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Angiogenic ProteinsEndothelial Growth FactorsPeptidesVascular Endothelial Growth Factor ANeovascularization, PhysiologicFibroblast Growth Factor 2Neovascularization, PathologicAngiogenesis Inducing AgentsVascular Endothelial Growth FactorsLymphokinesPeptide FragmentsPeptide LibraryVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-1Antimicrobial Cationic PeptidesEndothelial CellsPeptides, CyclicCells, CulturedReceptors, Vascular Endothelial Growth FactorAngiogenesis InhibitorsEndothelium, VascularOligopeptidesRNA, MessengerPeptide MappingAmino Acid SequenceIntercellular Signaling Peptides and ProteinsAngiopoietin-1CapillariesImmunohistochemistryMolecular Sequence DataNatriuretic Peptide, BrainReceptors, Growth FactorProtein BindingCell MovementAngiopoietin-2Signal TransductionCorneal NeovascularizationPregnancy ProteinsCell DivisionCell LineMice, Inbred C57BLBlood VesselsCell ProliferationRecombinant ProteinsCattleVasoactive Intestinal PeptideEnzyme-Linked Immunosorbent AssayBase SequenceReceptor, TIE-2Calcitonin Gene-Related PeptideUmbilical VeinsReverse Transcriptase Polymerase Chain ReactionHypoxia-Inducible Factor 1, alpha SubunitCell-Penetrating PeptidesReceptor Protein-Tyrosine KinasesHuman Umbilical Vein Endothelial CellsAntigens, CD31Blotting, WesternAllantoisPeptide BiosynthesisBinding SitesMice, NudePeptide YYCell Line, TumorThrombospondin 1HindlimbIschemiaDisease Models, AnimalTime FactorsKineticsPeptide Nucleic AcidsModels, MolecularChorioallantoic MembraneProtein ConformationNatriuretic Peptide, C-TypeDose-Response Relationship, DrugGene ExpressionChorionGene Expression RegulationCell HypoxiaCulture Media, ConditionedNatriuretic PeptidesTumor Cells, CulturedNeuropilin-1MicrocirculationGastrin-Releasing PeptideProtein Structure, SecondaryPeptide HydrolasesUp-RegulationChromatography, High Pressure LiquidTransfectionRats, Sprague-Dawley
VascularAngiogenesisExertSecretionAnti-inflammatoryPotentEndothelial cellFactorsInhibitorySerumMultifunctionalPDGFTissueClinicalCharacteristicsLesionsFactorBloodMembraneCellsHairVascular endothelialInhibitProteinsEndothelial cellsInhibitoryVivoMoleculesInhibitionSequenceReceptorsEnzymeGrowthGeneTherapyProteinInfectionEffectAgentsPatientsExpressionStandard
Vascular5
  • bFGF is a more potent angiogenic factor than VEGF ( vascular endothelial growth factor ) or PDGF ( platelet-derived growth factor ). (beauty104.com.tw)
  • Can the vascular endothelial growth factor (VEGF) and total estradiol 17β be used as a marker of equine oocyte maturation? (cloud-clone.com)
  • Expression of vascular endothelial growth factor (VEGF) has been linked to poor survival among osteosarcoma patients but the clinical relevance of monitoring blood and urine angiogenic factors is uncertain. (biomedcentral.com)
  • They include agents like vascular endothelial growth factor (VEGF) and blood vessel fibroblastic growth factor (bFGF). (unboundmedicine.com)
  • The vascular endothelium of the mature ovarian follicle maintains the capacity for rapid growth in response to angiogenic signals elaborated during the periovulatory process. (biomedcentral.com)
Angiogenesis4
  • A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and re-epithelization. (biomedcentral.com)
  • We further showed that transfection of integrin-linked kinase-siRNA decreased the protein degree of -even muscles actin and attenuated angiogenesis by lowering the connection of Q-dot tagged cells and secretion of angiogenic elements. (irjs.info)
  • Angiogenic Elements Secreted by MSCs Are Raised Under Hypoxic Circumstances It is more developed that another feasible system of MSCs taking part in Ureidopropionic acid tumor angiogenesis is normally by secretion of angiogenic elements. (irjs.info)
  • It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate -degrading enzymes activates bFGF, thus mediating the formation of new blood vessels , a process known as angiogenesis . (wikidoc.org)
Exert3
  • Endothelins exert their effects by binding to two distinct cell surface ET receptors, ET A and ET B . The ET B receptor (ET B R) binds the three peptide isotypes with equal affinity. (biomedcentral.com)
  • 14 Several SC factors such as peptides exert essential signals to promote hair regrowth. (benitonovas.com)
  • [11] However, a low concentration of bFGF (10 ng/mL) may exert an inhibitory effect on osteoblast differentiation . (wikidoc.org)
Secretion2
  • Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)
  • 05). As a total result, hypoxia improved the secretion of angiogenic elements of MSCs considerably, specifically in the circumstances that cocultured with U266 MSCs. (irjs.info)
Anti-inflammatory1
  • An anti-inflammatory bioactive peptide that soothes and calms irritated skin thanks to its antihistamine-like properties. (dermaspark.com)
Potent1
  • The endothelins, that includes three 21-aa peptides ET-1, ET-2 and ET-3, are potent vasoconstricting peptides, involved in the pathophysiology of different malignancies [ 1 , 2 ]. (biomedcentral.com)
Endothelial cell1
Factors6
  • This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
  • Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
  • Levels of VEGF and bFGF angiogenic factors are high in most osteosarcoma patients, but have no significant impact on response to chemotherapy or outcome in this large prospective series. (biomedcentral.com)
  • Many factors can contribute to high melanin concentrations. (dermaspark.com)
  • Soluble angiogenic factors 2.4.2. (docksci.com)
  • The granulosa cells and theca cells of the developing antral follicle and the steroidogenic cells of the corpus luteum produce and respond to angiogenic factors and vasoactive peptides. (biomedcentral.com)
Inhibitory1
  • Simvastatin dose dependently inhibited THP-1 cell migration mediated by monocyte chemoattractant protein 1, with a 50% inhibitory concentration of about 50 nM. (neuroprobe.com)
Serum3
  • VEGF and bFGF levels in serum and plasma and bFGF levels in urine were measured by ELISA at diagnosis, before surgery, and at the end of treatment. (biomedcentral.com)
  • High serum VEGF and bFGF levels were observed in respectively 61% and 51% of patients. (biomedcentral.com)
  • Serum and plasma VEGF values were not strongly correlated with one another ( r = 0.53). (biomedcentral.com)
Multifunctional1
  • A multifunctional bioactive peptide that promotes skin homeostasis and helps reduce redness and irritation caused by UV exposure, infection, and inflammation. (dermaspark.com)
PDGF1
  • The known degrees of the angiogenic elements including VEGF, PDGF, and bFGF had been assessed by ELISA. (irjs.info)
Tissue3
  • We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
  • A peptide secreted by the atrial tissue of the heart in response to an increase in blood pressure. (unboundmedicine.com)
  • In normal tissue, bFGF is present in basement membranes and in the subendothelial extracellular matrix of blood vessels . (wikidoc.org)
Clinical1
  • No significant association was found between blood or urinary bFGF levels and clinical characteristics, histological response, or survival. (biomedcentral.com)
Characteristics1
  • The aim of this study was to determine blood VEGF levels, and blood and urinary bFGF levels in osteosarcoma patients, and to investigate whether values at diagnosis or changes during treatment are associated with disease characteristics or outcome. (biomedcentral.com)
Lesions1
  • This peptide works to inhibit over-stimulation of the immune system and is particularly beneficial on active cystic lesions. (dermaspark.com)
Factor3
  • The aim of this study was to determine the prognostic significance of blood VEGF and blood and urinary basic fibroblast growth factor (bFGF) levels in osteosarcoma patients, both at diagnosis and during treatment. (biomedcentral.com)
  • However, a better knowledge of angiogenic factor levels and kinetics in body fluids during treatment is needed. (biomedcentral.com)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
Blood1
  • In addition, it is synthesized and secreted by human adipocytes and the concentration of FGF2 correlates with the BMI in blood samples. (wikidoc.org)
Membrane1
  • It stays membrane -bound as long as there is no signal peptide . (wikidoc.org)
Cells2
  • The contributions of vasoactive peptides generated by the luteal endothelin-1 and the renin-angiotensin systems are discussed in context with the function of endothelial cells during corpus luteum formation and regression. (biomedcentral.com)
  • Angiogenic elements secreted by mesenchymal stromal cells (MSCs) had been raised under Ureidopropionic acid hypoxic circumstances. (irjs.info)
Hair1
  • 22 The underlying mechanism is believed to be a higher concentration of dihydrotestosterone (DHT) to androgen-sensitive hair follicles, causing thinning of the dermal papillae and shortening of the anagen phase. (jcadonline.com)
Vascular endothelial3
  • Among the positive regulators are vascular endothelial growth factor (VEGF), fibronectin, 5-integrin, vascular endothelial cadherin, and transforming growth factor-1 (TGF-1). (medscape.com)
  • 8. The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. (nih.gov)
  • 18. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) in esophageal squamous cell carcinoma. (nih.gov)
Inhibit3
  • Thrombospondin-1 (TSP-1) is a potent antiangiogenic factor that has been shown to inhibit tumor growth by preventing endothelial cells from responding to a wide variety of angiogenic stimulators. (aacrjournals.org)
  • The human sulfatase 1 (hSulf-1) gene encodes an endosulfatase that functions to inhibit the heparin-binding growth factor signaling, including the basic fibroblast growth factor (bFGF)-mediated pathway, by desulfating the cell surface heparan sulfate proteoglycans (HSPGs). (oncotarget.com)
  • bFGF could stimulate cell cycle progression and inhibit cell apoptosis, this biological effect can be reversed by hSulf-1. (oncotarget.com)
Proteins2
  • Use of JNK inhibitory peptides derived in the JNK pathway scaffold protein, JIP Scaffold proteins, identified as JNK interacting proteins or JIPs, form an additional important characteristic of your JNK pathway. (her2signaling.com)
  • The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. (justia.com)
Endothelial cells2
Inhibitory1
  • Beta-catenin inhibitor kinase inhibitor Here we restrict our interest to reports over the efficacy of JNK inhibitory peptides appearing in the final many years considering the fact that that examine and we start off with recent research to the results in neuronal cells. (her2signaling.com)
Vivo3
  • METHODS: The in vivo survival and angiogenic activities of the spheroids or cell suspension composed of MSCs and ECFCs were measured in a murine hindlimb ischemia model and Matrigel plug assay. (bvsalud.org)
  • These peptides, within their cellpermeable type as a result of their conjugation to your Tat peptide , have already been employed to investigate results of JNK inhibition in cells and in vivo. (her2signaling.com)
  • The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. (justia.com)
Molecules2
  • 16. Angiogenic and lymphangiogenic molecules in hematological malignancies. (nih.gov)
  • Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules. (justia.com)
Inhibition1
  • In the current study, by reactivation of hSulf-1 expression and function in the hSulf-1-negative hepatocellular carcinoma (HCC) cell lines and HCC xenograft tumors, we found that hSulf-1 blocked the bFGF effect on the promotion of cell cycle and inhibition of apoptosis. (oncotarget.com)
Sequence1
  • We generated a rabbit antiserum against a peptide containing the RGD sequence of mouse lactadherin. (medscape.com)
Receptors2
  • 2. Immunohistochemical expression of angiogenic cytokines and their receptors in reactive benign lymph nodes and non-Hodgkin lymphoma. (nih.gov)
  • 7. Bone marrow immunohistochemical studies of angiogenic cytokines and their receptors in myelofibrosis with myeloid metaplasia. (nih.gov)
Enzyme2
  • Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo-peptidases. (biomedcentral.com)
  • The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). (nih.gov)
Growth4
  • Several studies indicate that hemangiomas are the outcome of an angiogenic growth factor effect. (medscape.com)
  • 7, 9, 10] Basic fibroblast growth factor (bFGF) and VEGF messenger RNAs are up-regulated in proliferative hemangiomas. (medscape.com)
  • Moreover, single spheroids of either MSCs or ECFCs secreted greater levels of pro-angiogenic factors than adherent cultured cells, and the hybrid spheroids of MSCs and ECFCs promoted the secretion of several pro-angiogenic factors, such as angiopoietin-2 and platelet-derived growth factor. (bvsalud.org)
  • In the nanotherapeutics approach, different forms of nanomaterials (nanoparticles, nanofibers, nanogels, nanoemulsion) that are loaded with antimicrobial agents, antimicrobial peptides, growth factors, interferons, and others through the delivery at wound site have been employed for the treatment of different types of wounds. (encyclopedia.pub)
Gene1
  • By RT-PCR, Mfge8 mRNA (which encodes lactadherin) was detected in mouse aorta and hindlimb muscle tissue, whereas expression of the gene encoding angiogenic Del-1 was undetectable (Fig. 1a). (medscape.com)
Therapy2
  • Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
  • NET RETREAT the CCTG NE1 trial has recently opened in North America looking to compare retreatment of Peptide Receptor Radionuclide Therapy versus standard treatment in patients with metastatic midgut neuroendocrine tumours. (queensu.ca)
Protein1
  • The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) pathways was suppressed by hSulf-1, which led to a decreased expression of the target genes Cyclin D1 and Survivin, then finally induced cell cycle arrest and apoptosis in HCC cells. (oncotarget.com)
Infection1
  • The advantages include an improved half-life and bioavailability of drugs, improved penetration of drugs into bacterial biofilms and tissue barriers, enhancement of interactions between drugs and microbes, and the ability to increase the concentration of drugs at infection sites [ 12 ] . (encyclopedia.pub)
Effect1
  • 12. [Study of the changes and effect of VEGF and bFGF in early stage of maxillofacial blast injury in rabbits]. (nih.gov)
Agents1
  • Moreover, nanoparticulate drug delivery systems using different nanocarriers provide sustained and controlled delivery of a wide range of drugs/therapeutic agents at an optimal concentration with an extended half-life, improved bioavailability, improved pharmacokinetic profiles, and decreased drug administration frequency [ 7 ][ 8 ] . (encyclopedia.pub)
Patients1
  • In contrast, in patients with vascular malformations, normal concentrations of bFGF are found in the urine. (medscape.com)
Expression1
  • 15. Correlation of bFGF, FGFR-1 and VEGF expression with vascularity and malignancy of human astrocytomas. (nih.gov)
Standard1
  • These consist of the standard L amino acid containing peptides TI JIP, TAT TIJIP and L JNKI, along with the Damino acid containing retroinverso peptide, D JNKI. (her2signaling.com)