transcriptional, post-transcriptional and translational regulation of Otx2 mRNA isoforms control specification and maintenance of forebrain and midbrain regional identities. (cnr.it)
The mutants exhibited forebrain and midface defects by E9.5, which persisted throughout development. (elifesciences.org)

Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
The dissertation topic focused on genetic patterns in Drosophila embryos and the various mutations that can occur throughout development (Resnik 2012). (wepapers.com)
Forty-two bisected samples were counted from either control or hhex -injected embryos. (xenbase.org)
Embryogenesis or embryogeny may be defined as the formation and development of embryos. (biologydiscussion.com)
Their embryos continue development until they attain a form resembling the adult. (biologydiscussion.com)
Embryos were injected at the 4-cell stage dorsally (A-C, double in situ hybridization for chordin and LacZ RNA as injection marker, in red), or 1 cell stage (D-R). Control embryos were injected solely with LacZ RNA (1 ng). (xenbase.org)

Role of Otx2 in Embryonic Stem Cells (ESCs): Otx2 is an intrinsic determinant required to maintain the ESC metastable state by antagonizing ground state pluripotency and promoting commitment to differentiation. (cnr.it)
We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differentiation of cell lineages during early mouse development. (silverchair.com)
in the proliferation and differentiation of mouse embryonic stem cells. (edu.au)

Developmental Genetics: Developmental genetics focuses on the genetic mechanisms that control development. (microbiologynote.com)
To unravel fundamental genetic mechanisms that control cell fate choice in vivo , we study embryonic development in a simple marine invertebrate, the ascidian Ciona intestinalis , belonging to the vertebrate sister group, the tunicates. (uibk.ac.at)
Dr. Yue Wang's laboratory investigates the molecular mechanisms that control the growth transition, particularly how cells establish and maintain the highly polarized hyphal morphogenesis. (a-star.edu.sg)
In the past few years, this lab has identified a number of central components of the polarity machinery as direct substrates of the Hgc1-Cdc28 kinase, providing new insights into the molecular mechanisms that control polarized morphogensis in C. albicans. (a-star.edu.sg)
My research is based on the need to understand the genetic mechanisms that control the establishment of the circuitry of the nervous system and for insights into the normal and pathological function of proteins that contribute to neurodegenerative disease. (kcl.ac.uk)

Identify the different processes and stages that occur during animal development. (uaeu.ac.ae)
Development of a single-celled zygote into an adult involves a series of steps or stages resulting in a gradual increase in the complexity of structure. (biologydiscussion.com)
The stages of embryonic development differ in various chordates, yet the chief phases are basically similar in all. (biologydiscussion.com)
The yolk also influences on the pattern of cleavage, on the morphogenetic movements of the blastomeres during gastrulation and on the type of development, i.e., indirect with larval forms or direct with juvenile stages. (biologydiscussion.com)
In some lower animals the amount of yolk is less in egg, so that the embryo hatches in earlier stages of development, called a larva. (biologydiscussion.com)
William Harvey (1578- 1657) and Marcello Malpighi (1628-1694) contributed information on the various stages of the development of chick on the basis of their studies with the help of simple lens. (biologydiscussion.com)

Temporal map during gastrulation of the retinoic acid effect on development and patterning of murine brain. (cnr.it)
The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. (unice.fr)
These observations suggest that, beyond its role in liver development, hhex controls specification of a vpp1 -positive endodermal cell population during gastrulation that is required for the formation of the ventral pancreas . (xenbase.org)
As early in development as the end of gastrulation, Tctn2 mutants displayed reduced activation of the Hedgehog (HH) pathway in the prechordal plate, the head organizer. (elifesciences.org)

We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. (irbbarcelona.org)
The Organizer cordially invites abstracts and full length research papers from all over the World to participate in the World Congress on "Stem Cell Research, Cancer Biology and Applied Biotechnology" (Biotech-2014) is the premier forum for the presentation of new advances and research results in the fields of theoretical, experimental, applied molecular biology, genetics, cell sciences, cancer biology, stem cell research and applied biotechnology. (iranconferences.ir)
As a postdoc in Manoj Duraisingh's lab at Harvard School of Public Health she performed a genetic screen to identify critical host factors for Plasmodium falciparum malaria using red blood cells derived from hematopoietic stem cells. (stanford.edu)

Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)

In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control. (cnr.it)
Through the development of novel live imaging assays we are now able to visualize this process in vivo, in the context of the development of the zebrafish neural tube. (unice.fr)

In the 1970s, Nusslein-Volhard focused her career on studying the genetic control of development in the fruit fly Drosophila melanogaster. (asu.edu)
Her main work with bicaudal allowed her to publish a paper in 1977, "Genetic analysis of pattern-formation in the embryo of Drosophila melanogaster. (wepapers.com)
obs) which are adding to the study of the molecular mechanisms that regulate the development of connectivity in the embryonic central nervous system (CNS) of Drosophila. (kcl.ac.uk)

We have shown that Myosin1D controls motile cilia orientation in the zebrafish left-right organizer, identifying this actin-binding motor protein as a conserved regulator of animal left-right asymmetry (Juan et al, 2018). (unice.fr)
Primary cilia are microtubule-based organelles present on diverse vertebrate cell types and critical for development. (elifesciences.org)

Alzheimer disease), genetic mutations (e.g. (intechopen.com)
Photoreceptor degeneration is an important topic for medical research, because more than 300 genetic mutations are associated with photoreceptor degeneration in humans. (oist.jp)

This identifies a crosstalk between EPHB6 and EGFR, and further experiments confirm the ability of EPHB6 to modulate EGFR signaling, enhancing the proliferation of cancer cells and tumor development. (bvsalud.org)

The overall goal of my lab is to elucidate genetic and cellular mechanisms controlling cortical development and contributing to neurodevelopmental pathologies and brain evolution. (ox.ac.uk)
Developmental neurobiology unit uses zebrafish as an animal model and will elucidate genetic program that regulate eye development. (oist.jp)

Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
During development, growing axons are guided to their appropriate targets by extracellular cues, the response to which depends crucially on the repertoire of receptors expressed by each axon and the intracellular mechanisms that transduce and regulate the response to these cues. (kcl.ac.uk)

However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers represent major etiological factors in numerous human diseases ( i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing and lifestyle (e.g. cancer, diabetes). (enhpathy.eu)
He suggested that during embryonic development the organs formed successively in an epigenetic manner. (biologydiscussion.com)

First described in 1924 by Hans Spemann and Hilde Mangold, the introduction of the organizer provided evidence that the fate of cells can be influenced by factors from other cell populations. (wikipedia.org)
In the three signal model, the dorsalizing signal from the organizer is mediated by bone morphogenic protein (BMP) gradients to give rise to cells of mesodermal fate. (wikipedia.org)
We study RNA binding proteins that control cell fate in the developing brain and are implicated in brain disease. (ox.ac.uk)
A combination of fate-mapping studies with genetic loss-of-function and gain-of-function experiments has been successfully used to uncover important molecular players in the development of the rodent telencephalon. (intechopen.com)
Simulations also predict in which conditions the dual control of gene expression by an activator and a repressor that are both under the control of ERK can induce a robust ON/OFF control of neural fate induction. (bvsalud.org)

In ascidians, a group of invertebrate chordates, geometry plays a key role in achieving this control. (bvsalud.org)

Organogenesis is highly regulated by genetic factors and molecular signaling mechanisms. (microbiologynote.com)

These results reveal that ciliary HH signaling mediates communication between the prechordal plate and the neurectoderm to provide cellular survival cues essential for development of the facial midline. (elifesciences.org)
In vertebrates, the establishment of L-R asymmetry is a conserved process initiated by breaking symmetry at an organising structure, consisting of an embryonic cavity at the midline that is filled with extraembryonic fluid. (bmj.com)

This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. (enhpathy.eu)
During development, cells undergo changes in gene expression patterns, leading to the development of distinct cell types and tissues. (microbiologynote.com)
The model describes signal transduction by the ERK pathway that is stimulated by FGF and attenuated by ephrin, and ERK-mediated control of Otx gene expression, which involves both an activator and a repressor of ETS-family transcription factors. (bvsalud.org)
The Control of synaptic gene expression. (edu.au)
Background Laterality in the vertebrate embryo is determined by left-right asymmetric gene expression driven by the flow of extraembryonic fluid across the embryonic node. (bmj.com)

MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. (stanford.edu)

He shared the 1995 Nobel Prize in Physiology or Medicine with Christiane Nüsslein-Volhard and Eric F. Wieschaus for work on genetic control of early embryonic development. (asu.edu)
Last not least, an increasing body of evidence suggests that membrane-bound extracellular vesicles play an important role in animal development and physiology. (unice.fr)

Evidence for an Otx2-dependent control of dorso-ventral patterning of the midbrain. (cnr.it)

However, little is known about its function in vertebrate development. (nature.com)
During vertebrate development, the retina is originally derived from anterior neural plate. (oist.jp)

Delta ligands and Notch receptors define a signaling pathway of major importance for development and disease. (unice.fr)

Through a better knowledge of how neural development normally occurs and how neurodegenerative pathologies develop we hope to provide information to aid neural regrowth and combat neural disease and injury. (kcl.ac.uk)

In parallel, we develop genetic tools to manipulate developmental processes and organoids. (irbbarcelona.org)
Our invited speakers and participants will discuss the multidisciplinary approaches required to investigate enhancer function as well as debate about the role of enhancers in fundamental biological processes ( e.g. embryonic development, evolution) and in the etiology of human disorders. (enhpathy.eu)
These processes are regulated by a combination of genetic programs, cell signaling, and physical forces. (microbiologynote.com)
Developmental biology employs a variety of techniques, including genetic analysis, molecular biology, imaging, and experimental manipulations, to investigate the processes underlying development. (microbiologynote.com)
In contrast, how other ESCRT-dependent processes such as the secretion of extracellular vesicles contribute to animal development remains largely to be understood. (unice.fr)
Through these projects, we will establish key concepts that govern development of multicellular organisms and also contribute to our understanding of pathological processes of human retinal diseases. (oist.jp)

How cell specification can be controlled in a reproducible manner is a fundamental question in developmental biology. (bvsalud.org)

The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
Animal development and homeostasis depend on precise temporal and spatial intercellular signaling. (xenbase.org)
Photoreceptors provide a useful model for studying such a surveillance mechanism of neuronal development and homeostasis, because there are many hereditary retinal diseases in humans associated with photoreceptor degeneration. (oist.jp)

In these mutants, the prechordal plate, an organizer of anterior head development, displayed defects in HH pathway activation at E8.0. (elifesciences.org)
In contrast, loss of the specific subunits of TRAPPII, another known Rab11-GEF, does not cause any defects on the eye development nor the transport of rhabdomere proteins, however, simultaneous loss of TRAPPII and Pcs shows severe defects on eye development. (sdbonline.org)
However, our understanding of the genetic causality for laterality defects in human beings remains relatively limited. (bmj.com)

Following this transplant, she observed the formation of a secondary embryonic primordium, consistent with their previous work. (wikipedia.org)
The overall aim of our research is to understand how the formation, function and dynamic remodeling of membrane-bound compartments governs the localization and activity of signaling molecules in animal development. (unice.fr)

Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
TAZ-AS202 expression is under the control of YAP/TAZ-containing transcriptional complexes. (bvsalud.org)
Sperber generously evaluates the Manifesto of the Communist Party as 'a literary masterpiece: compact, pithy, elegant, powerful and sarcastically amusing all at once, and was a deeply personal expression of Marx's own experiences and intellectual development. (blogspot.com)

These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)

This work provided the initial evidence to support the notion that there existed some "organization center" that was determined prior to the other embryonic tissue and influenced the determination of surrounding cells. (wikipedia.org)

Using a combination of genetic and live imaging approaches, we are aiming to dissect the functional links between neuro-epithelial polarity and Delta/Notch signalling. (unice.fr)

Our results from experiments and modeling suggest that Apcdd1 may coordinate the outputs of two signaling pathways that are central to animal development and human disease. (xenbase.org)

Differential dosage-dependent roles of OTX2 in specifying regional identities and neuronal cell types during brain development. (cnr.it)

Using unbiased bioinformatics approaches, we construct a cancer-related network of genetic interactions (GIs) of all Ephs and ephrins to assist in their therapeutic manipulation. (bvsalud.org)
Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)

Role of Otx1 in corticogenesis, pituitary functions and sense organs development. (cnr.it)
The meeting will feature sessions on cell signaling, clinical genetics, sense organs, development of animal models of craniofacial disorders, state-of-the-art imaging techniques, and the use of tissue engineering approaches for regenerative repair of craniofacial tissues. (grc.org)

Another major focus of our research is on post-transcriptional regulation during cortical development. (ox.ac.uk)
This talk will largely focus on our ongoing studies to understand how these layers of post-transcriptional regulation influence cortical development and disease. (ox.ac.uk)

The mechanisms of how this organizer operates has been the subject of decades of follow up research. (wikipedia.org)
NIAAA funding for its Research and Development (R&D) contract portfolio was $34.2 million. (nih.gov)
Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
The scientific program will feature a wide range of topics to highlight how interdisciplinary research has enabled us to push boundaries in our understanding of craniofacial research, including talks investigating the physics and mechanics of craniofacial development and regeneration. (grc.org)
Our research will open up new strategies to control Wnt signalling by altering its transport route in the tumour microenvironment. (exeter.ac.uk)

Sensitivity analyses and computations of Hill coefficients allow us to quantify the robustness of the specification mechanism controlled by cell surface area and to identify the respective role played by each signaling input. (bvsalud.org)

Another study found a genetic link between AP and synesthesia in a cohort of 768 subjects with self-documented AP. (jax.org)
The study of craniofacial development utilizes a variety of vertebrate species, including those that are not commonly used for laboratory studies. (grc.org)
logia = discourse) is a study of the origin and development of animals dealing with changes through which a fertilised egg must pass before it assumes the adult state. (biologydiscussion.com)

While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. (irbbarcelona.org)

They play a crucial role in development and are also important in adult organisms for tissue maintenance and regeneration. (microbiologynote.com)
Invited presentations by leading researchers and clinician scientists in the field will present new findings in craniofacial morphogenesis and regeneration, with specific focus on the role that mechanics plays in shaping development. (grc.org)
By understanding Wnt dissemination mechanisms, we will be able to control Wnt signalling in development, and regeneration. (exeter.ac.uk)

They have been also heavily implicated in cancer development and progression, with both oncogenic and tumor suppressor functions. (bvsalud.org)

My group has identified further molecules that may contribute to the development of the nervous system (Dolan et al. (kcl.ac.uk)

These data highlight the importance of membrane protein recycling during development. (sdbonline.org)

One line of inquiry is to understand genetic differences underlying human-specific brain development. (ox.ac.uk)
We are also interested in genetic changes that underlie human-specific brain development. (ox.ac.uk)
Due to the conserved nature of vertebrate cell behaviour, our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases - a prerequisite for the development of novel therapeutics. (exeter.ac.uk)

Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals. (bmj.com)

FIGURE 5 Diagram of a posterior view of the Left-Right organizer and its functions. (xenbase.org)

Periconceptional, fetal and neonatal period is crucial for organ development. (lu.se)

Anatomy53

Organisms25

Diseases4

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes77

Disciplines and Occupations5

Technology, Industry, Agriculture2

Humanities1

Information Science4

Health Care2

Earliest embryonic stages2

Dorsal4

Notochord2

Genes8

Spemann-Mangold6

Christiane Nusslei1

Precursors2

Forebrain2

Embryos6

Differentiation3

Mechanisms that control5

Stages6

Gastrulation4

Stem3

Murine1

Vivo2

Drosophila3

Cilia2

Mutations2

Proliferation1

Elucidate2

Regulate2

Epigenetic2

Fate5

Chordates1

Molecular signaling1

Midline2

Gene expression5

Cellular1

Physiology2

Dorso-ventral1

Vertebrate development2

Signaling pathway1

Neural1

Processes6

Fundamental1

Homeostasis3

Defects3

Formation2

Expression4

Proteins1

Determination1

Combination of genetic1

Pathways1

Neuronal1

Interactions2

Sense organs2

Post-transcriptional2

Research5

Specification1

Study3

Mammals1

Regeneration3

Progression1

Nervous system1

Membrane protein1

Human3

Role1

Left-Right1

Organ development1