Concentrations of sodium arsenite. Medical search. Frequent questions

In an in vitro mammalian cell gene mutation test performed similarly to OECD guideline 476, L5178Y/ TK+/- mouse lymphoma cells were exposed to sodium arsenate at concentrations of 26, 34, 46, 61 and 81 μg/mL in the absence of metabolic activation and the exposure duration was 3 hours. (europa.eu)
No significant increases in mutant frequency were observed following treatment of sodium arsenate in the absence of metabolic activation. (europa.eu)
Under the test conditions, sodium arsenate is not considered as mutagenic in mouse lymphoma L5178Y cells. (europa.eu)
Arsenic is found in mainly in two forms: arsenite and arsenate. (easyreport.in)
Both forms are toxic: arsenite disrupts sulfhydryl groups of proteins and interferes with enzyme function, whereas arsenate acts as a phosphate analog and can interfere with phosphate uptake and transport. (easyreport.in)
Resistance to arsenic species in both Gram-positive and Gram-negative organisms results from energy-dependent efflux of either arsenate or arsenite from the cell, mediated by the ars operon [4-6]. (easyreport.in)
The following reaction-oxidation of arsenite, (AsO 3) 3− -in aqueous solution proceeds only in the presence of sodium hydrogen carbonate, which acts as a buffer: In acidic solution, arsenate, (AsO 4 ) 3− , is reduced to arsenite, whereas, in strongly alkaline solution, iodine is unstable, and the reverse reaction occurs. (blackpointstudio.it)
The reaction involved is: I2 + 2Na2S2O3 2NaI + Na2S4O6 I2 + 2S2O32- 2I- + S4O62-In this equation I2 has been reduced to I- :- The following reaction-oxidation of arsenite, (AsO 3) 3− -in aqueous solution proceeds only in the presence of sodium hydrogen carbonate, which acts as a buffer: In acidic solution, arsenate, (AsO 4 ) 3− , is reduced to arsenite, whereas, in strongly alkaline solution, iodine is unstable, and the reverse reaction occurs. (blackpointstudio.it)
Because of the importance of this reaction in controlling the equilibrium concentrations of arsenate and phosphate in soil, in this research, arsenate adsorption on calcite was measured and modeled as a function of arsenate concentration and ionic strength and also in competition with phosphate. (ac.ir)
Adsorption isotherms showed that arsenate adsorption is affected by the ionic strength and the initial concentration of arsenate. (ac.ir)
Arsenate adsorption was also decreased with increasing phosphate concentration, but arsenate had no effect on phosphate adsorption indicating phosphate is adsorbed stronger than arsenate on calcite. (ac.ir)
Competitive adsorption of arsenate and arsenite on oxides and clay minerals. (ac.ir)
There are four oxidation states of arsenic (As) such as arsines and methyl arsines (As 3- ), elemental arsenic (As 0 ), arsenite (As 3+ ) and arsenate (As 5+ ), the inorganic form (As 3+ or As 5+ ). (ijpsr.com)
The arsenite (As 3+ ) is 10 times more toxic than arsenate (As 5+ ) 6, 7, 8, 9 . (ijpsr.com)
2 μm), as arsenate (+5 oxidation state) and arsenite (+3 oxidation state). (biomedcentral.com)
Relative effects of arsenate on sodium, phosphate, and glucose transport by the rabbit proximal tubule. (springer.com)

The US Geological Survey, in a study of all major aquifers in the United States, estimated that 7% of household wells have arsenic concentrations that exceed the Environmental Protection Agency's maximum contaminant level (MCL) of 10 ppb, leaving roughly 4.2 million people with the responsibility of taking corrective action themselves (Ayotte et al. (nationalacademies.org)
There is increasing evidence that dietary inorganic arsenic makes an important contribution to total inorganic arsenic exposure, particularly when inorganic arsenic concentrations in water are low. (nationalacademies.org)
2007). A recent evaluation of data on 2,323 children 6-17 years old who participated in 2003-2008 NHANES studies found that children who reported consuming rice had urinary arsenic concentrations that were nearly 40% higher than concentrations in those who did not consume rice (Davis et al. (nationalacademies.org)
Cell cycle analysis revealed arsenite-sensitive cells arrested in mitosis whereas arsenite-resistant cells did not, suggesting that induction of mitotic arrest occurs at lower intracellular arsenic concentrations. (uky.edu)
In the resveratrol + As 2 O 3 -treated group, activities of glutathione peroxidase, catalase, and superoxide dismutase, the ratio of reduced glutathione to oxidized glutathione, the total arsenic concentrations, and the percentage of methylated arsenic in urine were significantly increased. (springer.com)

However, the proliferative role of two endocrine disrupters, cadmium chloride and sodium arsenite, in lung adenocarcinoma is less clear. (bellarmine.edu)
NCI-H1793 adenocarcinoma lung cells were treated with the ERβ antagonist, PHTPP, before cells were treated for ten minutes with nanomolar concentrations of 17β-estradiol, cadmium chloride, or sodium arsenite. (bellarmine.edu)
These results support that cadmium chloride and sodium arsenite induce phosphorylation of ERK1/2 as expected. (bellarmine.edu)
Embryonic and/or larval stages of the leopard frog (Rana pipiens), domestic fowl (Gallus domesticus) and the goldfish (Carassiua auratus) were treated with cadmium chloride, mercuric chloride, lead chloride, zinc chloride and sodium arsenite. (uky.edu)

A375 and SK-Mel-2 cells were sensitive to clinically achievable concentrations of arsenite, whereas SK-Mel-3 and SK-Mel-28 cells required supratherapeutic levels for toxicity. (uky.edu)
Microorganisms have evolved a variety of mechanisms for coping with arsenic toxicity, including minimizing the amount of arsenic that enters the cell (e.g., through increased specificity of phosphate uptake), oxidizing the arsenite (through the activity of arsenite oxidase), or arsenite peroxidation with membrane lipids. (easyreport.in)
Organification of arsenite is an effective way for organisms to cope with arsenic toxicity. (biomedcentral.com)
Microbial communities are vital contributors to the global arsenic biocycle and represent a promising way to reduce arsenite toxicity. (biomedcentral.com)
Due to its toxicity in very low concentrations, and the fact that it is nearly impossible to detect, all private well owners should have an EPA certified analytical laboratory test their well water. (mwclearreflections.com)

The lack of arsenite-induced mitotic arrest in resistant cell lines was associated with a weakened spindle checkpoint resulting from reduced expression of spindle checkpoint protein BUBR1. (uky.edu)

Sanyal SK, Mou TJ, Chakrabarty RP, Hoque S, Hossain MA, Sultana M (2016): Diversity of arsenite oxidase gene and arsenotrophic bacteria in arsenic affected Bangladesh soils. (owsd.net)

This cycling process occurs depending upon few factors such as its oxidation state, speciation, concentrations and the presence of organic matter, competing ions, and other environmental factors ( e.g ., pH, redox). (ijpsr.com)
Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. (springer.com)

The chemical equation for the reaction described above is given by 4Na 2 S 2 O 3 3Na 2 SO 4 + Na 2 S 5 When exposed to dilute acids such as dilute hydrochloric acid, the sodium thiosulfate salt undergoes a decomposition reaction to yield sulphur along with sulphur dioxide. (blackpointstudio.it)
In the measurement of arsenic by AAS-HG there are several interference due to transition metal ions, which forms hydride during reaction with sodium borohydride, sodium hydroxide and hydrochloric acid [ 9 - 12 ]. (biomedcentral.com)

In Chinese hamster cells, arsenite did not induce ouabain-resistant mutants or thioguanine-resistant mutants. (europa.eu)

When evaluating whether a dose-dependent relationship was present, seventeen of the eighteen compounds led to greater DNA damage with increasing exposure concentrations. (cdc.gov)
As species concentrations in addition to other continuous variables were dichotomized by the medians and modelled as categorical variables in order to explore using the binary logistic regression possible associations between As exposure and semen quality. (biomedcentral.com)
Ingestion is the main route of exposure to other arsenites and arsenates for the general population. (cdc.gov)
OSHA PEL (permissible exposure limit) = 10 µg/m 3 as an 8-hour TWA concentration (as As) for inorganic arsenic (OSHA 2006). (cdc.gov)

Equation Sodium If you pipette a known volume of a solution containing copper(II) ions into a flask, and then add an excess of potassium iodide solution, you get the reaction we have just described. (blackpointstudio.it)
Write a balanced ionic equation for the reaction of sodium nitrite and potassium permanganate in an acidic solution. (blackpointstudio.it)
MRP2 mRNA and proteins levels could be markedly induced by remedies with metalloid salts including sodium arsenite [As(III)] and potassium antimonyl tartrate in principal rat and individual hepatocytes [22]. (healthanddietblog.info)

Sorption of phosphate on goethite at high concentrations. (ac.ir)

Local attraction of substrates and co-substrates enhances weak acid and base transmembrane transport, and principles in the attraction and facilitation of weak acid and base transport substrates, including monocarboxylates, ammonium, bicarbonate, and arsenite, plus protons as a co-substrate have been elucidated ( Epalle and Beitz 2022 ). (tcdb.org)

Adding sodium oxide to water produces sodium hydroxide. (blackpointstudio.it)

This metalloid occurs worldwide and many of its forms, especially arsenite [As(III)], cause various diseases including cancer. (biomedcentral.com)

Inhibition of glutathione synthesis, glutathione S-transferase (GST) activity, and multidrug resistance protein (MRP) transporter function attenuated arsenite resistance, consistent with studies suggesting that arsenite is extruded from the cell as a glutathione conjugate by MRP-1. (uky.edu)

Under the test conditions, sodium arsenite is not considered as mutagenic to E. coli or to Chinese hamster cells. (europa.eu)
A dose-related effect was observed: highest concentration (10-2 µM sodium arsenite) induces 28.33 and 22.4% hyperploid cells in first and second division respectively and 29% tetraploid cells. (europa.eu)
ICP-MS analysis indicated that arsenite-resistant SK-Mel-28 cells did not accumulate less arsenic than arsenite-sensitive A375 cells, suggesting that resistance was not attributable to reduced arsenic accumulation but rather to intrinsic properties of resistant cell lines. (uky.edu)
They are also found at the location where heavy metals concentration is extremely high enough to sustain the life, because heavy metals are well known toxic forms to living cells. (easyreport.in)
Heavy metals on the other hand are normally toxic to cells even at very low concentration, thus presents a serious threat to life forms. (easyreport.in)
Effects of Thuja occidentalis ethanolic extract on viability of A549 cell line (A) and L-132 cell line (B) Cells were exposed to Thuja occidentalis ethanolic extract for 24 h at different concentrations and the cell viability was determined by MTT assay. (jcimjournal.com)
Effects of Thuja occidentalis ethanolic extract on cellular proliferation tested by BrdU incorporation assay Cells were exposed to three different concentration of Thuja occidentalis ethanolic extract for 6, 12 and 24 h along with incorporation of BrdU. (jcimjournal.com)

Recent study shows that lung cancer is significantly higher in the areas where arsenic concentration is 1.77 ng/m 3 or more [ 8 ]. (biomedcentral.com)
Such studies become important when experimental results conclude that lung cancer is significantly higher in the areas where arsenic concentration is 1.77 ng/m 3 or more. (biomedcentral.com)
The concentrations of renal malondialdehyde, reactive oxygen species, 8-hydroxydeoxyguanosine, serum creatinine, blood urea nitrogen, and renal arsenic accumulation were significantly decreased and reduced renal morphologic injury was observed compared with the As 2 O 3 -treated group. (springer.com)

An in vitro gene mutation assay was conducted with sodium arsenite in the supF gene of pZ189 shuttle vector system in DNA repair proficient GM0637 human fibroblasts to determine whether arsenic alone induces mutation and whether the combination of arsenic and UV irradiation leads to a yield of mutants greater than the sum of the arsenic or UV treatments alone. (europa.eu)
The arsenite methylation activity of ArsR M and its ability to bind to its own gene promoter were confirmed. (biomedcentral.com)
Amazingly, we also discovered that these steady gene which encodes a copper concentration-dependent transcription aspect for the appearance of many genes mixed up in uptake of iron and copper [49]. (healthanddietblog.info)

Bifunctional protein ArsRM contributes to arsenite methylation and resistance in Brevundimonas sp. (biomedcentral.com)
M20 with arsenite and roxarsone resistance was isolated from aquaculture sewage. (biomedcentral.com)
A 3,011-bp arsenite resistance ars cluster arsHRNBC and a 5649-bp methionine biosynthesis met operon were found on the 3.315-Mb chromosome. (biomedcentral.com)
Expression of ArsR M in E. coli increased its arsenite resistance to 1.5 mM. (biomedcentral.com)

In an in vitro chromosomal aberration assay conducted similarly to OECD Guideline 473, whole blood cultures were incubated for 72 hours and treated with various concentrations (1-10-10 µM) of sodium arsenite for the last 24 hours. (europa.eu)
Using the comet assay, 16 compounds at 10 nM concentration, induced a significant amount of DNA damage compared to the control. (cdc.gov)

Uncertainty/variability in measurement of NO2 in ambient air using Sodium Arsenite (SA) manual monitoring method (also known as modified Jacob & Hochheiser method) has been assessed through co-located sampling. (deepdyve.com)

In the E. coli system, Trp+ revertants were not induced by arsenite in spot tests, treat and plate protocols, or fluctuation tests. (europa.eu)

been associated with urinary arsenic concentration, including inorganic arsenic and its metabolites monomethyl arsenic (MMA) and dimethyl arsenic (DMA), in pregnant women (Gilbert-Diamond et al. (nationalacademies.org)
Five urinary As species were analyzed by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Clinical information on the semen volume, sperm concentration and motility was employed to catalogue and evaluate semen quality according to WHO guidelines. (biomedcentral.com)

It is highly toxic even at low concentrations. (ijpsr.com)

Of all the food components of the US Market Basket Survey, rice-particularly rice grown in the south central United States-has the highest concentration of inorganic arsenic (Schoof et al. (nationalacademies.org)

Twenty four male Wistar rats were divided into 4 groups of 6 animals each and treated as follows: Group 1: sham control, 2: arsenic control (sodium arsenite @ 10 mg/kg b. wt orally for 4 wks), 3: Pre-treatment with NAC (@ 300 mg/kg orally for 2 wks) followed by sodium arsenite along with NAC (as per above doses) and 4: Sodium arsenite + NAC (as per above doses for 4 wks). (jnsbm.org)
The half maximal inhibitory concentration (IC 50 ) dose (282 μg/mL) was determined, and two other doses for dose-dependence study, one below the IC 50 dose (IC35 =188 μg/mL) and one above the IC 50 dose (IC65=376 μg/mL) were selected. (jcimjournal.com)

Restriction digest and DNA sequencing analyses indicated that arsenite alone produces large-scale rearrangements, frameshifts and base substitutions. (europa.eu)

The reaction of Ethanoic acid with Sodium. (blackpointstudio.it)
Sodium - Periodic Table This prevents any readily apparent reaction of equation 3. (blackpointstudio.it)
Assuming that sodium bicarbonate is the limiting reactant, determine the percent yield of a reaction between 2.01 g of sodium bicarbonate and 24.6 mL of 1.5 M acetic acid? (blackpointstudio.it)

Prolonged soil flooding causes an increase in dissolved As concentrations in paddy soils. (attentivelab.com)

Poisson distribution followed by student's t-test was used to assess the effects of sodium arsenite on mutant frequencies. (europa.eu)

The mutator effect of a tif-1 strain was partially blocked by arsenite. (europa.eu)
The minimum inhibitory concentration of the roxarsone resistant strain Brevundimonas sp. (biomedcentral.com)

A phorbol-12- myristate-13-acetate (16561298) (PMA) dose of 10 nanograms per milliliter, a phenol (108952) dose of 1mg/ml, and a sodium-arsenite (7784465) concentration of 4 millimolar were added to cell cultures. (cdc.gov)
Sodium arsenite treatment decreased circulating levels of estradiol in a dose and time-dependent manner, along with decrease in the levels of both LH and FSH. (biomedcentral.com)

After the analysis of data of seven diverse sites of Delhi, it has been concluded that during the period from 31st Jan. 2008 to 7th Feb. 2008 the arsenic concentration varies from 1.44 ± 0.25 to 5.58 ± 0.55 ng/m 3 with 95% confidence level (k = 2). (biomedcentral.com)

Arsenite did not cause the induction of lambda prophage. (europa.eu)

This leads to ecological problems and it is frequently present in high concentrations in drinking water. (easyreport.in)
This study was aimed at determination of the beryllium concentration and its temporal variation in stream water and sediment (mud). (deepdyve.com)
According to the U.S. Geological Survey and Centers for Disease Control and Prevention, an estimated 2.1 million people in the United States may be getting their drinking water from private water wells considered to have high concentrations of arsenic, presumed to be from natural sources. (mwclearreflections.com)

Under the test conditions, sodium arsenite was found to have an aneuploidogenic and a mitotic arrestant effect in cultured human lymphocytes. (europa.eu)
Sodium arsenite was tested at the concentrations of 1, 2.5 and 5.0 µM in GM 637 human fibroblasts for 72 hours and plasmid was irradiated with 320 J/m2. (europa.eu)
As it is a known human carcinogen it can adversely affect human health even at low concentrations (0.002mg/l) 10 . (ijpsr.com)

The purpose of this study was to determine if estrogen receptor β (ERβ), the predominant estrogen receptor in lung tissue, induces activation of ERK1/2 upon stimulation with cadmium and arsenite. (bellarmine.edu)

Although OAMs can accelerate reduction processes and increase DOM content in soils, the application of OAMs decreases available As content, thereby lowering As concentrations in rice plants19,20. (attentivelab.com)

Concentrations of mercury as low as 10 ppb, with continuous treatment, produced a 100% kill of frog embryos and a significant degree of lethality in chick embryos. (uky.edu)

These data suggest that arsenite has potential for treatment of solid tumors but a functional spindle checkpoint is a prerequisite for a positive response to its clinical application. (uky.edu)
The second most common POE treatment is to use a strong base anion exchange resin regenerated with sodium chloride. (mwclearreflections.com)

A higher concentration of. (seafwa.org)

Cadmium and lead also produced detectable levels of lethality and/or anomalous development when administered to chick embryos at concentrations of 10 ppb. (uky.edu)
It is considered particularly dangerous, like lead or mercury, even at low concentrations, and has no visible color, taste, or odor when present. (mwclearreflections.com)

In high enough concentrations, arsenic poisoning can result in vomiting and diarrhea, shock, and severe dehydration. (mwclearreflections.com)

Although, its natural sources are igneous and sedimentary rocks, the anthropogenic source of arsenic (As) plays an important role to maintain its concentration in our environment. (ijpsr.com)

Effect of added lattice ions on the charge properties and adsorption of sodium polyacrylate. (ac.ir)

The major benefits of many adsorption medias is the lack of need for regenerants such as sodium chloride, and the lack of arsenic dumping risk. (mwclearreflections.com)

However, overstimulation of ERK1/2 by PHTPP alone made it difficult to determine if ERβ is involved in cadmium and arsenite stimulated ERK1/2 activation. (bellarmine.edu)

Induced phosphorylation of ERK1/2 by these compounds is decreased in the presence of an estrogen receptor antagonist, ICI-182,780, suggesting that cadmium and arsenite stimulate these responses, in part, via a non-genomic estrogen signaling pathway. (bellarmine.edu)

Anatomy5

Diseases1

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes11

Information Science1

Health Care1

Arsenate16

Arsenic concentrations5

Cadmium chloride4

Toxicity5

Mitotic arrest1

Oxidase1

Oxidation state2

Hydrochloric acid2

Induce1

Exposure4

Potassium3

Phosphate1

Ammonium1

Hydroxide1

Metalloid1

Glutathione1

Cells7

Significantly3

Gene3

Resistance4

Assay2

Measurement1

Coli1

Urinary2

Toxic1

Highest concentration1

Doses2

Produces1

Reaction3

Soil1

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Strain2

Dose2

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Water3

Human3

Lung1

Rice1

Continuous1

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Lead2

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